Hepatoprotective and antioxidant properties of marine halophyte Luminetzera racemosa bark extract in CCL_4 induced hepatotoxicity

作     者：Murugesan Gnanadesigan Sundaram Ravikumar Samuel Jacob Inbaneson 

作者机构：School of Marine SciencesDepartment of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623409TamilnaduIndia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2011年第4卷第6期

页      面：462-465页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Antioxidant Hepatoprotective Histopathology Mangroves 

摘      要：Objective:To identify the hepatoprotective and antioxidant activity of Luminetzera racemosa （L racemosa）bark ***:Wistar albino rats were divided into 6 groups:Group 1 served as control;Group 2 served as hepatotoxin（CCL4 treated） group;Group 3 served as positive control（Silymarin） treated groups;Group 4,5 and 6 served as（100,200 and 300 mg/kg bw p.o.） L racemosa bark extract treated ***,in vitro antioxidant indexes,including DPPH, hydroxyl radical scavenging activity（HRSA）,NO,ferric reducing antioxidant power（FRAP）,lipid hydroperoxide（LPO） and super oxide dismutase（SOD） were also analyzed in the bark extract. Results:The results suggested that,the level of serum glutamate oxyloacetic transaminase（SCOT）, serum glutamic pyruvic transaminase（SGPT）,alkaline phosphatise（ALP）,bilurubin,cholesterol, sugar and lactate dehydrogenase（LDH） were significantly（P50 values were observed as（44.17±6.87）μ/mL,（42.45±2.81）μg/mL,（62.37±3.98）μg/mL,（54.24±3.09）μg/mL, （87.25±5.90）μg/mL and（71.54±5.42）μg/mL for ***,NO,FRAP,LPO and SOD radical scavenging activities,***:The hepatoprotective and antioxidant activities of the bark extract might be to the presence of unique chemical classes such as flavonoids, alkaloids and polyphenols.