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Amyloid-beta pathology-in.uced n.n.scale syn.ptic disruption.the case of the GABA_B-GIRK assembly

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n.ural Regen.ration.Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan.Alejan.ro Martín.Belmon.e Sergi Ferré Fran.isco Ciruela Syn.ptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain In.egrative n.urobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Un.t Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an.imbalan.e between.excitatory an. in.ibitory brain.n.tworks,leadin. to aberran. homeostatic syn.ptic *** has progressively been.recogn.zed as syn. ptopathy an. syn. ptic dysfun.tion.has been.iden.ified as a key compon.n. of its pathogen.sis (Schirin.i et al.,2020).Syn. ptic dysfun.tion.is believed to precede syn.pse loss,a primary biological correlate of cogn.tive declin. in.AD,in.vita bly associated with n.uron.l death.

关键词： Alzheimer pathology

Data-driven.drug reposition.n. usin. olfactory omics profiles:challen.es an. perspectives in.n.urodegen.ration

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n.ural Regen.ration.Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adrian. Cortés Mercedes Lachén.Mon.es Elen. An.ya-Cubero Joaquín.Fern.n.ez-Irigoyen.En.ique San.amaría Clin.cal n.uroproteomics Un.t Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven.drug reposition.n. usin. olfactory omics profiles-challen.es an. perspectives in.n.urodegen.ration.n.urodegen.rative diseases are characterized by progressive degen.ration.an. loss of n.uron.l fun.tion.in.the cen.ral n.rvous *** diseases are often.characterized as protein.pathies,which are disorders primarily driven.by the aggregation.or misfoldin. of specific amyloid protein. within.cells,leadin. to their dysfun.tion.an. even.ual *** the gain.of-fun.tion.hypothesis related to the aggregation.of these protein.,recen.ly,an.altern.tive hypothesis regardin. the loss-of-fun.tion.of the soluble mon.meric protein. durin. the process of aggregation.in.o amyloids is gain.n. *** last even. is called protein.pen.a an. refers to con.ition. characterized by a deficien.y or decrease in.the levels of specific soluble protein. in.the body(Ezzat et al.,2023).It has been.demon.trated that levels of soluble protein. in.olved in.n.urodegen.rative diseases are decreased.

关键词： diseases drug amyloid

n.urocircuit regen.ration.by extracellular matrix reprogrammin.

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n.ural Regen.ration.Research 2025年第8期20卷 2300-2301页

作者： Shen.zhan. Su Ian.n.Levasseur Kimberly M.Alon.e Departmen. of Medicin.l Chemistry University of WashingtonSeattleWAUSA Departmen. of Chemistry University of WashingtonSeattleWAUSA Departmen. of Medicin. University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain.s extracellular matrix(ECM),which is comprised of protein.an. glycosamin.glycan.GAG)scaffolds,con.titutes 20%-40% of the human.brain.an. is con.idered on. of the largest in.luen.ers on.brain.cell fun.tion.n.(Soles et al.,2023).Syn.hesized by n.ural an. glial cells,the brain.s ECM regulates a myriad of homeostatic cellular processes,in.ludin. n.uron.l plasticity an. firin.(Miyata et al.,2012),cation.bufferin.(Moraws ki et al.,2015),an. glia-n.uron.in.eraction.(An.erson.et al.,2016).Con.iderin. the diversity of fun.tion.,dyn.mic remodelin. of the brain.s ECM in.icates that this un.erstudied medium is an.active participan. in.both n.rmal physiology an. n.urological diseases.

关键词： matrix programmin.

Vagus n.rve stimulation.in.in.racerebral hemorrhage:the n.ed for further research

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n.ural Regen.ration.Research 2025年第11期20卷 3213-3214页

作者： Sheharyar S.Baig Ali n.Ali Arshad Majid Sheffield In.titute for Tran.lation.l n.uroscien.e Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus n.rve stimulation.Vn.)an. stroke:Stroke is the secon. leadin. cause of death an. the third leadin. cause of disability worldwide(Baig et al.,2023).There have been.sign.fican. paradigm shifts in.the man.gemen. of acute ischemic stroke through mechan.cal *** chron.c ischemic stroke,in.asive Vn. paired with rehabilitation.is associated with a sign.fican. in.rease in.upper limb motor recovery an. is FDA-approved(Baig et al.,2023).There are n. treatmen.s of similar efficacy in.acute in.racerebral hemorrhage(ICH)where several promisin. trials,e.g.,TICH-2,STOP-AUST,an. TRAIGE did n.t show improvemen.s in.fun.tion.l outcomes(Puy et al.,2023).

关键词： stimulation acute

ASYMPTOTIC An.LYSIS OF LIn.ARLY ELASTIC SHALLOW SHELLS WITH VARIABLE THICKn.SS

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Chin.se An.als of Mathematics,Series B 2001年第4期22卷 405-416页

作者： n. SABU Laboratoire d’An.lyse n.merique, Un.versite Pierre et Marie Curie, 4 Place Jussieu, 75005, Paris, Fran.e.E-mail: sabu@an..jussieu.fr Laboratoire d'An.lyse n.merique Université Pierre et Marie Curie 4 Place Jussieu 75005 Paris France

The author con.iders a lin.arly elastic shallow shell with variable thickn.ss an. shows that, as the thickn.ss of the shell goes to zero, the solution.of the three-dimen.ion.l equation. con.erges to the solution.of th... 详细信息

关键词： Asymptotic an.lysis Elastic shallow shells Vaiable thickn.ss

On.LACUn.RY STATISTICAL COn.ERGEn.E OF ORDER α

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Acta Mathematica Scien.ia 2014年第2期34卷 473-482页

作者： Hacer SEn.L Mikail et Departmen. of Mathematics Firat University

In.this article, we in.roduce the con.ept of lacun.ry statistical con.ergen.e of order a of real n.mber sequen.es an. give some in.lusion.relation. between.the sets of lacu- n.ry statistical con.ergen.e of order α an. stron. n. （p）-summability. Furthermore, some relation. between.the spaces n.α （p） an. Sθα are examin.d.

关键词： Statistical con.ergen.e lacun.ry sequen.e Cesaro summability

Viscous Modified Chaplygin.Gas in.Classical an. Loop Quan.um Cosmology

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Chin.se Physics Letters 2017年第6期34卷 139-143页

作者： D. Aberkan. n. Mebarki S. Ben.hikh Laboratoire de Physique Mathematique et Subatomique Mentouri University Constantine 25000 Algeria

We in.estigate the cosmological model of viscous modified Chaplygin.gas （VMCG） in.classical an. loop quan.um cosmology （LQC）. Firstly, we con.train.its equation.of state parameters in.the framework of stan.ard cosmology from Un.on.2.1 Sn. Ia data. Then. we probe the dyn.mical stability of this model in.a un.verse filled with VMCG an. baryon.c fluid in.LQC backgroun.. It is foun. that the model is very suitable with （χ2/d.o.f = 0.974） an. gives a good prediction.of the curren. values of the deceleration.parameter q0 =∈ （-0.60, -0.57） an. the effective state parameter ωeff∈ （-0.76, -0.74） that is con.isten. with the recen. observation.l data. The model can.also predict the time crossin. when.（ρDE ≈ Pmatter） at z = 0.75 an. can.solve the coin.iden.e problem. In.LQC backgroun., the Big Ban. sin.ularity foun. in.classical cosmology ceases to exist an. is replaced by a boun.e when.the Hubble parameter van.shes at ρtot≈ρc.

关键词： Viscous Modified Chaplygin.Gas in.Classical an. Loop Quan.um Cosmology

SOME GEOMetRIC PROPERTIES OF A n.W DIFFEREn.E SEQUEn.E SPACE In.OLVIn. LACUn.RY SEQUEn.ES

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Acta Mathematica Scien.ia 2013年第6期33卷 1711-1720页

作者： Murat KARAKAS Mikail et Vatan.KARAKAYA Departmen. of Mathematics Firat University Departmen. of Mathematical En.in.erin. Yildiz Technical UniversityDavutpasa Campus

In.this paper, we defin. a n.w gen.ralized differen.e sequen.e space in.olvin. lacun.ry sequen.e. Then. we examin. k-n.C property an. property （β） for this space an. also show that it is n.t rotun. where p = （pr）... 详细信息

关键词： differen.e sequen.e space lacun.ry sequen.e k-n.C property rotun.ity Luxemburg n.rm

Electron.Backscattered Diffraction.of Tran.gran.lar Crack Propagation.in.Soft Steel

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Chin.se Physics Letters 2007年第6期24卷 1759-1762页

作者： A. Boumaiza T. Baudin.n. Rouag R. Pen.lle Laboratoire Microstructures et Defauts Universit6 Mentouri Constantine Algdrie Laboratoire de Physico-Chimie de l'etat Solide UMR Cn.S 8648 Paris-Sud Orsay France

We con.ider the crack propagation.in.a soft steel sheet durin. the formation. The drawability is con.idered in.relation.with the structural an.sotropy, the mechan.cal behaviour is related to both the grain.morphology an. the texture. The structure heterogen.ity could lead to the apparition.of micro-cracks. The results show the texture effect on.the crack propagation.an. on.the crack arrest in.soft steel durin. the formation. The EBSD techn.que allows to show that the adjustmen. of the grain.orien.ation.from the in.tial main.compon.n. {111}（112） towards the deformation.orien.ation.{111}（110） in.ites a tran.-gran.lar crack through a grain.with in.tial {111}（112） orien.ation.in.a globally ductile material. It is the presen.e of grain. with {111}（110） orien.ation.which permits the closin. of micro-cracks.

关键词： In.TIATIOn GROWTH