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Cellular Chain Complex of Small Covers with Integer Coefficients and Its Application

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Acta Mathematica Sinica,English Series 2018年第11期34卷 1742-1754页

作者： Deng pin.LIU Department of Mathematics Guangxi Normal University

Let Pn be a simple n-polytope with a Z2-characteristic function λ. And h is a Morse function over Pn. Then the small cover Mn（λ） corresponding to the pair （Pn, λ） has a cell structure given by h. From this cell structure we can derive a cellular chain complex of Mn（λ） with integer coefficients. In this paper, firstly, we discuss the highest dimensional boundary morphism ？n of this cellular chain complex and get that ？n=0 or 2 by a natural way. And then, from the well-known result that the submanifold corresponding to （F, λF） is naturally a small cover with dimension k, where F is any k-face of Pn and λF is the restriction of λ on F, we get that ？k=0 or ±2 for 0 ≤ k 〈 n. Finally, by using the definition of inherited characteristic function which is the restriction of λ on the faces of Pn, we get a way to calculate the homology groups of Mn（λ）. Applying our result to a 3-small cover we have that the homology groups of any 3-small cover is torsion-free or has only 2-torsion.

关键词： Small cover homology group orientation CW-complex

Conceptual design of a Cs2LiLaBr6 scintillator‑based neutron total cross section spectrometer on the back‑n beam line at CSnS

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nuclear Science and Techniques 2023年第1期34卷 23-32页

作者： Da‑Jun Zhao Song Feng pin.Jing Cheng Rong Liu Wen Luo Hao‑Qiang Wang Jie‑Ming Xue Kun Zhu Bo Zheng School of nuclear Science and Technology University of South ChinaHengyang 421001China Institute of nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

To reduce the experimental uncertainty in the 235 U reson.n.e energy region and improve the detection efficiency for neutron total cross section measurements compared with those obtained with the neutron total cross section spectrometer(nTOX), a dedicated lithium-contain.n. scintillation detector has been developed on the Back-n beam line at the China Spallation.n.utron Source. The Fast Scintillator-based neutron Total Cross Section(FAST) spectrometer has been designed based on a Cs2Li La Br6(CLLB) scintillator considering the γ-ray flash and neutron environment on the Back-n beam line. The response of the CLLB scintillator to neutrons and γ-rays was evaluated with different 6Li/7 Li abundance ratios using Geant4. The neutron-γdiscrimination performance of the CLLB has been simulated considering different scintillation parameters, physical designs,and light readout modes. A cubic 6Li-enriched( > 90%) CLLB scintillator, which has a thickness of 4-9 mm and side length of no less than 50 mm to cover the Φ 50 mm neutron beam at the spectrometer position, has been proposed coupling to a side readout SiPM array to construct the FAST spectrometer. The developed simulation techniques for neutron-γ discrimination performance could provide technical support for other neutron-induced reaction measurements on the Back-n beam line.

关键词： neutron total cross section CLLB scintillator Geant4 Pulse shape discrimination(PSD)

Symptoms predicting health-related quality of life in prostate cancer patients treated with localized radiation therapy

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Family Medicine and Community Health 2017年第2期5卷 119-128页

作者： Chao-pin.Hsiao Mei-Kuang Chen Kathy J.Meyers Leorey n.Saligan The Frances Payne Bolton School of nursing Case Western Reserve UniversityClevelandOHUSA University of Arizona 3009 E 4th St.TucsonAZ 85716USA 3.National Institute of Nursing ResearchDivision of Intramural ResearchNational Institutes of Health9000 Rockville PikeBuilding Room 5E14 BethesdaMD 20892USA

