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具有极性反转的乳头状肾肿瘤:形态学、免疫组化和分子学研究

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临床与实验病理学杂志 2019年第8期35卷 910-910页

作者：魏建国(摘译) 方三高(审校) Al-Obaidy K I Eble J n Cheng L 浙江省绍兴市人民医院病理科绍兴312000 中国人民解放军陆军特色医学中心病理科重庆400042 不详

作者评估了特殊类型乳头状肾肿瘤的临床病理和染色体特征,并将其与1型和2型乳头状肾细胞癌进行比较。18例中,9例男性,9例女性;年龄范围46~80岁(平均64岁,中位年龄66岁);肿瘤直径0.6~3 cm(平均1.63 cm,中位直径1.4 cm);其中14例WHO/ISUP ... 详细信息

作者评估了特殊类型乳头状肾肿瘤的临床病理和染色体特征,并将其与1型和2型乳头状肾细胞癌进行比较。18例中,9例男性,9例女性;年龄范围46~80岁(平均64岁,中位年龄66岁);肿瘤直径0.6~3 cm(平均1.63 cm,中位直径1.4 cm);其中14例WHO/ISUP 2级,4例WHO/ISUP 1级,肿瘤分期均为pT1期。这类肿瘤具有细小纤维血管轴心的分支状乳头,被覆立方/柱状细胞,胞质颗粒状嗜酸性,管腔边缘光滑,核规则且多位于细胞顶端,偶尔核仁明显或不明显。5例形成小管状结构,9例有明显的胞质空泡,10例具有假包膜。18例肿瘤均无砂粒体、坏死、核分裂象和细胞内含铁血黄素沉积。相比之下,1型乳头状肾细胞癌具有纤细的乳头状结构,被覆单层细胞,胞质稀少,细胞核通常位于乳头状结构基底部呈单层排列,而2型乳头状肾细胞癌具有较宽的乳头状结构,表面被覆细胞呈假复层排列,胞质嗜酸性,核无规则分布。1型和2型乳头状肾细胞癌可见砂粒体、泡沫样巨噬细胞以及细胞内含铁血黄素沉积。免疫组化结果显示,18例肿瘤中ck(AE1/AE3)、EMA、MUC1、CD10、GATA3和L1CAM均阳性。

关键词：乳头状结构 GATA3 基底部泡沫样肿瘤分期假包膜肾肿瘤免疫组化

通心络胶囊对急性心梗PCI术后心肌微循环及心功能的影响

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现代生物医学进展 2018年第20期18卷 3879-3882页

作者：岳黎明李妍杨志偲宁小康畅辉陕西中医药大学附属医院心内科陕西咸阳712000 空军军医大学附属西京医院心内科陕西西安710000

目的:探讨通心络胶囊对急性心梗经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后心肌微循环及心功能的影响。方法:选取2014年1月-2017年6月我院收治的ST段抬高型急性心肌梗死需经PCI患者200例,按照治疗方法分为对照... 详细信息

目的:探讨通心络胶囊对急性心梗经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后心肌微循环及心功能的影响。方法:选取2014年1月-2017年6月我院收治的ST段抬高型急性心肌梗死需经PCI患者200例,按照治疗方法分为对照组、观察组,每组100例。对照组进行常规药物治疗,观察组联合通心络胶囊进行治疗。比较两组PCI后心肌梗死溶栓(thrombolysis in myocardial infarction,TIMI)血流分级与计帧值(corrected thrombolysis in myocardial frame count,CTFC)、ST段回落情况、肌酸磷酸激酶同工酶(creatine phosphokinase-isoenzyme-MB,ck-MB)峰值及峰值时间,治疗前后心功能相关指标的变化。结果:PCI术后,两组冠脉TIMI血流分级比较差异不显著(P>0.05),观察组CFTC显著低于对照组(P50%比例显著高于对照组(Pck-MB峰值及ck-MB峰值时间显著低于对照组(Pntricular ejection fraction,LVEF)、心脏指数(cardiac index,CI)均显著升高(Pntricular end-diastolic dimension,LVEDD)、左心室收缩末期内径(left ventricular end-systolic dimension,LVESD)均显著降低(P<0.05),且观察组的以上指标的改善明显优于对照组(P<0.05)。结论:通心络胶囊在急性心梗PCI后患者的应用中临床疗效良好,能够改善心肌微循环和心功能。

关键词：通心络胶囊经皮冠状动脉介入治疗心肌微循环心功能

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玉米秸秆对风沙土土壤微生物的影响

内蒙古林业科技 2019年第1期45卷 5-10页

作者：袁立敏张文军闫德仁黄海广刘博内蒙古自治区林业科学研究院内蒙古呼和浩特010010 内蒙古自治区森林资源资产评估管理中心内蒙古呼和浩特010010

本研究以新型沙袋沙障为研究对象,分别对不同内部添加物、不同外层材料袋沙障内部、外部风沙土土壤细菌、真菌、放线菌及土壤微生物总量进行了测定。结果表明:沙袋沙障内添加玉米秸秆、玉米芯营养物质能够有效改善沙袋沙障内部风沙土环... 详细信息

