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3D-Stacked Multistage Inertial Microfluidic Chip for High-Throughput Enrichment of Circulating Tumor Cells

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Cyborg and Bionic Systems 2022年第1期2022卷 200-209页

作者： X.Xu X.Huang J.Sun J.Chen G.Wu Y.Yao n.zhou S.Wang L.Sun Ministry of Education Key Laboratory of RF Circuits and Sytems Hangzhou Dianzi UniversityHangzhou310018 ZhejiangChina Institute for Translational Medicine Zhejang UniversityHangzhou310029 ZhejiangChina Key Laboratory of 3D Micro/nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou310024 Zhejiang China national Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China Clinical Research Center for Respiratory Disease West Chima HospitalSichuan UniversityChengdu 610065China Institute for Advanced Study Chengdu UniversityChengdu 610106China

Whether for cancer diagnosis or single-cell analysis,it remains a major dhallenge to isolate the target sample cells from a large background cell for high-efficiency downstream detection and analysis in an integrated ***,in this paper,we propose a 3D stacked multistage inertial microfluidic sorting chip for high-throughput enrichment of circulating tumor cells(CTCs)and convenient downstream *** this chip,the first stage is a spiral channel with a trapezoidal cross-section,which has better separation performance than a spiral channel with a rectangular *** second and third stages adopt symmetrical square serpentine channels with different rectangular cross-section widths for further separation and enrichment of sample cells reducing the outlet flow rate for easier downstream detection and *** multistage channel can separate 5 pum and 15 um particles with a separation efficiency of 92.37%and purity of 98.10%at a high inlet flow rate of 1.3 mL/***,it can separate tumor cells(SW480,A549,and Caki-1)from massive red blood cells(RBCs)with *** efficiency of>80%,separation purity of>90%,and a concentration fold of~*** proposed work is aimed at providing a high-throughput sample processing system that can be easily integrated with flowing sample detection methods for rapid CTC analysis.

关键词： fluid diagnosis separation

Hydrophobic long-chain two-dimensional perovskite scintillators for underwater X-ray imaging

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Rare Metals 2024年第1期43卷 175-185页

作者： Jin-Xiao Zheng Zi-An.zhou Tiao Feng Hui Li Cheng-Hua Sun nüWang Yang Tian Yong Zhao Shu-Yun.zhou Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Laboratory of Bioinspired Smart Interfacial Science and Technology of the Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Department of Engineering Physics Tsinghua University and Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China e-mail:yangt@***

The underwater X-ray imaging technology development is significant to subaqueous target reconnaissance/detection/identification, subfluvial archaeology,submerged resource exploration, etc. As the core of X-ray imaging detection, the scintillator has been plagued by inherent moisture absorption and decomposition, and strict requirements for seamless packaging and ***, we designed a manganese-doped two-dimensional(2D) perovskite scintillator modified by hydrophobic longchain organic amine through the combination of component and doping engineering. The modified perovskites show high water repellency that can be used as an underwater X-ray scintillator. X-ray images of aquatic organisms or other objects with a high spatial resolution of10 lp·mm^(-1) at a big view field(32 mm × 32 mm) were obtained by scintillation screen. This hydrophobic perovskite scintillator based on molecular design is of great promise in underwater X-ray nondestructive testing technology development.

关键词： Two-dimensional perovskite Hydrophobic Scintillators Underwater X-ray imaging Underwater nondestructive testing technology

The Ti-TAn plasmid toolbox for TurboID-based proximity labeling assays in nicotiana benthamiana

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Journal of Integrative Plant Biology 2024年第2期66卷 166-168页

作者： Huang Tan Yu zhou Erik Dinius Rosa Lozano-Durán Department of Plant Biochemistry Center for Plant MolecularBiology(ZMBP)Eberhard Karls UniversityTubingenD‐72076Germany

Protein-protein interactions and the formation of protein complexes play a central role in the regulation of virtually all aspects of *** identification and characterization of interactions between proteins is the bas... 详细信息

关键词： proximity complexes enable

Coke behavior with H_(2)O in a hydrogen-enriched blast furnace:A review

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 959-976页

作者： Feng zhou Daosheng Peng Kejiang Li Alberto n.Conejo Haotian Liao Zixin Xiong Dongtao Li Jianliang Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Chemical Engineering The University of QueenslandSt LuciaQLD 4072Australia Baosteel Central Research Institute(R&D Center of Wuhan Iron&Steel Co. Ltd.)Wuhan 430080China Shougang Research Institute of Technology Shougang Group Corporation Ltd.Beijing 100043China Beijing Key Laboratory of Green Recyclable Process for Iron and Steel Production Technology Beijing 100043China

