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An Investigation on the Formation of Submerged Bar Under Surges in Sandy Coastal Region

China Ocean Engineering 2012年第3期26卷 535-546页

作者： mustafa demirci M.Sami AKZ Civil Engineering Department Engineering FacultyMustafa Kemal UniversityskenderunHatay 31040Turkey Civil Engineering Department Engineering and Architecture Facultyukurova UniversityAdana 01100Turkey

Cross-shore sediment transport rate exposed to waves is very important for coastal morphology, the design of marine structures such as seawalls, jetties, breakwaters etc, and the prevention of coastal erosion and accretion due to onoff shore sediment transportation. In the present study, the experiments on cross-shore sediment transport are carried out in a laboratory wave channel with initial beach slopes of 1/8, 1/10 and 1/15. By using the regular waves with different deep-water wave steepnesses generated by a pedal-type wave generator, the geometrical characteristics of beach profiles under storm conditions and the parameters affecting on-off shore sediment transport are investigated for the beach materials with medium diameters of d50=0.25, 0.32, 0.45, 0.62 and 0.80 mm. The offshore bar geometric characteristics are the horizontal distances from the shoreline to the bar beginning （Xb）, crest （Xt）, and ending （Xs） points, the depth from the bar crest to the still water level （ht）, and the bar volume （Vbar）. The experimental results have indicated that when the deep-water steepness （Ha/L0） increased, the net movement to seaside increased. With the increasing wave steepness, the bars moved to widen herewith the vertical distances from still water level to the bar beginning （Xb）, crest （Xt） and ending （Xs） points and the horizontal distances from the coast line to the bar beginning, crest and ending points increased. It was also shown from experimental results that the horizontal distances from the bar beginning and ending points to the coast line increased with the decrease of the beach slope. The experimental results obtained from this study are compared with previous experimental work and found to be of the same magnitude as the experimental measurements and followed the expected basic trend.

关键词： cross-shore sediment transport beach profiles bar parameters experimental study

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Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-α treatment?

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World Journal of Gastroenterology 2005年第48期11卷 7688-7689页

作者： Mehmet Sahin Mehmet Isler Altug Senol mustafa demirci Zeynep Dilek Aydin Department of Internal Medicine Department of Microbiology and Parasitology

Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus （HCV） infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome.

关键词： Hepatitis C Interferon Fasciola hepatica

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Unusual Initial Presentation Of Celiac Disease in Children: Three Case Reports

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Open Journal of Pediatrics 2016年第1期6卷 53-59页

作者： Sevgi Buyukbese Sarsu mustafa demirci Department of Pediatric Surgery Cengiz Gokcek Obstetrics and Children’s Hospital Gaziantep Turkey Department of Radiology Cengiz Gokcek Obstetrics and Children’s Hospital Gaziantep Turkey

Background: The togetherness of invagination with celiac disease is an extremely rare condition especially in children. However, invagination may be the presenting symptom of celiac disease. Moreover, recurrent invaginations have been also reported in patients with celiac disease. Aim: To increase the awareness of clinicians about togetherness of these conditions. Case Presentation: Herein, we will discuss three children with diagnosis of celiac disease who presented with invagination and intestinal pseudo-obstruction. Conclusion: Children with pseudo-obstruction and invagination without an underlying etiology should be evaluated for the presence of celiac disease, especially if they have accompanying growth retardation or anemia and if they are at an unusual age for invagination. Further studies are warranted to elucidate the exact relationship of invagination with celiac disease.

关键词： Celiac Disease Invagination Intestinal Pseudo-Obstruction Children

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Esthetic and Functional Rehabilitation of Amelogenesis Imperfecta: Report of Four Cases with a One-Year Follow-Up

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Open Journal of Stomatology 2016年第4期6卷 103-113页

作者： Neslihan Tekce Gizem Guder mustafa demirci Safa Tuncer Alper Sinanoglu Emre Ozel Department of Restorative Dentistry Faculty of Dentistry University of Kocaeli Kocaeli Turkey Department of Conservative Dentistry Faculty of Dentistry Istanbul University Istanbul Turkey Department of Oral and Maxillofacial Radiology Faculty of Dentistry University of Kocaeli Kocaeli Turkey

In this report, we describe the performance of a conservative and minimally invasive dental approach in four patients exhibiting Amelogenesis Imperfecta (AI), a structural anomaly of the enamel. In each patient, approximately 0.5 mm of the most external, porous, and colored enamel layer was removed, and the teeth were restored using two different nanocomposites. Posterior restorations were completed with the same approach. As a result, this contemporary restorative system is a conservative and successful treatment option to restore the loss of oral esthetics and function due to AI. Rehabilitation with direct resin restorations is not only an inexpensive treatment choice, but also a more conservative technique that reduces the amount of preparation required for teeth that are already compromised.

