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Predictive value of E-cadherin and Ep CAM for detection of metastatic lymph node in early gastric cancer

Chinese Journal of Cancer Research 2020年第5期32卷 614-620页

作者： Bang Wool Eom Keun Won Ryu Hong Man Yoon myeong-cherl kook Center for Gastric Cancer National Cancer CenterGoyang-si 10408Republic of Korea

Objective:There has been a demand for a tumor-specific marker for metastatic lymph nodes in sentinel navigation surgery for gastric *** aim of this study is to analyze protein expression in both primary tumors and metastatic lymph nodes in early gastric cancer ***:We collected primary tumors and metastatic lymph nodes from 71 patients who underwent curative gastrectomy and pathologically diagnosed with T1 N1 or T1 N2(8 th Union for International Cancer Control 8 th edition/American Joint Committee on Cancer staging system)gastric *** was used to determine the expression of six cell membrane proteins,including carcinoembryonic antigen(CEA),E-cadherin,epithelial cell adhesion molecule(Ep CAM),P-cadherin,CD44 v6,and c-erb B2 in the patient ***:The expression of CEA,E-cadherin,Ep CAM,P-cadherin,CD44 v6 and c-erb B2 in the evaluable primary tumor samples was 75.4%,97.1%,100%,89.9%,11.1%and 7.2%,*** cases wherein both the primary tumor and metastatic lymph nodes were evaluable,double positivity(expression in both primary tumor and metastatic lymph nodes)was observed for CEA,E-cadherin,Ep CAM,P-cadherin,CD44 v6 and c-erb B2 in 53.2%,97.9%,98.1%,76.6%,0 and 6.8%of the cases,*** proportion of metastatic lymph nodes positive for CEA,E-cadherin,Ep CAM,P-cadherin,CD44 v6 and c-erb B2 was 71.4%,100%,98.1%,83.7%,0,and75%,respectively in primary tumors positive for the same ***:E-cadherin and Ep CAM had an overlap of 100%and 98.1%between the primary tumor and metastatic lymph nodes,***,E-cadherin and Ep CAM are potential molecular markers to detect metastatic lymph nodes in patients with early gastric cancer.

关键词： Gastric cancer tumor-associated protein E-cadherin EpCAM lymph node

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Gastric choriocarcinoma admixed with an α-fetoprotein-producing adenocarcinoma and separated adenocarcinoma

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World Journal of Gastroenterology 2009年第40期15卷 5106-5108页

作者： Bang Wool Eom So-Youn Jung Hongman Yoon myeong-cherl kook Keun Won Ryu Jun Ho Lee Young-Woo Kim Center for Gastric Cancer National Cancer Center

We report a case of gastric choriocarcinoma admixed with an α-fetoprotein (AFP)-producing adeno-carcinoma. A 70-year-old man was hospitalized for gastric cancer that was detected during screening by esophagogastroduodenoscopy (EGD). Initial laboratory data showed the increased serum level of AFP and EGD revealed a 5-cm ulcerofungating mass in the greater curvature of the gastric antrum. The patient underwent radical subtotal gastrectomywith D2 lymph node dissection and Billroth gastrojejunostomy. Histopathological evaluation confirmed double primary gastric cancer: gastric choriocarcinoma admixed with an AFP-producing adenocarcinoma and separated adenocarcinoma. At 2 wk postoperatively, his human chorionic gonadotropin and AFP levels had reduced and six cycles of adjuvant chemotherapy were initiated. No recurrence or distant metastasis was observed at 4 years postoperatively.

关键词： α-fetoproteins Adenocarcinoma Choriocarcinoma Stomach neoplasms

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Recent updates and current issues of sentinel node navigation surgery for early gastric cancer

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Chinese Journal of Cancer Research 2021年第2期33卷 142-149页

作者： Sung Gon Kim Bang Wool Eom Hong Man Yoon Chan Gyoo Kim myeong-cherl kook Young-Woo Kim Keun Won Ryu Center for Gastric Cancer Research Institute&HospitalNational Cancer CenterGoyang-si 410-769Republic of Korea

With the increase in the incidence of early gastric cancer(EGC),several endoscopic and laparoscopic approaches,such as endoscopic submucosal dissection and function-preserving gastrectomy,have been accepted as standard *** node navigation surgery(SNNS)is an ideal surgical option for preservation of most parts of the stomach and consequent maintenance of normal gastric function to improve quality of life in patients with *** many previous studies and clinical trials have demonstrated the safety and feasibility of the sentinel node concept in gastric cancer,the clinical application of SNNS is *** issues regarding technical standardization and oncological safety need to be *** several studies to resolve these problems are being actively performed,and SNNS might be an important surgical option in the treatment of gastric cancer in the future.

