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Double-Blin., Parallel Group St.dy t. Compare t.e Clin.cal Effect.ven.ss of Calcium Dobesilat. 500 mg BID vs. Calcium Dobesilat. LP 1 g OD, in.Pat.en.s wit. Chron.c Ven.us In.ufficien.y of t.e Lower Limbs

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In.ern.t.on.l Journ.l of Clin.cal Medicin. 2024年第5期15卷 211-223页

作者： Ramón.t.llez Mén.ez Maria Gon.ález Yibirin.David Rin.ón.Mat.t. Cen.ro Cln.co Prevaler Pampatar Nueva Esparta Venezuela Grupo Let. Guarenas Miranda Venezuela

Backgroun.: Chron.c ven.us in.ufficien.y (CVI) describes a con.it.on.t.at.affect. t.e ven.us syst.m of t.e lower ext.emit.es due t. ven.us hypert.n.ion.(VH. t.e prevalen.e is bet.een.5% - 30%. CVI is associat.d wit. older age, smokin., lower ext.emit. t.auma, presen.e of an.art.rioven.us shun., an. elevat.d est.ogen.levels. All pat.en.s should be in.t.ally t.eat.d wit. con.ervat.ve man.gemen.. Ven.act.ve drugs like calcium dobesilat. are useful. Object.ves: t.e primary object.ve compared t.e clin.cal improvemen. in.pat.en.s wit. CVI, grades 0 - 3 of t.e CEAP classificat.on.of chron.c ven.us disease, produced by t.o formulat.on. of calcium dobesilat.: calcium dobesilat. LP 1 g OD vs calcium dobesilat. 500 mg BID, immediat. release. t.e secon.ary object.ve assessed t.e side effect. of bot. formulat.on.. Met.od: All pat.en.s t.ok on. t.blet.an. on. capsule at.7 am, an. on. capsule at.7 pm, for 8 weeks. On. group received dobesilat. 1 g OD an. t.e ot.er group received dobesilat. 500 md BID. t.ey were evaluat.d aft.r 15, 30 an. 60 days of t.eat.en., usin. t.e sympt.m evaluat.on.scale. Result.: In.bot. groups, t.ere was a sign.fican. decrease in.t.e sympt.m score aft.r 15 days. Four pat.en.s in.t.e Dobesilat. OD group: had adverse effect., which did n.t.require suspen.ion.of t.eat.en.. In.t.e BID dobesilat. group, t.ere was on. t.erapeut.c failure, an. on. case of gast.ic discomfort. Con.lusion.: Prolon.ed-release Calcium dobesilat. 1 g OD is as effect.ve as calcium dobesilat. 500 mg BID for t.e t.eat.en. of pat.en.s wit. chron.c ven.us in.ufficien.y.

关键词： Chron.c Ven.us In.ufficien.y (CVI) Calcium Dobesilat. CEAP Classificat.on Adverse Effect. t.eat.en. Adheren.e

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t.e effect.ven.ss of differen. wear in.icat.rs in.quan.ifyin. wear on.railway wheels of freight.wagon.

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Railway En.in.erin. Scien.e 2024年第3期32卷 307-323页

作者： Philipe August. de Paula Pacheco M.Magelli Mat.eus Valen.e Lopes Pedro Hen.ique Alves Correa n.Zampieri n.Bosso Aut.lian. An.un.s dos San.os Federal In.t.t.t. of t.e Sout.east.of Min.s Gerais(IF Sudest. MG) Técnico PanamáStreet 45Santos DumontMG 36246-311Brazil Railway Laborat.ry(Lafer) Universidade Estadual de Campinas(UNICAMP)Mendeleyev Street 200CampinasSP 13083-872Brazil Depart.en. of Mechan.cal an. Aerospace En.in.erin. Politecnico Di TorinoC.so Duca degli Abruzzi 2410129 TurinItaly

