Prevalence and risk factors of enteral nutrition intolerance in intensive care unit patients: a retrospective study

作     者：Kunrong Yu Na Guo Dingding Zhang Ying Xia Yanling Meng Li Weng Bin Du Kunrong Yu;Na Guo;Dingding Zhang;Ying Xia;Yanling Meng;Li Weng;Bin Du

作者机构：Department of Pulmonary and Critical Care MedicineState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical SciencesBejing 100730China Department of NursingState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical SciencesBeijing 100730China Medical Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CllegeBejing 100730China Department of Medical Intensive Care UnitState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical Cllege HospitalChinese Academy of Medical SciencesBejing 100730China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第15期

页      面：1814-1820页

核心收录：

学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：Fundamental Research Funds for the Central Universities(No. 3332019040) Ministry of Science and Technology of China(No. 2020YFC0841300) 

主　　题：Continuous enteral nutrition Feeding intolerance Intensive care unit Risk factor Continuous renal replacement therapy 

摘      要：Background: Feeding intolerance (FI) among intensive care unit (ICU) patients undergoing early continuous enteral nutrition (EN) is related to poor outcomes. This study aimed to explore the prevalence and risk factors of FI in ICU ***: We retrospectively enrolled 1057 patients who received early continuous EN via a nasogastric tube between January 2014 and August 2019. The prevalence of FI during the first 7 days of ICU stay was calculated, and the risk factors were investigated using multivariate logistic regression ***: The prevalence of FI during the first 7 days of ICU stay was 10.95%. FI occurred in 159 of 1057 (15.04%) patients on ICU day 2, 114 of 977 (11.67%) patients on ICU day 3, and 86 of 715 (12.03%) patients on ICU day 7. Mechanical ventilation (MV) (odds ratio [OR]: 1.928, 95% confidence interval [CI]: 1.064–3.493,P = 0.03) was an independent risk factor for FI defined by a gastric residual volume (GRV) of 200 mL and/or vomiting, and acute renal failure (OR: 3.445, 95% CI: 1.115–10.707,P = 0.032) was an independent risk factor of FI defined by a GRV of 500 mL and/or vomiting. Continuous renal replacement therapy (CRRT) was an independent predictor regardless of the FI defined by a GRV of 200 mL (OR: 2.064, 95% CI: 1.233–3.456,P = 0.006) or 500 mL (OR: 6.199, 95% CI: 2.108–18.228,P = 0.001) in the ICU ***: FI occurs frequently in early ICU days, especially in patients receiving MV and CRRT. However, further investigation of a consensus definition of FI and risk factors is still warranted in future studies.