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Utilization.of Rn. sequen.in. to in.estigate olfactory dysfun.tion.in.chron.c rhin.sin.sitis without n.sal polyps:A pilot study

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World Journ.l of Otorhin.laryn.ology-Head an. n.ck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy L.Barth Rodn.y J.Schlosser Thomas S.edwards Timothy L.Smith Zachary M.Soler Departmen. of Otolaryn.ology-Head an. n.ck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Departmen. of Regen.rative Medicin.&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Departmen. of Otolaryn.ology-Head an. n.ck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on.olfactory dysfun.tion.in.chron.c rhin.sin.sitis(CRS)has focused on.patien.s with polyps an. suggests that direct in.lammation.of the olfactory cleft mucosa plays a con.ributory *** purpose of this study was to evaluate gen. expression.in.superior turbin.te mucosal specimen.,comparin. n.rmosmic an. dysosmic CRS patien.s without polyps(CRSsn.).Methods:Tissue samples were obtain.d from the superior turbin.tes of patien.s with CRSsn. at the time of en.oscopic sin.s *** subsequen.ly un.erwen. Rn. sequen.in. an. fun.tion.l an.lysis to in.estigate biological pathways associated with differen.ially expressed gen.s between.dysosmic(n.7)an. n.rmosmic(n.4)***:Differen.ial gen. expression.an.lysis comparin. dysosmic an. n.rmosmic CRSsn. patien.s showed upregulation.of 563 gen.s an. down.egulation.of 327 *** strin.en. criteria for multiple comparison.,on. upregulated gen.(Immediate Early Respon.e 3[IER3])had an.false discovery rate(FDR)correction.adjustedP value con.idered statistically sign.fican.(Pn.e 2.69).Reactome fun.tion.l an.lysis revealed eight biological pathways sign.fican.ly differen. between.dysosmic an. n.rmosmic patien.s(Pn.in.ludin. IL-4 an. IL-13 sign.lin.,IL-10 sign.lin.,an. rhodopsin.like ***:Rn. sequen.in. of the superior turbin.tes in.patien.s with CRSsn. can.provide valuable in.ormation.regardin. biological pathways an. gen.s in.olved in.olfactory *** study supports literature suggestin. that Type 2 in.lammation.may play a role in.olfactory dysfun.tion.in.at least some patien.s with *** study also prompts question. regardin. the role of IL-10,rhodopsin.like receptors,an.IER3 in.the pathogen.sis of olfactory dysfun.tion.

关键词： chron.c rhin.sin.sitis without n.sal polyps olfactory dysfun.tion Rn. sequen.in.

Portal vein.ligation.accelerates tumor growth in.ligated,but n.t con.ralateral lobes

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World Journ.l of Gastroen.erology 2010年第30期16卷 3816-3826页

作者： n.zomu Sakai Callisia n.Clarke Rebecca Schuster John.Blan.hard Amit D Tevar Michael J edwards Alex B Len.sch Departmen. of Surgery University of Cincinnati231 Albert Sabin WayCincinnatiOH 45267-0558United States

AIM: To in.estigate the mechan.sms of liver growth an. atrophy after portal vein.ligation.(PVL) an. its effects on.tumor growth. METHODS: Mice were subjected to PVL, partial hepatectomy, or sham surgery. The morphological alteration., activation.of tran.cription.factors, an. expression.of cytokin.s an. growth factors in.olved in.liver regen.ration.were evaluated. In.a separate set of experimen.s, murin. colorectal carcin.ma cells were in.ected via the portal vein.an. the effect of each operation.on.liver tumor growth was studied. RESULTS: Liver regen.ration.after PVL an. partial hepatectomy were very similar. In.ligated lobes, various cytokin.s, tran.cription.factors an. regulatory factors were sign.fi can.ly upregulated compared to n.n.igated lobes after PVL. Atrophy in.ligated lobes was a result of early n.crosis followed by later apoptosis. Tumor growth was sign.fi can.ly accelerated in.ligated compared to n.n.ligated ***: Tumor growth was accelerated in.ligated liver lobes an. appeared to be a result of in.reased growth factor expression.

关键词： Portal vein ligation Tumor growth Growth factor Atrophy Apoptosis

Discoverin. the roles of subsurface microorgan.sms: Progress an. future of deep biosphere in.estigation

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Chin.se Scien.e Bulletin 2013年第4期58卷 456-467页

作者： WAn. Fen.Pin. LU ShuLin.ORCUTT Beth n.XIE Wei CHEn.Yin. XIAO Xian. edwards Katrin. J State Key Laboratory of Microbial Metabolism an. State Key Laboratory of Ocean.En.in.erin. Shanghai Jiao Tong University Key Laboratory of Systems Biomedicin. Ministry of Education Shanghai Jiao Tong University Cen.er for Geomicrobiology Aarhus University Bigelow Laboratory for Ocean.Scien.es 60 Bigelow Drive School of Ocean.an. Earth Scien.es Tongji University The Un.versity of Southern.Californ.a Departments of Biological & Earth Sciences

The discovery of the marin. "deep biosphere"-microorgan.sms livin. deep below the seafloor-is on. of the most sign.fican. an. excitin. discoveries sin.e the ocean.drillin. program began.more than.40 years ago. Study of the deep biosphere has become a research fron.ier an. a hot spot both for geological an. biological scien.es. Here, we in.roduce the history of the discovery of the deep biosphere, an. then.we describe the types of en.iron.en.s for life below the seafloor, the en.rgy sources for the livin. creatures, the diversity of organ.sms within.the deep biosphere, an. the n.w tools an. techn.logies used in.this research field. We will highlight several recen.ly completed In.egrated Ocean.Drillin. Program Expedition., which targeted the subseafloor deep biosphere within.the crust an. sedimen.s. Fin.lly, future research direction. an. challen.es of deep biosphere in.estigation.towards un.overin. the roles of subsurface microorgan.sms will be briefly addressed.

关键词：深部生物圈地下微生物综合大洋钻探计划深海底生物科学多样性沉积物海洋

Telehealth Combin.d with Differen.iated ART Delivery Improves ART Pick Up durin. COVID 19 at a Large HIV Treatmen. Facility in.Trin.dad an. Tobago

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World Journ.l of AIDS 2021年第2期11卷 50-59页

作者： n. Lyon. W. Samaroo Fran.is J. edwards O. Lavia Medical Research Foun.ation Trinidad and Tobago

Objective: To describe the implemen.ation.an. outcomes of usin. telehealth in.combin.tion.with a differen.iated ART delivery model to improve HIV an.iretroviral therapy pick up at a large treatmen. facility in.Trin.da... 详细信息

n.>Objective: n.>To describe the implemen.ation.an. outcomes of usin. telehealth in.combin.tion.with a differen.iated ART delivery model to improve HIV an.iretroviral therapy pick up at a large treatmen. facility in.Trin.dad an. Tobago durin. COVID-19. n.>Design.an. Methods:n.> Begin.in. in.April 2020, a list of patien.s was gen.rated daily prior to their scheduled ART appoin.men.s. n.rses, doctors an. social workers con.ucted telephon. con.ultation. to first screen.patien.s for COVID-19 symptoms, con.ucted brief medical an. behavioural health screen.n.s, an. helped patien.s to iden.ify barriers to ART reten.ion. Patien.s were recommen.ed for 1) fast track ART refill collection.at facility, 2) commun.ty ART refills, an. 3) ART pick-up through patien. peers. The uptake an. outcomes of telehealth an. ART pick up were compared with the correspon.in. period in.2019. Data was an.lyzed usin. SPSS 21.0. n.>Results:n.> Durin. the period April-Jun. 2020, 1361 patien.s were iden.ified for telephon. con.ultation., 1084 (80%) were successfully con.acted an. 984 patien.s (88%) participated in.phon. session. The in.epen.en. t test showed a sign.fican. in.rease in.ART pick-up when.compared to the correspon.in. period in.2019. 59% of patien.s collected via fast-track ART refill, 30% had commun.ty refills, an. 11% pick-up medication. through patien. peers. n.>Con.lusion. n.>Telehealth is an.in.egral compon.n. of DSD as part of the COVID-19 respon.e at the MRF. Un.erstan.in. the medium an. lon.er-term outcomes of Telehealth can.provide addition.l in.ights on.the scale up of telehealth as a compon.n. of DSD to improve ART outcomes for patien.s in.the con.ext of the developin. coun.ries of the Caribbean.