关键词： Amelogenesis Imperfecta Nanohybrid Composite Nanofill Composite Universal Dentin Bonding Agents

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Evaluation of three methods for detection of methicillinresistant Staphylococcus aureus

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World Journal of Translational Medicine 2013年第2期2卷 27-31页

作者： Asli Gamze Sener Sevin Kirdar Ilhan Afsar mustafa demirci Microbiology and Clinical Microbiology Laboratory Ataturk Training and Research Hospital Department of Microbiology and Clinical Microbiology Adnan Menderes University

AIM: To evaluate GenoT ype methicillin-resistant Staphylococcus aureus(MRSA) Direct assay and cultivation for the identification of MRSA by using mec A polymerase chain reaction(PCR) as the "gold standard" ***: In total of 61 nasal specimens from patients at the intensive care unit were studied by GenoType MRSA Direct test, conventional culture method and automated bacterial identification system. The results of Geno Type MRSA Direct assay were compared to conventional culture method the identification of MRSA and mec A gene PCR as the "gold standard" method. The sensitivity, specificity, positive predictive value and negative predictive value were ***: In total, 61 specimens were studied. Fiftyfour specimens(88.5%) were negative by all three methods. Six swabs(9.8%) were found positive by GenoT ype MRSA Direct test, conventional culture method and automated bacterial identification system. The presence of mec A in these strains was confirmed by PCR. One swab sample was negative for culture meth-ods but MRSA and mecA gene were detected by GenoType MRSA Direct test and mec A PCR respectively. GenoT ype MRSA Direct test had a sensitivity of 100%(6/6) and a specificity of 100%(55/55), with a positive predictive value of 100% and a negative predictive value of 98%. Culture method of MRSA had a sensitivity of 83.3%(5/6) and a specificity of 98.2%(55/56). CONCLUSION: It was found that the GenoT ype MRSA Direct assay, which is a rapid and accurate test, is of the same sensitivity and specificity with mec A PCR. The GenoT ype MRSA Direct assay can be a better tool for rapid and accurate detection of MRSA in diagnostic laboratories.

关键词： Culture Methicillin-resistant Staphylococcus aureus Molecular assays

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In vitro effect of pantoprazole on lower esophageal sphincter tone in rats

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World Journal of Gastroenterology 2011年第46期17卷 5105-5109页

作者： mustafa Duman Mahmut zer Enver Rean Yeliz demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen Department of Gastrointestinal Surgery Kartal Kosuyolu Education and Research Hospital Department of Pharmacology Medical SchoolYeditepe University

AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)***:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the *** were anesthetized before *** tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room *** tissues were allowed to stabilize for 60 ***-sequently,the contractile response to 10-6 mol/L carba-chol was *** concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/***-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the ***:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated *** results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease.

关键词： Pantoprazole Lower esophageal sphincter,Gastroesophageal reflux disease

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Rates and associates of influenza and pneumococcus vaccination in diabetes mellitus:A nationwide cross-sectional study(TEMD vaccination study)

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World Journal of Diabetes 2021年第12期12卷 2107-2118页

作者： Ibrahim demirci Cem Haymana Serpil Salman Ilker Tasci Demet Corapcioglu Ali Kirik İlhan Yetkin mustafa Altay Tevfik Sabuncu Fahri Bayram Ilhan Satman Alper Sonmez 无 Department of Endocrinology and Metabolism Gulhane Training and Research HospitalAnkara 06190Turkey Department of Endocrinology and Metabolism Liv HospitalIstanbul 34000Turkey Department of Internal Medicine University of Health SciencesGulhane Faculty of MedicineAnkara 06018Turkey Department of Endocrinology and Metabolism Ankara UniversityFaculty of MedicineAnkara 06560Turkey Department of Internal Medicine Balıkesir UniversityFaculty of MedicineBalikesir 10145Turkey Department of Endocrinology and Metabolism Gazi UniversityFaculty of MedicineAnkara 06190Turkey Department of Endocrinology and Metabolism Kecioren Training and Research HospitalAnkara 06190Turkey Department of Endocrinology and Metabolism Harran UniversityFaculty of MedicineSanliurfa 63050Turkey Department of Endocrinology and Metabolism Erciyes UniversityFaculty of MedicineKayseri 38000Turkey Department of Endocrinology and Metabolism Istanbul UniversityFaculty of MedicineIstanbul 34000Turkey Department of Endocrinology and Metabolism University of Health SciencesGulhane Faculty of MedicineAnkara 06190Turkey TEMD Study Group

