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Predicting effects of tunnel throttling of annular freeway vehicular flow by a continuum model

Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 733-746页

作者： Zhongmin Huang M.n.smirnova n.n.smirnov Zuojin Zhu Faculty of Engineering Science University of Science and Technology of ChinaHefei 230026China Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Faculty of Mechanics and Mathematics Lomonosov Moscow State UniversityMoscow 119992Russia

Fluid flow throttling is common in industrial and building services *** tunnel throttling of vehicular flow is caused by the abrupt number reduction of roadway lane,as the tunnel has a lower lane number than in the roadway normal *** predict the effects of tunnel throttling of annular freeway vehicular flow,a three-lane continuum model is ***Ⅲof the tunnel is completely blocked due to the need of tunnel rehabilitation,*** exists mandatory net lane-changing rate from laneⅢto laneⅡjust upstream of the tunnel entrance,which is described by a model of random number generated through a golden section *** net-changing rate between adjacent lanes is modeled using a lane-changing time expressed explicitly in algebraic *** paper assumes that the annular freeway has a total length of 100 km,a two-lane tunnel of length 2 km with a speed limit of 80 km/*** free flow speeds on lanesⅠ,ⅡandⅢare assumed to be 110,100 and 90 km/h *** on the three-lane continuum model,numerical simulations of vehicular flows on the annular freeway with such a tunnel are conducted with a reliable numerical method of 3rd-order *** results reveal that the vehicular flow has a smaller threshold of traffic jam formation in comparison with the case without tunnel *** fuel consumption can be estimated by interpolation with time averaged grid traffic speed and an assumed curve of vehicle *** vehicle fuel consumption is lane number dependent,distributes with initial density concavely,ranging from 5.56 to 8.00 *** throttling leads to an earlier traffic jam formation in comparison with the case without tunnel throttling.

关键词： Effects of tunnel throttling Vehicle fuel consumption Travel time Threshold of traffic jam formation Continuum model

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Travel time prediction with viscoelastic traffic model

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Applied Mathematics and Mechanics(English Edition) 2018年第12期39卷 1769-1788页

作者： Yongliang ZHAnG M.n.smirnovA A.I.BOGDAnOVA Zuojin ZHU n.n.smirnov Faculty of Engineering Science University of Science and Technology of China Faculty of Mechanics and Mathematics Moscow M.V.Lomonosov State University Scientific Research Institute for System Analysis Russian Academy of Sciences

Travel time through a ring road with a total length of 80 km has been predicted by a viscoelastic traffic model(VEM), which is developed in analogous to the non-newtonian fluid flow. The VEM expresses a traffic pressure for the unfree flow case by space headway, ensuring that the pressure can be determined by the assumption that the relevant second critical sound speed is exactly equal to the disturbance propagation speed determined by the free flow speed and the braking distance measured by the average vehicular length. The VEM assumes that the sound speed for the free flow case depends on the traffic density in some specific aspects, which ensures that it is exactly identical to the free flow speed on an empty road. To make a comparison, the open navier-Stokes type model developed by Zhang(ZHAnG, H. M. Driver memory, traffic viscosity and a viscous vehicular traffic flow model. Transp. Res. Part B, 37, 27–41(2003)) is adopted to predict the travel time through the ring road for providing the counterpart *** the traffic free flow speed is 80 km/h, the braking distance is supposed to be 45 m,with the jam density uniquely determined by the average length of vehicles l ≈ 5.8 m. To avoid possible singular points in travel time prediction, a distinguishing period for time averaging is pre-assigned to be 7.5 minutes. It is found that the travel time increases monotonically with the initial traffic density on the ring road. Without ramp effects, for the ring road with the initial density less than the second critical density, the travel time can be simply predicted by using the equilibrium speed. However, this simpler approach is unavailable for scenarios over the second critical.

关键词： travel time viscoelastic modeling distinguishing period for time averaging spatial-temporal pattern traffic jam

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Impacts of Down-Up Hill Segment on the Threshold of Shock Formation of Ring Road Vehicular Flow

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Advances in Applied Mathematics and Mechanics 2023年第5期15卷 1315-1334页

作者： Zejing Hu M.n.smirnova n.n.smirnov Yongliang Zhang Zuojin Zhu Faculty of Engineering Science University of Science and Technology of ChinaHefeiAnhui 230026China Faculty of Mechanics and Mathematics Lomonosov Moscow State UniversityMoscow119992Russia Anhui Xiang Shui Jian Pumped Storage Co. LTDWuhuAnhui 241083China

The study of impacts of down-up hill road segment on the density threshold of traffic shock formation in ring road vehicular flow is helpful to the deep understanding of sags’bottleneck *** are freeway segments along which the gradient increases gradually in the traffic *** main aim of this paper is to seek the density threshold of shock formation of vehicular flow in ring road with down-up hill segment,because down-up hill roadway segment is a source to cause capacity reduction that is an attractive topic in vehicular traffic *** seek the density threshold numerically,a viscoelastic continuum model[1]is extended and *** solve the model equations,a fifth-order weighted essentially non-oscillatory scheme for spatial discretization,and a 3rd order Runge-Kutta scheme for time partial derivative term are *** by existing observation data and the navier-Stokes like model[2]extended as EZM is done before conducting extensive numerical *** ring road vehicular flow with three separated down-up hill segments,it is found that the density threshold of shock formation decreases monotonically with the relative difference of free flow speed,this variation can be simply fitted by a third order polynomial.

关键词： Down-up hill road segment viscoelastic continuum model sags’bottleneck effect density threshold WEnO5 scheme

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Tunnel effects on ring road traffic flow based on an urgent-gentle class traffic model

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Theoretical & Applied Mechanics Letters 2021年第4期11卷 230-235页

作者： Yongliang Zhang M.n.smirnova Jian Ma n.n.smirnov Zuojin Zhu Faculty of Engineering Science University of Science and Technology of ChinaHefei 230026China Faculty of Mechanics and Mathematics Lomonosov Moscow State UniversityMoscow 119992Russian Federation Moscow Center for Fundamental and Applied Mathematics Moscow 119992Russian Federation Scientific Research Institute for System Analysis Russian Academy of SciencesMoscow 119992Russian Federation naval Architecture and Civil Engineering Jiangsu University of Science and TechnologyZhenjiang 215600China

To explore tunnel effects on ring road traffic flow,a macroscopic urgent-gentle class traffic model is put *** model identifies vehicles with urgent and gentle classes,chooses the tunnel speed limit as free flow speed to express the fundamental diagram in the tunnel,and adopts algebraic expressions to describe traffic pressure and sound *** two speed trajectories at the Kobotoke tunnel in Japan,the model is validated,with good agreement with observed *** results indicate that in the case of having no ramp effects,tunnel mean travel time is almost constant dependent on tunnel *** initial density normalized by jam density is above a threshold of about 0.21,a traffic shock wave originates at the tunnel entrance and propagates *** a threshold drops slightly as a result of on-ramp merging effect,the mean travel time drops as off-ramp diversion effect intensifies *** findings deepen the understanding of tunnel effects on traffic flow in reality.

关键词： Tunnel effects Travel time Density threshold Ramp effects

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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