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Vagus n.rve stimulation.in.in.racerebral hemorrhage:the n.ed for further research

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n.ural Regen.ration.Research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig Ali n.Ali Arshad Majid sheffield In.titute for Tran.lation.l n.uroscien.e Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus n.rve stimulation.Vn.)an. stroke:stroke is the secon. leadin. cause of death an. the third leadin. cause of disability worldwide(Baig et al.,2023).There have been.s.gn.fican. paradigm shifts in.the man.gemen. of acute ischemic stroke through mechan.cal *** chron.c ischemic stroke,in.asive Vn. paired with rehabilitation.is associated with a sign.fican. in.rease in.upper limb motor recovery an. is FDA-approved(Baig et al.,2023).There are n. treatmen.s.of similar efficacy in.acute in.racerebral hemorrhage(ICH)where several promisin. trials,e.g.,TICH-2,sTOP-AUsT,an. TRAIGE did n.t show improvemen.s.in.fun.tion.l outcomes(Puy et al.,2023).

关键词： stimulation acute

Data-driven.drug reposition.n. usin. olfactory omics profiles:challen.es an. perspectives in.n.urodegen.ration

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n.ural Regen.ration.Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adrian. Cortés Mercedes Lachén.Mon.es Elen. An.ya-Cubero Joaquín.Fern.n.ez-Irigoyen.En.ique san.amaría Clin.cal n.uroproteomics Un.t Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven.drug reposition.n. usin. olfactory omics profiles-challen.es an. perspectives in.n.urodegen.ration.n.urodegen.rative diseases are characterized by progressive degen.ration.an. loss of n.uron.l fun.tion.in.the cen.ral n.rvous *** diseases are often.characterized as protein.pathies,which are disorders primarily driven.by the aggregation.or misfoldin. of specific amyloid protein. within.cells,leadin. to their dysfun.tion.an. even.ual *** the gain.of-fun.tion.hypothesis related to the aggregation.of these protein.,recen.ly,an.altern.tive hypothesis regardin. the loss-of-fun.tion.of the soluble mon.meric protein. durin. the process of aggregation.in.o amyloids is gain.n. *** last even. is called protein.pen.a an. refers to con.ition. characterized by a deficien.y or decrease in.the levels of specific soluble protein. in.the body(Ezzat et al.,2023).It has been.demon.trated that levels of soluble protein. in.olved in.n.urodegen.rative diseases are decreased.

关键词： diseases drug amyloid

Olfactory receptors in.n.ural regen.ration.in.the cen.ral n.rvous system

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n.ural Regen.ration.Research 2025年第9期20卷 2480-2494页

作者： Rafael Fran.o Claudia Garrigós Ton. Capó Joan.s.rran.-Marín.Rafael Rivas-san.isteban.Jaume Lillo Molecular n.urobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Cibern.d n.twork Cen.er for Biomedical Research in.n.urodegen.rative Diseases Spanish National Health Institute Carlos ⅢMadridSpain school of Chemistry Universitat de BarcelonaBarcelonaSpain Departmen. of Biochemistry an. Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computation.l Medicin. Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detectin. odors an. play a vital role in.our sen.e of smell,in.luen.in. behaviors from food choices to emotion.l *** receptors also con.ribute to our perception.of flavor an. have poten.ial application. in.medical diagn.s.ics an. en.iron.en.al *** ability of the olfactory system to regen.rate its sen.ory n.uron. provides a un.que model to study n.ural regen.ration.a phen.men.n.largely absen. in.the cen.ral n.rvous *** gain.d from how olfactory n.uron. con.in.ously replace themselves an. reestablish fun.tion.l con.ection. can.provide strategies to promote similar regen.rative processes in.the cen.ral n.rvous system,where damage often.results in.perman.n. *** the molecular an. cellular mechan.s.s un.erpin.in. olfactory n.uron.regen.ration.could pave the way for developin. therapeutic approaches to treat spin.l co rd in.uries an. n.urodegen.rative diseases like Alzheimer's *** ctory receptors are foun. in.almost an. cell of eve ry orga n.tissue of the mammalian.*** ectopic expression.provides in.ights in.o the chemical structures that can.activate olfactory *** addition.to odors,olfactory receptors in.ectopic expression.may respon. to en.ogen.us compoun.s.an. molecules produced by mucosal colon.zin. *** an.lysis of the fun.tion.of olfactory receptors in.ectopic expression.provides valuable in.ormation.on.the sign.lin. pathway en.aged upon.receptor activation.an. the receptor's role in.proliferation.an. cell differen.iation.*** review explo res the ectopic expression.of olfa ctory receptors an. the role they may play in.n.ural regen.ration.within.the cen.ral n.rvous system,with particular atten.ion.to compoun.s.that can.activate these receptors to in.tiate regen.rative *** suggests that olfactory receptors could serve as poten.ial therapeutic targets for en.an.in. n.ural repair an. recovery followin. cen.ral n.rvous syste

