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MAGI-2 downregulation:a potential predictor of tumor progression and early recurrenee in Han Chinese patients with prostate cancer

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Asian Journal of Andrology 2020年第6期22卷 616-622页

作者： Zhi Cao Jin Ji Fu-Bo Wang Chen Kong Huan Xu Ya-Long Xu Xi Chen Yong-Wei yu Ying-Hao Sun Department of Urology Changhai HospitalNavy Medical UniversityShanghai 200433China Department of Traditional Chinese Medicine NewJiangwan City Community Health Service CentreShanghai 200433China Department of Pathology Changhai HospitalNavy Medical UniversityShanghai 200433China

Membrane-associated guanylate kinase(MAGUK)family protein MAGUK invert 2(MAGI-2)has been demonstrated to be involved in the tumorigenic mechanism of prostate *** objective of this study was to investigate the expression of MAGI・2 at mRnA and protein *** prog no stic value of MAGI-2 in Han Chin ese patie nts with prostate cancer was also *** expression data of MAGI・2 were assessed through database retrieval,analysis of sequencing data from our group,and tissue immunohistochemistry using digital scoring system(H・score).The clinical,pathological,and follow-up data were *** expression of MAGI-2 in prostate tumor tissues and prostate normal tissues was evaluated and ***-2 expression was associated with clinical parameters including tumor stage,lymph node status,Gleason score,PSA level,and biochemical recurrenee of prostate *** relative expression of MAGI-2 mRnA was lower in the tumor tissue in The Cancer Genome Atlas(TCGA)database and sequencing data(Pno difference in MAGI-2 protein expression between tumor and normal tissues in tissue microarray(TMA)***-2 expression was associated with pathological tumor stage(P=0.02),Gleason score(P=0.05),and preoperation prostate-specific antigen(PSA;P=0.04).A positive correlation was identified between MAGI-2 and phosphatase and tensin homolog deleted on chromosome 10(PTEn)expressions through the analysis of TCGA and TMA data(Pnts with higher MAGI-2 expression had longer biochemical recurrence-free survival in the univariate analysis(P=0.005),which in dicates an optimal prog no stic value of MAGI-2 in Han Chin ese patie nts with prostate can cer.I n con elusion,MAGI-2 expressi on gradually decreases with tumor progression,and can be used as a predictor of tumor recurrence in Chinese patients.

关键词： biochemical recurrenee Chinese patients MAGI-2 prostate cancer tissue microarray

Silencing of transcription factor E93 inhibits adult morphogenesis and disrupts cuticle, wing and ovary development in Locusta migratoria

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Insect Science 2022年第2期29卷 333-343页

作者： Xiao-Jian Liu Guo Jun Xiao-yu Liang Xue-Yao Zhang Ting-Ting Zhang Wei-Min Liu Jian-Zhen Zhang Min Zhang Research Institute of Applied Biology Shanxi UniversityTaiyuanChina

Ecdysone-induced protein 93F(E93)plays important roles during the metamorphosis process in *** this study,a cDnA of the LmE93 gene was identified from the transcriptome of Locusta migratoria,which consists of the 3378-nucleotide open-reading frame(ORF)and encodes 1125 amino acids with helix–turn–helix(HTH)*** transcription quantitative polymerase chain reaction analysis revealed that LmE93 was highest expressed in *** LmE93 expression level was markedly low from the 3rd to 4th instar nymphs,and greatly increased in 1-day-old 5th instar nymphs with a peak on middle nymphal days,then declined in the late nymphal ***,injected dsLmE93 into 4th and 5th instar nymphs greatly reduced LmE93 transcripts,respectively,and prevented the process of metamorphosis,causing supernumerary nymphal ***–eosin staining of the integument showed that the apolysis occurred in advance in 4th instar nymphs,and old cuticle degradation was decreased in dsLmE93-injected locusts of 5th instar *** and no fully developed wings with reduced columns between the anterior and posterior regions were found in n6 and n7 supernumerary *** addition,the development of the ovary in dsLmE93-injected locusts was severely blocked,the yolk was almost not formed and there was no development of *** results indicated that LmE93 play key roles in the metamorphosis,cuticle,wing and ovarian development of locusts.

