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Neuroprotective effects of berry fruits on neurodegenerative diseases

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Neural Regeneration Research 2014年第16期9卷 1557-1566页

作者： Selvaraju Subash musthafa mohamed essa Samir Al-Adawi Mushtaq A.Memon Thamilarasan Manivasagam Mohammed Akbar Department of Food Science and Nutrition College of Agricultural and Marine Sciences Sultan Qaboos University Muscat Sultanate of Oman Ageing and Dementia Research Group Sultan Qaboos University College of Medicine and Health Sciences Sultan Qaboos University College of Veterinary Medicine Washington State University Department of Biochemistry and Biotechnology Annamalai University Section of Molecular Pharmacology and Toxicology Laboratory of Membrane Biochemistry and Biophysics National Institute on Alcohol Abuse and Alcoholism National Institutes of Health

Recent clinical research has demonstrated that berry fruits can prevent age-related neurodegenerative diseases and improve motor and cognitive functions. The berry fruits are also capable of modulating signaling pathways involved in inflammation, cell survival, neurotransmission and enhancing neuroplasticity. The neuroprotective effects of berry fruits on neurodegenerative diseases are related to phytochemicals such as anthocyanin, caffeic acid, catechin, quercetin, kaempferol and tannin. In this review, we made an attempt to clearly describe the beneficial effects of various types of berries as promising neuroprotective agents.

关键词： nerve regeneration berry fruit neurodegenerative disease neuroprotection Alzheimer'sdisease Parkinson's disease review neural regeneration

Inf luence of Spirulina platensis exudates on the endocrine and nervous systems of a mammalian model

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Asian Pacific Journal of Tropical Biomedicine 2015年第6期5卷 449-455页

作者： Samah Mamdouh mohamed Fathy Ashraf mohamed mohamed essa Zoology Department Faculty of Science Fayoum University Biology Department Faculty of Science Jazan University Botany Department Faculty of Science Fayoum University

Objective: To investigate the ef ect of intra-peritoneal injection of purii ed exudates of axenic Spirulina platensis on the mammalian endocrine and nervous systems. Methods: The intra-peritoneal injection of the cyanobacterial exudates in mice was applied. Sex hormonal levels of testosterone and progesterone were measured using radioimmunoassay while the follicular stimulating hormone and luteinizing hormone were evaluated by direct chemiluminescence. In addition, superoxide dismutase, catalase and glutathione peroxidase were monitored in the hippocampus region using spectrophotometric method. The levels of the hippocampal monoamines, dopamine, noradrenaline and serotonin were analyzed by high performance liquid chromatography while the acetyl choline neurotransmitter was measured by colorimetric method using choline/acetylcholine assay kit. Results: A sharp disruption in the sex hormones levels of testosterone, progesterone, follicular stimulating hormone and luteinizing hormone was demonstrated in the serum of the treated mice. At the same time, a signii cant reduction in the endogenous antioxidant defense enzymes, superoxide dismutase, catalase and glutathione peroxidase was observed in the hippocampus region of the injected mice. Moreover, levels of dopamine, noradrenaline, serotonin and acetyl choline neurotransmitter in the same region were signii cantly af ected as a result of the treatment with Spirulina i ltrate. The gas chromatography-mass spectrometer and liquid chromatography mass spectrometry/mass spectrometry analysis showed the presence of some sterol-like compounds in the cyanobacterial i ltrate. Conclusions: This study demonstrated the capability of Spirulina to release detrimental bioactive metabolites into their surrounding that can disrupt the mammalian endocrine and nervous systems.

