Epidemiological Aspects of Intrafamilial Spread of HCV Infection in Egyptian Population: A Pilot Study

作     者：Mahmoud El-Bendary Gamal Esmat Mustafa Neamatallah Emily Kamel Tarek Besheer Hatem Elalfy Maged El-Setouhy Dalia Omran 

作者机构：Department of Community Environmental and Occupational Medicine Ain-Shams Faculty of Medicine Ain-Shams University Cairo Egypt Medical Biochemistry Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt Public Health & Preventive Medicine Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt Tropical Medicine & Hepatology Department Cairo Faculty of Medicine Cairo University Giza Egypt Tropical Medicine & Hepatology Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt 

出 版 物：《Open Journal of Gastroenterology》 (肠胃病学期刊（英文）)

年 卷 期：2014年第4卷第5期

页      面：228-236页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：HCV Intrafamilial Transmission Epidemiology 

摘      要：Aim: Liver disease is a leading cause of morbidity and mortality among Egyptians. The major cause is infection with HCV, with 70 000 up to 140 000 newly reported cases annually. The objectives of this study were to determine the prevalence of anti-HCV antibodies among household contacts of HCV index cases and to identify the possible risk factors of transmission of HCV among Egyptian families. Material and Methods: The present external pilot study (double centre study) was performed on a convenient sample of 125 index cases and their 321 household family contacts recruited from Mansoura & Cairo University where 2 questionnaires were used to collect data from the index & their related contacts. The all were exposed to clinical examinations, routine laboratory testing & screening for the prevalence of Anti-HCV antibodies. Results: The prevalence of anti-HCV seropositivity among household contacts of index cases was found to be 13.7% which husbands of female index cases ranked first followed by wives of male index cases (36.36% versus 17.86% respectively,