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高生长速率下高声学Q石英的生长

地球与环境 1975年第1期 21-23页

作者： n.c.lias ,Ms.E.F.Grudenski ,刘国彬

水热生长的合成石英中高的声损失严重地降低其可用性,特别是对于高频应用更是如此。早巳知悉,声损失是与碱性生长溶液中以（OH）-形式进入晶格的间隙 H+有关的,H+则是为了补偿晶格中 Si+4位置上存在的非正四离子(Fe+3、Fe+2、cu+2、Al+3... 详细信息

水热生长的合成石英中高的声损失严重地降低其可用性,特别是对于高频应用更是如此。早巳知悉,声损失是与碱性生长溶液中以（OH）-形式进入晶格的间隙 H+有关的,H+则是为了补偿晶格中 Si+4位置上存在的非正四离子(Fe+3、Fe+2、cu+2、Al+3)的。

关键词：填充度生长速率高压釜高压容器石英硅氧矿物

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高生长率下高声学Q水晶的生长

人工晶体学报 1975年第1期 53-68页

作者： n.c.lias E.E.GRUDESKI E.D.KIOB R.A.LAUDISE 西屋电气公司西屋电气公司贝尔实验室贝尔实验室

本文报告了在100密耳/日(25毫米/日)以上的生长率下高声学 Q(>10～6)水晶的水热生长法。本方法与引起损耗的质子在水晶中的固相溶解度随生长温度的增高而减小的事实有密切关系。高 Q-高生长率生长的典型条件为:结晶温度-374℃;溶解区与... 详细信息

本文报告了在100密耳/日(25毫米/日)以上的生长率下高声学 Q(>10～6)水晶的水热生长法。本方法与引起损耗的质子在水晶中的固相溶解度随生长温度的增高而减小的事实有密切关系。高 Q-高生长率生长的典型条件为:结晶温度-374℃;溶解区与生长区之间的温度差△T-23℃;填充度-88%;压力-40000

关键词：填充度质子核子高压容器高压釜水热生长石英水晶生长率平衡常数分布常数晶体生长试验方程方程式

Impact-sliding wear response of 2.25cr1Mo steel tubes:Experimental and semi-analytical method

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Friction 2022年第3期10卷 473-490页

作者： Meigui YIn Thibaut cHAISE Liwen WAnG Daniel nÉlias Minhao ZHU Zhenbing cAI Tribology Research Institute Key Lab of Advanced Technologies of MaterialsSouthwest Jiaotong UniversityChengdu 610031China Univ Lyon INSA LyonCNRSLaMCoSUMR5259Villeurbanne 69621France Research Institute of Dongfang Electric corporation Chengdu 611731China

The impact-sliding wear behavior of steam generator tubes in nuclear power plants is complex owing to the dynamic nature of the mechanical response and self-induced tribological *** this study,the effects of impact and sliding velocity on the impact-sliding wear behavior of a 2.25cr1Mo steel tube are investigated experimentally and *** the experimental study,a wear test rig that can measure changes in the impact and friction forces as well as the compressive displacement over different wear cycles,both in real time,is designed.A semi-analytical model based on the Archard wear law and Hertz contact theory is used to predict *** results indicate that the impact dynamic effect by the impact velocity is more significant than that of the sliding velocity,and that both velocities affect the friction force and wear *** experimental results for the wear depth evolution agree well with the corresponding simulation predictions.

关键词： impact-sliding wear semi-analytical 2.25cr1Mo steel tube nuclear reactors

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes c.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGcs). However, the use of tnGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGcs and compared the various features of these improved silk^(+) tnGcs with the tubes without holes(silk^(–) tnGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton cellular communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced center for chronic Diseases(AccDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(cD90)

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David Vc Brito clévio nóbrega Algarve Biomedical center-Research Institute(ABc-RI) Campus GambelasFaroPortugal Algarve Biomedical center-(ABc) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMcB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight