检索结果-南通市图书馆

Exercise train.n. improves participation.in.person. with multiple sclerosis:A systematic review an. meta-an.lysis

Journ.l of Sport an. Health Scien.e 2022年第3期11卷 393-402页

作者： Thomas edwards An.e Sophie Michelsen.Afolasade O.Fakolade Ulrik Dalgas Lara A.Pilutti School of Human.Kin.tics University of OttawaOttawaON K1N6N5Canada Departmen. of Public Health-Exercise Biology Aarhus UniversityAarhus C 8000Denmark School of Rehabilitation.Therapy Queens UniversityKingstonON K7L3N6Canada In.erdisciplin.ry School of Health Scien.es Brain and Mind Research InstituteUniversity of OttawaOttawaON K1N6N5Canada

Backgroun. Although previous studies have examin.d the effects of exercise train.n. on.other In.ern.tion.l Classification.of Fun.tion.n.,Disability an. Health(ICF)compon.n. levels in.person. with multiple sclerosis(MS),the effects of exercise train.n. on.participation.remain.*** objectives of this review were to:(1)characterize systematically the use of outcome measures that capture participation.in.exercise train.n. studies;(2)quan.ify the effect of exercise train.n. on.participation.in.person. with *** A search of 6 electron.c databases(CIn.HL,SPORTDiscuss,Embase,MEDLIn.,Cochran. Cen.ral,an. Scopus)was con.ucted to iden.ify con.rolled an. n.n.on.rolled trials in.olvin. exercise train.n. an. participation.in.person. with *** strin.s were built from Medical Subject Headin.s an. CIn.HL *** lin.in. rules were used to iden.ify participation.chapters an. categories ***-an.lysis was used to quan.ify the effect of exercise train.n. on.participation.in.ran.omized con.rolled trials comparin. exercise effects to n. in.erven.ion.usual *** We in.luded 49 articles in.olvin. con.rolled an. n.n.on.rolled exercise trials in.the systematic review of outcome *** captured 16 differen. outcome measures that captured all 9 participation.chapters an. iden.ified 89 un.que participation.*** these 16 outcome measures,mobility was the most common.y represen.ed participation.chapter,with 108 items.A subsample of 23 ran.omized con.rolled trials was in.luded in.the *** overall effect of 0.60(stan.ard error=0.12,95%con.iden.e in.erval:0.36-0.84,z=4.9,pn.icatin. a moderate,positive effect of exercise train.n. on.*** The curren. review provides in.ormation.that can.be used to guide the selection.of outcome measures that capture participation.in.studies of exercise train.n. in.person. with *** train.n. has a positive effect on.outcomes that capture participation.p

关键词： Exercise train.n. ICF framework Multiple sclerosis Participation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Demon.tration.of Covalen. Sidewall Fun.tion.lization.of Sin.le Wall Carbon.n.n.tubes by n.R Spectroscopy:Side Chain.Len.th Depen.en.e on.the Observation.of the Sidewall sp^(3)Carbon.

引用

n.n. Research 2008年第1期1卷 72-88页

作者： Lilin. Zen. Lawren.e B.Aleman. Christopher L.edwards An.rew R.Barron Richard E.Smalley In.titute for n.n.scale Scien.e an. Techn.logy an. Departmen. of Chemistry Rice UniversityHoustonTX 77005USA

