Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-α treatment?

作     者：Mehmet Sahin Mehmet Isler Altug Senol Mustafa Demirci Zeynep Dilek Aydin 

作者机构：Department of Internal Medicine Department of Microbiology and Parasitology 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2005年第11卷第48期

页      面：7688-7689页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Hepatitis C Interferon Fasciola hepatica 

摘      要：Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus （HCV） infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome.