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瞿希贤音乐手稿的收藏、保存与研究

人民音乐 2020年第7期 50-55页

作者：郭娜中央音乐学院图书馆

说起瞿希贤,想必大家最熟悉的就是那首伴随着几代人成长的歌曲《听妈妈讲那过去的事情》。作为共和国成立后第一代女性作曲家,瞿希贤的主要音乐创作集中在20世纪50年代以后,她的音乐作品与国家的发展紧密相连。她经历着时代的变迁与发展... 详细信息

说起瞿希贤,想必大家最熟悉的就是那首伴随着几代人成长的歌曲《听妈妈讲那过去的事情》。作为共和国成立后第一代女性作曲家,瞿希贤的主要音乐创作集中在20世纪50年代以后,她的音乐作品与国家的发展紧密相连。她经历着时代的变迁与发展,创作并改编出大量既能展现时代精神风貌又被观众喜闻乐见的优秀作品.

关键词：瞿希贤女性作曲家音乐创作音乐作品时代的变迁紧密相连精神风貌优秀作品

Prevalence and risk factors of enteral nutrition intolerance in intensive care unit patients: a retrospective study

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Chinese Medical Journal 2022年第15期135卷 1814-1820页

作者： Kunrong Yu na guo Dingding Zhang Ying Xia Yanling Meng Li Weng Bin Du Department of Pulmonary and Critical Care Medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical SciencesBejing 100730China Department of Nursing State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical SciencesBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CllegeBejing 100730China Department of Medical Intensive Care Unit State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical SciencesBejing 100730China

Background: Feeding intolerance (FI) among intensive care unit (ICU) patients undergoing early continuous enteral nutrition (EN) is related to poor outcomes. This study aimed to explore the prevalence and risk factors of FI in ICU ***: We retrospectively enrolled 1057 patients who received early continuous EN via a nasogastric tube between January 2014 and August 2019. The prevalence of FI during the first 7 days of ICU stay was calculated, and the risk factors were investigated using multivariate logistic regression ***: The prevalence of FI during the first 7 days of ICU stay was 10.95%. FI occurred in 159 of 1057 (15.04%) patients on ICU day 2, 114 of 977 (11.67%) patients on ICU day 3, and 86 of 715 (12.03%) patients on ICU day 7. Mechanical ventilation (MV) (odds ratio [OR]: 1.928, 95% confidence interval [CI]: 1.064–3.493,P = 0.03) was an independent risk factor for FI defined by a gastric residual volume (GRV) of 200 mL and/or vomiting, and acute renal failure (OR: 3.445, 95% CI: 1.115–10.707,P = 0.032) was an independent risk factor of FI defined by a GRV of 500 mL and/or vomiting. Continuous renal replacement therapy (CRRT) was an independent predictor regardless of the FI defined by a GRV of 200 mL (OR: 2.064, 95% CI: 1.233–3.456,P = 0.006) or 500 mL (OR: 6.199, 95% CI: 2.108–18.228,P = 0.001) in the ICU ***: FI occurs frequently in early ICU days, especially in patients receiving MV and CRRT. However, further investigation of a consensus definition of FI and risk factors is still warranted in future studies.

关键词： Continuous enteral nutrition Feeding intolerance Intensive care unit Risk factor Continuous renal replacement therapy

Bio-characteristic profiling related to clinic:A new technology platform for quality evaluation of Chinese materia medica

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TMR Modern Herbal Medicine 2019年第4期2卷 215-224页

作者： Li-na Wen Ai-Ting Wang na guo Yumei Han Can Yan Dan Yan Beijing Shijitan Hospital Capital Medical University Beijing China Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use Beijing China International Cooperation & Co-construction Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use Beijing China. Experimental Research Center China Academy of Chinese Medical Sciences Beijing China. Beijing Physical Examination Center Beijing China. Guangzhou University of Chinese Medicine Guangzhou China.

Quality evaluation is a bottleneck restricting the modernization and internationalization of Chinese materia medica (CMM). Due to characteristics of multi-component, multi-efficacy, multi-target, the existing quality evaluation system still cannot fully meet quality control needs of CMM. Hence, the author put forward “Bio-characteristic profiling related to clinic, BPRC” academic concept, meanwhile, fully take the advantage of analysis method with clinical monitoring superiority or profiling characteristics, build up “BPRC” new technology platform, in order to realize “real-time, dynamic and full-range monitoring” new technologies of CMM quality evaluation system and promote the further development of CMM industry.