BACKGROUND Vaccination against influenza and pneumococcus is effective in reducing morbidity and mortality in patients with *** To investigate the prevalence of influenza and pneumococcal vaccinations and to search for the independent associates of vaccination in Turkish patients with *** In this cross-sectional,nationwide,multicenter study,adult patients with type 1 diabetes(T1DM)(n=454)and type 2 diabetes(T2DM)(n=4721),who were under follow-up for at least a year in the outpatient clinics,were consecutively ***,clinical,and laboratory parameters of patients were *** histories were documented according to the self-statements of the *** Patients with T1DM and T2DM had similar vaccination rates for influenza(23.6%vs 21.2%;P=0.240)and pneumococcus(8%vs 7%;P=0.451)*** diabetes duration and older age were the common independent associates of having vaccination for both types of diabetes *** education level,using statin treatment,and having optimal hemoglobin A1c levels were the common independent associates of influenza and pneumococcal vaccination in patients with *** TEMD Vaccination Study shows that patients with T1DM and T2DM had very low influenza and pneumococcal vaccination rates in *** lower rates of vaccination in certain populations urges the necessity of nationwide vaccination strategies targeting these populations.

关键词： Diabetes Influenza Pneumococcus Vaccination Type 1 diabetes Type 2 diabetes

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Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

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Chinese Journal of Cancer Research 2015年第4期27卷 408-416页

作者： Nedim Turan mustafa Benekli Olcun Umit Unal ?lkay Tugba Unek Didem Tastekin Faysal Dane Efnan Alg?n Sukran Ulger Tulay Eren Turkan Ozturk Topcu Esma Turkmen Nalan Akgül Babacan Gulnihal Tufan Zuhat Urakci Basak Oven Ustaalioglu Ozlem Sonmez Uysal Ozlem Balvan Ercelep Burcu Yapar Taskoylu Asude Aksoy mustafa Canhoroz Umut demirci Erkan Dogan Veli Berk Ozan Balakan Ahmet ?iyar Ekinci Mukremin Uysal ?brahim Petekkaya Sel?uk Cemil Ozturk ?nder Tonyal? Bülent ?etin Mehmet Naci Aldemir Kaan Helvac? Nuriye Ozdemir ?lhan Oztop Ugur Coskun Aytug Uner Ahmet Ozet Suleyman Buyukberber Department of Medical Oncology Faculty of Medicine Cumhuriyet University Department of Medical Oncology Faculty of Medicine Gazi University Department of Medical Oncology Faculty of Medicine Dokuz Eylul University Department of Medical Oncology Faculty of Medicine Necmettin Erbakan University Department of Medical Oncology Faculty of Medicine Marmara University Department of Radiation Oncology Faculty of Medicine Gazi University Department of Medical Oncology Numune Education and Research Hospital Department of Medical Oncology Faculty of Medicine Karadeniz Technical University Department of Medical Oncology Faculty of Medicine Trakya University Department of Medical Oncology Rize Education and Research Hospital Department of Medical Oncology Faculty of Medicine Dicle University Department of Medical Oncology Dr.Lutfi Kirdar Kartal Education and Research Hospital Department of Medical Oncology Sakarya Education and Research Hospital Department of Medical Oncology Faculty of Medicine Pamukkale University Department of Medical Oncology Faculty of Medicine Inonu University Department of Medical Oncology Faculty of Medicine Firat University Department of Medical Oncology Dr.Abdurrahman Yurtaslan Education and Research Hospital Department of Medical Oncology Faculty of Medicine Yuzuncu Yil University Department of Medical Oncology Faculty of Medicine Erciyes University Department of Medical Oncology Faculty of Medicine Sutcu Imam University Department of Medical Oncology Diyarbakir Education and Research Hospital Department of Medical Oncology Faculty of Medicine Kocatepe University Department of Medical Oncology Dr.Ersin Arslan State Hospital Department of Medical Oncology Education and Research Hospital Ad?yaman University Department of Medical Oncology Faculty of Medicine Mustafa Kemal University Department of Medical Oncology Faculty of Medicine Ataturk University

Background： We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma（PAC）.Methods： A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and ***： Of 563 patients, 472 received adjuvant chemotherapy（CT） alone, chemoradiotherapy（CRT） alone, and chemoradiotherapy plus chemotherapy（CRT-CT） were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival（RFS） and overall survival（OS） were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant differencebetween groups when patients with node-negative disease or patients with or without positive surgical margins were ***： Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.

关键词： Pancreatic adenocarcinoma adjuvant chemotherapy(adjuvant CT) adjuvant radiotherapy

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