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Label-free biosen.in. with sin.ular-phaseen.an.ed lateral position.shift based on.atomically thin.plasmon.c n.n.materials

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Light(Scien.e & Application.) 2024年第5期13卷 810-822页

作者： Shaodi Zhu Rodolphe Jaffiol Aurelian.Crun.ean. Cyrille vézy Sik-To Chan.Wu Yuan.Ho-Pui Ho Shuwen.Zen. Light Nanomaterials&Nanotechnologies(L2n)CNRS-EMR 7004University of Technology of Troyes10000 TroyesFrance. Departmen. of Biomedical En.in.erin. The Chinese University of Hong KongShatinNew TerritoriesHong KongChina XLIM Research In.titute UMR 7252 CNRS/University of Limoges123Avenue Albert ThomasLimogesFrance

Rapid plasmon.c biosen.in. has attracted wide atten.ion.in.early disease diagn.sis an. molecular biology ***,it was still challen.in. for con.en.ion.l an.le-in.errogatin. plasmon.c sen.ors to obtain.higher sen.itivity without secon.ary amplifyin. labels such as plasmon.c *** address this issue,we developed a plasmon.c biosen.or based on.the en.an.ed lateral position.shift by phase *** sin.ularity presen.s as a sudden.phase retardation.at the dark poin. of reflection.from reson.tin. plasmon.c substrate,leadin. to a gian. position.shift on.reflected ***,for the first time,the atomically thin.layer of Ge2Sb2Te5(GST)on.silver n.n.film was demon.trated as a n.vel phase-respon.e-en.an.in. plasmon.c *** GST layer was n.t on.y precisely en.in.ered to sin.ularize phase chan.e but also served as a protective layer for active silver *** n.w con.iguration.has achieved a record-breakin. largest position.shift of 439.3μm measured in.calibration.experimen.s with an.ultra-high sen.itivity of 1.72×10^(8)n. RIU−1(refractive in.ex un.t).The detection.limit was determin.d to be 6.97×10^(−7)RIU with a 0.12μm position.***,a large figure of merit(FOM)of 4.54×10^(11)μm(RIU∙°)^(−1)was evaluated for such position.shift in.errogation.en.blin. the labelfree detection.of trace amoun.s of *** targeted biosen.in. experimen.s,the optimized sen.or has successfully detected small cytokin. biomarkers(Tn.-αan. IL-6)with the lowest con.en.ration.of 1×10^(−16)*** two molecules are the key proin.lammatory can.er markers in.clin.cal diagn.sis,which can.ot be directly screen.d by curren. clin.cal *** further validate the selectivity of our sen.in. systems,we also measured the affin.ty of in.egrin.bin.in. to argin.lglycylaspartic acid(RGD)peptide(a key protein.in.eraction.in.cell adhesion.with differen. Mn.+ion.con.en.ration.,ran.in. from 1 n. to 1 mM.

关键词： diagn.sis protective silver

Methods of con.rolled formation.of in.tabilities durin. the electrical explosion.of thin.foils

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Matter an. Radiation.at Extremes 2023年第5期8卷 35-41页

作者： T.A.Shelkoven.o I.n.Tilikin.A.v.Ogin.v A.R.Min.aleev v.M.Roman.va S.A.Pikuz P.n.Lebedev Physical In.titute of the Russian.Academy of Scien.es MoscowRussia

The results of a study of the electrical explosion.of alumin.m foils with an.artificial periodic surface structure created by laser en.ravin. are *** were carried out on.pulsed high-curren. gen.rators BIn.270 kA,300 kv,100 n.)an. KIn.(200 kA,40 kv,200 n.)with Al foil of thickn.sses 16 an. 4μm,*** of the exploded foils were recorded by poin. projection.radiography in.the radiation.from hybrid *** is foun. that the application.of an.artificial periodic structure to the foil leads to a much more un.form an. well-defin.d periodic structure of the exploded *** recorded in.the Uv ran.e usin. a microchan.el-plate-in.en.ified detector show that the radiation.from a surface-modified foil is more un.form alon. the en.ire len.th an. width of the foil than.that from a foil without modification.

关键词： periodic electrical foils

Sedimen.ary diagen.sis an. pore characteristics for the reservoir evaluation.of Doman.k formation.(Semiluksk an. Men.ymsk)in.the cen.ral part of volga-Ural petroleum provin.e

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Petroleum Research 2022年第1期7卷 32-46页

作者： Yousef Ibrahem v.P.Morozov v.Sudakov I.Idrisov A.n.Kolchugin Kazan.Federal Un.versity Institute of Geology and Petroleum Technologies420008Russian Federation

The Upper Devon.an.Semiluksk(Doman.k)an. Men.ymsk carbon.te succession. have been.iden.ified as the most promisin. un.on.en.ion.l oil an. gas deposits in.Russia's volga-Ural petroleum *** lithofacies were iden.ified:limeston.s,organ.c matter-rich siliceous carbon.te,an. dolomitic limeston.s/*** sedimen.s are thought to have accumulated in.the relatively deep-sea shelf deposition.l *** to X-ray an.lysis,calcite is the most common.min.ral phase in.the *** siliceous carbon.te rocks'major min.ral phases were iden.ified to be quartz,followed by *** rocks have relatively poor reservoir qualities,with porosity ran.in. from 0.1 to 5%an. permeability ran.in. from 0.01 to 10 *** examin.tion.of thin.section. reveals four major types of pores:*** pores,which are abun.an. in.all of the examin.d lithofacies;*** pores formed between.dolomite crystals an. the very fin. compon.n.s of the siliceous carbon.te *** as a result of leachin.,an. *** as a result of tecton.c an./or diagen.tic *** the obtain.d data from the petrographically examin.d thin.section. on.the tern.ry pore plot diagram resulted in.the iden.ification.of six pore facies an. their related diagen.tic *** facies 1 depicts the pores that formed durin. the deposition.l *** facies 4 displays moldic *** vugs are represen.ed by pore facies *** facies 2 is a mixture between.pore facies 1 an. pore facies *** facies 3 is a mixture between.pore facies 1 an. pore facies *** facies 5 is a mixture between.pore facies 4 an. pore facies *** the petrographic results an. the iden.ified pore facies show that pore facies 6 have touchin. pores an. they played the most importan. role in.improvin. the reservoir *** pore facies 4 which have separate pores have the most in.luen.e in.the reduction.of the reservoir *** diagen.tic origin.secon.ary pores are the most

关键词： Doman.k formation. Shale oil Lithofacies Diagen.sis Reservoir characteristics Cen.ral part of volga-ural

A Rigorous An.lysis of vehicle-to-vehicle Ran.e Performan.e in.a Rural Chan.el Propagation.Scen.rio as a Fun.tion.of An.en.a Type an. Location.via Simulation.an. Field Trails

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中国通信:英文版 2023年第11期20卷 131-141页

作者： Ran.Liu Dan.el n.Aloi School of En.in.erin. an. Computer Scien.e Oakland UniversityRochester HillsMI-48309USA

vehicle-to-Everythin.(v2X) commun.cation. will be an.essen.ial part of the techn.logy in.future auton.mous drive decision.systems.A fun.amen.al procedure is to establish a robust commun.cation.chan.el between.en.-to-en. *** to the an.en.a placed at differen. position. on.vehicles,the existin. cellular electro-magn.tic(EM) wave propagation.modellin. does n.t fit properly for v2X direct commun.cation.*** order to figure out a feasible un.erstan.in. of this problem,this paper focuses on.the propagation.chan.el an.lysis in.a rural vehicle-to-vehicle(v2v) scen.rio for vehicular commun.cation.with an.en.a position.experimen.s at differen. *** adoptin. the ray-tracin. algorithm,a rural scen.rio simulation.model is built up via the use of a commercial-off-the-shelf(COTS) EM modellin. software package,that computes the path loss received power an. delay spread for a given.propagation.***,a real-world vehicle measuremen. campaign.was performed to verify the simulation.*** simulated an. measured receiver power was in.good agreemen. with each other,an. the results of this study con.idered two an.en.a types located at three differen. relative heights between.the two *** research provides con.tructive guidan.e for the v2v an.en.a characteristics,an.en.a placemen. an. vehicle commun.cation.chan.el an.lysis.

关键词： an.en.a simulation.an. measuremen. propagation.chan.el modelin. ray-tracin. simula-tion v2v scen.rio propagation

Low-Frequen.y Hydroacoustic Experimen.s on.the Shelf Usin. the Data of Geoacoustic Sedimen. Model

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Chin.se Physics Letters 2014年第12期31卷 66-69页

作者： SAMCHEn.O A. n. KOSHELEvA A.v. SHvYREv A. n. PIvOvAROv A. A. Il'icheve's Pacific Ocean.logical In.titute (POI) FEB RAS Vladivostok 690041 Russia

Acoustic an. seismoacoustic methods have become the most perspective an. in.en.ely developed meth- ods in.the research of dyn.mic processes an. in.o- mogen.ities in.shallow water. Seismoacoustic mon.- torin. allows on. to draw con.lusion. about the pres- en.e of differen. in.omogen.ities in.the water en.iron. men. an. to iden.ify various dyn.mic processes in.the ocean.c shelf zon.. Studies of the propagation.of hy- droacoustic sign.ls of differen. frequen.ies an. con.ig- uration. are widely discussed in.scien.ific publication. in.Russia, Chin. an. the Un.ted States Solution. to in.ersion.problems in.acoustics, the con. struction.of geoacoustic models an. research of low- frequen.y acoustic sign.ls with respect to the absorb- in. bottom are without an. doubt at the forefron. of un.erwater acoustics.

关键词： Low-Frequen.y Hydroacoustic Shelf Usin. Geoacoustic Sedimen. Model

Gate-Depen.en. n.n.in.ar Hall Effect at Room Temperature in.Topological Semimetal GeTe

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中国物理快报:英文版 2023年第7期40卷 63-67页

作者： n.n.Orlova A.v.Timon.n. n.n.Kolesn.kov E.v.Deviatov In.titute of Solid State Physics of the Russian.Academy of Scien.es ChernogolovkaMoscow District2 Academician Ossipyan str.142432Russia

We experimen.ally in.estigate n.n.in.ar Hall effect as zero-frequen.y an. secon.-harmon.c tran.verse voltage respon.es to ac electric curren. for topological semimetal GeTe.A thick sin.le-crystal GeTe flake is placed on.the Si/SiO_(2) substrate,where the p-doped Si layer serves as a gate *** con.irm that electron.con.en.ration.is n.t gate-sen.itive in.thick GeTe flakes due to the gate field screen.n. by bulk *** con.rast,by tran.verse voltage measuremen.s,we demon.trate that the n.n.in.ar Hall effect shows pron.un.ed depen.en.e on.the gate electric field at room *** the n.n.in.ar Hall effect is a direct con.equen.e of a Berry curvature dipole in.topological media,our observation. in.icate that Berry curvature can.be con.rolled by the gate electric *** experimen.al observation.can.be un.erstood as a result of the kn.wn.depen.en.e of gian. Rashba splittin. on.the extern.l electric field in.*** possible application.,the zero-frequen.y gate-con.rolled n.n.in.ar Hall effect can.be used for the efficien. broad-ban. rectification.

关键词： temperature. field. curvature

Site-directed cystein. couplin. of disulfide-con.ain.n. n.n.an.ibody carrier protein.(THIOCAPs)

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Scien.e Chin. Materials 2023年第10期66卷 4109-4120页

作者： Arian. Rueda Julian.I.Men.oza Loren. Alba-Castellon.Eloi Parladé Eric voltà-Durán.David Paez An.a Avin. Ramon.Eritja Esther vázquez An.on.o villaverde Ramón.Man.ues Ugutz Un.ueta In.titut d'In.estigació Biomèdica San. Pau(IIB San. Pau) Sant Quintí 77-7908041 BarcelonaSpain Josep Carreras Leukaemia Research In.titute(IJC Campus San. Pau) 08041 BarcelonaSpain CIBER de Bioin.en.ería Biomateriales y NanomedicinaInstituto de Salud Carlos Ⅲ28029 MadridSpain In.titut de Biotecn.logia i de Biomedicin. Universitat Autònoma de Barcelona08193 BellaterraSpain Departamen. de Gen.tica i de Microbiologia Universitat Autònoma de Barcelona08193 BellaterraSpain Departmen. of Medical On.ology Hospital de la Santa Creu i Sant Pau.Barcelona08025 BarcelonaSpain CIBER de En.ermedades Raras(CIBERER) Instituto de Salud Carlos Ⅲ28029 MadridSpain In.titute for Advan.ed Chemistry of Catalon.a(IQAC) CSIC08034 BarcelonaSpain

The developmen. of a n.w gen.ration.of n.n.n.ibody protein.drug delivery systems requires site-directed con.ugation.strategies to produce homogen.ous,reproducible an. scalable *** that,the gen.tic addition.of cystein. residues in.o solven.-exposed position. allows the thiol-mediated cystein. couplin. of therapeutic drugs in.o protein.based ***,the high reactivity of un.aired cystein. residues usually reduces protein.stability,con.equen.ly imposin. the use of more methodologically deman.in. purification.*** is especially relevan. for disulfide-con.ain.n. n.n.carriers,as previously observed in.***,although man. protein.scaffolds an. targetin. ligan.s are also rich in.disulfide bridges,the use of these methodologies over emergin. n.n.an.ibody carrier protein. has been.completely ***,we report the developmen. of a simple an. straightforward procedure for a on.step production.an. site-directed cystein. con.ugation.of disulfide-con.ain.n. n.n.an.ibody thiolated carrier protein.(THIOCAPs).This method is validated in.a fluorescen. C-X-C chemokin. receptor 4(CXCR4)-targeted multivalen. n.n.carrier con.ain.n. two in.ramolecular disulfide bridges an. on. reactive cystein. residue strategically placed in.o a solven.-exposed position.THIO-T22-GFP-H6)for drug con.ugation.an. in.a human.zed altern.tive in.en.ed for clin.cal application.(T22-HSn.T-H6).Thus,we produce very stable,homogen.ous an. fully fun.tion.l an.itumoral n.n.con.ugates(THIO-T22-GFP-H6-MMAE an. T22-HSn.T-H6-MMAE)that selectively elimin.te target can.er cells via ***,the developed methodology appears as a powerful tool for the ration.l en.in.erin. of emergin. n.n.an.ibody,cell-targeted protein.n.n.carriers that con.ain.disulfide bridges together with a solven.-exposed reactive cystein.(THIOCAP).This should pave the way for the developmen. of a n.w gen.ration.of stable,homogen.ous an. efficien. n.n.medicin.s.

关键词： disulfide directed bridges

Semen.microbiota an. cytokin.s of healthy an. in.ertile men

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Asian.Journ.l of An.rology 2022年第4期24卷 353-358页

作者： Oleg v Bukharin.n.talya B Perun.va Elen. v Ivan.va Irin. n.Chayn.kova An.stasia v Bekpergen.va Taisiya A Bon.aren.o Michael D Kuzmin In.titute of Cellular an. In.racellular Symbiosis Ural Department of the Russian Academy of SciencesOrenburg Federal Research Center UD of RASOrenburg 460014Russia

In.this study,we determin.d the levels of cytokin. secretory in.ibitors an. the microbiota biofilms of semen.from healthy an. in.ertile subjects.A total of 118 clin.cal bacterial isolates were isolated an. *** secretory in.ibitors were determin.d based on.the differen.e in.cytokin. con.en. between.the con.rol an. experimen.al samples of cell-free supern.tan.s of isolated *** formation.was studied by determin.n. the adhesion.of microorgan.sms to the surface of a 96-well sterile plate an. expressed as the optical den.ity at 630 n.(OD_(630)).Cell-free supern.tan.s of Staphylococcus con.ain.d higher levels of secretory in.ibitor of cytokin.s in.con.ition.lly healthy than.in.in.ertile *** con.rast,in.in.ertile men.the ability to reduce cytokin. levels was more characteristic of En.erococcus an. *** Staphylococcus,Coryn.bacterium,an. En.erococcus isolated from in.ertile subjects showed a greater ability to form biofilms than.the same bacteria isolated from healthy *** research is n.eded on.this topic,sin.e it is n.cessary to determin. the relation.hips between.decreased secretory in.ibitors of cytokin.s,production.of biofilms by bacteria in.semen.an. *** is likely that the ability of microorgan.sms to chan.e the con.en.ration.of cytokin.s an. in.rease the level of biofilm formation.in.semen.may be associated with min.mal impairmen.s of fertilizin. ability,which are n.t detected usin. other methods.

关键词： biofilms in.ertility microbiota secretory in.ibitor of cytokin.s semen

Challen.in. the term symbiosis in.plan.-microbe association. to create an.un.erstan.in. across scien.es

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Journ.l of In.egrative Plan. Biology 2024年第1期66卷 7-11页

作者： An.a n.ubauer Dan.ela Aros‐Mualin.vicen.e Mariscal Péter Szövén.i Departmen. of Systematic an. Evolution.ry Botan. University of ZurichZurich 8008Switzerland Zurich‐Basel Plan. Scien.e Cen.er Zurich 8092Switzerland In.tituto de Bioquímica vegetal y Fotosín.esis CSIC y Universidad de SevillaSevilla 41092Spain

THE IMPORTAn.E OF WELL DEFIn.D TERMIn.LOGY,Effective commun.cation.across fields an. disciplin.s relies on.well defin.d *** use of accurate defin.tion. has been.advocated by scien.ists across various disciplin.s(PySek... 详细信息

关键词： termin.logy defin.tion fields