关键词： Bio-characteristic profiling related to clinic Correlation efficacy Quality evaluation of Chinese materia medica

SEVEN CASES OF EPITHELIAL OVARIAN CARCINOMA WITH BRAIN METASTASIS

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Chinese Medical Sciences Journal 2008年第1期23卷 19-22页

作者： Jia-xin Yang Keng Shen Ying Shan Li-na guo Hui-fang Huang Jing-he Lang Ming Wu Ling-ya Pan Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To summarize the clinical characteristics, treatment, and prognosis of brain metastasis in patients with epithelial ovarian carcinoma. Metbods Retrospective analysis was conducted in 7 cases of brain metastases of epithelial ovarian carcinoma from January 1986 to March 2007 in Peking Union Medical College Hospital for summarizing therapy results and prognosisaffecting factors. Results Incidence of brain metastases of epithelial ovarian carcinoma was about 0. 66% （7/1 055 ）. Serous adenocarcinoma was the predominant pathological type in 4 cases and the subsequent was adenocarcinoma in 3 cases. All the patients were diagnosed at late stage, 6 cases with the International Federation of Gynecology and Obstetrics （HGO） stage Ⅲc and 1 with FIGO stage IV. The mean duration from diagnosis of ovarian carcinoma to brain metastasis was 32.7 ± 20. 0 months （range, 23-73 months）. Single metastasis focus occurred in 43% of cases and multiple metastases in 57% of cases. Fifty-seven percent of patients presented extracranial metastasis. Serum CA125 played a role in monitoring reoccur- rence and brain metastases. The average survival time was about 12 months. Better treatment with prolonged survival could be achieved by combination of operation and chemotherapy or combination of radiotherapy with chemotherapy. Concltusions As a rare condition, brain metastasis of epithelial ovarian carcinoma is rising in incidence with improved treatment of ovarian carcinoma and prolonged survival. However, brain metastasis indicates bad prognosis which can be improved by combined therapy.

关键词： ovarian carcinoma brain metastasis cytoreductive therapy chemotherapy

Study of recombinant human interleukin-12 for treatment of complications after radiotherapy for tumor patients

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World Journal of Clinical Oncology 2017年第2期8卷 158-167页

作者： na guo Wen-Qin Wang Xiao-Jing Gong Lei Gao Li-Rong Yang Wei-na Yu Hong-Yu Shen Ling-Qin Wan Xi-Feng Jia Yi-Shan Wang Yi Zhao Center for Tumor Treatment People’s Liberation Army 107~(th)Hospital Academy of Military Medical Sciences Sanatorium for Retired Cadres Kang Litai Pharmaceutical Co.Ltd

AIM To evaluate the treatment effects of recombinant human interleukin-12(rh IL-12) on radiotherapy complications, such as severe myelosuppression or pancytopenia, the decline or imbalance of immune function, *** The patients received high-dose and short-course precise radiotherapy, such as Cyber knife and image-guided radiotherapy(IGRT), which can cause myelosuppression or pancytopenia and immune function decline within a short time. One-hundred subjects were enrolled in the study, and 50 were randomized to a treatment group which used rh IL-12 and 50 were randomized to a control group which used symptomatic and supportive therapy after radiotherapy. The 50 subjects in the treatment group were further divided into five subgroups and intervenedwith rh IL-12 at a dose of 50, 100, 150, 200 or 250 ng/kg respectively. The dose-effect relationship was observed. RESULTS Rh IL-12 significantly attenuated the decrease of peripheral blood cells in the treatment group, and immune function was improved after treatment. Due to the different radiation doses, there was a fluctuation within 12 h after treatment but mostly showing an increasing trend. As to the clinical manifestations, 2 patients in the 250 ng/kg subgroup showed low fever after administration, 1 patient in the 200 ng/kg subgroup and 2 patients in the 250 ng/kg subgroup showed mild impairment of liver function during the observation *** Rh IL-12 has effective therapeutic and protective effects on complications following radiotherapy, such as the decline of blood cells, myelosuppression and the decline or imbalance of immune function, which indicated good prospects for development and application.

关键词： Recombinant human interleukin-12 Cancer prevention Radiotherapy complications Clinical research

Formation Process and Properties of Phytic Acid Conversion Coatings on Magnesium

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Journal of Surface Engineered Materials and Advanced Technology 2011年第1期1卷 15-21页

作者： Jian-Rui Liu Yi-na guo Wei-Dong Huang 不详

A chromium-free conversion coating treatment for magnesium by phytic acid solution was studied. The formation process of phytic acid conversion coating was studied through measuring the open circuit potential (OCP) and weight change of the pure magnesium in the different conversion treatment time. The morphologies and compositions of the coatings were determined by SEM and EDS respectively. The conversion coating has the multideck structure with netlike morphology which is similar to the chromate conversion coating, and is mainly composed of Mg, P, O and C. The contents of C and P and the size of the cracks in different layers decrease from the external layer to the inner layer. The hydroxyl groups and phosphate carboxyl groups in the coating which have the similar properties to organic paintcoat are beneficial to the combination of substrate and organic paintcoat. The formation mechanism and thickness variation of the conversion coatings are also discussed.

