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Extracellular vesicles as tools and targets in therapy for diseases

Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.Baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil muzafar a.macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

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Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

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Signal Transduction and Targeted Therapy 2021年第2期6卷 324-338页

作者： Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael EI-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris muzafar a.macha Functional and Molecular Imaging Laboratory Cancer Research DepartmentSidra MedicineDohaQatar Department of Zoology School of Life SciencesCentral University of KashmirGanderbalJammu&KashmirIndia Department of Nephrology All India Institute of Medical SciencesNew DelhiIndia Department of Biochemistry All India Institute of Medical SciencesNew DelhiIndia Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaJammu&KashmirIndia Laboratory of Cancer Immunogenomics Cancer Research DepartmentSidra MedicineDohaQatar Department of Surgery University of MiamiMiamiFLUSA Academic Health System Hamad Medical CorporationDohaQatar Department of Biochemisty and Molecular Biology University of Nebraska Medical CenterOmahaNEUSA Eppley Institute for Research in Cancer and Alied Diseases University of Nebraska Medical CenterOmahaNEUSA Buffet Cancer Center University of Nebraska Medical CenterOmahaNEUSA Laboratory Animal Research Center Qatar UniversityDohaQatar

Head and neck squamous cell carcinoma(HNSCC)is a very aggressive disease with a poor prognosis for advanced-stage *** clinical,genomic,and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of *** signifcant advances in multimodal therapeutic interventions,failure to cure and recurrence are common and account for most *** is becoming increasingly apparent that tumor microenvironment(TME)plays a critical role in HNSCC tumorigenesis,promotes the evolution of aggressive tumors and resistance to therapy,and thereby adversely affects the prognosis.A complete understanding of the TME factors,together with the highly complex tumor-stromal interactions,can lead to new therapeutic interventions in ***,different molecular and immune landscapes between HPV^(+ve) and HPV^(-ve)(human papillomavirus)HNSCC tumors offer new opportunities for developing individualized,targeted chemoimmunotherapy(CIT)*** review highlights the current understanding of the complexity between HPV^(+ve) and HPV^(-ve) HNSCC TME and various tumor-stromal cross-talk modulating processes,including epithelial-mesenchymal transition(EMT),anoikis resistance,angiogenesis,immune surveillance,metastatic niche,therapeutic resistance,and development of an aggressive tumor ***,we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV^(+ve) and HPV^(-ve) HNSCC.

关键词： targeted squamous thereby

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Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy

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Cancer Communications 2022年第8期42卷 689-715页

作者： Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris muzafar a.macha Laboratory of Molecular and Metabolic Imaging Cancer Research DepartmentSidra MedicineDoha 26999Qatar Department of Medical Oncology Dr.B.R.Ambedkar Institute Rotary Cancer HospitalAll India Institute of Medical Sciences(AIIMS)New Delhi 110029India Department of Biotechnology School of Life SciencesCentral University of KashmirGanderbalJammu&Kashmir 191201India Division of Translational Medicine Research BranchSidra MedicineDoha 26999Qatar Genomics Core Facility QBRIQatar FoundationDoha 34110Qatar Department of Pathology Sher-I-Kashmir Institute of Medical SciencesSrinagarJammu&Kashmir 190011India Department of Diagnostic Imaging St.Jude Children’s Research HospitalMemphisTN 38105USA Center for Advanced Metabolic Imaging in Precision Medicine Department of RadiologyPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA Academic Health System Hamad Medical CorporationDoha 3050Qatar Translational Research Institute Hamad Medical CorporationDoha 3050Qatar Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE 68198USA Laboratory Animal Research Center Qatar UniversityDoha 2713Qatar Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaJammu&Kashmir 192122India

Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of *** inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth *** complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease *** evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive *** cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for ***,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC *** also outlined the potential of this crosstalk as a novel therapeutic target for *** major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review.

关键词： chemokine colorectal cancer cytokine drug resistance epithelial-mesenchymal transition immunosuppression immunotherapy inflammation metastasis tumor microenvironment

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Correction: Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

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Signal Transduction and Targeted Therapy 2021年第3期6卷 1069-1069页

作者： Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael El-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris muzafar a.macha Functional and Molecular Imaging Laboratory Cancer Research Department Sidra Medicine Doha Qatar Department of Zoology School of Life Sciences Central University of Kashmir Ganderbal Jammu & Kashmir India Department of Biotechnology School of Life Sciences Central University of Kashmir Ganderbal Jammu & Kashmir India Department of Nephrology All India Institute of Medical Sciences New Delhi India Department of Biochemistry All India Institute of Medical Sciences New Delhi India Watson-Crick Centre for Molecular Medicine Islamic University of Science and Technology Awantipora Jammu & Kashmir India Laboratory of Cancer Immunogenomics Cancer Research Department Sidra Medicine Doha Qatar Department of Surgery University of Miami Miami FL USA Academic Health System Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Biology University of Nebraska Medical Center Omaha NE USA Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center Omaha NE USA Buffett Cancer Center University of Nebraska Medical Center Omaha NE USA Laboratory Animal Research Center Qatar University Doha Qatar

Correction to:Signal Transduction and Targeted Therapy https://***/10.1038/s41392-020-00419-w,published online 12 January 2021 After online publication of the article1,the authors noticed an error in affiliation of co-authors *** *** is erroneously linked to Sidra Medicine,Doha,Qatar who is actually working at the Department of Biotechnology,School of Life Sciences,Central University of Kashmir,Ganderbal,Jammu&Kashmir,***,the department name"Cancer Research Department"for the first author Ajaz *** is missing.

关键词： Cancer squamous targeted

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Unsteady flow of a Maxwell nanofluid over a stretching surface in the presence of magnetohydrodynamie and thermal radiation effects

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Propulsion and Power Research 2017年第1期6卷 31-40页

作者： macha Madhu Naikoti Kishan Ali J.Chamkha Department of Mathematics Osmania UniversityHyderabad-7TSIndia Mechanical Engineering Department Prince Mohammad Bin Fahd UniversityAl-Khobar 31952Kingdom of Saudi Arabia

The problem of unsteady magnetohydrodynamic(MHD)boundary layer flow of a non-Newtonian Maxwell nanofluid over a stretching surface with thennal radiation is *** Maxwell model is used to characterize the non-Newtonian fluid *** appropriate similarity transformation Is employed to transform the governing partial differential equations of mass,momentum,energy and nanoparticle concentration into ordinary differential *** coupled non-linear ordinary differential equations are solved by using the variational finite element *** flow features and the heat transfer characteristics and nanoparticle volume fraction are analyzed and discussed in detail for several sets of values of the governing flow *** results for the skin-friction coefficient,local Nusselt number and the local Sherwood number are presented in tables for various values of the flow controlling parameters.

关键词： Unsteady flow Stretching surface Maxwell nanofluid Magnetohydrodynamic(MHD) Thermal radiation

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Wafer-scale MOCVD growth of monolayer M0S2 on sapphire and SiO2

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Nano Research 2019年第10期12卷 2646-2652页

作者： Huanyao Cun Michal macha HoKwon Kim Ke Liu Yanfei Zhao Thomas LaGrange Andras Kis Aleksa ndra Radeno vic Laboratory of Nanoscale Biology Institute of BioengineeringEcole Polytechnique Federate de Lausanne(EPFL)1015 LausanneSwitzerland Nanoscale Electronics and Structures Electrical Engineering InstituteEcole Poly technique Federate de Lausanne(EPFL)1015 LausanneSwitzerland Nanoscale Electronics and Structures Institute of Materials Science and EngineeringEcole Poly technique Federate de Lausanne(EPFL)1015 LausanneSwitzerland Interdisciplinary Center for Electron Microscopy(CIME) Ecole Polytechnique Federale de Lausanne(EPFL)1015 LausanneSwitzerland

High-quality and large-scale growth of monolayer molybdenum disulfide(MoS2)has caught intensive attention because of its potential in many applications due to unique electronic ***,we report the wafer-scale growth of high-quality mono layer MoS2 on singlecrystalline sapphire and also on SiO2 substrates by a facile metal-organic chemical vapor deposit!on(MOCVD)*** to growth,an aqueous solution of sodium molybdate(Na2MoO4)is spun onto the substrates as the molybdenum precursor and diethyl sulfide((C2H5)2S)is used as the sulfur precursor duri ng the *** grown MoS2 films exhibit crystal I i nity,good electrical performa nee(electro n mobility of 22 cm2·V^-1·s^-1)and structural continuity maintained over the entire *** sapphire substrates are reusable for subsequent *** same method is applied for the synthesis of tungsten disulfide(WS2).Our work provides a facile,reproducible and cost-efficient method for the scalable fabricati on of high-quality mono layer MoS2 for versatile applicati ons,such as electro nic and optoelectr onic devices as well as the membranes for desalination and power generation.

关键词： molybdenum disulfide two-dimensional(2D)materials metal-organic chemical vapor deposition(MOCVD) wafer-scale fabrication

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高压注射碘对比剂过程中中心静脉导管的完好性

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国际医学放射学杂志 2010年第1期 86-87页

作者： D.B.macha R.C.Nelson L.E.Howle J.W.Hollingsworth S.T.Schindera 涂景恋 Department of Radiology Allergy and Critical Care MedicineDuke University Medical Center

目的评价广泛应用的无孔三腔中心静脉导管的最大腔(16G)是否能够耐受CT血管成像要求的高流速。材料与方法体外测试42个导管,包括10个新的和32个使用过的(平均在体留置时间5d)。在16G中心静脉导管管腔的中央持续监测注射压力。使用高压... 详细信息

目的评价广泛应用的无孔三腔中心静脉导管的最大腔(16G)是否能够耐受CT血管成像要求的高流速。材料与方法体外测试42个导管,包括10个新的和32个使用过的(平均在体留置时间5d)。在16G中心静脉导管管腔的中央持续监测注射压力。使用高压注射器向导管内注入300mg I/mL和370mg I/mL的碘必

关键词：中心静脉导管高压注射碘必乐

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氩等离子体表面凝固在支气管病学中的应用

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国外医学（呼吸系统分册） 2000年第4期20卷 218-219页

作者： Reichle G Freitag L Kullmann HJ Prenzel R macha HN Farin G 刘辉国高亚东华中科技大学同济医学院附属同济医院呼吸内科德国蒂宾根大学Hemer肺科医院和医学研究中心华中科技大学同济医学院病理生理教研室武汉430030

氩等离子体表面凝固(argoplasmacoagulation,APC)是一种应用高频电流将电离的氢气(等离子体)无接触地热凝固组织的方法。由364例患者的前瞻性研究,表明APC是一种有效、安全的支气管肿瘤摘除和止血方法。它不仅可在局麻下由可曲支气管镜... 详细信息

氩等离子体表面凝固(argoplasmacoagulation,APC)是一种应用高频电流将电离的氢气(等离子体)无接触地热凝固组织的方法。由364例患者的前瞻性研究,表明APC是一种有效、安全的支气管肿瘤摘除和止血方法。它不仅可在局麻下由可曲支气管镜,而且也可在全麻下由硬质支气管镜进行,与激光相比,APC费用少,而止血效果更好,与其他方法合用,可丰富支气管介入内镜学手段。

关键词：氩等离子体表面凝固 Na:YAG激光肺肿瘤

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异位的胃黏膜是否为食管上段症状的另一原因

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 29-29页

作者： macha S. Reddy S. Rabah R. V. Tolia 虎小毅 Pediatric Gastroenterology Children' s Hospital of Michigan 3901 Beaubien Boulevard Detroit MI 48201-2196United States Dr.

Objective: To determine prospectively the incidence of an inlet patch (IP) in children requiring esophagogastroduodenoscopy (EGD) and assess the prevalence of presenting symptoms between children with and without an IP. Study design: All patients undergoing EGD in a 2-year period were assessed for the presence of an IPwith biopsy confirmation. IP, distal esophagus, and stomach biopsy specimens were blindly reviewed by a pathologist for the presence and degree of inflammation and intestinal metaplasia. Symptoms from children with and without an IP were compared. Results: From 407 EGDs done by a single endoscopist, 24 patients had confirmed IP (incidence of 5.9% ). The presence and degree of inflammation were always relatively greater in the columnar mucosa of the IP than in the antral/body gastric mucosa in the same patient (P = .0027)-Inflammation was similar in the squamous epithelium around the IP and in the distal esophagus (P = .46). Two patients had intestinalmetaplasia of the IP. The patients with IPs had a higher prevalence of respiratory symptoms than the control group (P = .03). Conclusions: Children with IPs may have a higher frequency of respiratory symptoms. Periodic surveillance should be performed in children with intestinal metaplasia of an IP.

关键词：异位胃黏膜症状发生率食管上段十二指肠镜检查炎症程度内窥镜检查者活组织检查肠化生发生情况病理学家

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