关键词： Sentinel node navigation surgery function-preserving surgery early gastric cancer SENORITA

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Factors associated with metastasis in superior mesenteric vein lymph node in subtotal gastrectomy for gastric cancer:Retrospective case control study

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Chinese Journal of Cancer Research 2020年第1期32卷 43-50页

作者： Won Ho Han Jungnam Joo Bang Wool Eom Keun Won Ryu Young-Woo Kim myeong-cherl kook Hong Man Yoon Center for Gastric Cancer Research Institute&HospitalNational Cancer CenterGoyang-si 410-769Republic of Korea Division of Cancer Epidemiology and Prevention National Cancer CenterGoyang-si 410-769Republic of Korea

Objective: The revised Japanese treatment guideline for gastric cancer recommends dissection of the superior mesenteric vein lymph node(No. 14v LN) if there is metastasis in infrapyloric lymph node(No. 6 LN). However,it is still controversial whether LN dissection is necessary. The aim of this study was to investigate the factors associated with metastasis in No. 14v ***: Patients who underwent D2 lymphadenectomy between 2003 and 2010 were included. We excluded patients who underwent total gastrectomy, had multiple lesions, or had missing data about the status of metastasis in the LNs that were included in D2 lymphadenectomy. Clinicopathologic characteristics and the metastasis in regional LNs were compared between patients with No. 14v LN metastasis(14v+) and those without(14v-).Results: Five hundred sixty patients were included in this study. Univariate analysis showed that old age, larger tumor size, tumor location, differentiation, lymphatic invasion, venous invasion, perineural invasion, T classification, and N classification were related to metastasis in No. 14v LN. Multivariate analysis showed differentiation(P=0.027) and N classification(P<0.001) were independent related factors. Metastasis in infrapyloric lymph node(No. 6 LN) and proxiaml splenic lymph node(No. 11p LN) was independently associated with metastasis in No. 14v ***: Differentiation and N classification were independent factors associated with No. 14v LN metastasis, and No. 6 and No. 11p LN metastasis were independent risk factors for No. 14v LN metastasis.

关键词： Gastric cancer gastrectomy lymphadenectomy superior mesenteric vein risk factor

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Current status and challenges in sentinel node navigation surgery for early gastric cancer

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Chinese Journal of Cancer Research 2017年第2期29卷 93-99页

作者： Bang Wool Eom Young-II Kim Hong Man Yoon Soo-Jeong Cho Jong Yeul Lee Chan GyooKim Soo Jin Kim Ji Yoon Rho Seok Ki Kim myeong-cherl kook Young-Woo Kim Keun Won center for gastric cancer national cancer centerrepublic of korea center for diagnostic oncology national cancer centerrepublic of korea

Although a number of feasibility studies for sentinel node （SN） concepts in gastric cancer have been conducted since 2000, there remains a debate regarding detailed detection techniques and oncological safety. Two important multicenter phase II clinical trials were performed in Japan that used different methods and reached different conclusions; one confirmed acceptable results with a false-negative rate of 7%, and the other showed an unacceptably high false-negative rate of 46.4%. The Sentinel Node Oriented Tailored Approach （SENORITA） trial is a multicenter randomized controlled phase 1/I trial being performed in Korea. Patient enrollment is now complete and the long-term results are currently awaited. Recently, an image-guided SN mapping technique using infrared ray/fluorescence was introduced. This method might be a promising technology because it allows the clear visualization of SNs. With regard to the primary tumor, the non-exposed endoscopic wall-inversion surgery technique and non-exposure endolaparoscopic full-thickness resection with simple suturing technique have been reported. These methods prevent abdominal infection and tumor seeding and can be good alternatives to conventional laparoscopic gastric wedge resection. For indications, SN navigation surgery can be extended to patients who underwent non-curative endoscopic resection. Although a few studies have been performed on these patients, sentinel concepts may be beneficial to patients as they omit the need for additional gastrectomy. SN navigation surgery can lead to actual organ-preserving surgery and plays a key role in improving the quality of life of patients with early gastric cancer in the future.