Objective:Patient-reported health-related quality-of-life(HRQOL)measures can provide guidance for treatment decision making,symptom management,and discharge *** is often influenced by the distress experienced by patients from disease or treatment-related *** study aimed to identify symptoms that can predict changes in HRQOL in men undergo-ing external beam radiation therapy(EBRT)for n.n.etastatic prostate cancer(nMPC).Methods:Fifty-one men with nMPC scheduled for EBRT were assessed at the baseline,at the midpoint of EBRT,and at the end of *** participants received 38-42 daily doses of EBRT(five times a week),depending on the stage of their *** questionnaires were administered to evaluate depressive symptoms,urinary and sexual functions,bowel issues,symp-tom-related distress,fatigue,and *** correlations,repeated-measures AnOVA,and multiple regressions examined the relationships among ***:Intensification of symptoms and increased symptom-related distress,with a corre-sponding decline in HRQOL,were observed during EBRT in men with *** in symp-toms and symptom distress were associated with changes in HRQOL at the midpoint of EBRT(r=-0.37 to-0.6,P=0.05)and at the end of EBRT(r=-0.3 to-0.47,P=0.01)compared with the *** regression model comprising age,body mass index,Gleason score,T category,androgen-deprivation therapy use,radiation dose received,symptoms(urinary/sexual/bowel prob-lems,fatigue),and overall symptom distress explained 70%of the variance in predicting *** problems and fatigue significantly predicted the decline in HRQOL during ***:Identifying specific symptoms that can influence HRQOL during EBRT for nMPC can provide feasible interventional targets to improve treatment outcomes.

关键词： Symptoms symptom distress health-related quality of life prostate cancer radia-tion therapy

海豚屋数字仿生训练系统对孤独症谱系障碍儿童及其父亲的影响

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中国医药指南 2024年第6期22卷 9-11页

作者：周菲郭敬民刘桂华郭翀周小娟葛品福建医科大学妇儿临床医学院福建省妇幼保健院儿童保健中心福州350001

目的探讨海豚屋数字仿生训练系统对孤独症谱系障碍(ASD)儿童的核心症状改善情况及其父亲的影响。方法采用前瞻性临床随机对照研究法,将100例ASD儿童及其父亲按照随机数字表法分为对照组和试验组,每组50例。对照组采取应用行为分析法(ABA... 详细信息

目的探讨海豚屋数字仿生训练系统对孤独症谱系障碍(ASD)儿童的核心症状改善情况及其父亲的影响。方法采用前瞻性临床随机对照研究法,将100例ASD儿童及其父亲按照随机数字表法分为对照组和试验组,每组50例。对照组采取应用行为分析法(ABA)干预,试验组在ABA基础上联合使用父亲共同参与式海豚屋数字仿生训练系统干预。采用ABC、CARS、PSI-SF、SDS、SAS评估干预前后ASD儿童的核心症状及其父亲的亲职压力和焦虑、抑郁水平。结果干预后试验组ASD儿童CARS总分,ABC感觉、社交、语言维度和总分得分均低于对照组(P<0.05)。干预后试验组父亲的PSI-SF困难儿童维度得分和总分低于对照组(P<0.05)。结论在ABA干预的基础上联合海豚屋数字仿生训练系统可改善ASD儿童的核心症状,减轻父亲的亲职压力。

关键词：数字仿生训练孤独症谱系障碍儿童父亲亲职压力

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梨小食心虫卵黄原蛋白基因的鉴定及表达分析

山西农业科学 2024年第2期52卷 58-64页

作者：霍楠胡军孙江吕品王苑馨杨军罗进仓贾栋山西农业大学植物保护学院山西太谷030801 甘肃省农业科学院植物保护研究所甘肃兰州730070

为明确重要果树害虫梨小食心虫(Grapholita molesta)卵黄原蛋白(Vitellogen.n.Vg)基因功能及其生殖调控机制,为GmVg基因功能的深入研究奠定理论基础,克隆鉴定了梨小食心虫卵黄原蛋白基因(GmVg)并进行生物信息学分析,通过qRT-PCR分析GmV... 详细信息