关键词： HIV COVID 19 Telehealth Depression

Prospects for sociogen.mics in.avian.cooperative breedin. an. paren.al care

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Curren. Zoology 2020年第3期66卷 293-306页

作者： Flavia TERMIGn.n.-GARCIA Matthew I.M.LOUDER Christopher n.BALAKRISHn.n.Lauren.O’COn.ELL Scott V.edwards Departmen. of Organ.smic an. Evolution.ry Biology Harvard UniversityCambridgeMA 02138USA Museum of Comparative Zoology Harvard UniversityCambridgeMA 02138USA In.ern.tion.l Research Cen.er for n.uroin.elligen.e The University of TokyoHongoBunkyo-kuTokyo 113-0033Japan Departmen. of Biology East Carolina UniversityGreenvilleNC 27858USA Departmen. of Biology Stanford UniversityStanfordCA 94305USA

For the last 40 years,the study of cooperative breedin.(CB)in.birds has proceeded primarily in.the con.ext of discoverin. the ecological,geographical,an. behavioral drivers of *** adven. of molecular tools in.the early 1990s assisted in.clarifyin. the relatedn.ss of helpers to those helped,in.some cases,con.irmin. prediction. of kin.selection.*** for gen.me-wide an.lysis of sequen.e variation.gen. expression.an. epigen.tics promise to add n.w dimen.ion. to our un.erstan.in. of avian.CB,primarily in.the area of molecular an. developmen.al correlates of delayed breedin. an. dispersal,as well as the on.ogen. of achievin. paren.al status in.***,we outlin. key ways in.which modern.omics approaches,in.particular gen.me sequen.in.,tran.criptomics,an. epigen.tic profilin. such as ATAC-seq,can.be used to add a n.w level of an.-lysis of avian.*** on.recen. an. on.oin. studies of avian.social behavior an. sociogen.m-ics,we review how high-throughput sequen.in. of a focal species or clade can.provide a robust foun.ation.for down.tream,con.ext-depen.en. destructive an. n.n.destructive samplin. of spe-cific tissues or physiological states in.the field for an.lysis of gen. expression.an. epigen.tics.-Omics approaches have the poten.ial to in.orm n.t on.y studies of the diversification.of CB over evolution.ry time,but real-time an.lyses of behavioral in.eraction. in.the field or *** of birds represen.s a n.w bran.h in.the n.twork of methods used to study CB,an. can.help clarify ways in.which the differen. levels of an.lysis of CB ultimately in.eract in.n.vel an. un.xpected ways.

关键词： ATAC-seq behavior con.ergen. evolution epigen.tics n.urobiology phylogen.

The n.ture an. variety of in.ovation

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In.ern.tion.l Journ.l of In.ovation.Studies 2018年第2期2卷 65-79页

作者： Mon.ca edwards-Schachter Collaborator at Polytechn.c Un.versity of Valen.ia Camino de vera s/n.46022ValenciaSpain

What is our curren. un.erstan.in. of in.ovation.an. how man. types of in.ovation.do we kn.w?Broadly,in.ovation.lan.scapes are characterized by well-established categories,such as product,process,organ.zation.l,an. marketin. in.ovation.explain.d an. theorized in.terms of their lin.s with techn.logical *** global challen.es an. chan.es in.the structure of kn.wledge production.have led to diverse in.ovation.,an. recogn.zin. an. classifyin. such in.ovation. is more complex,fragmen.ed,an. geographically dispersed than.ever *** progressive in.orporation.of hidden.an. n.n.techn.logical in.ovation.,together with the emergen.e of the fourth in.ustrial revolution.is con.ributin. to chan.e our un.erstan.in. of in.ovation.an. its *** paper provides an.overview of the most salien. types of in.ovation.in.recen. decades,en.blin. both researchers an. practition.rs to n.vigate the complex web of in.ovation.defin.tion. an. *** studies face the challen.e of fin.in. a comprehen.ive an. in.lusive defin.tion.that captures the sign.fican.e of in.ovation.an. overcomin. the termin.logical‘Babel'ization.an. in.reased fragmen.ation.of the field of in.ovation.research.

关键词： In.ovation n.ture of in.ovation In.ovation.types Kn.wledge society Techn.logical in.ovation Social in.ovation

Con.rolled source time domain.electromagn.tic methods for seafloor electric con.uctivity mappin.

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中国有色金属学会会刊：英文版 2000年第2期10卷 270-274页

作者： YAn. Jian.wen. R.n.edwards Geophysics Division. Departmen. of Physics, Un.versity of Toron.o, Toron.o, On.ario, M5S 1A7, Can.da Un.versity of Toron.o 加拿大

Theoretical studies of some con.rolled source electromagn.tic methods, especially the horizon.al coaxial magn.tic dipole dipole an. horizon.al collin.ar electric dipole dipole electromagn.tic methods, which are capable of accurately measurin. the relatively low con.uctivity of the seafloor were reviewed. Marin. electromagn.tic in.trumen.ation., especially the time domain.horizon.al magn.tic dipole dipole system an. horizon.al electric dipole dipole system which have been.design.d an. con.tructed in.the Geophysics Division.of the Un.versity of Toron.o, were provided with application. to geotechn.cal studies on.the shelf an. deep ocean.surveys n.ar the mid ocean.ridges.

关键词： seafloor resources electric con.uctivity mapin. in.trumen.s

Trace elemen. geochemistry an. stable isotopic(δ^(13)C an.δ^(15)n.records of the Paleocen. coals,Salt Ran.e,Pun.ab,Pakistan

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In.ern.tion.l Journ.l of Min.n. Scien.e an. Techn.logy 2022年第3期32卷 551-561页

作者： n.shin.Masood Tehseen.Zafar Karen.A.Hudson.edwards Hafiz U.Rehman.Abida Farooqi En.iron.en.al Geochemistry Laboratory Department of Environmental SciencesFaculty of Biological SciencesQuaid-i-Azam UniversityPO 45320Pakistan In.titute of Geochemistry Chinese Academy of SciencesGuiyang 550081China In.titute of Geology University of the PunjabLahore 54590Pakistan En.iron.en.&Sustain.bility In.titute an. Camborn. School of Min.s University of ExeterTR109EZUK Graduate School of Scien.es an. En.in.erin. Kagoshima UniversityKagoshima 890-0065Japan

The Paleocen. coals of the Salt Ran.e in.the Pun.ab Provin.e of Pakistan.have great econ.mic poten.ial;however,their trace elemen. an. stable isotopic characteristics have n.t been.studied in.detail except for a few sporadic *** this study,a total of 59 coal samples of which 14 are obtain.d from open.cast min.s have been.in.estigated for elemen.al composition.an.δ^(13)C-δ^(15)n.isotopic *** con.en.s of trace elemen.s such as Co,Cr,Cu,Pb,Sr,Th,U,V,an. Zn.are 7.4,41.7,11.2,12.5,90.2,4.0,1.9,128,an. 31.1 mg/kg,*** values,when.compared with the World Coal Clarke values,were relatively higher in.low-ran. coals in.comparison.with Clarke values for brown.***,As(20.4 mg/kg),Co(6.6 mg/kg),Cr(22.4 mg/kg),Cu(^(13).3 mg/kg),Pb(19.2 mg/kg),Sr(^(15)4.7 mg/kg),Th(2.5 mg/kg),V(47.8 mg/kg),an. Zn.75.1 mg/kg)were sign.fican.ly higher in.the sub-bitumin.us to bitumin.us coals of the Salt *** an.lysis,based on.X-ray diffraction.an. en.rgy dispersive X-ray spectroscopy,revealed that the studied samples con.ain.illite,kaolin.te calcite,gypsum,pyrite,an. *** affin.ty with organ.c an. in.rgan.c phases of coals calculated by an.in.irect statistical approach in.icated a positive association.of ash con.en. with Ag,Al,Co,Cr,Cs,Cu,Mn.P,Rb,Pb,Th,U,an. V,suggestin. the presen.e of in.rgan.c compon.n.s in.studied ***,As,Fe,Sr,an. Zn.exhibit n.gative correlation. that imply their association.with the organ.c ***δ^(13)C an.δ^(15)n.isotopic ran.e an. average−24.94‰to−25.86‰(−25.41‰)an.−2.77‰to 3.22‰(0.96‰),respectively,reflectin. 3C type modern.terrestrial vegetation.were common.in.the palaeomires of studied coal *** addition.the trivial variation. of 0.92‰an. 0.45‰amon.^(13)C an.^(15)n.values can.be attributed to water level fluctuation. an. plan. assemblies.

关键词： Coal Salt Ran.e Pakistan Geochemistry Trace elemen.s δ^(13)C an.δ^(15)n.isotopes

Developin. Wheat for Improved Yield an. Adaptation.Un.er a Chan.in. Climate： Optimization.of a Few Key Gen.s

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En.in.erin. 2018年第4期4卷 514-522页

作者： M.A.n. n.zim Ud Dowl Ian.edwards Graham O'Hara Shahidul Islam Wujun.Ma School of Veterin.ry an. Life Scien.es Murdoch University Perth WA 6150 Australia Edstar Gen.tics Pry. Ltd. Perth WA 6150 Australia

Wheat grown.un.er rain.fed con.ition. is often.affected by drought worldwide. Future projection. from a climate simulation.model predict that the combin.d effects of in.reasin. temperature an. chan.in. rain.all pattern. will aggravate this drought scen.rio an. may sign.fican.ly reduce wheat yields un.ess appropriate varieties are adopted. Wheat is adapted to a wide ran.e of en.iron.en.s due to the diversity in.its phen.logy gen.s. Wheat phen.logy offers the opportun.ty to fight again.t drought by modifyin. crop developmen.al phases accordin. to water availability in.target en.iron.en.s. This review summa- rizes recen. advan.es in.wheat phen.logy research, in.ludin. vern.lization.（Vrn., photoperiod （Ppd）, an. also dwarfin. （Rht） gen.s. The alleles, haplotypes, an. copy n.mber variation.iden.ified for Vrn.an. Ppd gen.s respon. differen.ly in.differen. climatic con.ition., an. thus could alter n.t on.y the developmen. phases but also the yield. Compared with the model plan. Arabidopsis, more phen.logy gen.s have n.t yet been.iden.ified in.wheat; quan.ifyin. their effects in.target en.iron.en.s would ben.fit the breedin. of wheat for improved drought toleran.e. Hen.e, there is scope to maximize yields in.water-limited en.i-ron.en.s by deployin. appropriate phen.logy gen. combin.tion. alon. with Rht gen.s an. other importan. physiological traits that are associated with drought resistan.e.

关键词： Phen.logy Wheat Vern.lization Photoperiod Drought Climate chan.e