Predictive value of E-cadherin and Ep CAM for detection of metastatic lymph node in early gastric cancer

作     者：Bang Wool Eom Keun Won Ryu Hong Man Yoon Myeong-Cherl Kook Bang Wool Eom;Keun Won Ryu;Hong Man Yoon;Myeong-Cherl Kook

作者机构：Center for Gastric CancerNational Cancer CenterGoyang-si 10408Republic of Korea 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2020年第32卷第5期

页      面：614-620页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a grant of the National Cancer Center(No.NCC-0910560 NCC-1010490 and NCC1710360) 

主　　题：Gastric cancer tumor-associated protein E-cadherin EpCAM lymph node 

摘      要：Objective:There has been a demand for a tumor-specific marker for metastatic lymph nodes in sentinel navigation surgery for gastric *** aim of this study is to analyze protein expression in both primary tumors and metastatic lymph nodes in early gastric cancer ***:We collected primary tumors and metastatic lymph nodes from 71 patients who underwent curative gastrectomy and pathologically diagnosed with T1 N1 or T1 N2(8 th Union for International Cancer Control 8 th edition/American Joint Committee on Cancer staging system)gastric *** was used to determine the expression of six cell membrane proteins,including carcinoembryonic antigen(CEA),E-cadherin,epithelial cell adhesion molecule(Ep CAM),P-cadherin,CD44 v6,and c-erb B2 in the patient ***:The expression of CEA,E-cadherin,Ep CAM,P-cadherin,CD44 v6 and c-erb B2 in the evaluable primary tumor samples was 75.4%,97.1%,100%,89.9%,11.1%and 7.2%,*** cases wherein both the primary tumor and metastatic lymph nodes were evaluable,double positivity(expression in both primary tumor and metastatic lymph nodes)was observed for CEA,E-cadherin,Ep CAM,P-cadherin,CD44 v6 and c-erb B2 in 53.2%,97.9%,98.1%,76.6%,0 and 6.8%of the cases,*** proportion of metastatic lymph nodes positive for CEA,E-cadherin,Ep CAM,P-cadherin,CD44 v6 and c-erb B2 was 71.4%,100%,98.1%,83.7%,0,and75%,respectively in primary tumors positive for the same ***:E-cadherin and Ep CAM had an overlap of 100%and 98.1%between the primary tumor and metastatic lymph nodes,***,E-cadherin and Ep CAM are potential molecular markers to detect metastatic lymph nodes in patients with early gastric cancer.