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Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 348-352页

作者： Sundaram Ravikumar murugesan gnanadesigan chool of Marine Sciences Department of Oceanography and Coastal Area Studies.Alagappa University

Objective:To identify the hepatoprotective and in vitro antioxidant activity of Lumnitzera racemosa(***) leaf ***:Animals in Group 1 served as vehicle control. Group 2 served as hepatotoxin(CCL_4 treated) *** 3 served as positive control(Silyntarin) group,and Group 4.S and ft served as(73,150 and 300 nig/kg bw p.o.)*** leaf extract treated ***,in vitro antioxidant DPPH,hydroxyl radical scavenging activity(HRSA),NO,ferric reducing antioxidant power(FRAP),lipid hydroperoxide(LPO) and super oxide dismutase(SOD) were also analyzed for the leaf ***:The levels of the serum parameters such as serum glutamic oxaloacetic transaminase(SGOT).serum glutamic pyruvic transaminase(SGPT).alkaline phosphatase(ALP),bilirubin,cholesterol(CHL).sugar and lactate dehydrogenase(LDH) were significantly increased in COL_4 treated rats when compared with the control group(P<0.05).But the *** leaf extract treated rats showed maximum reduction of SGOT[(210.16±19.63)IU/L].SGPT[(82.37±13.87) IU/L].ALP[(197.63±23.4.3)IU/L],bilurubilt[(2.13 ±0.84) mg/dL].cholesterol[(163.83± 13.63) mg/dL].sugar[(93.00±7.63) mg/dL]and LDH[(1134.00) ±285.00)IU/L]were observed with the high dose(300 mg/kg bw) of leaf extract treated rats. Histopathological scores showed that,no visible changes were observed with high dose(300 mg/ kgbw) of leaf extract treated rats except few mild *** IC_(50) values were observed as(56.37 ±4.87)μg/mL,(57.68±1.98) μg/mL,(64.15±2.90)μg/mL,(61.94±3.98)μg/mL,(94.53± 1.68) μg/mL and(69.7±2.65)μg/mL for DPPH,HRSA,NO,FRAP,LPO and SOL) radical scavenging activities, ***:In conclusion,the hepatoprotective effect of the *** leaf extract might be due to the presence of phenolic groups,terpenoids and alkaloids and in vitro antioxidant properties.

关键词： Antioxidant CCL_4 Histopathology Mangroves Hepatoprotective activity Lumnitzera racemosa Histopathological Phenolic Alkaloid Antioxidant property Hepatoprotective Radical scavenging activity Phenolic Alkaloid

Hepatoprotective and antioxidant properties of marine halophyte Luminetzera racemosa bark extract in CCL_4 induced hepatotoxicity

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Asian Pacific Journal of Tropical Medicine 2011年第6期4卷 462-465页

作者： murugesan gnanadesigan Sundaram Ravikumar Samuel Jacob Inbaneson School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623409TamilnaduIndia

Objective:To identify the hepatoprotective and antioxidant activity of Luminetzera racemosa （L racemosa）bark ***:Wistar albino rats were divided into 6 groups:Group 1 served as control;Group 2 served as hepatotoxin（CCL4 treated） group;Group 3 served as positive control（Silymarin） treated groups;Group 4,5 and 6 served as（100,200 and 300 mg/kg bw p.o.） L racemosa bark extract treated ***,in vitro antioxidant indexes,including DPPH, hydroxyl radical scavenging activity（HRSA）,NO,ferric reducing antioxidant power（FRAP）,lipid hydroperoxide（LPO） and super oxide dismutase（SOD） were also analyzed in the bark extract. Results:The results suggested that,the level of serum glutamate oxyloacetic transaminase（SCOT）, serum glutamic pyruvic transaminase（SGPT）,alkaline phosphatise（ALP）,bilurubin,cholesterol, sugar and lactate dehydrogenase（LDH） were significantly（P50 values were observed as（44.17±6.87）μ/mL,（42.45±2.81）μg/mL,（62.37±3.98）μg/mL,（54.24±3.09）μg/mL, （87.25±5.90）μg/mL and（71.54±5.42）μg/mL for ***,NO,FRAP,LPO and SOD radical scavenging activities,***:The hepatoprotective and antioxidant activities of the bark extract might be to the presence of unique chemical classes such as flavonoids, alkaloids and polyphenols.