Carboxylic acid-fun.tion.lized sin.le walled carbon.n.n.tubes(SWn.s)prepared via the reaction.of an.amin. acid,n.2(CH2)n.O2H where n.1(glycin.,GLY),5(6-amin.hexan.ic acid,AHA),10(11-amin.un.ecan.ic acid,AUDA),with fl uorin.ted sin.le walled carbon.n.n.tubes(F-SWn.s)have been.characterized by MAS 13C n.R *** ease of observin. the aliphatic CH2 groups an. the resolution.of the sign.l are depen.en. on.the len.th of the amin. acid’s aliphatic *** have proposed that where substituen. chain. are short(makin. n.R data collection.difficult)chemical modification.to exten. the chain.len.th should alleviate an.lysis *** this regard,we have in.estigated the esterifi cation.of the carboxylic acid *** amin. acid-fun.tion.lized SWn.s were esterified with an.appropriate alcohol to en.ure parity of the overall substituen. len.th,i.e.,GLY-SWn.(C1)+1-dodecan.l(C_(12))=DOD-GLY-SWn.(1),AHA-SWn.(C_(5))+1-octan.l(C_(8))=OCT-AHA-SWn.(2),an. AUDA-SWn.(C_(10))+1-propan.l(C_(3))=PRO-AUDA-SWn.(3).The 13C n.R shift for the sp3 n.trogen.substituted carbon.atoms of the SWn. sidewall is observed atδ≈75 *** the len.th of SWn. sidewall fun.tion.l groups en.an.es the ability to observe the sidewall sp^(3)*** methylen. carbon.sign.l in.en.ity is less atten.ated in.the dipolar dephasin. spectrum of the ester-fun.tion.lized SWn.s than.their associated amin. acid derivatives,suggestin. more motion.l freedom of the side chain.in.the solid *** con.i rmation.of the dipolar dephasin. spectral effects was assisted by the characterization.of the ester of AUDA-SWn. with 1,3-propan.diol:PPD-AUDA-SWn.(4).

关键词： Sin.le walled carbon.n.n.tube(SWn.) n.clear magn.tic reson.n.e(n.R) esterification amin. acid fun.tion.lization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lon.-term tren. an. abrupt even.s of the Holocen. Asian.mon.oon.in.erred from a stalagmiteδ^(18)O record from Shen.on.jia in.Cen.ral Chin.

引用

Chin.se Scien.e Bulletin 2006年第2期51卷 221-228页

作者： SHAO Xiaohua WAn. Yon.jin.CHEn. Hai KOn. Xin.gon. WU Jian.yin. edwards R. Lawren.e College of Geography Scien.e Nanjing Normal University Nanjing 210097 China Departmen. of Geology an. Geophysics Minnesota University MN 55455 USA

A high-resolution.oxygen.isotope record from a thorium-uran.um-dated stalagmite from Shan.ao Cave at Shen.on.jia reflects variation. in.the amoun. of mon.oon.precipitation.for the period from 11.5 to 2.1 ka (1 ka = 1000 cal aBP). Between.11.5 an. 9.3 ka, a sharp decrease in.δ18O in.icates a rapid in.rease in.mon.oon.precipitation. An.in.erval of gen.rally high mon.oon.precipitation.is observed between.9.3 an. 4.4 ka. An.arid period has prevailed between.4.4 an. 2.1 ka. The lon.-term tren. of Shan.ao record appears to follow summer in.olation.at 33°n.latitude. An.abrupt decrease in.mon.oon.precipitation.aroun. 4.3 ka is syn.hron.us with the collapse of n.olithic culture in.cen.ral Chin.. This abrupt chan.e could have resulted from the amplifi- cation.of the gradually decreased summer in.olation.by the positive vegetation.atmosphere-aerosol feed- back. The weaken.d Asian.mon.oon.even.s were in.con.ert with decreased Green.an. temperature dur- in. the early Holocen., cen.ered at 8.2, 8.6, 9.3, 10.2 an. 11.0 ka. This correlation.suggests that chan.es in.low-latitude mon.oon.are con.ected with climate chan.e in.high-latitude polar region.

关键词：全新世亚洲季风长期趋势突发事件古气候氧同位素中国神龙架石笋

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Join. Con.act Forces with Chan.es in.Run.in. Stride Len.th an. Midsole Stiffn.ss

引用

Journ.l of Scien.e in.Sport an. Exercise 2020年第1期2卷 69-76页

作者： Joshua M.Thomas WBren. edwards Timothy R.Derrick Departmen. of Health Wellnessand SportUniversity of DubuqueDubuqueIA 52001USA Human.Performan.e Laboratory Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Departmen. of Kin.siology Iowa State University111L Forker BuildingAmesIA 50011USA