Railway in.rast.uct.re relies on.t.e dyn.mic in.eract.on.bet.een.wheels an. rails;t.us,assessin. wheel wear is a crit.cal aspect.of main.en.n.e an. *** paper focuses on.t.e wheel-rail wear in.icat.r t.gamma(t.).Amidst.it. use,it.becomes apparen. t.at.t.,while valuable,fails t. provide a comprehen.ive reflect.on.of t.e act.al mat.rial removal an. act.al con.act.format.which mean. t.at.usin. on.y t.as a t.rget.for opt.mizat.on.of profiles is n.t.*** t.is work,t.ree differen. freight.wagon. are evaluat.d:a met.r-gauge an. a broad-gauge heavy haul vehicles from Sout. American.railways,an. a st.n.ard-gauge freight.vehicle operat.d in.Europe,wit. differen. axle loads an. dissimilar n.w wheel/rail *** vehicles are subject.d t. comprehen.ive mult.body simulat.on. on.various *** simulat.on. aimed t. elucidat. t.e in.ricat. relat.on.hip bet.een.differen. wear in.icat.rs:t.,wear in.ex,mat.rial removal,an. maximum wear dept.,un.er diverse curves,n.n.compen.at.d lat.ral accelerat.on.(A_(n.)),an. *** fin.in.s showed a correlat.on.of 0.96 bet.een.t.an. wear dept. an. 0.82 bet.een.wear in.ex an. mat.rial removed for t.e out.r *** t.e result.,t.e t.is bet.er t.an.t.e wear in.ex t. be used when.an.lyzin. wear dept. while t.e wear in.ex is more suit.d t. foresee t.e mat.rial *** result. also show t.e low in.luen.e of A_(n.)on.wear in.ex an. t..By con.iderin. t.ese fact.rs t.get.er,t.e st.dy aims t. improve t.e un.erst.n.in. of wheel-rail wear by select.n. t.e best.wear an.lysis approaches based on.t.e effect.ven.ss of each paramet.r.

关键词： Wear in.ex Wear volume Wear modelin. Dyn.mic simulat.on

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Organ.c ferroelast.c en.n.iomers wit. high t. an. large dielect.ic swit.hin. rat.o t.iggered by order-disorder an. displacive phase t.an.it.on

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Chin.se Chemical Let.ers 2024年第10期35卷 228-232页

作者： Zhaohon. Chen.Men.zhen.Li Jin.ei lan Shen.qian.Hu Xiaogan. Chen Ordered Mat.er Scien.e Research Cen.er Nanchang UniversityNanchang 330031China

Molecular-based ferroelast.cs wit. dielect.ic swit.hin. propert.es are highly desirable for t.eir applicat.on. on.microelect.on.c dielect.ic swit.hes,sen.ors,dat. st.rage,an. so ***,t.e curren. report. most.y focus on.organ.c-in.rgan.c hybrids con.ain.n. t.xic heavy met.l at.ms,an. t.e relat.vely low phase t.an.it.on.t.mperat.re limit. t.eir *** t.is paper,low-t.xic organ.c salt.ferroelast.c en.n.iomers(R/S)-4-fluoro-1-azabicyclo[3.2.1]oct.n.um chloride[(R/S)-F-321]were design.d an. syn.hesized un.er t.e in.roducin. chiralit. *** un.ergo a 432F422-t.pe ferroelast.c phase t.an.it.on.wit. a high Curie t.mperat.re(t.)of 470 K,simult.n.ously exhibit.n. excellen. dielect.ic swit.hin. *** addit.on.t. t.e ordered-disordered movemen. of cat.on.,t.e sign.fican. displacemen. of an.on. is also respon.ible for such high t. an. large dielect.ic swit.hin. rat.os,which is very rare in.molecular-based swit.hin. *** work en.iches t.e developmen. of molecular ferroelast.c swit.hin. mat.rials an. gives in.pirat.on.for t.e explorat.on.of en.iron.en.ally frien.ly high t. organ.c salt.ferroelast.cs wit. promin.n. swit.hin. performan.es.

关键词： Organ.c salt En.n.iomers Ferroelast.c Dielect.ic swit.hin. Phaset.an.it.on

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Developmen. of Fat.y Acid Biomarkers for t.e Iden.ificat.on.of Wild an. Aquacult.red Sea Cucumber (Apost.chopus japon.cus)

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Journ.l of Ocean.Un.versit. of Chin. 2016年第1期15卷 177-183页

作者： P. A. Zadorozhn.j t. n. Pivn.n.o n. n. Kovalev In.t.t.t. of Chemist.y Russian Academy of Sciences Far Eastern Branch Vladivostok 690022 Russia Far East.rn.St.t. t.chn.cal Fisheries Un.versit. Vladivostok 690087 Russia

In.t.is st.dy,t.e fat.y acids(FAs) of t.e organ. an. t.ssues of sea cucumber(Apost.chopus japon.cus) were profiled in.order t. compare t.e FA composit.on.of sea cucumber collect.d from n.t.ral habit.t.wild) an. cages(cult.red).t.e differen.es in.FA con.en.s in.dermomuscular t.be,peripharyn.eal an.ulus,gon.d an. in.est.n.(wit. or wit.out.con.en.) bet.een.t.e wild an. t.e cult.red were *** main.fat.y acids in.all organ. an. t.ssues were 20:5n.3,16:1n.7,20:4n.6,22:6n.3,18:0,an. 18:*** basically differen. FAs of body wall an. digest.ve t.be were 16:1n.7,18:1n.9 an. 20:*** rat.o of sat.rat.d t. mon.-an. polyun.at.rat.d FAs in.digest.ve t.be was in.epen.en. on.in.ide con.en. while t.ere was a redist.ibut.on.of t.e t.t.l amoun. of n.3 an. n.6 fat.y *** comparison.of FA composit.on.of t.e wild an. t.e cult.red sea cucumber showed t.at.20:5n.3,16:1n.7 an. 18:1n.7 predomin.t.d t.e wild while 20:4n.6 predomin.t.d t.e *** con.en. of bran.hed-chain.fat.y acids in.t.e wild was 3%–4% an. about.9% in.t.e *** possible FAs for iden.ifyin. t.e wild an. t.e cult.red sea cucumbers were *** was suggest.d t.at.t.e in.exes such as t.e rat.o of eit.er(n.3:n.6) t.(n.7:n.6) or(n.3) +(n.7) t.(n.6) may serve as t.e biomarkers dist.n.uishin. t.e wild an. t.e cult.red sea cucumber.

关键词： Apost.chopusjapon.cus fat.y acid t.ssue organ aquacult.re biomarker

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St.dy on.preparat.on.charact.rizat.on.an. applicat.on.of mixed-coloran.s t.ermochromic microcapsules

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Part.cuology 2024年第5期88卷 89-97页

作者： lan Zhou Jin.pen. Ye Qin.e Cai Guojin.Liu Mehran.Dadgar Guochen. Zhu Guoqin. Zhan. College of t.xt.le Scien.e an. En.in.erin. (In.ern.t.on.l In.t.t.t. of Silk) Zhejiang Sci-Tech UniversityHangzhou310018China School of Mat.rials Scien.e& En.in.erin. Zhejiang Sci-Tech UniversityHangzhou310018China Depart.en. of t.xt.le University of NeyshaburAdib BoulevardKhorasan Razavi ProvinceIran Zhejian. Charmin. Dyein. an. Fin.shin. Co. LtdJiaxing314500China Zhejian. Provin.ial In.ovat.on.Cen.er of Advan.ed t.xt.le t.chn.logy Shaoxing312000China

In.order t. expan. t.e color-chan.e ran.e an. make t.e discolorat.on.t.mperat.re suit.ble for t.e daily t.xt.les,a n.w formulat.on.of mixed-coloran.s t.ermochromic core mat.rial is design.d,in.which cryst.l violet.lact.n.(CVL)is t.e basic color former,bisphen.l A(BPA)is t.e developer,especially t.e solven.-based dye an. dodecyl dedecan.at. are used as t.e ext.n.ed dye an. t.e solven.,*** elect.on.microscope(SEM),differen.ial scan.in. calorimet.r(DSC)an. t.ermogravimet.ic an.lyzer(t.A)were applied t. st.dy t.e morphology,en.apsulat.on.rat.,n.n.isot.ermal cryst.llizat.on.behavior an. t.ermal st.bilit. of t.e mixed-coloran. t.ermochromic microcapsules(MCt.s)prepared by in.sit. *** result. show t.at.MCt.s have good sphericit.,un.form part.cle size,good t.ermal st.bilit. an. t.e en.apsulat.on.rat. can.reach 86.73%.Un.er t.e n.n.isot.ermal con.it.on.,t.e en.apsulat.on.of formaldehyde-melamin. resin.wall mat.rial can.slight.y reduce t.e cryst.llizat.on.rat. of t.e solven.,but.does n.t.affect.t.e relat.ve cryst.llin.t.,t.ermal propert.es an. discolorat.on.sen.it.vit. of t.e core *** t.e variet. of ambien. t.mperat.res in.t.e ran.e of 20–35℃,t.e prin.ed cot.on.fabrics wit. MCt.s could chan.e color reversibly bet.een.differen. t.n.s wit. good reliabilit. an. durabilit.,an. exhibit.more gorgeous colors t.an.t.e common.t.ermochromic mat.rials.

关键词： t.ermochromic microcapsule Color-chan.e ran.e Phase-chan.e mat.rial Cryst.llizat.on.behavior

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Cerebral ven.us sin.s t.rombosis:chan.in. t.en.s in.t.e in.iden.e,age an. gen.er(fin.in.s from t.e CMC Vellore CVt.regist.y)

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St.oke & Vascular n.urology 2024年第3期9卷 252-257页

作者： An.el Miraclin.t.John.Davis Prasad George Abraham n.n.n.Mahasampat. Gowri Deept. Bal At.f Iqbal Ahmed Shaikh Rohit.n.Ben.amin.Appaswamy t.irumal Prabhakar Ajit. Sivadasan.Vivek Mat.ew San.it. Aaron Depart.en. of n.urological Scien.es Christian Medical CollegeVelloreTamil NaduIndia Depart.en. of Biost.t.st.cs Christian Medical CollegeVelloreTamil NaduIndia

Backgroun. Mult.ple cerebral ven.us sin.s t.rombosis(CVt.regist.ies from various geographical region. in.icat. t.at.female gen.er,t.e use of con.racept.ve pills,pregn.n.y an. puerperium are import.n. risk *** t.is st.dy,we report.t.e chan.es in.t.e epidemiology of pat.en.s wit. CVt.man.ged over t.e past.26 *** t.e CMC Vellore CVt.regist.y is a prospect.vely main.ain.d dat.base at.t.e Christ.an.Medical College,Vellore sin.e Jan.ary *** soft.are was used t. an.lyse t.e dat. an. assess t.e chan.es in.t.e in.iden.e,age an. gen.er dist.ibut.on.over t.e previous 26 *** Amon. 1701 pat.en.s t.eat.d durin. t.e st.dy period,908(53%)were women.an. 793(47%)were *** mean.in.iden.e of CVt.was 49 per 100000 admission. before 2010,which in.reased t. 96 per 100000 aft.r *** gen.er had a higher odds of developin. CVt.OR–2.07(CI 1.68 t. 2.55,pt.is could be at.ribut.d t. t.e declin.n. in.iden.e of post.art.m CVt.aft.r 2010 compared wit. t.e decade before 2010(50%vs 20%).t.e mean.age at.presen.at.on.had in.reased from 24.5 t. 33.2 years in.t.e last.*** t.ere was a clear chan.e in.t.e gen.er pat.ern.from bein. a con.it.on.wit. female prepon.eran.e,t. on. where equal or more men.are bein. *** in.iden.e of post.art.m CVt.cases could be t.e drivin. *** in.rease in.t.e overall in.iden.e of CVt.cases was n.t.d,probably due t. a higher in.ex of clin.cal suspicion.an. bet.er diagn.st.c imagin. modalit.es.

关键词： CVt drivin. main.ain.d

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Immun. respon.e t. in.ct.vat.d bact.rial vect.r carryin. t.e recombin.n. K39 an.igen.of Leishman.a in.an.um in.mice

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Asian.Pacific Journ.l of t.opical Biomedicin. 2024年第5期14卷 199-206页

作者： Lucelin. S.Araújo Brun. B.Silva Eduarda n.F.n.San.os Arn.ldo S.Bezerra Samuel S.Frot. Assis R.Mon.en.gro Eridan.O.P.t.Florean.Maurício Fvan.t.lburg Maria Izabel F.Guedes Laborat.ry of Biot.chn.logy an. Molecular Biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil Facult. of Vet.rin.ry Medicin. State University of CearáFortalezaBrazil

Object.ve:t. evaluat. t.e immun.logical respon.e elicit.d by an.in.ct.vat.d bact.rial vect.r carryin. t.e K39 an.igen.of Leishman.a in.an.um,an. a purified ***:Mice were subject.d t. t.e followin. t.eat.en.s:(1)Purified recombin.n. K39(rK39)prot.in.at.a 20μg dose wit. complet. Freun.’s adjuvan.;(2)In.ct.vat.d Escherichia coli(BL21 DE3)carryin. t.e K39 prot.in.at.an.equivalen. t.t.l prot.in.con.en. of 200μg;(3)In.ct.vat.d bact.ria lackin. t.e K39 prot.in.(4)n.n.immun.zed con.rol *** mon.t.rin. was *** groups were challen.ed by in.raperit.n.al in.ect.on.of 10^(7) Leishman.a in.an.um *** eut.an.sia,t.e liver an. spleen.were collect.d t. an.lyze t.e levels of t.0},IFn.γ,IL-12,IL-4,an. ***:Mice immun.zed wit. purified rK39 or t.e in.ct.vat.d bact.rial vect.r carryin. t.e K39 an.igen.of Leishman.a in.an.um showed a lon.-last.n. immun. respon.e wit. high levels of polyclon.l an.ibodies specifically recogn.zin. t.e recombin.n. *** IgG1 subclass was t.e predomin.n. immun.globulin.however,t.e in.uct.on.of IgG2a an. t.e profile of cyt.kin.s produced were in.icat.ve of t.e in.uct.on.of a mixed-t.pe ***:t.e in.ct.vat.d bact.rial vect.r carryin. t.e K39 an.igen.as well as t.e purified an.igen.can.in.uce a lon.-last.n. immun. respon.e in.immun.zed mice,predomin.n.ly favourin. a t.2 profile respon.e.

关键词： Visceral leishman.asis K39 In.ct.vat.d bact.rial vect.r Vaccin. Immun. respon.e t.1 t.2 Leishman.a in.an.um

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Some Fixed Poin. t.eorems for Expan.ion.on.o Mappin.s on.Con. Met.ic Spaces

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Act. Mat.emat.ca Sin.ca,En.lish Series 2011年第6期27卷 1101-1106页

作者： Chin.aman.t. AAGE Jagan.at. n. SALUn.E School of Mat.emat.cal Scien.es North Maharashtra University Jalgaon 425001 India

t.is paper presen.s some fixed poin. t.eorems for expan.ion.selfmaps on.complet. con. met.ic spaces.

关键词： Con. met.ic space n.rmal con.s fixed poin.

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Review on.elect.omagn.t.c weldin. of dissimilar mat.rials

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Fron.iers of Mechan.cal En.in.erin. 2016年第4期11卷 363-373页

作者： K. SHAn.HALA t. n. SREEn.VASA Mechan.cal Depart.en. AMC Engineering College Bangalore IndiaE-mail: kshanthala2@***

Elect.omagn.t.c weldin. (EMW) is a high-speed join.n. t.chn.que t.at.is used t. join.similar or dissimilar met.ls, as well as met.ls t. n.n.met.ls. t.is t.chn.que uses elect.omagn.t.c force t. main.y join.con.uct.ve mat.rials. Un.ike con.en.ion.l join.n. processes, t.e weld in.erface does n.t.melt. t.us keepin. t.e mat.rial propert.es in.act. Ext.emely high velocit. an. st.ain.rat. in.olved in.t.e process facilit.t. ext.n.in. t.e EMW t.chn.que for join.n. several mat.rials. In.t.is paper, t.e research an. progress in.elect.omagn.t.c weldin. are reviewed from various perspect.ves t. provide a basis for furt.er research.

关键词： elect.omagn.t.c weldin. impact dissimilar mat.rials

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Human.Eosin.phil Cell Man.pulat.on.by Opt.cal t.eezers

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Open.Journ.l of Biophysics 2024年第3期14卷 330-338页

作者： Pavel Yale Jean.Michel Edoukoua Kon.n.Abadê An.e-Boris n.guessan.Michel Abaka Kouacou Jérémie t. Zoueu Laborat.ire dIn.t.umen.at.on Image et Spectroscopie (L2IS) Institut National Polytechnique Houphout-Boigny (INPHB) Yamoussoukro Cte dIvoire Laborat.ire de Chimie et.de Physique Appliques Sciences et Techniques Universit Alassane Ouattara Bouak Cte dIvoire

In.t.is work, lat.ral deformat.on.of human.eosin.phil cell durin. t.e lat.ral in.en.at.on.by an.opt.cally t.apped microbead of diamet.r 4.5 µm is st.died. t.e images were capt.red usin. a CCD camera an. t.e Bolt.man. st.t.st.cs met.od was used for force calibrat.on. Usin. t.e Hert. model, we calculat.d an. compared t.e elast.c moduli result.n. from t.e lat.ral force, showin. t.at.t.e differen.es are import.n. an. t.e force should be con.idered. Besides t.e lat.ral compon.n., t.e set.p also allows us t. examin. t.e lat.ral cell-bead in.eract.on. t.e mean.values of t.e propert.es obt.in.d, in.part.cular t.e elast.c st.ffn.ss an. t.e shear st.ffn.ss, were Eh = (37.76 ± 2.85) µn.m an. Gh = (12.57 ± 0.32) µn.m. t.ese result. show t.at.t.e lat.ral in.en.at.on.can.t.erefore be used as a rout.n. met.od for cell st.dy, because it.en.bled us t. man.pulat. t.e cell wit.out.con.act.wit. t.e laser.

关键词： Opt.cal t.eezers Human.Eosin.phil Cell In.en.at.on Shear St.ffn.ss

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