关键词： Antioxidant Hepatoprotective Histopathology Mangroves

In vitro antiplasmodial activity of methanolic extracts from seaweeds of South West Coast of India

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Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 862-865页

作者： S Ravikumar G Ramanathan M gnanadesigan A Ramu V Vijayakumar School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi - 623 409Ramanathapuram DistrictTamil NaduIndia Department of Microbiology V.H.S.N.College.Virudhunagar DistrictTamil NaduIndia School of Chemistry Department of Inorganic ChemistryMadurai Kamaraj UniversityMadurai DistrictTamil NaduIndia

Objective:To identify the in vitro antiplasmodial activity of seaweed plants against Plasmodium falciparum ***:A total of eight seaweeds were collecled from Kanvakumari district,Tainilnadu,*** in vitro antiplasmodial activity was performed in 96 well plates against Plasmodium falciparum,and preliminary phytochemcial analysis were performed for the ***:Of the selected plants Enteromorpha intestinalis(2.61%) showed maximum percentage of *** minimum concentration of inhibitory(IC_(50)) value was observed with Chaetomorpha antennina[(26.37±4.14)μg/ml.]further,the positive controls such as chloroquine and artemether showed antiplasmodial activities(IC_(50)) with(19.10±5.93) and(6.03±0.21)μg/mL concentrations,*** preliminary phytochemical analysis of the seaweed extracts showed a variety of phytochemical constituents such as carboxylic acids,phenols,protein, resins,steroids and ***:The antiplasmodial activity of the seaweed extract might due to the presence of sugars and phenolic *** the present findings,it is concluded that,the seaweed extract of Chaetomorpha antennina can be further used as a putative antiplasmodial drugs in near future.

关键词： Antiplasmodial activity IC_(50) Phytochemical Seaweeds Plasmodium falciparum

Anticancer property of sediment actinomycetes against MCF-7 and MDA-MB-231 cell lines

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 92-96页

作者： Ravikumar S Fredimoses M gnanadesigan M School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623 409Ramanathapuram District Department of Biotechnology K.S.Rangasamy College of Arts & ScienceThiruchengodu- 637209Namakkal District

ObjectiveTo investigate the anticancer property of marine sediment actinomycetes against two different breast cancer cell *** vitro anticancer activity was carried out against breast (MCF-7 and MDA-MB-231) cancer cell lines. Partial sequences of the 16s rRNA gene, phylogenetic tree construction, multiple sequence analysis and secondary structure analysis were also carried out with the actinomycetes *** the selected five actinomycete isolates, ACT01 and ACT02 showed the IC50 value with (10.13±0.92) and (22.34±5.82) μg/mL concentrations, respectively for MCF-7 cell line at 48 h, but ACT01 showed the minimum (18.54±2.49 μg/mL) level of IC50 value with MDA-MB-231 cell line. Further, the 16s rRNA partial sequences of ACT01, ACT02, ACT03, ACT04 and ACT05 isolates were also deposited in NCBI data bank with the accession numbers of GQ478246, GQ478247, GQ478248, GQ478249 and GQ478250, respectively. The phylogenetic tree analysis showed that, the isolates of ACT02 and ACT03 were represented in group I and III, respectively, but ACT01 and ACT02 were represented in group II. The multiple sequence alignment of the actinomycete isolates showed that, the maximum identical conserved regions were identified with the nucleotide regions of 125 to 221st base pairs, 65 to 119th base pairs and 55, 48 and 31st base pairs. Secondary structure prediction of the 16s rRNA showed that, the maximum free energy was consumed with ACT03 isolate (-45.4 kkal/mol) and the minimum free energy was consumed with ACT04 isolate (?7.6 kkal/mol).ConclusionsThe actinomycete isolates of ACT01 and ACT02 (GQ478246 and GQ478247) which are isolated from sediment sample can be further used as anticancer agents against breast cancer cell lines.

关键词： Actinomycetes Breast cancer MCF–7 MDA–MB–231 Phylogenetic tree Anticancer property Multiple sequence analysis Secondary structure analysis Sediment Anticaner agent Cell line

Biosynthesis of silver nanoparticles by using mangrove plant extract and their potential mosquito larvicidal property

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Asian Pacific Journal of Tropical Medicine 2011年第10期4卷 799-803页

作者： M gnanadesigan M Anand S Ravikumar M Maruthupandy V Vijayakumar S Selvam M Dhineshkumar AK Kumaraguru School of Energy Environmental and Natural ResourcesDepartment of Marine and Coastal StudiesMadurai Kamaraj UniversityMadurai-625021Tamil NaduIndia School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623409Ramanathapuram DistrictTamil NaduIndia School of Chemistry Department of Inorganic ChemistryMadurai Kamaraj UniversityMadurai-625021Tamil NaduIndia School of Chemistry Department of Industrial ChemistryAlagappa UniversityKaraikudi-630003Tamil NaduIndia

Objective:To identify the larvicidal activities of silver nano particles synthesised with Rhizophora mucronata（***） leaf extract against the larvae of Aedes aegypti（***） and Culex quinquefasciatus（***）.Methods:In vitro larvicidal activities such as LC50 and LC90 were assessed for the *** and *** larval ***, characterisation such as UV,XRD,FTIR and AFM analysis were carried out for the synthesised silver nano ***:The LC50 value of the synthesised silver nano particle was identified as 0.585 and 0.891 mgg/L for *** and *** larvae respectively. Further,the LG90 values are also identified as 2.615 and 6.291 mg/L for *** and Cx. quinquefasciatus species *** synthesised silver nanoparticles have maximum absorption at 420 nm with the average size of 60-95 *** XRD data showed 20 intense values with various degrees such as 37.10°,47.66°,63.97°and 70.01°.The FTIR data showed prominent peaks in（3 426.89,2 925.49,2 869.56,2 346.95,1 631.49,1 031.73,669.18 and 455.12） different ***:The biosynthesis of silver nanoparticles with leaf aqueous extract of R. mucronata provides potential source for the larvicidal activity against mosquito borne diseases.

关键词： Biosynthesis Mangroves Larvicidal

Antagonistic properties of seagrass associated Streptomyces ***-1:A source for anthraquinone rich compound

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Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 887-890页

作者： S.Ravikumar M.gnanadesigan A.Saravanan N.Monisha V.Brindha S.Muthumari School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi campusThondi-623 409Ramanathapuram DistrictTamilnaduIndia Department of Microbiology Selvamm Arts and Science CollegeNamakkal-637 003TamilnaduIndia Department of Biotechnology AVS College of Arts and ScienceSalemTamilnaduIndia Department of Biotechnology Thassim Beevi Abdul Kader College for WomenKilakarai-623 517Ramanathapuram DistrictTamilnaduIndia Departemt of Biotechnology Meenakshi Ramasamy Arts and Science CollegeThathanur-621 804Ariyalur DistrictTamilnaduIndia

Objective:To identify the antibacterial potential of seagrass(Syringodium isoetifoliutn) associate microbes against bacterial ***:Eumeration of microbial associates were analyzed with leaf and root samples of Syringodium *** and MBC were calculated for bacterial pathogens with microbial *** and GC-MS analysis were calculated for Actinomycetes sp.(Act01) which was the most ***:Of the isolated microbial associates phosphatase producing bacterial isolates were identified as maximum [(26l.78±35.09) CFU×10~4/g]counts in root *** the selected microbial isolates Actinomycete sp(Act01) showed broad spectrum of antibacterial activity against antibiotic resistant and fish bacterial *** analysis of Act01 showed maximum identities(99%) with the Streptomyces sp.(GU5500072).The 16s rDNA secondary structure of Act01 showed the free energy values as -366.3 kkal/*** GC-MS analysis Act01 showed maximum retention value with 23.742 RT and the corresponding chemical class was identified as 1,4-dihydroxy-2-(3- hydroxybutyl)-9,10-anthraquinone 9,***:In conclusion,Streptomyces sp. (GU045544.1) from Syringodium isoetifolium could be used as potential antibacterial agent.

关键词： Actinomycetes sp. MIC MBC Phylogenetic analysis Syringodium isoetifolium