为明确重要果树害虫梨小食心虫(Grapholita molesta)卵黄原蛋白(Vitellogen.n.Vg)基因功能及其生殖调控机制,为GmVg基因功能的深入研究奠定理论基础,克隆鉴定了梨小食心虫卵黄原蛋白基因(GmVg)并进行生物信息学分析,通过qRT-PCR分析GmVg在梨小食心虫不同发育时期、不同性别和不同组织的表达模式。结果表明,GmVg基因全长5 573 bp,开放阅读框(ORF)5 364 bp,编码1 787个氨基酸,信号肽长度为15个氨基酸,分子式为C_(9041)H_(14090)n_(2544)O_(2743)S_(57);氨基酸组成中丙氨酸(Ala)、谷氨酸(Gln)和丝氨酸(Ser)占比最大,分别为8.2%、7.9%和7.8%,酸性残基的数量(Asp+Glu)为187个,碱性残基的数量(Arg+Lys)为204个,预测蛋白质分子质量和等电点分别为204.1 ku和8.79,具有Vitellogen.n.n、DUF1943和VWD共3个典型保守结构域。GmVg成虫期的表达量显著高于卵、幼虫和蛹期,且羽化后24 h时达到峰值。GmVg的表达具有性别特异性,在雄虫中表达量极低。GmVg在雌成虫头部、卵巢和脂肪体中的表达呈现组织特异性,其中脂肪体显著高表达,分别是头部和卵巢表达量的21.49倍和16.4倍。

关键词：梨小食心虫卵黄原蛋白基因克隆发育时期表达组织表达

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中医五音疗法干预气虚质人群临床观察

河北中医 2024年第7期46卷 1065-1069,1073页

作者：高昭曾静吕品黄梦文王稼心彭艳文提桂香中国中医科学院广安门医院治未病中心北京100053 国家中医药管理局中国中医药科技发展中心北京100191

目的观察中医五音疗法对未病状态的气虚质人群的干预效果及安全性,为中医五音疗法在体质偏颇人群的应用提供循证医学证据。方法将76例气虚质患者按照随机数字表法分为2组,对照组38例予统一生活方式干预,治疗组38例在对照组干预基础上加... 详细信息

目的观察中医五音疗法对未病状态的气虚质人群的干预效果及安全性,为中医五音疗法在体质偏颇人群的应用提供循证医学证据。方法将76例气虚质患者按照随机数字表法分为2组,对照组38例予统一生活方式干预,治疗组38例在对照组干预基础上加中医五音疗法干预,2组均干预6个月。记录2组治疗前后中医气虚质评分、五脏病位维度气虚量表评分、简明健康调查量表(SF-36)评分、疲劳评定量表(FAI)评分;对2组进行安全性评价。结果最终共75例受试者完成全程干预,其中治疗组完成干预37例,对照组完成干预38例。2组治疗后气虚质各症状评分均较本组治疗前降低(P0.05),均未出现不良反应。结论生活方式结合中医五音疗法对气虚质人群干预效果明显,且安全性较高。

关键词：气虚质五音疗法治未病

吴茱萸次碱对脂多糖致小鼠神经炎症和认知功能障碍的作用研究

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世界中西医结合杂志 2024年第1期19卷 97-101页

作者：刘昌福邓钢龙春频刘星林欧阳敏萍乡卫生职业学院江西萍乡337000

目的研究吴茱萸次碱对脂多糖诱发的C57BL/6n小鼠学习记忆障碍的改善作用及其作用机制探讨。方法将54只7周龄C57BL/6n小鼠经水迷宫筛选合格后按随机数字表法分为对照组、模型组、多奈哌齐组、吴茱萸次碱低、中、高剂量组。除正常组注射... 详细信息

