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Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer

World Journal of Gastroenterology 2011年第27期17卷 3220-3228页

作者： Fusun Ozmen M Mahir Ozmen Evren Ozdemir munevver moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu Department of Basic Oncology Hacettepe University Institute of Oncology06100 Ankara Turkey Department of General Surgery Ankara Numune Teaching and Research Hospital06100 Ankara Turkey Department of Emergency Medicine Hacettepe University Medical School06100 Ankara Turkey Department of Medical Oncology Hacettepe University Institute of Oncology06100 Ankara Turkey Department of Pathology Ankara Numune Teaching and Research Hospital06100 Ankara Turkey Department of Biostatistics and Medical Informatics Hacettepe University Faculty of Medicine06100 AnkaraTurkey

AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric ***: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry.

关键词：基因表达水平 CD44 淋巴管血管内皮生长因子受体胃癌 mRNA水平病理组织学聚合酶链反应

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Effects of Exogenous Indole Butyric Acid and Callus Formation on the Anti-oxidant Activity, Total Phenolic, and Anthocyanin Constituents of Mulberry Cuttings

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Journal of Integrative Plant Biology 2006年第7期48卷 832-837页

作者： Aysel Sivaci munevver Sokmen Department of Biology Sinop Science and Literature Faculty Ondokuz Mayis University Sinop Turkey Department of Chemistry Faculty of Science and Literature Cumhuriyet University Sivas Turkey

In order to evaluate the effects of exogenous indole butyric acid （IBA） and callus formation on the antioxidant activity, total phenolics, and anthocyanin constituents of Morus nigra L. and M. alba L. cuttings, we investigated the variations before and after the treatment. The results indicate that anti-oxidant ability, total phenolic, and anthocyanin constituents of the callus stems of both Morus species were higher than those of non-callus forming species. There were also increases observed in anti-oxidant ability, total phenolic, and anthocyanin constituents of calli treated with IBA （1 000-3 000 mg/L）.

关键词： anthocyanin anti-oxidant activity callus cutting indole butyric acid mulberry phenolics.

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Premature newborn with intracardiac fungus balls and endocarditis which is curable only with anti-fungal therapy: Case presentation

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Case Reports in Clinical Medicine 2013年第5期2卷 315-317页

作者： Mecnun Cetin Serkan Ozen munevver Yildirimer Murat Deveci Senol Coskun Metehan Kizilkaya Division of Pediatric Cardiology Department of Pediatrics Faculty of Medicine Celal Bayar University Manisa Turkey Division of Pediatric Cardiology Department of Pediatrics Faculty of Medicine Celal Bayar University Manisa Turkey

Invasive fungal infections often caused by Candida species are infections which have high morbidity and mortality rates in newborn infants. 5% of the cases have also concomitant endocarditis and this causes mortality rates over 60%. Thus it has vital importance to diagnose and treat these patients with endocarditis in early stages. Most preferred treatment option is a surgical incision in addition to systemic anti-fungal therapy. Here we presented an extremely low birth weight, premature newborn with endocarditis caused by Candida tropicalis and cured solely by systemic anti-fungal treatment without the need for surgical intervention.

关键词： Invasive Fungal Infection Endocarditis Candida tropicalis

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Is There Any Relationship between Maternal Vitamin D Levels and Asymptomatic Bacteriuria? A Preliminary Study

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Open Journal of Obstetrics and Gynecology 2020年第12期10卷 1677-1685页

作者： Emel Kurtoglu Ozdes Bahattin Avci Samettin Celik Gokhan Ocal Serap Polat Feyza munevver Yaran Taskin Ozdes Migraci Tosun Arif Kokcu Department of Obstetrics and Gynecology Memorial Hizmet Hospital Istanbul Turkey Department of Biochemistry Faculty of Medicine Ondokuz Mayis University Samsun Turkey Maternity Hospital Samsun Training and Research Hospital Samsun Turkey Department of Obstetrics and Gynecology Buyuk Anadolu Hospital Samsun Turkey Department of Obstetrics and Gynecology Private Meditech Hospital Ordu Turkey Obstetrics and Gynecology Independent researcher Istanbul Turkey Forensic Medicine Independent researcher Istanbul Turkey Department of Obstetrics and Gynecology Faculty of Medicine Ondokuz Mayis University Samsun Turkey Department of Obstetrics and Gynecology Medical Park Samsun Hospital Samsun Turkey

Hypothesis: Vitamin D has been considered to play important roles in maintaining pregnancy. Also, this vitamin is considered to regulate immune response and thus may be important for pregnant women also to maintain no-infection of which preterm delivery is especially important. Since vitamin D regulates maternal anti-infection function and since Asymptomatic bacteriuria (ASB) causes various adverse outcomes in pregnancy, we hypothesized that maternal serum vitamin D level may be related with the presence/absence of ASB. The present study was an effort to determine this. The study included 215 pregnant women, attended the Ondokuz Mayis University Hospital antenatal care polyclinic, Samsun, Turkey, in the summer for initial visits between 6- and 14-weeks’ gestation. Women with symptoms suggestive of urinary tract infection, a history of antibiotic use within the previous two weeks, ongoing antibiotic therapy or urinary system instrumentation, a diagnosis of vitamin D insufficiency or deficiency, and those taking vitamin D supplements were excluded. Demographic data features of the sampled women were analyzed retrospectively. 10 ml maternal peripheral venous blood samples were collected and the concentrations of 25(OH)D3 in the serum were analyzed. Mid-stream morning urine samples were obtained and analyzed at the microbiology laboratory according to established procedures. ASB was reported if bacteria were present at specified quantitative counts (≥105

关键词： Pregnancy Asymptomatic Bacteriuria Vitamin D Perinatal Complication Supplementation

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