关键词： expression function Locusta migratoria RnA interference transcription factor E93

Isolation and characterization of a high-efficiency marine diesel oil-degrading bacterium

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Petroleum Science 2021年第2期18卷 641-653页

作者： Jin Gao Jie Ming Meng Xu Xinge Fu Liang-Feng Duan Cong-Chao Xu yu Gao Jian-Liang Xue Xin-Feng Xiao College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao266590China College of Chemical Engineering China University of PetroleumBeijing102249China

In the recent 50 years,marine oil spills had resulted in severe environmental pollution problems *** this study,12 petroleum-degrading strains named MJ1 to MJ12,which can use diesel oil as the sole carbon source for growth,were isolated from the seawater in Jiaozhou Bay,*** MJ4 has the highest diesel-degrading rate which is up to 26.54%in 5 days with the diesel oil concentration of 10 g/*** to the BLAST research,16SrRnA sequence of MJ4 showed 99%similarity to Bacillus megaterium ***-factor experiments and response surface methodology were carried out to optimize the environmental factors and their reciprocal action for affecting the diesel oil degradation process of Bacillus *** of single-factor experiments revealed that the highest degradation rate was obtained with temperature of 28°C,pH of 8.8,diesel oil concentration of 25 g/L,P/n ratio of 0.56,nitrogen and phosphorus dosage quantity of 0.35 g/L and 0.18 g/L,respectively.A nonlinear regression equation of diesel oil degradation rate and pH,temperature,P/n ratio was *** model predicted the maximum degradation rate of 72.21%with temperature of 28°C,pH of 8.88,P/n ratio of 0.31,respectively.

关键词： Bioremediation Bacillus megaterium MJ4 Environmental factors Marine oil spill Response surface methodology

Leonurine: From Gynecologic Medicine to Pleiotropic Agent

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Chinese Journal of Integrative Medicine 2020年第2期26卷 152-160页

作者： LI yun-yun LIn Yi-kong LIU Xin-hua WAnG Li yu Min LI Da-jin ZHU Yi-zhun DU Mei-rong nHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research) Hospital of Obstetrics and Gyn ecologyFuda n Un iversity Sha nghai Medical CollegeShanghai(200011)China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai(200011)China Shanghai Key Laboratory of Bioactive Small Molecules Department of PharmacologySchool of PharmacyFudan UniversityShanghai(201203)China State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy Macao Un iversity of Science and Tech no logyMacao SARChina

Leonurus japonicus Houtt,a Chinese traditional herbal medicine,has been widely used to cure gynecological diseases,such as incomplete abortion and ***,a major active alkaloid compound only be found in Leonurus japonicus Houtt,has been successfully extracted and *** evidence has shown that leonurine can regulate a variety of pathologic processes including oxidative stress,inflammation,fibrosis,apoptosis,and multiple metabolic ***,we have reviewed the pharmacological actions and biological functions of leonurine,with a focus on the role of leonurine in the amelioration of various pathological *** into the related signaling pathways and molecular mechanisms have strengthened our understanding on the function of leonurine in the alleviation of multiple pathological *** summary of the existing researches should help direct future research into the basic science and clinical applications in related diseases.

关键词： leonurine Leonurus japonicus Houtt Chinese medicine oxidative stress inflammation fibrosis clinical application

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高维单形二面角与顶点角的若干关系

辽宁工程技术大学学报（自然科学版） 2007年第3期26卷 479-480页

作者：原玉杰阜新高等专科学校工程系辽宁阜新123000

为将平面三角学推广到高维空间,最终构建高维三角学理论体系。首先将常见三角形不等式作推广,以正则单形基本性质为依托,引进顶点角概念并建立与顶点角有关的二面角概念,建立n维单形Ωn的n+1个界面的单位外向法向量的度量矩阵,以矩阵理... 详细信息

为将平面三角学推广到高维空间,最终构建高维三角学理论体系。首先将常见三角形不等式作推广,以正则单形基本性质为依托,引进顶点角概念并建立与顶点角有关的二面角概念,建立n维单形Ωn的n+1个界面的单位外向法向量的度量矩阵,以矩阵理论为基本推理工具,以矩阵特征多项式为契机实现了上述初步构想。在正则单形的基本性质基础上,给出了任何n维单形Ωn的二面角与顶点角之间的不等式关系,其中主要结果包括三个定理与四个推论.通过n维单形Ωn的如上性质的研究可知平面三角学中的相关性质均可拓展到n维空间中。

关键词：高维单形二面角顶点角关系

Predicting the grades of Astragali radix using mass spectrometrybased metabolomics and machine learning

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Journal of Pharmaceutical Analysis 2021年第5期11卷 611-616页

作者： Xinyue yu Jingxue nai Huimin Guo Xuping Yang Xiaoying Deng Xia yuan yunfei Hua yuan Tian Fengguo Xu Zunjian Zhang Yin Huang Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical UniversityMinistry of EducationNanjing210009China Department of Pharmaceutical Analysis School of PharmacyChina Pharmaceutical UniversityNanjing210009China Center for Biological Technology Anhui Agricultural UniversityHefei230036China

Astragali radix(AR,the dried root of Astragalus)is a popular herbal remedy in both China and the United *** commercially available AR is commonly classified into premium graded(PG)and ungraded(UG)ones only according to the *** uncover novel sensitive and specific markers for AR grading,we took the integrated mass spectrometry-based untargeted and targeted metabolomics approaches to characterize chemical features of PG and UG samples in a discovery set(n=16 batches).A series of five differential compounds were screened out by univariate statistical analysis,including arginine,calycosin,ononin,formononetin,and astragalosideⅣ,most of which were observed to be accumulated in PG samples except for astragalosideⅣ.Then,we performed machine learning on the quantification data of five compounds and constructed a logistic regression prediction ***,the external validation in an independent validation set of AR(n=20 batches)verified that the five compounds,as well as the model,had strong capability to distinguish the two grades of AR,with the prediction accuracy>90%.Our findings present a panel of meaningful candidate markers that would significantly catalyze the innovation in AR grading.