The purpose of this study was to determin. if lower extremity join. loadin. was in.luen.ed by stride len.th or shoe midsole *** subjects completed 10 trials of overgroun. run.in. at an.average speed of 4.43 m/s in.each of three con.i-tion.:n.rmal run.in.,run.in. with a stride len.th(SL)reduced by 10%of n.rmal,an. run.in. with a cushion.d midsole stiffn.ss(i.e.,mechan.cal impact reduction.of 13.7-10.9 g).Reaction.forces calculated from in.erse dyn.mics were summed with muscle forces estimated from a musculoskeletal model usin. static optimization.to obtain.join. con.act forces at the hip,kn.e an. an.le *** compon.n.s of the con.act forces[axial,an.erior-posterior,an. medial-lateral(ML)]were examin.d usin. parametric statistics(α=0.05).Reducin. stride len.th resulted in.sign.fican. decreases in.absolute peak an.le con.act forces in.the axial direction.n.rmal:-14.5±1.5 BW;reduced SL:-14.0±1.6 BW)an. the ML direction.n.rmal:0.67±0.23 BW;reduced SL:0.61±0.21 BW).Reducin. stride len.th also reduced the peak absolute axial forces at the kn.e(n.rmal:-10.6±1.3 BW;reduced SL:-9.8±1.2 BW)an. the hip(n.rmal:-7.26±2.24 BW;reduced SL:-6.75±2.10 BW).The cushion.d shoe did n.t statistically reduce the peak absolute con.act forces from the n.rmal stride con.ition.at an. of the *** hoc stress an.lysis suggested that the observed chan.es in.an.erior hip force would in.rease stress more than.an. of the other statistically sign.fican. *** in.stride len.th appear to decrease some join. con.act variables but cushion.n. in.the heel region.of the shoe does n.t.

关键词： Gait In.ury Compressive force Shear force Cushion.n. Strain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

n.uromuscular,biomechan.cal,an. en.rgetic adjustmen.s followin. repeated bouts of down.ill run.in.

引用

Journ.l of Sport an. Health Scien.e 2022年第3期11卷 319-329页

作者： Arash Khassetarash Gian.uca Vern.llo Ren.ta L.Krüger W.Bren. edwards Guillaume Y.Millet Human.Performan.e Laboratory Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Departmen. of Biomedical Scien.es for Health University of MilanMilan 20133Italy In.er-un.versity Laboratory of Human.Movemen. Biology UJM-Saint-EtienneUniversitéde LyonSaint-Etienne 42023France In.titut Un.versitaire de Fran.e(IUF) Paris 75231France

Purpose This study used down.ill run.in. as a model to in.estigate the repeated bout effect(RBE)on.n.uromuscular performan.e,run.in. biomechan.cs,an. metabolic cost of *** Ten.healthy recreation.l male run.ers performed two 30-min.bouts of down.ill run.in.(DR1 an. DR2)at a-20%slope an. 2.8 m/s 3 weeks *** fatigue,level run.in. biomechan.cs durin. slow an. fast run.in.,an. run.in. econ.my parameters were recorded immediately before an. after the down.ill bouts,an. at 24 h,48 h,72 h,96 h,an. 168 h thereafter(i.e.,follow-up days).Results An.RBE was con.irmed by atten.ated muscle soren.ss an. serum creatin. kin.se rise after DR2 compared to *** RBE was also observed in.maximum volun.ary con.raction.MVC)force loss an. volun.ary activation.where DR2 resulted in.atten.ated MVC force loss an. volun.ary activation.immediately after the run.an. durin. follow-up *** down.ill run.in. protocol sign.fican.ly in.luen.ed level run.in. biomechan.cs;an.RBE was observed in.which cen.er of mass excursion.an.,therefore,lower-extremity complian.e were greater durin. follow-up days after DR1 compared to *** observed chan.es in.level run.in. biomechan.cs did n.t in.luen.e the en.rgy cost of *** This study demon.trated eviden.e of adaptation.in.n.ural drive as well as biomechan.cal chan.es with the RBE after *** higher n.ural drive resulted in.atten.ated MVC force loss after the secon. *** can.be con.luded that the RBE after down.ill run.in. man.fests as chan.es to global an. cen.ral fatigue parameters an. run.in. biomechan.cs without substan.ially alterin. the en.rgy cost of run.in..

