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Effects of spironolactone on electrical and structural remodeling of atrium in congestive heart failure dogs

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Chinese Medical Journal 2008年第1期121卷 38-42页

作者： YANG Shu-sen HAN Wei ZHOU Hong-yan DONG Guo WANG Bai-chun HUO Hong WEI na cao Yong ZHOU Guo XIU Chun-hong LI Wei-min Department of Cardiology First Clinical College of HarbinMedical University Harbin Heilongjiang 150001 China

Background Renin-angiotensin-aldosterone system has been demonstrated to be associated with both congestive heart failure （CHF） and atrial fibrillation （AF）. This study investigated the effects of spironolactone, a kind of aldosterone antagonist, on atrial electrical remodeling and fibrosis in CHF dogs induced by chronic rapid ventricular pacing. Methods Twenty one dogs were randomly divided into sham-operated group, control group, and spironolactone group. In control group and spironolactone group, dogs were ventricular paced at 220 beats per minute for 6 weeks. Additionally, spironolactone at 15 ***.d1 was given to dogs 1 week before rapid ventricular pacing until pacing stopped. Transthoracic and transoesophageal echocardiographic examinations were performed to detect structural and functional changes of the atrium. Swan2 Ganz floating catheters were used to measure hemadynamics variances. Atrial effective refractory period （AERP）, AERP dispersion （AERPd） conduction velocity （CV） were determined. The inducib atrial fibrosis was quantified with Masson staining. intra- and inter-atrium conduction time （CT） and intra-atrium ity and duration of AF were also measured in all groups. Finally, Results AERP did not change significantly after dogs were ventricular paced for 6 weeks. However, AERPd, intra- and inter-atrium CT increased significantly, and CV decreased apparently, which was negatively correlated to the atrial fibrosis （r=-0.74, P〈0.05）. Simultaneously, left atriums were enlarged and cardiac hemadynamics worsened in pacing dogs. Although spironolactone could not affect cardiac hemadynamics effectively, it can obviously improve left atrial ejection fraction （P〈0.05）. Spironolactone treatment did not alter AERP duration, but this medicine dramatically decreased AERPd （P〈0.05）, shortened intra- and inter-atrium conduction time （P〈0.05）, and increased atrium CV. Moreover, spironolactone decreased the inducibility and duration of AF （P〈0.05）, as well as atrial f

关键词： spironolactone heart failure cardiac remodeling fibrosis

EBV-associated lymphoproliferative disease post-CAR-T cell therapy

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Frontiers of Medicine 2024年第2期18卷 394-398页

作者： Shiyuan Zhang Xiaoxi Zhou Shangkun Zhang na Wang Tongcun Zhang Donghua Zhang Qilin Ao Yang cao Liang Huang Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Immunotherapy Research Center for Hematologic Diseases of Hubei Province Wuhan430030China Institute of Biology and Medicine College of Life and Health SciencesWuhan University of Science and TechnologyWuhan430081China Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300020China Tianjin Institutes of Health Science Tianjin301600China

Epstein–Barr virus(EBV)-associated lymphoproliferative diseases(EBV-LPDs)are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cell transplantation(HSCT).However,their occurrence and treatment post-chimeric antigen receptor-modified T(CAR-T)cell therapy has not been *** patients had been diagnosed with EBV-positive aggressive B-cell lymphoma and experienced relapses after multiple lines of *** receiving CAR-T cell therapy in tandem with autologous HSCT,the patients achieved complete ***,with a median time of 38.5 months after CAR-T cell therapy,B-cell-derived EBV-LPDs were diagnosed,and they were relieved through the administration of immune checkpoint inhibitor or B-cell-depleting ***,our report suggests that EBV-LPDs may represent a long-term adverse event after CAR-T cell therapy,especially in patients who previously had EBV-positive disorders,and they can be resolved by immune normalization strategy or B-cell depleting therapy.

关键词： EBV-associated lymphoproliferative disease chimeric antigen receptor T-cell autologous stem cell transplantation immune checkpoint inhibitor

Etching-free pixel definition in InGaN green micro-LEDs

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Light(Science & Applications) 2024年第8期13卷 1655-1665页

作者： Zhiyuan Liu Yi Lu Haicheng cao Glen Isaac Maciel Garcia Tingang Liu Xiao Tang na Xiao Raul Aguileta Vazquez Mingtao Nong Xiaohang Li Advanced Semiconductor Laboratory Electrical and Computer Engineering ProgramCEMSE DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia

The traditional plasma etching process for defining micro-LED pixels could lead to significant sidewall *** near sidewall regions act as non-radiative recombination centers and paths for current leakage,significantly deteriorating device *** this study,we demonstrated a novel selective thermal oxidation(STO)method that allowed pixel definition without undergoing plasma damage and subsequent dielectric *** annealing in ambient air oxidized and reshaped the LED structure,such as p-layers and InGaN/GaN multiple quantum ***,the pixel areas beneath the pre-deposited SiO_(2)layer were selectively and effectively *** was demonstrated that prolonged thermal annealing time enhanced the insulating properties of the oxide,significantly reducing LED leakage ***,applying a thicker SiO_(2)protective layer minimized device resistance and boosted device efficiency *** the STO method,InGaN green micro-LED arrays with 50-,30-,and 10-μm pixel sizes were manufactured and *** results indicated that after 4 h of air annealing and with a 3.5-μm SiO_(2)protective layer,the 10-μm pixel array exhibited leakage currents density 1.2×10^(-6)A/cm^(2)at-10 V voltage and a peak on-wafer external quantum efficiency of~6.48%.This work suggests that the STO method could become an effective approach for future micro-LED manufacturing to mitigate adverse LED efficiency size effects due to the plasma etching and improve device ***-LEDs fabricated through the STO method can be applied to micro-displays,visible light communication,and optical interconnect-based *** planar pixel geometry will provide more possibilities for the monolithic integration of driving circuits with ***,the STO method is not limited to micro-LED fabrication and can be extended to design other III-nitride devices,such as photodetectors,laser diodes,high-electron-mobility transistors

关键词： annealing protective quantum

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非线性波动方程的新数值迭代方法

物理学报 2020年第3期69卷 163-169页

作者：曹娜陈时曹辉王成会刘航陕西师范大学物理学与信息技术学院陕西省超声学重点实验室

提出了一种新的求解非线性波动方程的数值迭代法,它是一种半解析的方法.与完全的数值计算方法扰法相比,它能够考虑各阶谐波的相互作用,且能够满足能量守恒定律.用它研究了非线性声波在液体中的传播性质,结果表明,在微扰法适用的声强范... 详细信息

提出了一种新的求解非线性波动方程的数值迭代法,它是一种半解析的方法.与完全的数值计算方法扰法相比,它能够考虑各阶谐波的相互作用,且能够满足能量守恒定律.用它研究了非线性声波在液体中的传播性质,结果表明,在微扰法适用的声强范围内迭代法也适用,在微扰法不适用的一个较宽的声强范围内迭代法依然适用.

关键词：非线性声学数值迭代法能流密度

Functional role of circRna CHRC through miR-431-5p/KLF15 signaling axis in the progression of heart failure

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Journal of Genetics and Genomics 2024年第8期51卷 844-854页

作者： Yi Hu Huaming cao Jie Sheng Yizhuo Sun Yuping Zhu Qin Lin na Yi Siyu He Luying Peng Li Li State Key Laboratory of Cardiology and Medical Innovation Center Shanghai East HospitalTongji University School of MedicineShanghai 200120China Shanghai Arrhythmias Research Center Shanghai East HospitalTongji University School of MedicineShanghai 200120China Laboratory of Molecular Genetics and Stem Cell Differentiation Tongji University School of MedicineShanghai 200120China Department of Cardiology Shanghai Shibei HospitalShanghai 200435China Research Units of Origin and Regulation of Heart Rhythm Chinese Academy of Medical SciencesShanghai 200120China

Pathological myocardial hypertrophy is a common early clinical manifestation of heart failure,with noncoding Rnas exerting regulatory ***,the molecular function of circular Rnas(circRnas)in the progression from cardiac hypertrophy to heart failure remains *** uncover functional circRnas and identify the core circRna signaling pathway in heart failure,we construct a global triple network(microRna,circRna,and mRna)based on the competitive endogenous Rna(ceRna)*** observe that cardiac hypertrophy-related circRna(circRna CHRC),within the ceRna network,is down-regulated in both transverse aortic constriction mice and Ang-II--treated primary mouse *** circRna CHRC increases cross-sectional cell area,atrial natriuretic peptide,andβ-myosin heavy chain levels in primary mouse *** screening shows that circRna CHRC targets the miR-431-5p/KLF15 axis implicated in heart failure progression in vivo and in *** with anti-Ago2-Rna confirms the interaction between circRna CHRC and miR-431-5p,while miR-431-5p mimics reverse Klf15 activation caused by circRna CHRC *** summary,circRna CHRC attenuates cardiac hypertrophy via sponging miR-431-5p to maintain the normal level of Klf15 expression.

关键词： circRna CHRC Heart failure CeRna miR-431-4p KIf15

绿色低碳发展视域下高职农业人才培育路径分析

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安徽农学通报 2024年第18期30卷 115-118页

作者：徐宁张方园曹娜韩瑞超孙晓慧李建彬李国良王闯聊城职业技术学院聊城市东昌府区张炉集镇政府聊城市茌平区农业发展服务中心

本文对绿色低碳发展视域下现代农业人才培育的必要性进行分析，包括推动产业结构转型升级，促进乡村经济持续化发展。从新农科理念的引领力、产业技术核心支撑力2个方面入手，对农业人才培养面临的挑战进行探究。并分析了高职院校高质... 详细信息

本文对绿色低碳发展视域下现代农业人才培育的必要性进行分析，包括推动产业结构转型升级，促进乡村经济持续化发展。从新农科理念的引领力、产业技术核心支撑力2个方面入手，对农业人才培养面临的挑战进行探究。并分析了高职院校高质量农业人才的科学培育路径，包括采用学历教育、继续教育和终身教育等多样化教育形式，聚焦绿色农业发展理念；开发线上教学、线下教学和随身教学等多元化培养方式，构建绿色农业人才培养体系。目的在于促进涉农专业科技人才培养创新，为高职院校人才培养科学系统化融入绿色低碳发展理念，提高人才培养质量提供参考，助力乡村振兴。

关键词：乡村振兴绿色低碳发展涉农专业现代农业人才

分层级延续性护理模式运用于糖尿病足患者中的效果及对足部并发症发生率的影响

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中国全科医学 2021年第S1期24卷 199-202页

作者：曹娜浙江省嘉兴市第一医院 314000

目的探讨分层级延续性护理模式运用于糖尿病足患者的效果及对足部并发症发生率的影响。方法选取2019年1月—2020年1月嘉兴市第一医院收治的80例糖尿病足患者,依据护理方法不同分为对照组与研究组,对照组进行常规护理,研究组进行分层级... 详细信息

目的探讨分层级延续性护理模式运用于糖尿病足患者的效果及对足部并发症发生率的影响。方法选取2019年1月—2020年1月嘉兴市第一医院收治的80例糖尿病足患者,依据护理方法不同分为对照组与研究组,对照组进行常规护理,研究组进行分层级延续性护理。比较两组患者知识掌握率、并发症发生率、自我管理能力、生活质量、血糖水平。结果与对照组比较,研究组知识掌握率更高,并发症发生率更低(P0.05),治疗后,两组自我管理能力评分均明显升高,与对照组比较,研究组自我管理能力评分更高(P0.05),治疗后,两组血糖水平均明显降低,与对照组比较,研究组糖化血红蛋白、空腹血糖与餐后2h血糖指标更低(P<0.05);与对照组比较,研究组住院与溃疡愈合时间更短(P<0.05)。结论对糖尿病足患者进行分层级延续性护理,效果理想,可改善患者血糖水平,提高知识掌握率与生活质量,降低并发症发生率,可实现疾病自我管理,可缩短疾病恢复时间。因此,分层级延续性护理模式应在糖尿病足患者临床护理中广泛应用。

关键词：分层级延续性护理糖尿病足并发症生活质量

Identification of novel biomarkers for varicocele using iTRAQ LC-MS/MS technology

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Chinese Medical Journal 2024年第3期137卷 371-372页

作者： Xianfeng Lu na Li Lufang Li Yongai Wu Xuefeng Lyu Yingli cao Jianrong Liu Qin Qin Department of Pediatrics Shanxi Provincial People’s HospitalTaiyuanShanxi 030012China Department of Reproductive Genetics Heping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxi 046099China Department of Biochemistry Basic Medicine CollegeShanxi Medical UniversityTaiyuanShanxi 030607China Reproductive Medical Department Shanxi Provincial People’s HospitalTaiyuanShanxi 030012China

To the Editor:Varicocele(VC)is a vascular disease and considered as the main cause of male infertility.^([1])The incidence of VC in the common male population was 4.4–22.6%,of which the incidence of primary infertility was 35–40%,while the incidence of secondary infertility was as high as 80%.^([2])The exact pathophysiological mechanism of male infertility caused by VC and regulative molecules are still *** and definite molecular markers of VC disease are helpful for early prevention and timely *** study aimed to screen candidate regulative molecules playing a role in male infertility caused by VC.

关键词： prevention incidence exact

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元代文人画的三种创作走向

民族艺术研究 2010年第3期23卷 98-101页

作者：曹娜山西师范大学临汾学院

从唐代伊始,文人画的发展经历了数百年的历程,在元代这一文人画的成熟期里,形成了三种发展走向,即以高克恭为代表的米点墨戏的创作方法,以赵孟頫为代表的功力深厚的通才式画法,以及以元四家为代表的以画遣兴、转变视觉方式的绘胸中山水... 详细信息

从唐代伊始,文人画的发展经历了数百年的历程,在元代这一文人画的成熟期里,形成了三种发展走向,即以高克恭为代表的米点墨戏的创作方法,以赵孟頫为代表的功力深厚的通才式画法,以及以元四家为代表的以画遣兴、转变视觉方式的绘胸中山水的士人风格。因元代画家们不断的创作实践与理论探索,文人画最终被提高到超越于画法的精神高度,对后世影响深远。

关键词：元代文入画三种走向