本研究以新型沙袋沙障为研究对象,分别对不同内部添加物、不同外层材料袋沙障内部、外部风沙土土壤细菌、真菌、放线菌及土壤微生物总量进行了测定。结果表明:沙袋沙障内添加玉米秸秆、玉米芯营养物质能够有效改善沙袋沙障内部风沙土环境,沙障内部微生物数量显著提高,微生物总数量分别达到了7.35×10~7 cfu/g、9.47×10~7 cfu/g,分别是对照(只灌装风沙土)沙袋沙障的113.11倍、145.62倍,并且添加玉米芯的作用效果更加显著,土壤微生物总数比添加玉米秸秆的高28.77%;添加玉米秸秆、玉米芯均对土壤真菌的影响较大,真菌数量可升高至微生物总数量的50%以上;玉米秸秆、玉米芯添加量越多,微生物数量越多,添加物体积百分比达到20%时,土壤微生物总数达到了1.01×10~8 cfu/g,随着添加量的继续增加,沙障内微生物数量无显著增加趋势;3种外层材料黄麻纤维、玻璃纤维、稻草沙袋沙障内部微生物总数排序为黄麻纤维>稻草>玻璃纤维,黄麻纤维沙障内部土壤细菌、真菌、放线菌三者总数分别比稻草、玻璃纤维的高58.80%、112.64%。

关键词：沙袋沙障外层材料填充物细菌真菌放线菌库布齐沙漠

BTH不同处理方式对‘红地球’葡萄果实品质的影响

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西部林业科学 2017年第3期46卷 51-59页

作者：邵建辉马春花朱书生祖艳群李元云南农业大学农业生物多样性与病虫害控制教育部重点实验室云南昆明650201 云南农业大学园林园艺学院云南昆明650201 云南农业大学资源与环境学院云南昆明650201

为明确植物诱抗剂BTH不同处理方式对葡萄果实品质的影响。以避雨栽培条件下的‘红地球’葡萄为试验材料,在葡萄转色初期进行不同浓度(30mg/L,60mg/L和120mg/L)的BTH喷穗处理(FO)和全树喷施(FT)处理,研究BTH不同浓度和处理方式对‘红地... 详细信息

为明确植物诱抗剂BTH不同处理方式对葡萄果实品质的影响。以避雨栽培条件下的‘红地球’葡萄为试验材料,在葡萄转色初期进行不同浓度(30mg/L,60mg/L和120mg/L)的BTH喷穗处理(FO)和全树喷施(FT)处理,研究BTH不同浓度和处理方式对‘红地球’葡萄的果实形态指标(纵径、横径和单果重),颜色指标(L~*,a~*、b~*、C和h°,CIRG),可溶性总糖含量、可溶性固形物含量、可滴定酸含量、固酸比、pH值、总酚和类黄酮含量的影响。试验结果表明,BTH各种处理方式均可显著提高葡萄果面的颜色指数CIRG(18.30%~41.91%),总花色素苷(21.21%~117.42%)、总酚(43%~64%)和类黄酮(7.75%~26.36%)含量。将单果重、果形指数、可溶性固形物、可溶性总糖、可滴定酸、固酸比、总花色素苷、CIRG、总酚和类黄酮等10个指标作为综合评价指标,采用隶属函数值法对BTH各种处理后的葡萄果实品质进行了综合评价,结果显示‘红地球’葡萄在果实转色初期不同浓度BTH两种喷施方式(FO或FT)均可提高‘红地球’葡萄果实的综合品质,打分排序结果为FO-60>FO-120>FO-30>FT-30>FT-60>FT-120>ck,果穗喷施(FO)处理的整体效果要好于全树喷施(FT)处理,以60mg/L BTH果穗喷施(FO)处理效果最好。

关键词：苯并(1,2,3)噻二唑-7-硫代羧酸甲酯(BTH) 红地球转色期果实品质

Mechanical, thermal and interfacial properties of Carbon-Kevlar reinforced epoxy composite

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Materials Engineering Research 2019年第2期1卷 56-63页

作者： Milon Hossain Kamrun n. Keya nasrin A. Kona naimul Islam Farjana A. Koly Mubarak A. Khan Abu Bakar Siddiquee Jumana Mahmud Ruhul A. Khan Institute of Radiation and Polymer Technology Bangladesh Atomic Energy Commission Dhaka 1000 Bangladesh. Department of Textile Engineering Khulna University of Engineering & Technology Khulna 9203 Bangladesh Department of Textile Engineering Mawlana Bhashani Science and Technology University Tangail 1902 Bangladesh