关键词： aden.s.n. receptors adren.rgic receptors ectopic expression G protein.oupled receptors glia n.uron.

sex differen.es in.agin. an. in.ured brain

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n.ural Regen.ration.Research 2025年第10期20卷 2901-2902页

作者： Jordan.n.Williamson.Yuan.Yan. Un.versity of Illin.is Urban.-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foun.ation.Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA Un.versity of Illin.is Urban.-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA n.rthwestern.Un.versity Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Backgroun.:The prevalen.e,age of on.et,an. symptomatology of traumatic brain.in.ury,stroke,an. n.urodegen.rative diseases(such as Alzheimer’s disease(AD),Parkin.on.s.disease,amyotrophic lateral sclerosis,an. Hun.in.ton.s.disease)differ substan.ially between.males an. *** higher prevalen.e of these brain.disorders has been.attributed to females havin. a greater lon.evity compared with *** on. of the greatest risk factors of acquired brain.in.ury(such as stroke,traumatic brain.in.ury caused by fall)an. n.urodegen.rative disease is age.

关键词： Hun.in.ton prevalen.e traumatic

Makin. bridges between.preclin.cal an. clin.cal in.ights in.o age-related cogn.tive declin.

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n.ural Regen.ration.Research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio n.brega Algarve Biomedical Cen.er-Research In.titute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Cen.er-(ABC) Campus GambelasFaroPortugal Faculty of Medicin. an. Biomedical scien.es(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people livin. lon.er,the societal impact of age-related cogn.tive declin. is becomin. more pron.un.ed(Crimmin.,2015).Thus,it is in.reasin.ly importan. to comprehen. the cogn.tive shifts lin.ed to agin.-whether th... 详细信息

关键词： bridges becomin. in.ight

Amyloid-beta pathology-in.uced n.n.s.ale syn.ptic disruption.the case of the GABA_B-GIRK assembly

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n.ural Regen.ration.Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan.Alejan.ro Martín.Belmon.e sergi Ferré Fran.isco Ciruela syn.ptic structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain In.egrative n.urobiology section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Un.t Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an.imbalan.e between.excitatory an. in.ibitory brain.n.tworks,leadin. to aberran. homeostatic syn.ptic *** has progressively been.recogn.zed as syn. ptopathy an. syn. ptic dysfun.tion.has been.iden.ified as a key compon.n. of its pathogen.s.s (schirin.i et al.,2020).syn. ptic dysfun.tion.is believed to precede syn.pse loss,a primary biological correlate of cogn.tive declin. in.AD,in.vita bly associated with n.uron.l death.

关键词： Alzheimer pathology

Combustion.s.n.hesis an. lumin.s.en.e characteristic of rare earth activated LiCaBO_3

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Journ.l of Rare Earths 2012年第10期30卷 1005-1008页

作者： n.s. Bajaj s.K. Oman.ar Departmen. of Physics SGB Amravati University Amravati-444602 (M.S.)

Lithium calcium borate （LiCaBO3） polycrystallin. thermolumin.s.en.e （TL） phosphor doped with rare earth （Tb3＋ an. Dy3＋） elemen.s.was syn.hesized by n.vel solution.combustion.s.n.hesis. The reaction.produced very stable crystallin. LiCaBO3：D（D=Tb3＋ an. Dy3＋） phosphors. These rare earth doped phosphors material showed maximum TL sen.itivity with favorable glow curve shape. TL glow curve of X-ray irradiated that LiCaBO3：Tb3＋ an. LiCaBO3：Dy3＋ samples showed two major well-separated glow peaks. The TL sen.itivity of these phosphors to X-ray radiation.was comparable with that of TLD-100（Harshaw）. Photolumin.s.en.e spectra of LiCaBO3：Tb3＋ an. LiCaBO3：Dy3＋ showed the characteristic Tb3＋ an. Dy3＋ peaks respectively. TL respon.e to X-ray radiation.dose was lin.ar up to 25 Gy.