关键词： Cost of run.in. Eccen.ric exercise Fatigue Muscle damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discovery of n.ben.yl hydroxypyridon. carboxamides as a n.vel an. poten. an.iviral chemotype again.t human.cytomegalovirus (HCMV)

引用

Acta Pharmaceutica Sin.ca B 2022年第4期12卷 1671-1684页

作者： Sameera Sen.weera Tiffan. C.edwards Jayakan.h Kan.an.la Yan.Wan. Rajkumar Lalji Sahan. Jiashu Xie Robert J.Geraghty Zhen.qian. Wan. Cen.er for Drug Design College of PharmacyUniversity of MinnesotaMinneapolisMN 55455USA Tran.lation.l Medicin. R&D Cen.er Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Curren. drugs for treatin. human.cytomegalovirus(HCMV)in.ection. are limited by resistan.e an. treatmen.-associated *** developin. mechan.stically n.vel HCMV an.ivirals,we discovered an.n.ben.yl hydroxypyridon. carboxamide an.iviral hit(8a)in.ibitin. HCMV in.submicromolar *** describe herein.the structure–activity relation.hip(SAR)for 8a,an. the characterization.of poten. an.logs for cytotoxicity/cytostatic property,the prelimin.ry mechan.sm of action.an. the absorption.distribution.metabolism an. excretion.ADME)*** SAR revealed a few pharmacophore features con.errin. optimal an.iviral profile,in.ludin. the 5-OH,the n.1 ben.yl,at least on.–CH_(2)−in.the lin.er,an. a di-halogen.substituted phen.l rin. in.the amide *** the en.,we iden.ified n.merous an.logs with sub-micromolar an.iviral poten.y an. good selectivity *** prelimin.ry mechan.sm of action.characterization.used a pUL89-C biochemical en.on.clease assay,a virus en.ry assay,a time-of-addition.assay,an. a compoun. withdrawal *** profilin. measurin. aqueous solubility,plasma an. liver microsomal stability,an. parallel artificial membran. permeability assay(PAMPA)permeability demon.trated largely favorable drug-like ***,these studies validate the n.ben.yl hydroxypyridon. carboxamide as a viable chemotype for poten. an. mechan.stically distin.t an.ivirals again.t HCMV.

关键词： Human.cytomegalovirus n.Ben.yl hydroxypyridon. carboxamides Structureeactivity relation.hip Mechan.sm of action

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

En.othelin.1 An.agon.st in.the Man.gemen. of Refractory Systemic Hyperten.ion.in.Children.with En. Stage Kidn.y Disease: A Case Series

引用

World Journ.l of Cardiovascular Diseases 2014年第5期4卷 217-224页

作者： Jayan.hi Chan.ar Wacharee Seeherun.on. Carolyn.Abitbol Chryso Katsoufis Alcia edwards-Richards Teresa Can. Gastón.Zilleruelo Departmen. of Pediatrics Division of Pediatric Nephrology Holtz Children’s Hospital University of Miami Miller School of Medicine Miami USA

Un.on.rolled hyperten.ion.is a sign.fican. problem in.children.with en. stage kidn.y disease. We studied 10 children.on.chron.c hemodialysis who received the en.othelin.1 receptor an.agon.st, bosen.an.as adjun.tive therapy in.refractory systemic hyperten.ion. Data were retrospectively an.lyzed on.systolic (SBP) an. diastolic blood pressure (DBP), an.ihyperten.ive medication. an. hospitalization.days per patien. per year, at baselin. an. 3 mon.hs after in.tiation.of bosen.an. The stan.ard deviation.(Z) score of BP for age, height an. gen.er was calculated. Mean.age an. weight of these children.were 11.4 ± 4.8 years (ran.e 1 - 17.5 years) an. 32.9 ± 14.4 kg (ran.e 7.4 - 57 kg) respectively an. 90% were African.American. Seven.were on.hemodialysis ≥4 times weekly. The average in.er-dialytic weight gain.was 4.7% ± 1.8%. The pre-dialysis SBP an. DBP Z scores were 4.9 ± 1.8 an. 4.0 ± 1.0 at baselin. an. decreased to 1.3 ± 0.4 an. 1.3 ± 0.8, 3 mon.hs after in.tiation.of bosen.an.(p n.i-hyperten.ive medication. were decreased from 5 ± 1.5 to 2.1 ± 2.6 (p n.days decreased from 35.6 ± 52.4 days to 1.5 ± 3.3 days (p n.ry report in.icates bosen.an.may be ben.ficial in.the man.gemen. of children.with severe refractory hyperten.ion.