Twill woven Carbon-Kevlar (ck) fabric was reinforced in epoxy matrix by conventional hand lay-up process. The fabric weight fraction in the composites was kept around 58% and stacking sequence was varied from single to five plies. Tensile test was performed and the fracture surface after tensile test was evaluated by scanning electron microscope (SEM). The test result revealed that the tensile properties are strongly dependent on the number of plies. Three point flexural test of the composite was also carried and an increasing trend was observed. Maximum impact energy was recorded for ck3 sample by 202.7 KJ/m2. Thermal stability of the composite was studied via the thermo gravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FT-IR) result show interaction between fiber and matrix material. Finally, ck fabric reinforced epoxy-based composites showed balanced and tailor-able mechanical properties by varying the number of plies, suitable for desired applications in many areas including building, construction, marine, automotive etc.

关键词： Carbon-Kevlar fabric epoxy polymer composites mechanical properties thermal properties

结肠直肠腺瘤与腺癌中p16、p53和p63的免疫组化表达研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 11-11页

作者： Carneiro F.P. Ramalho L.n.Z. Britto-Garcia S. 刘丽娜 Department of Pathology Faculty of Medicine of Ribeiro PretoUniversity of So PauloAv Bandeirantes 390014049-900 Ribeiro PretoSPBrazil Dr.

PURPOSE: The aim of this study was to investigate the immunohistochemical expression of p16, p53, and p63 proteins according to some pathologic parameters related to colorectal adenomas and adenocarcinomas such as grade of dysplasia and histologic type. METHODS: Immunohistochemistry with the antibodies p16, p53, and p63 was performed in tubular, tubularvillous, and villous adenomas (n = 30) and in well, moderately, and poorly differentiated adenocarcinomas (n = 30). The p63-positive cases were submitted to double immunolabeling with the cytokeratin 5 (ck5). RESULTS: The p16 and p53 labelings were observed in some adenomas and adenocarcinomas but without any association with p63 expression, histologic type, or grade of differentiation of the neoplasm. P63 expression was found mainly in the villous adenomas and in the poorly differentiated adenocarcinomas. The poorly differentiated adenocarcinomas also exhibited coexpression of ck5 and p63. COnCLUSIOnS: Despite both p16 and p53 having been detected in colorectal neoplasms, they were not related to the different histologic variables nor to the expression of p63. However, p63 expression was closely associated with villous adenomas and poorly differentiated adenocarcinomas. Thus, p63 may represent a marker of poor differentiation in colorectal neoplasms. The coexpression of p63 and ck5 observed in this study could be related to divergent differentiation during the development of colorectal cancer, although further studies are warranted to refine the understanding of this process.

关键词：结肠直肠腺瘤 p16 p53 p63 绒毛状腺瘤结肠直肠肿瘤病理学参数结肠直肠癌肿瘤分化程度

叶面喷施茉莉酸甲酯对马铃薯微型薯生长及产量的影响

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亚热带植物科学 2020年第4期49卷 247-252页

作者：杨天宇韩小女徐尤先汤金香展康吴劲松王蕾中国科学院昆明植物研究所云南昆明650201 宣威市马铃薯种薯研发中心云南宣威655400 中国科学院大学北京100049

以‘云薯505’马铃薯(Solanum tuberosum‘Yunshu 505’)为材料,测定马铃薯块茎发育初期四个阶段茉莉酸含量,并以叶面喷施方式,研究茉莉酸甲酯对马铃薯生长和块茎产量的影响。结果表明,马铃薯块茎膨大过程中,茉莉酸的积累水平不断升高... 详细信息

以‘云薯505’马铃薯(Solanum tuberosum‘Yunshu 505’)为材料,测定马铃薯块茎发育初期四个阶段茉莉酸含量,并以叶面喷施方式,研究茉莉酸甲酯对马铃薯生长和块茎产量的影响。结果表明,马铃薯块茎膨大过程中,茉莉酸的积累水平不断升高。在微型薯生产中,使用100μmol·L^-1茉莉酸甲酯在结薯期以不同频率喷施叶面,测量并统计植株、块茎性状及产量变化。结果表明,与对照(ck)相比,1次·d^-1处理茎粗增加36.1%,2次·d^-1处理的叶绿素含量降低20.1%。此外,植株的叶色、茎色、花色、株型等生长性状及块茎大小整齐度、薯形、皮色、肉色、薯皮类型、芽眼深浅、裂薯率、大薯空心率等块茎性状在各组间没有显著差异。2次·d^-1、1次·d^-1、1次·2d^-1、ck四种处理的植株存活率分别为45.57%、100.00%、100.00%、87.29%;前三种喷施频率处理折合产量较ck分别增加-15.61%、8.77%、12.11%。综合分析,马铃薯在块茎形成初期茉莉酸积累水平不断升高,以1次·2d^-1频率叶面喷施100μmol·L^-1茉莉酸甲酯,马铃薯微型薯的产量增加最大且不影响生长。