关键词： Magnesium Chemical Conversion Coatings Phytic Acid Formation Mechanism

An efficient Mn1-yCeyOx composite oxide mesoporous catalysts for catalytic combustion of aromatic hydrocarbon

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An efficient Mn1-yCeyOx composite oxide mesoporous catalysts...

The Hematopoietic and Immunomodulatory Effect of rhIL-12 for Liver Cancer

第二十六届大气污染防治技术研讨会

作者： na guo Luxiang Jiang Dengtai Wang Zuwu Wang School of Resource and Environmental Sciences Wuhan University

A simple and effective method, utilizing the molten metal salts from heated solid metal salt sources as the solvents to dissolve a polymerizable, was successfully synthesized catalysts with a mesoporous structure. A series of MnCeO composite oxide catalysts were prepared by a molten polymerization method. The characteristics of the catalysts were investigated by using the X-ray diffraction（XRD）, Brunauer Emmett Teller（BET）, X-ray photoelectron spectroscopy（XPS） and H2temperature programmed reduction（H-TPR）. Compared with pure MnO and CeO catalysts, MnCeO catalyst have higher redox property and ability to adsorbed oxygen species. The catalysts were investigated for the catalytic combustion of toluene and CB, which were the typical volatile organic compounds（VOCs）. Based on the T90%, the catalytic activity ranking was: MnCeO>MnO>MnCeO>MnCeO>CeO. The MnCeO catalyst displayed the best activity for toluene oxidation at 207 ℃ and for CB oxidation at 350 ℃ under the different Mn/Ce ratios. Furthermore, MnCeO exhibited excellent catalytic stability for 20 h in the catalytic oxidation of toluene and CB. Doping of an appropriate amount of Ce increases the Mnand Ce on the catalyst surface, thereby increasing the number of oxygen vacancies. The good catalytic performance of MnCeO is attributed to the active oxygen species on the surface, low-temperature reducing ability and oxygen vacancies. We hope that this work will provide an industrially strategy for the preparation of hybrid multi-metal oxides and is a promising candidate for developing efficient MnCeO catalysts for the catalytic combustion in VOC removal.

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第1期5卷 33-41页

作者： Xiaojing Gong na guo Lingqin Wan Xifeng Jia Yishan Wang Binzhou Medical University Yantai China Center for Tumor Diagnosis and Treatment of the Whole Army 107th Hospital of the People’s Liberation Army Yantai China

Purpose: To explore the effect of rhIL-12 on the number of the blood cells and CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells in liver cancer patients following radiation therapy. Methods: We selected forty liver cancer patients who carried out by cyber knife (the patients were given 5 Gy every time for 5 times continuously) to observe the size of the tumor. After thirty hours, rhIL-12 was injected into the liver cancer patients via subcutaneous at the concentration of 50 ng/kg, 100 ng/kg, 200 ng/kg and 300 ng/kg in different patients, respectively. And there were ten patients in the four groups, respectively. The twenty patients who were selected from the hospital without rhIL-12 treatment were used as controls. All the blood cells were collected from different groups on day 0, hour 12, day 7, day 14, day 21 and day 28 after rhIL-12 treatment, respectively. The full number of blood cells in every group was analyzed by ELISA. The number of CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells were detected by Flow Cytometry. After one month with rhIL-12 treatment, ECOG and WHO were used to evaluate the prognosis of liver cancer. Results: In present study, we found that the number of blood cells was significantly decreased on day 0 - day 3, while recovered from day 7 - day 14 and down-regulated on day 21 after rhIL-12 treatment. The number of CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells was elevated with any concentration of rhIL-12. Furthermore, results showed that number of white blood cells was obviously higher than in patients without rhIL-12 treatment (P < 0.05). However, there was no significant difference of erythrocyte and platelet, between groups treated with rhIL-12 and control groups. In addition, the immune cells including CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells were reduced on day 0 - day 3, recovered from day 7, and then decreased from day 21 in rhIL-12 treatment groups related to control groups (P < 0.05). Furthermore, studies showed that five patien

关键词： rhIL-12 Liver Cancer Blood Cells CD4/8+ T CD45+ Leukocytes CD56+ NK Cells

Next-generation sequencing-based identification of EGFR and NOTCH2 complementary mutations in non-small cell lung cancer

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Next-generation sequencing-based identification of EGFR and ...