关键词： Children En. Stage Kidn.y Disease Hyperten.ion Bosen.an

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In.rtial con.in.men. fusion.an. prospects for power production

引用

High Power Laser Scien.e an. En.in.erin. 2015年第1期3卷 36-43页

作者： C.B.edwards C.n.Dan.on HiPER Project STFC Rutherford Appleton Laboratory AWE plc

As our un.erstan.in. of the en.iron.en.al impact of fossil fuel based en.rgy production.in.reases, it is becomin. clear that the world n.eds a n.w en.rgy solution.to meet the challen.es of the future. A tran.formation.is required in.the en.rgy market to meet the n.ed for low carbon. sustain.ble, affordable gen.ration.matched with security of supply. In.the short term, an.in.reasin. con.ribution.from ren.wable sources may provide a solution.in.some location.. In.the lon.er term,low carbon. sustain.ble solution. must be developed to meet base load en.rgy deman., if the world is to avoid an.ever in.reasin. en.rgy gap an. the atten.an. political in.tabilities. Laser-driven.in.rtial fusion.en.rgy(IFE) may offer such a solution.

关键词： ICF IFE in.rtial con.in.men. fusion in.rtial fusion en.rgy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

杨树树干液流时空动态研究

引用

林业科学研究 1993年第4期6卷 368-372页

作者：刘奉觉 edwards W.R.n. 郑世锴巨关升王广举卢永农新西兰园艺与食品研究所 privatebag11030 中国林业科学研究院林业研究所北京100091 山东省沂南县林业局

用热脉冲技术测定了2年生与6年生I-69杨树干液流时空动态的变化与蒸腾耗水量,结果表明:杨树干部液流仅发生在边材部位,同一年轮上各处的流速相近;径向不同位点夜间流速相近,趋于零,而白天变异较大,一般外层流速高于内层,由外向内流速逐... 详细信息

用热脉冲技术测定了2年生与6年生I-69杨树干液流时空动态的变化与蒸腾耗水量,结果表明:杨树干部液流仅发生在边材部位,同一年轮上各处的流速相近;径向不同位点夜间流速相近,趋于零,而白天变异较大,一般外层流速高于内层,由外向内流速逐渐减低,各处流速都随白天气象因子的变化而波动,整体变化呈现宽峰状曲线。凌晨与傍晚时流速分布出现暂时异常。树干断面流量与日蒸腾耗水量,2年生树分别为3～6L/h与13.6～22.8L,6年生树为20～35L/h与89.2～152.6L。

关键词：杨树树干液流

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

遗传性血色病与运动障碍无关

引用

世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 12-13页

作者： Russo n. edwards M. An.rews T. K.P. Bhatia 江山 Sobell Dept. Motor n.urosci. M. Institute of Neurology University College London Queen Square LondonWC1N 3BG United Kingdom

Hereditary haemochromatosis (HH) is a common.autosomal recessive systemic iron.overload disorder in.which Cn. man.festation., particularly movemen. disorders, have been.reported. We report a 63 year old woman.with familial HH with a four year history of progressive gait disturban.e, chorea, an. mild cervical an. laryn.eal dyston.a. Her movemen. disorder was thought to be related to the haemochromatosis. On.further in.estigation. an.lysis for the Hun.in.ton. s disease expan.ion.was positive. A review of the seven.published cases of movemen. disorders associated with HH as well as data con.ern.n. brain.iron.deposition.in.this con.ition.leads us to debate the causal lin. between.movemen. disorders an. HH. We suggest that ovemen. disorders are rare in.association.with HH, an. that such patien.s should be thoroughly in.estigated for an.ther cause for their movemen. diorder.

关键词：遗传性血色病运动障碍肌张力障碍舞蹈症喉肌颈肌族性进行性加重因果关系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：