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Epidemiological Aspects of Intrafamilial Spread of HCV Infection in Egyptian Population: A Pilot Study

Open Journal of Gastroenterology 2014年第5期4卷 228-236页

作者： Mahmoud El-Bendary Gamal Esmat mustafa neamatallah Emily Kamel Tarek Besheer Hatem Elalfy Maged El-Setouhy Dalia Omran Department of Community Environmental and Occupational Medicine Ain-Shams Faculty of Medicine Ain-Shams University Cairo Egypt Medical Biochemistry Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt Public Health & Preventive Medicine Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt Tropical Medicine & Hepatology Department Cairo Faculty of Medicine Cairo University Giza Egypt Tropical Medicine & Hepatology Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt

Aim: Liver disease is a leading cause of morbidity and mortality among Egyptians. The major cause is infection with HCV, with 70 000 up to 140 000 newly reported cases annually. The objectives of this study were to determine the prevalence of anti-HCV antibodies among household contacts of HCV index cases and to identify the possible risk factors of transmission of HCV among Egyptian families. Material and Methods: The present external pilot study (double centre study) was performed on a convenient sample of 125 index cases and their 321 household family contacts recruited from Mansoura & Cairo University where 2 questionnaires were used to collect data from the index & their related contacts. The all were exposed to clinical examinations, routine laboratory testing & screening for the prevalence of Anti-HCV antibodies. Results: The prevalence of anti-HCV seropositivity among household contacts of index cases was found to be 13.7% which husbands of female index cases ranked first followed by wives of male index cases (36.36% versus 17.86% respectively,

关键词： HCV Intrafamilial Transmission Epidemiology

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