Hydrogen-enriched blast furnace ironmaking has become an essential route to reduce CO_(2)emissions in the ironmaking ***,hydrogen-enriched reduction produces large amounts of H_(2)O,which places new demands on coke quality in a blast *** a hydrogen-rich blast furnace,the presence of H_(2)O promotes the solution loss *** result improves the reactivity of coke,which is 20%-30%higher in a pure H_(2)O atmosphere than in a pure CO_(2)*** activation energy range is 110-300 kJ/mol between coke and CO_(2)and 80-170 kJ/mol between coke and H_(2)***_(2)and H_(2)O are shown to have different effects on coke degradation *** review provides a comprehensive overview of the effect of H_(2)O on the structure and properties of *** exploring the interactions between H_(2)O and coke,several unresolved issues in the field requiring further research were *** review aims to provide valuable insights into coke behavior in hydrogen-rich environments and promote the further development of hydrogen-rich blast furnace ironmaking processes.

关键词： hydrogen ironmaking coke behavior blast furnace gasification microstructure kinetics

Laser welding study of vacuum sintered HUST-1 lunar regolith simulant

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Science China(Technological Sciences) 2024年第9期67卷 2905-2918页

作者： HAn WenBin DInG LieYun.zhou Cheng zhou Yan DAnG Fen national Center of Technology Innovation for Digital Construction Huazhong University of Science and TechnologyWuhan 430074China School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan 730074China

Efforts are underway to establish a permanent lunar base on the Moon. In situ lunar regolith is anticipated to be useful as a building material after sintering. However, sintering lunar regolith into a large-scale structure presents challenges. Therefore, the key to lunar construction lies in assembling multiple small-sized sintered modules into a stable, large-sized structure. This study explored the feasibility of welding the sintered HUST-1 lunar regolith simulant(HLRS) using a laser device and conducted experiments using lasers of varying power. The microstructure, mineral composition, element distribution, and shear strength of the welded joint were investigated. A few low-melting minerals were fused and vaporized during welding, leading to the generation of thermal decomposition gas. Furthermore, the welded joint exhibited numerous micro-cracks, pores, and bubbles,resulting in reduced weld shear strength. Finally, the influence of laser power on weld shear strength was investigated, revealing that the highest shear strength(15.69 n/cm) was achieved at a laser power of 1000 W. This study demonstrates the feasibility of laser welding of sintered HLRS for the first time, with potential applications in lunar base construction.

关键词： lunar regolith vacuum sintering laser welding weld shear strength lunar base

Fluidization stability and periodic fluctuations in gas–solid separation fluidized bed using Geldart A dense medium

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Particuology 2024年第7期90卷 522-534页

作者： Weijin Liu Dan Wang Liang Dong Enhui zhou Tatiana Aleksandrova Chenyang zhou Chenlong Duan Key Laboratory of Coal Processing and Efficient Utilization(China University of Mining&Technology) Ministry of EducationXuzhou 221116China School of Chemical Engineering&Technology China University of Mining&TechnologyXuzhou 221116China Department of Chemical and Biochemical Engineering The University of Western OntarioLondonOntario N6A 5B9Canada Mineral Processing Department Saint Petersburg Mining UniversitySt.Petersburg 199106Russia

Gas–solid separation fluidized bed is a typical method for coal separation without water *** A particles is also considered as the ideal dense medium to strengthen separation *** stability reflects the bed pressure fluctuations and the distribution of bubble and emulsion phases,affecting the separation *** the main frequency of pressure fluctuations can directly reflect the degree of pressure ***,the detailed fluidization stability is analyzed combined the method of standard deviation of pressure fluctuations,power spectral density,etc.,for Geldart A *** results showed that maintaining an appropriate gas velocity resulted in an average bed pressure of around 2000 *** main frequency is mainly concentrated around 1–1.5 ***,a prediction model of the main frequency of pressure fluctuations is established,and the error can be controlled within±*** investigation further proved the stable fluidization of Geldart A particles and provides a method for predicting the main frequency of pressure fluctuations in the gas–solid separation fluidized bed.

关键词： Geldart A dense medium Fluidization stability Periodic fluctuations Pressure fluctuations frequency Gas–solid separation fluidized bed

Bivariate attribution of the compound hot and dry summer of 2022 on the Tibetan Plateau

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Science China Earth Sciences 2024年第7期67卷 2122-2136页

作者： Baiquan.zhou Panmao ZHAI Zhen LIAO State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081China