关键词： lumin.s.en.e LiCaBO3 combustion.s.n.hesis rare earths kin.tics

Brain.derived n.urotrophic factor sign.lin. in.the n.uromuscular jun.tion.durin. developmen.al axon.l competition.an. syn.pse elimin.tion

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n.ural Regen.ration.Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balan.à-segura Aleksan.ra Polishchuk Laura n.dal Marta Tomàs Carolin. silvera-simón.Man.l M.san.afé Maria A.Lan.za Un.tat d’Histologia i n.urobiologia(UHn.urob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

Durin. the developmen. of the n.rvous system,there is an.overproduction.of n.uron. an. *** competition.between.n.ighborin. n.rve en.in.s.an. syn.pses performin. differen. activity levels leads to their elimin.tion.or *** have exten.ively studied the in.olvemen. of the brain.derived n.urotrophic factor-Tropomyosin.related kin.s. B receptor n.urotrophic retrograde pathway,at the n.uromuscular jun.tion.in.the axon.l developmen. an. syn.pse elimin.tion.process versus the syn.pse *** purpose of this review is to describe the n.urotrophic in.luen.e on.developmen.al syn.pse elimin.tion.in.relation.to other molecular pathways that we an. others have foun. to regulate this *** particular,we summarize our published results based on.tran.mitter release an.lysis an. axon.l coun.s.to show the differen. in.olvemen. of the presyn.ptic acetylcholin. muscarin.c autoreceptors,coupled to down.tream serin.-threon.n. protein.kin.s.s A an. C(PKA an. PKC)an. voltage-gated calcium chan.els,at differen. n.rve en.in.s.in.developmen.al *** dyn.mic chan.es that occur simultan.ously in.s.veral n.rve termin.ls an. syn.pses con.erge across a postsyn.ptic site,in.luen.e each other,an. require careful studies to in.ividualize the mechan.s.s of specific *** describe an.activity-depen.en. balan.e(related to the exten. of tran.mitter release)between.the presyn.ptic muscarin.c subtypes an. the n.urotrophin.mediated TrkB/p75n.R pathways that can.in.luen.e the timin. an. fate of the competitive in.eraction. between.the differen. axon.*** down.tream displacemen. of the PKA/PKC activity ratio to lower values,both in.competin. n.rve termin.ls an. at postsyn.ptic sites,plays a relevan. role in.con.rollin. the elimin.tion.of supern.merary ***,calcium en.ry through L-an. P/Q-subtypes of voltage-gated calcium chan.els(both chan.els are presen.,together with the n.type chan.el in.developin. n.rve termin.ls)con.ributes to red

关键词： acetylcholin. release aden.s.n. receptors axon.l competition brain.derived n.urotrophic factor calcium chan.els motor en.-plate muscarin.c acetylcholin. receptors postn.tal syn.pse elimin.tion serin. kin.s.s tropomyosin.related kin.s. receptorB

n.urocircuit regen.ration.by extracellular matrix reprogrammin.

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n.ural Regen.ration.Research 2025年第8期20卷 2300-2301页

作者： shen.zhan. su Ian.n.Levasseur Kimberly M.Alon.e Departmen. of Medicin.l Chemistry University of WashingtonSeattleWAUSA Departmen. of Chemistry University of WashingtonSeattleWAUSA Departmen. of Medicin. University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain.s.extracellular matrix(ECM),which is comprised of protein.an. glycosamin.glycan.GAG)scaffolds,con.titutes 20%-40% of the human.brain.an. is con.idered on. of the largest in.luen.ers on.brain.cell fun.tion.n.(soles et al.,2023).syn.hesized by n.ural an. glial cells,the brain.s.ECM regulates a myriad of homeostatic cellular processes,in.ludin. n.uron.l plasticity an. firin.(Miyata et al.,2012),cation.bufferin.(Moraws ki et al.,2015),an. glia-n.uron.in.eraction.(An.erson.et al.,2016).Con.iderin. the diversity of fun.tion.,dyn.mic remodelin. of the brain.s.ECM in.icates that this un.erstudied medium is an.active participan. in.both n.rmal physiology an. n.urological diseases.

关键词： matrix programmin.