关键词： Sentinel node navigation surgery early gastric cancer SENORITA

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Biopathologic features and clinical significance of micrometatasis in the lymph node of early gastric cancer

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World Journal of Gastroenterology 2015年第2期21卷 667-674页

作者： Min Jung Jo Ji Yeon Park Joon Seon Song myeong-cherl kook Keun Won Ryu Soo-Jeong Cho Jun Ho Lee Byung-Ho Nam Eun Kyung Hong Il Ju Choi Young-Woo Kim Gastric Cancer Branch Research Institute and HospitalNational Cancer CenterGoyang-si 410-769South Korea Department of Pathology Research Institute and HospitalNational Cancer CenterGoyangsi 410-769South Korea Cancer Registration and Biostatistics Branch and Center for Clinical Trial National Cancer CenterGoyangsi 410-769South Korea

AIM: To evaluate the biopathologic features and clinical significance of nodal micrometastasis(MI) in early gastric cancer(EGC).METHODS: Among 1022 EGC patients who underwent gastrectomy with lymphadenectomy of D1 + β or more from March 2001 to December 2005 at the Korean National Cancer Center, available nodal metastasis was found in 90 p T1N1 patients. Nodal metastasis was confirmed by immunohistochemistry(IHC) with cytokeratin and patients were classified into MI and macrometastasis(MA) groups based on the main tumor burden according to the 6th International Union Against Cancer/American Joint Committee on Cancer staging system; the main tumor burden with a diameter of greater than 0.2 mm but no greater than 2 mm as MI, and greater than 2 mm as MA of the representative metastatic node. Proliferative and apoptotic activities of the primary tumor and the nodal metastasis were measured by IHC with Ki-67 and terminal deoxynucleotidyl transferase d UTP nick end labeling, respectively. Biopathologic and clinical features of the patients were analyzed and compared between MI and MA groups. Patients with recurrence were compared with those without recurrence to identify risk factors for ***: Thirty-seven patients showed MI and the other 53 patients revealed MA in the lymph node; the incidence of patients with MI and MA was 41.1% and 58.9%. The main tumor burden was 0.9 and 4.6 mm in the representative metastatic node, respectively. Japanese N2 stations were more frequently involved in MA group(20.9%) than in MI group(10.3%) butthe difference was not statistically different(P = 0.338). Proliferative and apoptotic activities of MI were decreased than those of MA(26.7% vs 40.5%, P = 0.004 and 1.0% vs 3.0%, P < 0.001, respectively). However, nodal MI in the current study showed a relatively high proliferative activity and an equivalent apoptotic activity compared to other cancers in the previously published studies. Recurrence was observed in 6 patients during

关键词： Early gastric cancer Sentinel node biopsy Lymphade

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Potential reduction in carbon fixation capacity under climate change in a Pinus koraiensis forest

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Forest Ecosystems 2024年第2期11卷 152-161页

作者： Dong kook Woo Department of Civil Engineering Keimyung UniversityDaegu42601Republic of Korea

There has been an increasing recognition of the crucial role of forests, responsible for sequestering atmospheric CO_(2), as a moral imperative for mitigating the pace of climate change. The complexity of evaluating climate change impacts on forest carbon and water dynamics lies in the diverse acclimations of forests to changing environments. In this study, we assessed two of the most common acclimation traits, namely leaf area index and the maximum rate of carboxylation(V_(cmax)), to explore the potential acclimation pathways of Pinus koraiensis under climate change. We used a mechanistic and process-based ecohydrological model applied to a P. koraiensis forest in Mt. Taehwa, South Korea. We conducted numerical investigations into the impacts of(i) Shared Socioeconomic Pathways 2–4.5(SSP2-4.5) and 5–8.5(SSP5-8.5),(ii) elevated atmospheric CO_(2) and temperature, and(iii) acclimations of leaf area index and V_(cmax)on the carbon and water dynamics of P. koraiensis. We found that there was a reduction in net primary productivity(NPP) under the SSP2-4.5 scenario, but not under SSP5-8.5, compared to the baseline, due to an imbalance between increases in atmospheric CO_(2) and temperature. A decrease in leaf area index and an increase in V_(cmax)of P. koraiensis were expected if acclimations were made to reduce its leaf temperature. Under such acclimation pathways, it would be expected that the well-known CO_(2) fertilizer effects on NPP would be attenuated.