The extraordinarily high temperatures experienced during the summer of 2022 on the Tibetan Plateau(TP)demand attention when compared with its typical climatic *** absence of precipitation alongside the elevated temperatures resulted in 2022 being the hottest and driest summer on record on the TP since at least *** the susceptibility of the TP to climate change,this study employed large-ensemble simulations from the HadGEM3-A-n216 attribution system,together with a copula-based joint probability distribution,to investigate the influence of anthropogenic forcing,primarily global greenhouse gas emissions,on this unprecedented compound hot and dry event(CHDE).Findings revealed that the return period for the 2022 CHDE on the TP exceeds 4000 years,as determined from the fitted joint distributions derived using observational data spanning *** CHDE was directly linked to large-scale circulation anomalies,including the control of equivalent-barotropic high-pressure anomalies and the northward displacement of the subtropical westerly jet ***,anthropogenic forcing has,to some extent,promoted the surface warming and increased variability in precipitation on the TP in summer,establishing conditions conducive for the 2022 CHDE from a long-term climate change *** return period for a 2022-like CHDE on the TP was estimated to be approximately 283 years(142-613 years)by the large ensemble forced by both anthropogenic activities and natural ***,ensemble simulations driven solely by natural forcing indicated that the likelihood of occurrence of a 2022-like CHDE was almost *** outcomes underscore that the contribution of anthropogenic forcing to the probability of a 2022-like CHDE was 100%,implying that without anthropogenically induced global warming,a comparable CHDE akin to that observed in 2022 on the TP would not be possible.

关键词： Compound hot and dry event Tibetan Plateau Bivariate event attribution Anthropogenic forcing

Efficient Direct Decomposition of nO over La_(0.8)A_(0.2)niO_(3)(A=K, Ba, Y) Catalysts under Microwave Irradiation

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 17-23页

作者：王浩 ZHAO Zijian DUAn Xinghui zhou Shijia School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

La_(0.8)A_(0.2)niO_(3) (A=K,Ba,Y) catalysts supported on the microwave-absorbing ceramic heating carrier were prepared by the sol-gel *** crystalline phase and the catalytic activity of the La_(0.8)A_(0.2)niO_(3)catalysts were characterized by XRD and H_(2) temperature-programmed reduction (TPR).The effects of reaction temperature,oxygen concentration,and gas flow rate on the direct decomposition of nitric oxide over the synthesized catalysts were studied under microwave irradiation (2.45 GHz).The XRD results indicated that the La_(0.8)A_(0.2)niO_(3) catalysts formed an ABO_(3) perovskite structure,and the H_(2)-TPR results revealed that the relative reducibility of the catalysts increased in the order of La_(0.8)K_(0.2)niO_(3)>La_(0.8)Ba_(0.2)niO_(3)>La_(0.8)Y_(0.2)ni O_(3).Under microwave irradiation,the highest nO conversion amounted to 98.9%,which was obtained with the La_(0.8)K_(0.2)niO_(3) catalyst at 400℃.The oxygen concentration did not inhibit the nO decomposition on the La_(0.8)A_(0.2)niO_(3) catalysts,thus the n_(2) selectivity exceeded 99.8%under excess oxygen at 550℃.The nOconversion of the La_(0.8)A_(0.2)niO_(3) catalysts decreased linearly with the increase in the gas flow rate.

关键词： microwave catalysis direct decomposition of nO microwave-absorbing heating ceramics perovskite catalyst

Hot Deformation Behavior and Workability of a new ni–W–Cr Superalloy for Molten Salt Reactors

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1453-1466页

作者： Long Liu Zijian.zhou Jie Yu Xinguang Wang Chuanyong Cui Rui Zhang Yizhou zhou Xiaofeng Sun Shi‑Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Fushun Special Steel Co. LtdFushun 113000China

The hot deformation behavior of a newly developed ni–W–Cr superalloy for use in 800℃molten salt reactors(MSRs)was looked into by isothermal compression tests in the temperature range of 1050–1200℃with a strain rate of 0.001–1 s^(−1)under a true strain of *** Arrhenius-type model for the ni–W–Cr superalloy was constructed by fitting the corrected flow stress *** this model,the effect of dispersion of solid solution elements during thermal deformation on microstructure evolution was considered,as well as the effects of friction and adiabatic heating on the temperature and strain rate-dependent variation of flow *** hot deformation activation energy of the ni–W–Cr superalloy was 323 kJ/mol,which was less than that of the Hastelloy n alloy(currently used in MSRs).According to the rectified flow stress data,processing maps were *** conjunction with the corresponding deformation microstructures,the flow instability domains of the ni–W–Cr superalloy were determined to be 1050–1160℃/0.03–1 s^(−1)and 1170–1200℃/0.001–0.09 s^(−1).In these deformation conditions,a locally inhomogeneous microstructure was caused by flow-i.e.,incomplete dynamic recrystallization and hot working parameters should avoid sliding into these *** ideal processing hot deformation domain for the ni–W–Cr superalloy was determined to be 1170–1200℃/0.6–1 s^(−1).

关键词： ni-W-Cr Superalloy Hot deformation behavior Constitutive equation Processing map Microstructure evolution