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Vagus.n.rve s.imulation.in.in.racerebral hemorrhage:the n.ed for further res.arch

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n.ural Regen.ration.Res.arch 2025年第11期20卷 3213-3214页

作者： s.eharyar s.Baig Ali n.Ali Ars.ad Majid s.effield In.titute for Tran.lation.l n.uros.ien.e Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus.n.rve s.imulation.Vn.)an. s.roke:s.roke is.the s.con. leadin. caus. of death an. the third leadin. caus. of dis.bility worldwide(Baig et al.,2023).There have been.s.gn.fican. paradigm s.ifts.in.the man.gemen. of acute is.hemic s.roke through mechan.cal *** chron.c is.hemic s.roke,in.as.ve Vn. paired with rehabilitation.is.as.ociated with a s.gn.fican. in.reas. in.upper limb motor recovery an. is.FDA-approved(Baig et al.,2023).There are n. treatmen.s.of s.milar efficacy in.acute in.racerebral hemorrhage(ICH)where s.veral promis.n. trials.e.g.,TICH-2,s.OP-AUs.,an. TRAIGE did n.t s.ow improvemen.s.in.fun.tion.l outcomes.Puy et al.,2023).

关键词： s.imulation acute

Green.ion.c metal-organ.c frameworks.as.n.n.catalys.s.for CO_(2)fixation

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n.n. Res.arch 2025年第1期18卷 260-269页

作者： n.ria Martín.Miguel Maireles.Porcar Julián.s.n.hez Velan.ia Belén.Altava Fran.is.o G.Cirujan. Eduardo García-Verdugo Departamen.o de Química In.rgán.ca y Orgán.ca Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,n.,an. Zn.is.-reticular coordin.tion.polymers.of 2,5-dihydroxyterphthalic acid(H_(2)dot)can.be rapidly obtain.d un.er room temperature an. aqueous.con.ition. us.n. either s.dium or ammon.um hydroxide as.the bas.s.to deproton.te the *** us. of metal bromides.an. tetrabutylammon.um hydroxide(TBAOH)as.the bas. allows.the green.s.n.hes.s.of ion.c metal-organ.c frameworks.MOFs.,characterized by X-ray diffraction.XRD),Fourier tran.form in.rared(FTIR),s.an.in. electron.micros.opy(s.M),thermo gravimetric an.lys.s.TGA),H-n.clear magn.tic res.n.n.e(n.R),elemen.al an.lys.s.an. X-ray photoelectron.s.ectros.opy(XPs.,an. employed in.the pres.ure,s.lven.,an. additive-free CO_(2)fixation.to epoxides.by its.cycloaddition.to epichlorohydrin.exhibitin. a cooperative behavior between.the MOF an. the ion.c liquid formed within.the framework,achievin. TOn. of the con.in.d tetrabutylammon.um bromide(TBABr)up to 700.

关键词： metal-organ.c frameworks.MOFs. ion.c liquids heterogen.ous.catalys.s CO_(2)con.ers.on

Brain.derived n.urotrophic factor s.gn.lin. in.the n.uromus.ular jun.tion.durin. developmen.al axon.l competition.an. s.n.ps. elimin.tion

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n.ural Regen.ration.Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balan.à-s.gura Aleks.n.ra Polis.chuk Laura n.dal Marta Tomàs.Carolin. s.lvera-s.món.Man.l M.s.n.afé Maria A.Lan.za Un.tat d’His.ologia i n.urobiologia(UHn.urob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

Durin. the developmen. of the n.rvous.s.s.em,there is.an.overproduction.of n.uron. an. *** competition.between.n.ighborin. n.rve en.in.s.an. s.n.ps.s.performin. differen. activity levels.leads.to their elimin.tion.or *** have exten.ively s.udied the in.olvemen. of the brain.derived n.urotrophic factor-Tropomyos.n.related kin.s. B receptor n.urotrophic retrograde pathway,at the n.uromus.ular jun.tion.in.the axon.l developmen. an. s.n.ps. elimin.tion.proces. vers.s.the s.n.ps. *** purpos. of this.review is.to des.ribe the n.urotrophic in.luen.e on.developmen.al s.n.ps. elimin.tion.in.relation.to other molecular pathways.that we an. others.have foun. to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on.tran.mitter releas. an.lys.s.an. axon.l coun.s.to s.ow the differen. in.olvemen. of the pres.n.ptic acetylcholin. mus.arin.c autoreceptors.coupled to down.tream s.rin.-threon.n. protein.kin.s.s.A an. C(PKA an. PKC)an. voltage-gated calcium chan.els.at differen. n.rve en.in.s.in.developmen.al *** dyn.mic chan.es.that occur s.multan.ous.y in.s.veral n.rve termin.ls.an. s.n.ps.s.con.erge acros. a pos.s.n.ptic s.te,in.luen.e each other,an. require careful s.udies.to in.ividualize the mechan.s.s.of s.ecific *** des.ribe an.activity-depen.en. balan.e(related to the exten. of tran.mitter releas.)between.the pres.n.ptic mus.arin.c s.btypes.an. the n.urotrophin.mediated TrkB/p75n.R pathways.that can.in.luen.e the timin. an. fate of the competitive in.eraction. between.the differen. axon.*** down.tream dis.lacemen. of the PKA/PKC activity ratio to lower values.both in.competin. n.rve termin.ls.an. at pos.s.n.ptic s.tes.plays.a relevan. role in.con.rollin. the elimin.tion.of s.pern.merary ***,calcium en.ry through L-an. P/Q-s.btypes.of voltage-gated calcium chan.els.both chan.els.are pres.n.,together with the n.type chan.el in.developin. n.rve termin.ls.con.ributes.to red

关键词： acetylcholin. releas. aden.s.n. receptors axon.l competition brain.derived n.urotrophic factor calcium chan.els motor en.-plate mus.arin.c acetylcholin. receptors pos.n.tal s.n.ps. elimin.tion s.rin. kin.s.s tropomyos.n.related kin.s. receptorB

Olfactory receptors.in.n.ural regen.ration.in.the cen.ral n.rvous.s.s.em

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n.ural Regen.ration.Res.arch 2025年第9期20卷 2480-2494页

作者： Rafael Fran.o Claudia Garrigós.Ton. Capó Joan.s.rran.-Marín.Rafael Rivas.s.n.is.eban.Jaume Lillo Molecular n.urobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Cibern.d n.twork Cen.er for Biomedical Res.arch in.n.urodegen.rative Dis.as.s Spanish National Health Institute Carlos ⅢMadridSpain s.hool of Chemis.ry Universitat de BarcelonaBarcelonaSpain Departmen. of Biochemis.ry an. Phys.ology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computation.l Medicin. Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors.are crucial for detectin. odors.an. play a vital role in.our s.n.e of s.ell,in.luen.in. behaviors.from food choices.to emotion.l *** receptors.als. con.ribute to our perception.of flavor an. have poten.ial application. in.medical diagn.s.ics.an. en.iron.en.al *** ability of the olfactory s.s.em to regen.rate its.s.n.ory n.uron. provides.a un.que model to s.udy n.ural regen.ration.a phen.men.n.largely abs.n. in.the cen.ral n.rvous.*** gain.d from how olfactory n.uron. con.in.ous.y replace thems.lves.an. rees.ablis. fun.tion.l con.ection. can.provide s.rategies.to promote s.milar regen.rative proces.es.in.the cen.ral n.rvous.s.s.em,where damage often.res.lts.in.perman.n. *** the molecular an. cellular mechan.s.s.un.erpin.in. olfactory n.uron.regen.ration.could pave the way for developin. therapeutic approaches.to treat s.in.l co rd in.uries.an. n.urodegen.rative dis.as.s.like Alzheimer's.*** ctory receptors.are foun. in.almos. an. cell of eve ry orga n.tis.ue of the mammalian.*** ectopic expres.ion.provides.in.ights.in.o the chemical s.ructures.that can.activate olfactory *** addition.to odors.olfactory receptors.in.ectopic expres.ion.may res.on. to en.ogen.us.compoun.s.an. molecules.produced by mucos.l colon.zin. *** an.lys.s.of the fun.tion.of olfactory receptors.in.ectopic expres.ion.provides.valuable in.ormation.on.the s.gn.lin. pathway en.aged upon.receptor activation.an. the receptor's.role in.proliferation.an. cell differen.iation.*** review explo res.the ectopic expres.ion.of olfa ctory receptors.an. the role they may play in.n.ural regen.ration.within.the cen.ral n.rvous.s.s.em,with particular atten.ion.to compoun.s.that can.activate thes. receptors.to in.tiate regen.rative *** s.gges.s.that olfactory receptors.could s.rve as.poten.ial therapeutic targets.for en.an.in. n.ural repair an. recovery followin. cen.ral n.rvous.s.s.e

关键词： aden.s.n. receptors adren.rgic receptors ectopic expres.ion G protein.oupled receptors glia n.uron.

Data-driven.drug repos.tion.n. us.n. olfactory omics.profiles.challen.es.an. pers.ectives.in.n.urodegen.ration

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n.ural Regen.ration.Res.arch 2025年第7期20卷 1997-1998页

作者： Paz Cartas.Cejudo Adrian. Cortés.Mercedes.Lachén.Mon.es.Elen. An.ya-Cubero Joaquín.Fern.n.ez-Irigoyen.En.ique s.n.amaría Clin.cal n.uroproteomics.Un.t Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven.drug repos.tion.n. us.n. olfactory omics.profiles.challen.es.an. pers.ectives.in.n.urodegen.ration.n.urodegen.rative dis.as.s.are characterized by progres.ive degen.ration.an. los. of n.uron.l fun.tion.in.the cen.ral n.rvous.*** dis.as.s.are often.characterized as.protein.pathies.which are dis.rders.primarily driven.by the aggregation.or mis.oldin. of s.ecific amyloid protein. within.cells.leadin. to their dys.un.tion.an. even.ual *** the gain.of-fun.tion.hypothes.s.related to the aggregation.of thes. protein.,recen.ly,an.altern.tive hypothes.s.regardin. the los.-of-fun.tion.of the s.luble mon.meric protein. durin. the proces. of aggregation.in.o amyloids.is.gain.n. *** las. even. is.called protein.pen.a an. refers.to con.ition. characterized by a deficien.y or decreas. in.the levels.of s.ecific s.luble protein. in.the body(Ezzat et al.,2023).It has.been.demon.trated that levels.of s.luble protein. in.olved in.n.urodegen.rative dis.as.s.are decreas.d.

关键词： dis.as.s drug amyloid

Chloride bin.in. an. time-depen.en. s.rface chloride con.en. models.for fly as. con.rete

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Fron.iers.of s.ructural an. Civil En.in.erin. 2016年第1期10卷 112-120页

作者： s. MUTHULIn.AM B. n. RAO Departmen. of Civil En.in.erin. SSN College of Engineering Kalavakkam 603 110 India s.ructural En.in.erin. Divis.on Department of Civil Engineering Indian Institute of Technology Madras Chennai 600 036 India

Corros.on.of embedded rebars.is.a clas.ical deterioration.mechan.s. of rein.orced con.rete s.ructures.expos.d to chloride en.iron.en.s. s.ch en.iron.en.s.can.be attributed to the pres.n.e of s.awater, deicin. or s.a-s.lts. which have high con.en.ration. of chloride ion. Chloride in.res. in.o con.rete, es.en.ial for in.ucin. rebar corros.on. is.a complex in.eraction.between.man. phys.cal an. chemical proces.es. The curren. s.udy propos.s.two chloride in.res. parameter models.for fly as. con.rete, n.mely： 1） s.rface chloride con.en. un.er tidal expos.re con.ition. an. 2） chloride bin.in.. Firs., in.on.is.en.ies.in.s.rface chloride con.en. an. chloride bin.in. models.reported in.literature, due to them n.t bein. in.lin. with pas. res.arch s.udies. are poin.ed out. s.con.ly, to avoid s.ch in.on.is.en.ies. s.rface chloride con.en. an. chloride bin.in. models.for fly as. con.rete are propos.d bas.d upon.the experimen.al work don. by other res.archers. It is.obs.rved that, propos.d models.are s.mple, con.is.en. an. in.lin. with pas. res.arch s.udies.reported in.literature.

关键词： bin.in. is.therms chloride in.res. con.rete fly as. s.rface chloride con.en.

Complemen.ary roles.of glial cells.in.gen.ratin. region.s.ecific n.uroin.lammatory res.on.es.an. phagocytos.s.in.Parkin.on.s.dis.as.

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n.ural Regen.ration.Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Un.vers.dad de n.varra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Un.vers.dad de n.varra PamplonaSpain Idis.0} Instituto de Investigación Sanitaria de NavarraPamplonaSpain

n.uroin.lammation.is.as.ociated with Parkin.on.s.dis.as.:Reactive glios.s.an. n.uroin.lammation.are hallmarks.of Parkin.on.s.dis.as.(PD),a multis.s.em n.urodegen.rative dis.rder characterized by a progres.ive los. of dopamin.rgic *** has.lon. been.con.idered a mere con.equen.e of n.uron.l los.,but whether it promotes.PD or is.a key player in.dis.as. progres.ion.remain. to be *** leukocyte an.igen.

关键词： in.lammation leukocyte gen.ratin.

Effects.of s.bs.rate Temperature an. Vacuum An.ealin. on.Properties.of ITO Films.Prepared by Radio-Frquen.y Magn.tron.s.utterin.

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Chin.s. Phys.cs.Letters 2010年第10期27卷 213-216页

作者： n. Boon.opakorn.n. s.ipon.pun.C. Than.chayan.n. s. Dan.tip Departmen. of Phys.cs Mahidol University Bangkok 10400 Thailand n.tion.l Metal an. Materials.Techn.logy Klongluang Prathumthani 10120 Thailand Cen.er for n.n.s.ien.e an. n.n.techn.logy Mahidol University Bangkok 10400 Thailand

In.ium tin.oxide （ITO） films.were prepared by rf magn.tron.s.utterin. un.er two con.ition.：（i） at s.bs.rate temperature Ts.from room temperature （RT） to 350℃ （ii） with addition.l pos.-an.ealin. in.vacuum at 400℃ for 30 min.in.comparis.n.of their crys.allin. s.ructures. an. electrical-optical properties.of the films.depos.ted. From the experimen.al res.lts. it is.foun. that, un.er the firs. con.ition. the crys.allin. s.ructures.an. the electrical-optical properties.of the films.are improved with the in.reas.n. Ts. Un.er the other con.ition. i.e. with the addition.l pos.-an.ealin., the films.exhibit higher degree of crys.allin.ties.an. better electrical-optical properties. Un.er the two depos.tion.con.ition., in.er-relation.between.electrical-optical properties.an. the crys.allin. s.ructure is.obs.rved clearly. However, even.un.er the s.me an.ealin. con.ition. it is.obs.rved that improved properties.of the films.are differen., depen.in. on.their depos.tion.temperatures. which implies.that an.in.tial s.age of the ITO film before an.ealin. is.an.importan. factor for the film＇s.properties.improved after an.ealin.. The res.s.ivity of 2.33 × 10-4 Ω·cm can.be achieved at Ts.of 350℃after an.ealin..

关键词： Packagin. materials Films Temperature Additives Optical properties Electricity Properties Property Poles

Regulator of G protein.s.gn.lin. 6 mediates.exercis.-in.uced recovery of hippocampal n.urogen.s.s.learn.n.,an. memory in.a mous. model of Alzheimer’s.dis.as.

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n.ural Regen.ration.Res.arch 2025年第10期20卷 2969-2981页

作者： Macken.ie M.s.icer Jian.i Yan. Dan.el Fu Alis.n.n.DeVore Maris.l Lauffer n.lufer s.Atas.y Den.z Atas.y Rory A.Fis.er Departmen. of n.uros.ien.e an. Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa n.uros.ien.e In.titute University of Iowa Carver College of MedicineIowa CityIAUSA In.erdis.iplin.ry Graduate Program in.Molecular Medicin. University of Iowa Carver College of MedicineIowa CityIAUSA n.ural Circuits.an. Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal n.uron.l los. caus.s.cogn.tive dys.un.tion.in.Alzheimer’s.*** hippocampal n.urogen.s.s.is.reduced in.patien.s.with Alzheimer’s.*** s.imulates.adult hippocampal n.urogen.s.s.in.roden.s.an. improves.memory an. s.ows.cogn.tive declin. in.patien.s.with Alzheimer’s.***,the molecular pathways.for exercis.-in.uced adult hippocampal n.urogen.s.s.an. improved cogn.tion.in.Alzheimer’s.dis.as. are poorly ***,regulator of G protein.s.gn.lin. 6(RGs.)was.iden.ified as.the mediator of volun.ary run.in.-in.uced adult hippocampal n.urogen.s.s.in.***,we gen.rated n.vel RGs.fl/fl;APP_(s.E) mice an. us.d retroviral approaches.to examin. the impact of RGs. deletion.from den.ate gyrus.n.uron.l progen.tor cells.on.volun.ary run.in.-in.uced adult hippocampal n.urogen.s.s.an. cogn.tion.in.an.amyloid-bas.d Alzheimer’s.dis.as. mous. *** foun. that volun.ary run.in. in.APP_(s.E) mice res.ored their hippocampal cogn.tive impairmen.s.to that of con.rol *** cogn.tive res.ue was.abolis.ed by RGs. deletion.in.den.ate gyrus.n.uron.l progen.tor cells.which als. abolis.ed run.in.-mediated in.reas.s.in.adult hippocampal *** hippocampal n.urogen.s.s.was.reduced in.s.den.ary APP_(s.E) mice vers.s.con.rol mice,with bas.l adult hippocampal n.urogen.s.s.reduced by RGs. deletion.in.den.ate gyrus.n.ural precurs.r ***6 was.expres.ed in.n.uron. within.the den.ate gyrus.of patien.s.with Alzheimer’s.dis.as. with s.gn.fican. los. of thes. RGs.-expres.in. ***,RGs. mediated volun.ary run.in.-in.uced res.ue of impaired cogn.tion.an. adult hippocampal n.urogen.s.s.in.APP_(s.E) mice,iden.ifyin. RGs. in.den.ate gyrus.n.ural precurs.r cells.as.a pos.ible therapeutic target in.Alzheimer’s.dis.as..

关键词： adult hippocampal n.urogen.s.s Alzheimer’s.dis.as. den.ate gyrus exercis. learn.n./memory n.ural precurs.r cells regulator of G protein.s.gn.lin. 6(RGs.)