关键词： Climate change NEP Pinus koraiensis Warming Acclimation

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Optimal Center-of-Mass Pivot Effect of Spinal Motion in Feline Galloping

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Journal of Bionic Engineering 2020年第5期17卷 970-977页

作者： Young kook Kim Dongwon Yun LV R&D team Electro-technology R&D CenterLS ELECTRIC Co.LtdCheongju 28437South Korea Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988South Korea

In this paper,we studied the acceleration behavior of a quadruped animal during a galloping *** the development of many quadruped robotic systems has been focused on dynamic movements,it is obvious that guidance from the dynamic behavior of quadruped animals is needed for robotics *** fulfill this demand,this paper deals with analysis of the galloping motions of a domestic cat,which is well known for its excellent acceleration performance among four-legged *** on the planar motion capture environment,the movement data of a galloping feline was acquired and the dynamic motions were estimated using a spring-mass *** particular,the effects of the position and angle of the center-of-mass of the cat,angular displacement of the spine,and angular velocity of the spine were analyzed and are discussed *** this process,it was possible to understand the dynamic movement characteristics of the cat,and to understand the relationships between,and the influences of,these *** this analysis,we provide significant data applicable to the design of joint movements in quadruped robot systems.

关键词： quadrupedalism feline galloping domestic cat center-of-mass

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Biomimetic Quadruped Robot with a Spinal Joint and Optimal Spinal Motion via Reinforcement Learning

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Journal of Bionic Engineering 2021年第6期18卷 1280-1290页

作者： Young kook Kim Woojin Seol Jihyuk Park LV R&D Team Electro-technology R&D CenterLS Electric Co.LtdCheongju28437Republic of Korea Digital Innovation Unit Korea Hydro&Nuclear Power Co.Ltd1312-gil YuseongdaeroYusung-guDaejeon34101Republic of Korea Department of Automotive Engineering College of Mechanical and IT EngineeringYeungnam University280 Daehak-roGyeongsanGyeongbuk38541Republic of Korea

Feline animals can run quickly using spinal joints as well as the joints that make up their four *** paper describes the development of a quadruped robot including a spinal joint that biomimics feline *** developed robot platform consists of four legs with a double 4-bar linkage type and one simplified rotary *** addition,Q-learning,a type of machine learning,was used to find the optimal motion profile of the spinal *** bounding gait was implemented on the robot system using the motion profile of the spinal joint,and it was confirmed that using the spinal joint can achieve a faster Center of Mass(CoM)forward speed than not using the spinal *** the motion profile obtained through Q-learning did not exactly match the spinal angle of a feline animal,which is more multiarticular than that of the developed robot,the tendency of the actual feline animal spinal motion profile,which is sinusoidal,was similar.

关键词： Quadruped robot system Bioinspired methods Legged robots Machine learning Q-learning

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Preparation of TiAlN/ZrN and TiCrN/ZrN multilayers by RF magnetron sputtering

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中国有色金属学会会刊：英文版 2009年第4期19卷 795-799页

作者： Jong-kook LEE G won-Seung YANG Department of Advanced Materials Engineering Chosun University BK21 Education Center of Mould Technology for Advanced Materials and Parts Chosun University

Titanium-based nitride coatings on cutting tools,press molds and dies can be used to prolong their life cycle because of their superior corrosion and oxidation ***/ZrN and TiCrN/ZrN multilayer coatings were prepared by RF magnetron sputtering,and their microstructural evolution and corrosion resistance during heat treatment were *** TiAlN/ZrN and TiCrN/ZrN multilayer coatings are degraded by heating up to 600 ℃ with the formation of oxides particles on the *** the heat treatment,the TiCrN/ZrN and TiAlN/ZrN multilayer coatings show the lowest corrosion current density and the highest polarization resistance at temperature range of 400-500 ℃.Consequently,the TiAlN/ZrN and TiCrN/ZrN multilayer coatings show good corrosion resistance at temperature range of 400-500 ℃ during heating.

关键词：射频磁控溅射溅射制备氮化锆多层膜钛铝耐腐蚀性腐蚀电流密度

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