关键词：马铃薯微型薯茉莉酸甲酯叶面喷施

ST段抬高型心肌梗死患者接受直接冠状动脉成形术后早期再梗死的预测因素和临床意义

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 13-13页

作者： De Luca G. Ernst n. van't Hof A.W.J. H. Suryapranata 尹涛 Department of Cardiology ISALA Klinieken Hospital De Weezenlanden Zwolle Netherlands Dr.

Background: Recurrent infarction after fibrinolytic therapy has been shown to be associated with increased mortality. The aim of this study was to analyze predictors and outcome of reinfarction in a consecutive series of patients undergoing primary angioplasty. Methods: Our population is represented by a total of 1955 patients with ST-segment elevation myocardial infarction treated by primary angioplasty between 1997 to 2002. All clinical, angiographic, and follow-up data were prospectively collected. Early reinfarction was defined when two clinical criteria were satisfied within 30 days after the procedure:(1)recurrent ischemic symptoms for >15 minutes after resolution of symptoms from initial MI;(2) new ST-T-wave changes or new Q waves;(3) reelevation in creatine kinase(ck) or ck-MB to higher levels than normal(or by another 20%if already higher than normal). Results: Early reinfarction was observed in 75(3.8%) patients. At multivariate analysis, advanced Killip class(P=.002), poor preprocedural TIMI flow(P=.014), administration of IIb-IIIa inhibitors(P=.02), and diabetes(P=.038) were independent predictors of 30-day reinfarction. A total of 107(5.6%) patients had died. Early reinfarction was associated with a significantly higher mortality(22.7%vs 4.9%, Pn after adjustment for confounding factors(blood pressure, diabetes, Killip class, preprocedural TIMI flow, coronary stenting, multivessel disease, anterior infarct location, preprocedural stenosis, and administration of IIb-IIIa inhibitors)(HR 3.32, 95%CI 1.88-5.84, Pnclusions: This study showed that, among patients undergoing primary angioplasty for ST-segment elevation myocardial infarction, advanced Killip class at presentation, poor preprocedural TIMI flow, the use of IIb-IIIa inhibitors, and diabetes are independently associated with 30-day reinfarction. Early reinfarction is an independent predictor of 1-year mortality.

关键词：再梗死冠状动脉成形术 ST段抬高多支血管病变冠状动脉支架缺血症状狭窄程度研究人群受体拮

Measurement of Ξcc++ production in pp collisions at s1/2=13 TeV

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Chinese Physics C 2020年第2期44卷 13-23页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves Jr S.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann J.J.Back S.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi V.Batozskaya B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin S.Belin V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim S.Benson S.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom M.S.Bieker S.Bifani P.Billoir A.Bizzeti M.Bjørn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar n.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk T.J.V.Bowcock C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani R.Cenci J.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.cholak M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo A.Comerma-Montells A.Contu n.Cooke G.Coombs S.Coquereau G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska A.Crocombe M.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo J.Dalseno C.D' Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3UniversitéParis-SaclayOrsayFrance LPnHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland InFn Sezione di Bari BariItaly InFn Sezione di Bologna BolognaItaly InFn Sezione di Ferrara FerraraItaly InFn Sezione di Firenze FirenzeItaly InFn Laboratori nazionali di Frascati FrascatiItaly InFn Sezione di Genova GenovaItaly InFn Sezione di Milano-Bicocca MilanoItaly InFn Sezione di Milano MilanoItaly InFn Sezione di Cagliari MonserratoItaly InFn Sezione di Padova PadovaItaly InFn Sezione di Pisa PisaItaly InFn Sezione di Roma Tor Vergata RomaItaly InFn Sezione di Roma La Sapienza RomaItaly nikhef national Institute for Subatomic Physics AmsterdamNetherlands nikhef national Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk niewodniczanski Institute of nuclear Physics Polish Academy of Sciences KrakówPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakówPoland nationa

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4nd the rapidity range2.0n this measurement correspond to an integrated luminosity of 1.7fb^-1,recorded by the LHCb experiment during *** ratio of the ■ production cross-section times the branching fraction of the■→∧^+ck^-π^+ π^+decay relative to the prompt ∧^+c production cross-section is found to be(2.22±0.27±0.29)×10^-4,assuming the central value of the measured lifetime,where the first uncertainty is statistical and the second systematic.

关键词： doubly charmed baryons hadron production QCD