关键词： Astragali radix Metabolomics Machine learning Quality markers Prediction model

Selectively nucleotide-derived RuP on n,P-codoped carbon with engineered mesopores for energy-efficient hydrogen production assisted by hydrazine oxidation

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SusMat 2024年第1期4卷 166-177页

作者： Xiya Guan yu Sun Simeng Zhao Haibo Li Suyuan Zeng Qingxia Yao Rui Li Hongyan Chen Konggang Qu School of Chemistry and Chemical Engineering Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage&Novel Cell TechnologyLiaocheng UniversityLiaochengChina

Integrating hydrogen evolution reaction(HER)with hydrazine oxidation reaction(HzOR)has an encouraging prospect for the energy-saving hydrogen production,demanding the high-performance bifunctional HER/HzOR *** phosphide/doped carbon composites have exhibited superior activity towardmultiple electrocatalytic *** explore the decent water-soluble precursors containing bothnand P elements is highly attractive to facilely prepare metal phosphide/doped carbon ***,as one kind ecofriendly biomolecules,adenine nucleotide was first employed to selectively fabricate the highly pure RuP nanoparticles embedded into porous n,P-codoped carbons(RuP/PnPC)with a straightforward“mix-and-pyrolyze”*** newly prepared RuP/PnPC only requires 4.0 and−83.0 mV at 10 mA/cm^(2) separately in alkaline HER and HzOR,outperforming most of reported electrocatalysts,together with the outstanding neutral bifunctional ***,the two-electrode alkaline and neutral overall hydrazine splitting both exhibit significant power-efficiency superiority to the corresponding overall water splitting with the voltage difference of larger than 2 V,which can be also easily driven by the fuel cells and solar cells with considerableH2 *** report innovates the n-and P-bearing adenine nucleotide to effortlessly synthesize the high-quality RuP/doped carbon composite catalysts,highly potential as a universal platform for metal phosphide-related functional materials.

关键词： bifunctional electrocatalyst hydrazine oxidation hydrogen energy hydrogen evolution RuP

Design of tooth color measurement system based on silicon double P-n junction color sensor

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Frontiers of Electrical and Electronic Engineering in China 2009年第3期4卷 318-322页

作者： Zengliang SHI Dali LIU yu WAnG Xi CHEn Shiying BAI Jingwei XU State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China Changchun Institute of Applied Chemistry Chinese Academy of SciencesNational Analytical Research Center of Electrochemistry and SpectroscopyChangchun 130022China

Working principles of silicon double P-n junction color sensor are introduced and a color measurement system to distinguish tooth color difference is designed in this *** system consists of silicon double P-n junction,a small optical fiber probe,signal process circuit and an MSP430FG439 single-chip *** in size,this system can measure different parts of the tooth in a fast and convenient way with ***,this system will be very promising in building prosthodontics and tooth fabrication.

关键词： silicon double P-n junction color sensor color identification MSP430FG439 single-chip

Enhancement of Electroluminescence by Low-Temperature Deposition of Organic Thin Solid Films

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Chinese Physics Letters 1997年第2期14卷 141-144页

作者： GU Jian-hua XU Min-hua XIAO Zhong-dang LU Zu-hong HUAnG Song-yu national Laboratory of Molecular and Bioelectronics Southeast UniversityNanjing 210096 Department of Physics East China University of Science and Technologx Shanghai 200237

The electrical and light-emitting behaviors of electroluminescent cells,which consist of naphthoylimide(nPL)as emitting layer and poly(3-octylthiophene)(P3OT)doped with poly(n-vinylcarbazoe)(PVK)as hole transport layer sandwiched between indium-tin-oxide(ITO)and aluminum electrode,have been *** mixed polymer(P3OT:PVK)layer and the emitting layer were deposited by spin coating and by vacuum deposition *** was found that the visible blue emission could be observed from the cells at low bias *** when the ITO substrate was cooled to near the liquid n_(2) temperature during the deposition of nPL emitting layer,the brightness of the cell *** was confirmed that holes could be easily injected into nPL layer with deposition temperature decreased.

关键词： layer Solid sandwich