目的研究吴茱萸次碱对脂多糖诱发的C57BL/6n小鼠学习记忆障碍的改善作用及其作用机制探讨。方法将54只7周龄C57BL/6n小鼠经水迷宫筛选合格后按随机数字表法分为对照组、模型组、多奈哌齐组、吴茱萸次碱低、中、高剂量组。除正常组注射等体积生理盐水外,其他组腹腔注射2 mg/kg脂多糖溶液。造模成功后,正常组和模型组给予等体积0.9%生理盐水,多奈哌齐组给予5 mg/kg多奈哌齐、吴茱萸次碱低、中、高剂量组分别给予0.97 mg/kg、3.03 mg/kg、9 mg/kg吴茱萸次碱。连续给药2周后,以Morris水迷宫评价小鼠空间记忆能力。取脑进行HE和Tunel染色并以试剂盒测定脑组织中TnF-α、MDA、GSH-PX、GSH、IL-6、IL-10水平。结果与对照组比较,模型组C57BL/6n小鼠穿台次数明显减少,上台时间和距离明显增加,TnF-α、MDA、IL-6、IL-10水平明显升高,GSH-px和GSH水平和海马神经细胞明显减少。与模型组比较,5 mg/kg多奈哌齐和0.97 mg/kg、3.03 mg/kg、9.00 mg/kg吴茱萸次碱给药后使穿越平台次数明显增加,上台时间和距离明显降低,使脑内TnF-α、MDA、IL-10、IL-6水平明显降低,减少神经细胞的损伤,而5 mg/kg多奈哌齐和3.03 mg/kg、9.00 mg/kg吴茱萸次碱给药使GSH-px、GSH明显升高。结论吴茱萸次碱可以通过下调大脑内的炎症反应、氧化应激及修复海马的损伤来改善C57BL/6n小鼠的学习记忆障碍。

关键词：吴茱萸次碱记忆障碍炎症

Molecular dynamics studies of the inhibitory mechanism of copper(Ⅱ) on aggregation of amyloid β-peptide

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Chinese Chemical Letters 2007年第3期18卷 357-360页

作者： Yong Jiao pin.Yang Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University Taiyuan 030006 China

The inhibitory mechanism of copper（Ⅱ） on the aggegation of amyloid β-peptide （Aβ） was investigated by molecular dynamics simulations. The binding mode ofcopper（Ⅱ） with Aβ is characterized by the imidazole nitrogen atom, nπ, of the histidine residue H 13, acting as the anchoring site, and the backbone＇s deprotoned amide nitogen atoms as the main binding sites. Drove by the coordination bonds and their induced hydrogen bond net, the conformations of Aβ converted from β-sheet n.n.β-sheet conformations, which destabilized the aggregation of Aβ into fibrils.

关键词： Copper(Ⅱ) Amyloid β-peptide Inhibitory mechanism Alzheimer's disease Molecular dynamics Radial distribution function (RDF)

SARS-CoV-2 nsp8 induces mitophagy by damaging mitochondria

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Virologica Sinica 2023年第4期38卷 520-530页

作者： Shan Zong Yan Wu Weiling Li Qiang You Qian Peng Chenghai Wang pin.Wan Tao Bai Yanling Ma Binlian Sun Jialu Qiao Wuhan Institute of Biomedical Sciences School of MedicineJianghan UniversityWuhan430056China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China Hubei Key Laboratory of Wudang Local Chinese Medicine Research Hubei University of MedicineShiyan442000China Division of Gastroenterology Tongji Medical CollegeHua Zhong University of Science and TechnologyWuhan430030China Department of Respiratory and Critical Care Medicine Hubei Province Clinical Research Center for Major Respiratory DiseasesNHC Key Laboratory of Pulmonary DiseasesUnion HospitalTongji Medical CollegeHua Zhong University of Science and TechnologyWuhan430030China

Autophagy plays an important role in the interaction between viruses and host ***-CoV-2 infection can disrupt the autophagy process in target ***,the precise molecular mechanism is still *** this study,we discovered that the nsp8 of SARS-CoV-2 could cause an increasing accumulation of autophagosomes by preventing the fusion of autophagosomes and *** further investigation,we found that nsp8 was present on mitochondria and can damage mitochondria to initiate *** results of experiments with immunofluorescence revealed that nsp8 induced incomplete ***,both domains of nsp8 orchestrated their function during nsp8-induced mitophagy,in which the n-terminal domain colocalized with mitochondria and the C-terminal domain induced auto/*** novel finding expands our understanding of the function of nsp8 in promoting mitochondrial damage and inducing incomplete mitophagy,which helps us to understand the etiology of COVID-19 as well as open up new pathways for creating SARS-CoV-2 treatment methods.

关键词： SARS-CoV-2 nsp8 Autophagy Mitophagy Mitochondrial damage