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Autoantibodies related to ataxia and other central nervous system manifestations of gluten enteropathy

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World Journal of Clinical Cases 2024年第12期12卷 2031-2039页

作者： Tsvetelina Velikova Georgi Vasilev Russka Shumnalieva Lyubomir Chervenkov Dimitrina georgieva Miteva Milena Gulinac Stamatios Priftis Snezhina Lazova Medical Faculty Sofia University"St.Kliment Ohridski"Sofia 1407Bulgaria Clinic of neurology and Department of Emergency Medicine UMHAT"Sv.Georgi"Plovdiv 4000Bulgaria Department of Rheumatology Clinic of RheumatologyUniversity Hospital"St.Ivan Rilski"Medical University-SofiaSofia 1612Bulgaria Department of Diagnostic Imaging Medical University PlovdivPlovdiv 4000Bulgaria Department of Genetics Faculty of BiologySofia University"St.Kliment Ohridski"Sofia 1164Bulgaria Department of General and Clinical Pathology Medical University of PlovdivPlovdiv 4002Bulgaria Department of Healthcare Faculty of Public Health“Prof.Tsekomir VodenicharovMDDSc”Medical University of SofiaSofia 1407Bulgaria Department of Pediatric University Hospital"N.I.Pirogov"Sofia 1606Bulgaria

Gluten ataxia and other central nervous system disorders could be linked to gluten enteropathy and related *** this narrative review,we focus on the various neuro-logical manifestations in patients with gluten sensitivity/celiac disease,immunological and autoimmune mechanisms of ataxia in connection to gluten sensitivity and the autoantibodies that could be used as a biomarker for diagnosing and *** focused on the anti-gliadin antibodies,antibodies to different isoforms of tissue transglutaminase(TG)(anti-TG2,3,and 6 antibodies),anti-glycine receptor antibodies,anti-glutamine acid decarboxylase antibodies,anti-deamidated gliadin peptides antibodies,*** studies found a higher prevalence of these antibodies in patients with gluten sensitivity and neurological dysfunction,presented as different neurological *** also discuss the role of a gluten-free diet on the clinical improvement of patients and also on imaging of these disorders.

关键词： Gluten ataxia Celiac disease Gluten enteropathy Autoantibodies Anti-gliadin antibodies Anti-bodies to tissue transglutaminase Anti-tissue transglutaminase antibodies Anti-transglutaminase 6 antibodies Anti-glycine receptor antibodies Anti-glutamine acid decarboxylase antibodies

Dual-polarization multiplexing amorphous Si:H grating couplers for silicon photonic transmitters in the photonic BiCMOS backend of line

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Frontiers of Optoelectronics 2022年第1期15卷 143-155页

作者： Galina georgieva Christian Mai Pascal M.Seiler Anna Peczek Lars Zimmermann Hochfrequenztechnik-Photonik/Siliziumphotonik Technische Universität BerlinStraße des 17.Juni 13510623 BerlinGermany IHP-Leibnitz Institut für innovative Mikroelektronik Im Technologiepark 2515236 Frankfurt(Oder)Germany IHP Solutions GmbH Im Technologiepark 715236 Frankfurt(Oder)Germany

In this paper,we report on polarization combining two-dimensional grating couplers(2D GCs)on amorphous Si:H,fabricated in the backend of line of a photonic BiCMOS *** 2D GCs can be used as an interface of a hybrid silicon photonic coherent transmitter,which can be implemented on bulk Si *** fabricated 2D GCs operate in the telecom C-band and show an experimental coupling efficiency of−5 dB with a wafer variation of±1.2 *** for efficiency enhancement and improved performance stability in future design generations are outlined and extension toward O-band devices is also investigated.

关键词： Hybrid integration Photonic BiCMOS Amorphous silicon Two-dimensional grating coupler(2D GC) Dual-polarization coherent communication Silicon photonics

High-Temperature Thermodynamic Investigation of nano-Dispersed nitrides Obtained in Thermal Plasma

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Plasma Science and Technology 2007年第2期9卷 174-176页

作者： M. georgieva G. VISSOKOV Iv. GRAnCHAROV L. BRAKALOV Department of Technology of Inorganic Substances University of Chemical Technology andMetal|urgy 8 K. Okhridski Blvd. 1756 Sofia Bulgaria

The nitrides of transient metals have a high hardness, thermal stability, remarkable wear resistance in aggressive chemical mediums, melted metals and alloys, high corrosion resistance, and low coefficient of electric resistance. Under the conditions of low-temperature argon plasma （LTP）, thermodynamic investigations were conducted in the process of obtaining of A1n, Tin and Si3n4 in a temperature range of 1000 K to 6000 K. To investigate the thermodynamic possibility of obtaining nitrides, a computer model was used which provided the equilibrium composition of gaseous and solid phases at different temperatures. The conditions for chemical equilibrium of the system were based on the minimization of Gibbs＇ energy.

关键词： plasma-chemical treatment nitrides thermodynamic analysis

On the diversity of fungi from soda soils

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Fungal Diversity 2016年第1期76卷 27-74页

作者： Alexey A.Grum-Grzhimaylo Marina L.georgieva Sofiya A.Bondarenko Alfons J.M.Debets Elena n.Bilanenko Laboratory of Genetics Plant Sciences GroupWageningen UniversityDroevendaalsesteeg 16708 PB WageningenThe Netherlands Gause Institute of new Antibiotics Federal State Budgetary Scientific InstitutionBol’shaya Pirogovskaya 11119021 MoscowRussia Faculty of Biology Lomonosov Moscow State UniversityLeninskie Gory 1-12119234 MoscowRussia

The diversity of filamentous fungi that can grow at high ambient pH values(i.e.,8–11)remains largely *** we study 100 alkalitolerant and alkaliphilic isolates from the soils around the basin of soda lakes in Asia and Africa to assess the major evolutionary lineages and morphologies pertinent to the alkaliphilic trait in filamentous *** Emericellopsis lineage(Hypocreales,Hypocreomycetidae),along with Plectosphaerellaceae(Hypocreomycetidae),Pleosporaceae(Dothideomycetes),Chaetomiaceae(Sordariomycetidae)families appeared to be overrepresented with strong alkalitolerants and effective *** particular,Sodiomyces species(Plectosphaerellaceae),Acrostalagmus luteoalbus(Plectosphaerellaceae),Emericellopsis alkalina(Hypocreales),Thielavia sp.(Chaetomiaceae),and Alternaria ***(Pleosporaceae)grew best at high ambient *** pH tolerance of Chordomyces antarcticum,Acrostalagmus luteoalbus and some other species was largely affected by the presence of extra na+in the growth *** alkalitolerants included Scopulariopsis members(Microascales),Fusarium,Cladosporium,and many asexual acremonium-like species from *** alkalitolerants were represented by sporadic isolates of Penicillium,Purpureocillium lilacinum,and Alternaria alternata species,with the growth optimum at neutral or acidic *** alkalitolerants develop loose dry chains of spores easily dispersed by *** presence at low frequency with the growth optimum at neutral or acidic pH leads us to treat them as transient species in the alkaline soils,as those are also ubiquitous saprobes in normal *** phylogenetic analyses show that the alkaliphilic trait in filamentous fungi has evolved several *** lineages harboring strong alkalitolerants derived from the known marine-borne fungi(Emericellopsis,Alternaria ***),or fall within the fungi associated with halophytic grasses(Pleosporaceae).Soda soils contain a diversity of fungi that ra

关键词： Alkaliphilic fungi pH Soda soils Extremophile Sodiomyces Acrostalagmus Chordomyces Verticillium Emericellopsis Acremonium Scopulariopsis Alternaria Thielavia Plectosphaerellaceae Pleosporaceae

Sustainable energy management of solar greenhouses using open weather data on MACQU platform

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International Journal of Agricultural and Biological Engineering 2018年第1期11卷 74-82页

作者： Li Li Jieyu Li Haihua Wang Ts.georgieva K.P.Ferentinos K.G.Arvanitis n.A.Sigrimis Key Laboratory on Modern Precision Agriculture System Integration Research of Ministry of Education China Agricultural UniversityBeijing 100083China Key Laboratory of Agricultural Information Acquisition Technology of Ministry of Agriculture China Agricultural UniversityBeijing 100083China Department of Automatics and Mechatronics University of RuseRuse 7017Bulgaria Hellenic Agricultural Organization“Demeter” Institute of Soil&Water ResourcesDept.of Agricultural Engineering61 Dimokratias Av.13561AthensGreece&Research Advisor at Geomations SAspinoff of Agricultural University of Athens Department of natural Resources Management&Agricultural Engineering Agricultural University of AthensAthens 11855Greece Director R&D Department Geosmart IKEspinout of Geomations of AUANafplio 21100Greece

Precision energy management is very important for sustainability development of solar greenhouses,since huge energy demand for agricultural production both in quantity and quality.A proactive energy management,according to the optimal energy utilization in a look-ahead period with weather prediction,is presented and tested in this research.A multi-input-multi-output linear model of the energy balance of solar greenhouses based on on-line identification system can simulate greenhouse behavior and allow for predictive *** good time allocation of available solar energy can be achieved by intelligent use of controls,such as store/retrieve fans and ventilation windows,*** energy to warm up the air or to be stored in the storage elements(wall,soil,etc.)or to be exhausted to *** proactive energy management can select an optimal trajectory of air temperature for the forecasted weather period to minimize plants’thermal‘cost’defined by an‘expert’in terms of set-points for the specific *** selection of temperature trajectory is formulated as a generalized traveling salesman problem(GTSP)with precedence constraints and is solved by a genetic algorithm(GA)in this *** simulation study showed good potential for energy saving and timely allocation to prevent excessive crop *** active control elements in addition to predefining and applying,within energy constraints,optimal climate in the greenhouse,it also reduces the energy deficit,*** working hours of the‘heater’in the sustained freezing weather,as well as the ventilation hours,that is,more energy harvest in the warm *** intelligent solar greenhouse management system is being migrated to the web for serving a‘customer base’in the Internet Plus *** capacity,of the concrete ground CAUA system(CAUA is an abbreviations from both China Agricultural University and Agricultural University of Athens),to implement web‘updates’of criteria,open weather data and models,on which control

关键词： solar greenhouse precision energy management energy-saving open weather data traveling salesman optimization

The effect of flutamide on the physical working capacity and activity of some of the key enzymes for the energy supply in adult rats

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Asian Journal of Andrology 2017年第4期19卷 444-448页

作者： Katerina n.georgieva Penka A Angelova Fani D Gerginska Dora D Terzieva Mihaela S Shishmanova-Doseva Slavi D Delchev Valentine V Vasilev Department of Physiology Faculty of Medicine Medical University of Plovdiv Plovdiv 4000 Bulgaria Department of Anatomy Histology and Embryology Faculty of Medicine Medical University of Plovdiv Plovdiv 4000 Bulgaria Department of Clinical Chemistry Faculty of Pharmacy Medical University of Plovdiv Plovdiv 4000 Bulgaria Department of Pharmacology and Drug Toxicology Faculty of Pharmacy Medical University of Plovdiv Plovdiv 4000 Bulgaria

The aim of the study was to assess the effects of androgen receptor antagonists on the physical working capacity and activity of some of the key muscle enzymes for the energy supply in rats. Young adult male Wistar rats were divided into two groups. One group received 15 mg kg-1 of flutamide daily for 6 days a week and the other group served as control for 8 weeks. At the beginning and at the end of the experiment, all rats were subjected to submaximal running endurance （SRE）, maximum time to exhaustion （MTE）, and maximal sprinting speed （MSS） tests. At the end of the trial, maximum oxygen consumption （VO2max） test was performed and the levels of testosterone, erythrocytes, hemoglobin as well as enzyme activity of succinate dehydrogenase （SDH）, lactate dehydrogenase （LDH）, and nAD.H2-cytochrome-c reductase （nAD.H2） of the gastrocnemius muscle were measured. Serum testosterone of the flutamide-treated rats was higher than that of the controls, which verifies the effectiveness of the dose chosen. MTE and SRE of the anti-androgen-treated group were lower compared with the initial values. Flutamide treatment decreased the activity of SDH and nAD.H2 compared with the controls. We found no effect of the anti-androgen treatment on MSS, VO2max, running economy, LDH activity, and hematological variables. Our findings indicate that the maintenance of the submaximal and maximal running endurance as well as the activity of some of the key enzymes associated with muscle oxidative capacity is connected with androgen effects mediated by androgen receptors.

关键词： anti-androgen maximum oxygen consumption maximum time to exhaustion mitochondrial enzymes running economy submaximal running endurance

The Role of nanodispersed nitrides in the Sintering of Silicon nitride Ceramics

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Plasma Science and Technology 2010年第1期12卷 46-48页

作者： M.georgieva G.VISSOKOV I.GRAnCHAROV R.F.SILVA F.J.OLIVEIRA Department of Technology of Inorganic Substances University of Chemical Technology and Metallurgy Institute of Catalysis Bulgarian Academy of Sciences Ceramics and Glass Eng. Department CICECO University of Aveiro

The synthesis of ceramics based on silicon nitride using nanopowders of Tin and Si3n4 as additives was studied. The ceramic compositions were pressurelessly sintered under ni- trogen atmosphere at different temperatures （1550℃, 1650℃ and 1750℃） with a heating rate of 10℃/min and a holding time of 2 h. The nanodispersed nitrides （nDn） were produced by electric-arc plasma synthesis and characterized. The ceramic composites obtained with nanoparticles of 1wt% to 5wt% Tin and 20wt% Si3n4 were characterized by scanning electron microscopy （SEM）, atom force microscopy （AFM） and energy-dispersive spectrometry （EDX）. The effect of the addition of nanodispersed powders on the mechanical properties and microstructure of Si3n4 ceramics was investigated.

关键词： silicon nitride ceramics nanocomposites nanopowders

Toward coherent O-band data center interconnects

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Frontiers of Optoelectronics 2021年第4期14卷 414-425页

作者： Pascal M.SEILER Galina georgieva Georg WInZER Anna PECZEK Karsten VOIGT Stefan LISCHKE Adel FATEMI Lars ZIMMERMAnn Technische Universität Berlin Chair of SiliziumphotonikBerlin 10623Germany IHP–Leibniz-Institut für innovative Mikroelektronik Frankfurt(Oder)15236Germany Technische Universität Berlin Chair of Hochfrequenztechnik-PhotonikBerlin 10623Germany IHP Solutions GmbH Frankfurt(Oder)15236Germany

Upcoming generations of coherent intra/inter data center interconnects currently lack a clear path toward a reduction of cost and power consumption,which are the driving factors for these data *** this work,the tradeoffs associated with a transition from coherent C-band to O-band silicon photonics are addressed and *** discussion includes the fundamental components of coherent data links,namely the optical components,fiber link and *** a major component of these links,a monolithic silicon photonic BiCMOS O-band coherent receiver is evaluated for its potential performance and compared to an analogous C-band device.

关键词： coherent communication data center O-band silicon photonics

Quantitative Assessment of Foveal Avascular Zone in Patients with Early and Intermediate nonexudative Age-Related Macular Degeneration Using Optical Coherence Tomography-Angiography

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Open Journal of Ophthalmology 2018年第3期8卷 133-139页

作者： Vladimir Stavrev nelly Sivkova Desislava Koleva-georgieva Department of Ophthalmology Faculty of Medicine Medical University of Plovdiv Plovdiv Bulgaria

Optical coherence tomography-angiography (OCT-A) is a relatively new non-invasive imaging technique which provides three-dimensional visualization of the retinal and choroidal microvasculature. Recently, OCT-A is widely used in the diagnosis of age-related macular degeneration (AMD). Purpose: To compare 3 quantitative indexes of foveal avascular zone (FAZ)—area (A), perimeter (Pm), and circularity (C) in patients with early and intermediate nonexudative AMD and healthy subjects using OCT-A. Methods: Eighty-nine patients with nonexudative AMD (n = 89 eyes) were enrolled in the study. They were compared with sex- and age-matched control group of 66 healthy subjects (n = 66 eyes). The patients with nonexudative AMD were divided into 2 subgroups—early AMD (n = 42 eyes) and intermediate AMD (n = 47 eyes). All participants underwent OCT-A (3 × 3 mm scans, Cirrus HD-OCT, Angioplex, Carl Zeiss Meditec, Dublin, CA). Results: There was no statistically significant difference in all 3 assessed indexes between the early AMD subgroup and the control group (A ? P = 0.139;Pm ? P = 0.230;and C ? P = 0.191). There was also no statistically significant difference in all 3 assessed indexes between the intermediate AMD subgroup and the control group (A ? P = 0.106, Pm ? P = 0.124, and C ? P = 0.102, respectively). Conclusions: According to our results from the assessment of FAZ in patients with early and intermediate AMD, we hypothesize that macular perfusion remains fairly unchanged in the nonexudative stages of the disease. OCT-A is a reliable technique for visualizing and quantifying FAZ in patients with nonexudative AMD.

关键词： Age-Related Macular Degeneration Optical Coherence Tomography-Angiography Foveal Avascular Zone