关键词： Spirulina platensis Sterol-like compounds Sex hormones Antioxidant enzymes Neurotransmitters

Phytoconstituents Profiling of Indigenous Herbal Drugs and Its in vitro Microbial,in Silico Biological Examination against Severe Acute Respiratory Syndrome Coronavirus 2

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 121-136页

作者： T.H.mohamed Ahadu Shareef Mmohamed Divan Masood Irfan Navabshan MSaiyad musthafa Department of Chemistry The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia School of Computer Applications B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Crescent School of Pharmacy B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Department of Zoology The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia

Background:Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda traditional herbal medicines may promote host resistance against infection by bacteria,viruses,and fungi which are easily accessible at inexpensive with no *** herbal medicines are used to cure sore throat,cough,fever,lung cancer,and asthma patients in developing South Asian *** traditional herbal medicines acted a crucial role in the prevention and control of coronavirus disease 2019(COVID-19).Aims and Objectives:This research article aimed at conducting phytochemistry,antimicrobial activity,COVID-19 docking and some spectroscopic(Infrared,Ultraviolet,13C-Nuclear Magnetic Resonance(13C-NMR),1H-NMR,and Mass Spectra)characterizations of the polyherbal drugs were carried ***,In-vitro and In-silico analyses were performed to measure activity against *** Performance-Liquid Chromatography(HPLC),Gas Chromatography-Mass Spectrometry(GC-MS),antimicrobial,and docking studies were carried *** preliminary phytochemical assay and bioactive compounds were screened using HPLC and *** study is an attempt to assess the promising effects of selected polyherbal indigenous drugs such as Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda phytoconstituents against the severe acute respiratory syndrome coronavirus-2(SARS-Co V-2).Materials and Methods:The extract of the selected polyherbal formulations showed high-to-moderate preventive effects on the growth inhibition in the pathogenic bacterium,namely Streptococcus oralis,Staphylococcus aureus,Propionibacterium acnes,Pseudomonas aeruginosa,Escherichia coli,and Proteus vulgaris,and three fungal Candida albicans,Aspergillus fumigatus,and Aspergillus *** docking study evaluates the pharmacological activity of bioactive chemical compounds with SARS-Co V-2 NSP5(PDB ID:7nxh)and SARS-Co V-2 Omicron spike protein with human angiotensin-converting enzyme 2(ACE-2)(PDB ID:7wk6).Results:In this study,for the first time,we at

关键词： Antimicrobial herbal drug Omicron and coronavirus disease 2019 phytochemicals spectroscopic

Silencing of Astrocyte Elevated Gene-1 (AEG-1) inhibits the proliferative and invasive potential through interaction with Exostosin-1 (EXT-1) in primary and metastatic colon cancer cells

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BIOCELL 2021年第3期45卷 563-576页

作者： SUSHMITHA SRIRAMULU SARUBALA MALAYAPERUMAL SUMAN K.NANDY ANTARA BANERJEE musthafa M OHAMED essa SARAVANABABU CHIDAMBARAM M.WALID QORONFLEH SURAJIT PATHAK Department of Medical Biotechnology Faculty of Allied Health SciencesChettinad Academy of Research and Education(CARE)Chettinad Hospital and Research Institute(CHRI)ChennaiIndia Bioinformatics Centre Department of RDAPNorth-Eastern Hill UniversityTuraIndia Department of Food Science and Nutrition CAMSSultan Qaboos UniversityMuscatOman Ageing and Dementia Research Group Sultan Qaboos UniversityMuscatOman Department of Pharmacology JSS College of PharmacyJSS Academy of Higher Education&ResearchMysuruIndia Research&Policy Department World Innovation Summit for Health(WISH)Qatar FoundationDohaQatar Q3CG Research Institute(QRI) Research&Policy DivisionYpsilantiMI 48917USA

Colon cancer is the third major cause of cancer deaths,accounting for about 8%in terms of mortality *** present study aims to explore the effect of silencing Astrocyte Elevated Gene-1(AEG-1),a metastasis mediating factor,and how it interacts with Exostosin-1(EXT-1)protein to inhibit the proliferative and invasive potential in colon cancer *** siRNA transfection was performed using AEG-1 siRNA in SW480 and SW620 colon cancer cell lines,and the expression levels of mRNA and protein were analyzed by Real-time PCR and Immunofluorescence.A simple bioinformatics approach was carried out to identify the possible interactions between AEG-1 and EXT-1 using Easy Networks and Pathway Commons *** survival and clonal efficiency were determined using Cell Counting Kit-8 assay and clonogenic assay,apoptosis using flow cytometry analysis,migration and invasion using scratch and Transwell assays,*** siRNA transfection significantly suppressed the expression of AEG-1 in mRNA and protein levels on SW480 and SW620 colon cancer *** our results,we found that EXT-1 mRNA and protein level was significantly upregulated in AEG-1 siRNA transfected ***,treatment with AEG-1 siRNA inhibited the proliferation,clonogenic ability,migration,and invasion and also induced *** the bioinformatic approach,our data analyses pointed towards the crosstalk between AEG-1 and EXT-1 mediated through Patched-1(PTCH-1)*** current results demonstrated that silencing AEG-1 can restrain cell proliferation,migration,and invasion,ultimately leading to *** AEG-1 siRNA transfected cells,PTCH-1 activity might be modulated by several genes and,in turn,affects the EXT-1 ***,these observations not only provide insight into the interplay between AEG-1 and EXT-1 but also suggest that AEG-1 may represent a possible candidate therapeutic target through interaction with EXT-1 in colon cancer.

关键词： Oncogene EXT-1 siRNA Colon cancer AEG-1

Micro-fabrication of ceramics:Additive manufacturing and conventional technologies

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Journal of Advanced Ceramics 2021年第1期10卷 1-27页

作者： Hany HASSANIN Khamis essa Amr ELSHAER mohamed IMBABY Heba H.EL-MONGY Tamer A.EL-SAYED School of Engineering Canterbury Christ Church UniversityCanterburyCT11QUUK University of Birmingham EdgbastonB152TTUK Kingston University London Penrhyn RoadKingston Upon ThamesSurreyKT12EEUK Department of Mechanical Design Faculty of EngineeringMatariaHelwan UniversityP.O.Box.11718CairoEgypt Jubail University College Mechanical EngineeringKingdom of Saudi Arabia Center for Applied Dynamics Research(CADR) School of EngineeringUniversity of AberdeenAberdeenAB243UEUK

Ceramic materials are increasingly used in micro-electro-mechanical systems(MEMS)as they offer many advantages such as high-temperature resistance,high wear resistance,low density,and favourable mechanical and chemical properties at elevated ***,with the emerging of additive manufacturing,the use of ceramics for functional and structural MEMS raises new opportunities and *** paper provides an extensive review of the manufacturing processes used for ceramic-based MEMS,including additive and conventional manufacturing *** review covers the micro-fabrication techniques of ceramics with the focus on their operating principles,main features,and processed *** that need to be addressed in applying additive technologies in MEMS include ceramic printing on wafers,post-processing at the micro-level,resolution,and quality *** paper also sheds light on the new possibilities of ceramic additive micro-fabrication and their potential applications,which indicates a promising future.

关键词： micro-electro-mechanical system(MEMS) micro-fabrication ceramics micro parts additive manufacturing

Q-switched giant pulsed erbium-doped all-fiber laser with V_(2)ZnC MAX phase saturable absorber

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Optoelectronics Letters 2024年第6期20卷 321-329页

作者： Kawther M musthafa Azura Hamzah Ooi Wei Ling Ahmad Haziq Aiman Rosol Norliza mohamed Sulaiman Wadi Harun Malaysia-Japan International Institute of Technology Universiti Teknologi MalaysiaKuala Lumpur 54100Malaysia Razak Faculty of Technology and Informatics Universiti Teknologi MalaysiaKuala Lumpur 54100Malaysia Department of Electrical Engineering University of MalayaKuala Lumpur 50603Malaysia1

MXenes,drawn from MAX phases,are special two-dimensional substances with numerous advantages in nonlinear optics,specifically in giant and ultrashort pulsed-laser ***_(3)C_(2)T_(x)and Ti_(2)CT_(x)nanosheets however rapidly deteriorate under ambient conditions,limiting their *** paper demonstrates how excellent modulation depth of one of the MAX phase compounds vanadium zinc carbide(V_2ZnC)makes it a brilliant saturable absorber(SA)in passively Q-switched all-fiber pulsed lasers,integrated such that a 16.73-μm V_(2)ZnC-polyvinyl alcohol(PVA)thin film acts as SA in the *** and non-saturable absorptions were found to be 13.2%and 10.47%,while saturation optical intensity and modulation depth were 6.25 k W/cm^(2)and 12.43%,respectively,illustrating the optical *** superiority of MAX-PVA,fabricated in four distinct ratios,was demonstrated by the fact that it self-starts a giant pulsed laser at pump power as low as 22.5 mW and firmly accomplished 120.6 kHz repetition rate with a pulse width of 2.08μ*** is a fine SA for the use of pulsed-laser production using all-fiber laser due to fabrication simplicity and great optical,thermophysical,and mechanical qualities.

关键词： MAX Q-switched giant pulsed erbium-doped all-fiber laser with V_(2)ZnC MAX phase saturable absorber

Cooling and lubrication techniques in grinding:A state-of-the-art review,applications,and sustainability assessment

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Chinese Journal of Aeronautics 2023年第7期36卷 76-113页

作者： Ahmed mohamed Mahmoud IBRAHIM Wei LI Abdel-Hamid ISMAIL MOURAD mohamed A.E.OMER Fadl A.essa Ahmed Mustafa ABD EL-NABY Mohammad S.Al SOUFI Muhammad F.EZZAT Ammar ElSHEIKH College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China Production Engineering and Mechanical Design Department Faculty of EngineeringMinia UniversityEl Minya 61519Egypt Mechanical and Aerospace Engineering Department College of EngineeringUnited Arab Emirates UniversityAl-Ain 15551United Arab Emirates Department of Production Engineering and Mechanical Design Faculty of EngineeringTanta UniversityTanta 31527Egypt Mechanical Engineering Department Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh 33516Egypt Mechanical Engineering Department College of Engineering and Islamic ArchitectureUmm Al-Qura UniversityMakkah 24231Saudi Arabia Mechanical Engineering Department Faculty of EngineeringUniversity of AlbertaEdmonton T6G 2R3Canada Automotive and Tractors Engineering Department Faculty of EngineeringMinia UniversityEl Minya 61519Egypt Tokyo Institute of Technology Tokyo 152-8550Japan

Grinding technology is an essential manufacturing operation,in particular,when a component with a superfinishing and an ultra-resolution is *** the required strict quality checklist with maintaining a high level of productivity and sustainability is a substantive *** recent paper outlines the lubrication and cooling technologies and mediums that are used for ***,it provides a basis for a critical assessment of the different lubrication/cooling techniques in terms of machining outputs,environmental impact,hygiene effect,***,the paper put light on the sustainability of different cooling/lubrication *** sustainability of machining aims to get the product with the best accuracy and surface quality,minimum energy consumption,low environmental impact,reasonable economy,and minimum effect on worker’s *** paper revealed that despite some cooling/lubrication mediums like mineral oils and semisynthetic,afford sufficient lubrication or cooling,they have a significant negative impact on the environment and public *** the other hand,emulsions can overcome environmental problems but the economy and the energy consumption during grinding are still a matter of *** and vegetable oils are considered eco-friendly oils,but they suffer from a lack of thermal stability which affects their ability of efficiently *** the cooling medium with the lowest amount can achieve the goal of the economy but it may be reflected negatively on the ***,cryogenic lubrication doesn’t provide sufficient lubrication to reduce friction and hence energy *** research described in the paper is such a comprehensive compilation of knowledge regarding the machinability and machining performance under different cooling and lubrication systems that it will aid the next generation of scientists in identifying current advancements as well as potential future directions of research on ecolo

关键词： Cryogenic cooling Dry lubrication Minimum quantity lubrication Precision grinding Solid lubrication Sustainable machining Vegetable oils

A comprehensive review on residual stresses in turning

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Advances in Manufacturing 2022年第2期10卷 287-312页

作者： Ammar H.Elsheikh S.Shanmugan T.Muthuramalingam Amrit Kumar Thakur F.A.essa Ahmed mohamed Mahmoud Ibrahim Ahmed O.Mosleh Department of Production Engineering and Mechanical Design Facultyof EngineeringTanta UniversityTanta 31527Egypt Research Centre for Solar Energy Department of PhysicsKoneru Lakshmaiah Education FoundationVaddeswaramAndhra Pradesh 522502India Department of Mechatronics Engineering SRM Institute of Science and TechnologyChennai 603203India Department of Mechanical Engineering KPR Institute Engineering and TechnologyCoimbatoreTamilnaduIndia Department of Mechanical Engineering Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh 33516Egypt Production Engineering and Mechanical Design Department Faculty of EngineeringMinia UniversityMinya 61519Egypt Shoubra Faculty of Engineering Benha UniversityBenhaEgypt

Residual stresses induced during turning processes can affect thequality and performance of machined products,depending on its direction and *** stresses can be highly detrimental as they can lead to creeping,fatigue,and stress corrosion *** final state of residual stresses in a workpiece depends on its material as well as the cutting-tool configuration such as tool geometry/coating,cooling and wear conditions,and process parameters including the cutting speed,depth-ofcut and ***,there have been disagreements in some literatures regarding influences of the abovementioned factors on residual stresses due to different cutting conditions,tool parameters and workpiece materials used in the specific *** review paper categorizes different methods in experimental,numerical and analytical approaches employed for determining induced residual stresses and their relationships with cutting conditions in a turning *** is presented for the effects of different cutting conditions and parameters on the final residual stresses state.

关键词： Residual stresses Machining Turning:Process parameters

High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia

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World Journal of Pediatric Surgery 2022年第1期5卷 12-17页

作者： essa A Adawi Mazen Ahmed Ghanem Ahmed Mazen Ghanem Manal A Safan mohamed G Elsayed Mohammed A Aqeel Urology Jazan UniversityJazanSaudi Arabia Urology Menoufia University Faculty of MedicineAI Rehab CityNew CairoEgypt GP Cairo University Kasr Alainy Faculty of MedicineAI Rehab CityNew CairoEgypt Department of Medical Biochemistry and Molecular Biology Menoufia University Faculty of MedicineAI Rehab CityNew CairoEgypt Pediatric Surgery Jazan UniversityJazanSaudi Arabia Department of Anesthesia and Critical Care Jazan UniversityJazanSaudi Arabia

Objective This study aimed to evaluate the predictive value of platelet volume indices(PVI),such as mean platelet volume(MPV),platelet distribution width(PDW),and plateletcrit(PCT),as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia(SCA)who underwent surgical *** Forty-eight patients with SCA with testicular torsion and 46 male control subjects were enrolled in the *** patients underwent scrotal color Doppler ultrasonography before surgery,and PVI(MPV,PDW,and PCT)values were measured in all *** duration and testicular volume were also *** The testicular salvage rate in patients with SCA was 73%after *** showed that MPV,PDW,and PCT values were significantly higher in torsed SCA as compared with controls(p<0.05).Orchiectomy in patients with SCA showed significantly higher MPV,PDW,and PCT values than the orchiopexy group(p<0.05).The MPV values of orchiectomy patients showed a higher significant cut-off of≥11.5 fL,which is higher than in torsed patients without SCA,as an indicator of testis *** also demonstrated a higher significant cut-off of≥12.7 fL for detorsion outcomes in patients with *** duration of less than 7 hours was also significantly correlated with orchiopexy(p≤0.001).Univariate analysis showed that higher MPV,increased PDW,and symptom duration were indicative of the outcome of testicular detorsion in *** analysis showed that increased PDW and symptom duration are prognostic parameters for testicular viability in *** Increased PDW and symptom duration can be used as parameters for predicting testicular detorsion outcomes in patients with steady-state SCA.

关键词： patients anemia torsion