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采用智能集成电路VK05的APFC电路设计

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电子设计应用 2003年第12期 69-71页

作者： n.aiello F.Gennaro 意法半导体

引言智能功率集成电路VK05专门用于半桥电子镇流器电路,采用的纵向智能功率(VIPower)专利技术,在发射极开关(共射-共基)结构内集成一个单片功率双极结型晶体管(BJT)和场效应MOS晶体管.VK05的内部结构如图1所示.该器件有5个连接引脚,其中... 详细信息

引言智能功率集成电路VK05专门用于半桥电子镇流器电路,采用的纵向智能功率(VIPower)专利技术,在发射极开关(共射-共基)结构内集成一个单片功率双极结型晶体管(BJT)和场效应MOS晶体管.VK05的内部结构如图1所示.该器件有5个连接引脚,其中有3个控制引脚:用于启动电子镇流器的Diac,用于自驱动半桥同步开关的Sec、用于频率设置的Osc.功率级由一个BVces=600V、IC=400mA的高压功率BJT和一个Vds=60V的低压功率场效应MOS晶体管组成.

关键词：智能集成电路 VK05 APFC电路电路设计半桥电子镇流器电路

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电子变压器用的智能功率晶体管

世界电子元器件 1998年第10期 45-48页

作者： n.aiello V.Graziano V.Sukumar 意法微电子有限公司

VB348LDIH是用新的纵向功率IC工艺过程设计和制造的,它是一种具有五条引线的PEnTAWATT(5瓦)功率器件,非常适用于电子变压器应用,价格也适中。这个IC由一个高压双极型MOS发射极开关功率级、驱动电路系统和保护部件(包括过温和过流关断电... 详细信息

VB348LDIH是用新的纵向功率IC工艺过程设计和制造的,它是一种具有五条引线的PEnTAWATT(5瓦)功率器件,非常适用于电子变压器应用,价格也适中。这个IC由一个高压双极型MOS发射极开关功率级、驱动电路系统和保护部件(包括过温和过流关断电路)组成。该IC的主要优点是:过温和过流保护,集成DIAC(二极管交流开关)功能,及寄生参数的变化控制。

关键词：电子变压器智能型功率晶体管

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一种用于光伏分布式系统的新型架构

电力电子 2012年第1期10卷 36-39页

作者： Francesco Gennaro n.aiello G.Scuderi R.Attanasio STMicroelectronics 黄海王剑北京交通大学电气工程学院

在如今的光伏发电站中,为了获得更高的母线电压,以适应并网逆变器的运行,电池板通常是串联的,并根据装机容量,再将许多串联的电池板并联起来。这种方法被称为"集中式",这是因为整个阵列板被连接到一个电能变换器,并由它负责电能管理。... 详细信息

在如今的光伏发电站中,为了获得更高的母线电压,以适应并网逆变器的运行,电池板通常是串联的,并根据装机容量,再将许多串联的电池板并联起来。这种方法被称为"集中式",这是因为整个阵列板被连接到一个电能变换器,并由它负责电能管理。另一方面,由"分布式"方法组成的系统的电能管理是在电池板层面执行的,采用的是"智能接线盒"(SJB),它配备了一个内嵌MPPT算法的DC/DC变换器。这种技术有几个优点,包括增加能源生产(6%-15%)以及减少维修。许多适用于分布式方法的拓扑结构已推向市场,但从成本或应用的角度来看它们表现出了一定的局限性。然而,数以百万计的电池板已配备智能接线盒,体现了一种新的技术和市场趋势。本文提出了一种新型的、适用与分布式方法的架构,它可以克服上述的缺点。这种新的方案将最终打开分布式光伏系统的市场,带来巨大的能源生产进步和投资回报。

关键词：光伏分布式系统能源生产

nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology