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Presentation delay in breast cancer patients and its association with sociodemographic factors in North Pakistan

Chinese Journal of Cancer Research 2015年第3期27卷 288-293页

作者： muhammad Aleem Khan Sheharyar Hanif Sundas Iqbal muhammad Faheem Shahzad Sehrish Shafique muhammad taha Khan Department of Nuclear Medicine Nuclear MedicineOncology and Radiotherapy Institute Department of Medicine Ziauddin Medical University Armed Forces Institute of Cardiology Department of Physiology Rawal Institute of Health Sciences Nuffield Brentwood Hospital

Background： There is strong evidence that delayed diagnosis of breast cancer is associated with poor survival. The objectives were to determine the frequency of breast cancer patients with delayed presentation, the reasons of delay and its association with different socio-demographic variables in our ***： We interviewed 315 histologically confirmed breast cancer patients. Delay was defined as more than 3 months from appearance of symptoms to the consultation from doctor. Questions were asked from each patient which could reflect their understanding about the disease and which could be the likely reasons for their delayed ***： A total of 39.01%（n=123） of patients presented late and out of those, 40.7% wasted time using alternative medicines; 25.2% were not having enough resources; 17.1% presented late due to painless lump; 10.6% felt shyness and 6.5% presented late due to other reasons. Higher age, negative family history, 〈8 school years of education and low to middle socio-economic status were significantly associated with delayed presentation（P〈0.05）. Education and socioeconomic status were two independent variables related to the delayed presentation after adjustment for others [odds ratios（OR） of 2.26, 2.29 and 95% confidence intervals（CI） was 1.25-4.10, 1.06-4.94 respectively].Conclusions： Significant percentage of women with breast cancer in North Pakistan is experiencing presentation delay due to their misconceptions about the disease. Coordinated efforts with public health department are needed to educate the focused groups and mitigating the barriers identified in the study. Long term impact will be reduced overall burden of the disease in the region.

关键词： Breast cancer delayed diagnosis survival

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Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies

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Chinese Chemical Letters 2016年第5期27卷 693-697页

作者： Fazal Rahim muhammad Ali Shifa Ullah Umer Rashid Hayat Ullah muhammad taha muhammad Tariq Javed Wajid Rehman Aftab Ahmad Khan Obaid Ur Rahman Abid muhammad Bilal Department of Chemistry Hazara University Department of Chemistry COMSATS Institute of Information Technology Department of Biochemistry and Biotechnology The Islamia University of Bahawalpur Atta-ur-Rahman Institute for Natural Product Discovery Universiti Teknologi MARA (UiTM)Puncak Alam Campus Faculty of Applied Science UiTM Department of Environmental Science COMSATS Institute of Information Technology

Bis-thiobarbiturate derivatives 1-15 have been synthesized, characterized by 1HNMR and El-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with iC50 values ranging 7.45 ± 0.12 - 74.24 ± 0.81 μmol/L while the standard thiourea behaved normally （ICso = 21.10 ±0.12）. Compounds I （IC50= 7.45 ± 0.12 ]μmol/L）, 9 （IC50 =18,17 ± 1.03 bmol/L） and 13 （IC50= 8.61 ± 0.45 bmol/L） showed excellent urease inhibitory activity in the series. Molecular modeling studies were performed to understand the binding site with the bimetallic nickel center of the enzyme. Structure-activity relationship has also been established for these compounds. This study identified bis- thiobarbiturate as a novel class of urease inhibitors.

关键词： Thiobarbituric acid Synthesis Urease inhibition Molecular docking studies

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Morpholine hydrazone scaffold： Synthesis, anticancer activity and docking studies

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Chinese Chemical Letters 2017年第3期28卷 607-611页

作者： muhammad taha Syed Adnan Ali Shah muhammad Afifi Manar Zulkeflee Sadia Sultan Abdul Wadood Fazal Rahim Nor Hadiani Ismail Atta-ur-Rahman Institute for Natural Product Discovery (AuRlns) Universiti Teknologi MARA Puncak Alam Campus 42300 Bandar Puncak Alam SelangorD. E. Malaysia Faculty of Applied Science UiTM Shah Alam 40450 Shah Alam Selangor D.E. Malaysia Faculty of Pharrnacy Universiti Teknologi MARA Puncat~ Alam Campus 42300 Baadar Puncak Alam Selangor D.E. Malaysia Department of Biochemistry Abdul Wali Khan University Mardan 23200 Pakistan Department of Chemistry Hazara University Mansehra 21300 Pakistan

In this paper, synthesis and anticancer activities of morpholine hydrazones scaffold（1-17） thoroughly studied. Small series of morpholine hydrazones synthesized by treating 5-morpholinothiophene-2-carbaldehyde with different aryl hydrazides to form morpholine hydrazones scaffold（1-17）. The in vitro anticancer potential of all these compounds was checked against human cancer cell lines like Hep G2（human hepatocellular liver carcinoma） and MCF-7（human breast adenocarcinoma）. Analogs 13 had similar substantial cytotoxic effects towards Hep G2 with IC_（50） value 6.31±1.03μmmol/L when compared with the standard Doxorubicin（IC_（50）value 6.00±0.80μmmol/L）; while compounds 5,8 and 9 showed potent cytotoxicity against MCF-7 with IC_（50） value 7.08±0.42μmmol/L, 1.26±0.34μmmol/L and11.22±0.22μmmol/L respectively when compared with the standard Tamoxifen（IC_（50）= 11.00±0.40μmol/L）. Molecular docking studies also performed to understand the binding interaction.

关键词： Morpholine hydrazones Synthesis HepG2 MCF-7 Molecular docking

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基于采用新优化技术的动态电压恢复器对电能质量补偿的研究

基于采用新优化技术的动态电压恢复器对电能质量补偿的研究

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作者： muhammad taha ALI（塔哈）华北电力大学

学位级别：硕士

随着世界的不断现代化,它具有最重要的品质是优质高效可靠的电力。如今,越来越多的复杂设备被研发出,他们对电能质量非常敏感。即使轻微的几十毫秒的电力扰动,如电压骤降,电压骤升,电力谐波,都可以引起大量设备故障,导致巨大的损失。为... 详细信息

随着世界的不断现代化,它具有最重要的品质是优质高效可靠的电力。如今,越来越多的复杂设备被研发出,他们对电能质量非常敏感。即使轻微的几十毫秒的电力扰动,如电压骤降,电压骤升,电力谐波,都可以引起大量设备故障,导致巨大的损失。为了解决电能质量问题,客户定制电源(CUPS)正被用于电力系统配电网络,其中最有效的和高效率的设备是动态电压恢复器(DVR)。正如名字所说的,动态电压恢复器是一种电力电子设备,用于补偿电压干扰和谐波,并为负载侧提供恒定功率,而且其优点包括成本低,体积小,对干扰响应快。本文的重点是采用新的优化技术来改善DVR补偿电能质量的性能,主要是是基于PWM控制方案、DQ0变换、PI控制器。这些技术相结合不但可以使DVR的额定功率最小,而且还可以使其控制精度更高。基于MATLAB/SIMULINK环境,本文设计和分析了基于新的优化技术的DVR性能。

关键词：动态电压恢复器客户定制电源 PWM控制 dq0变换 PI控制器优化

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巴基斯坦海运绿色供应链运营管理发展策略研究

巴基斯坦海运绿色供应链运营管理发展策略研究

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作者： Hafiz muhammad taha Khan Sherwani（可汗）大连海事大学

学位级别：硕士

随着现代社会的发展,世界主要国家认识到,由于土地资源的日益减少,重视开发海洋资源作为替代成为重中之重。考虑到环境可持续性在这一过程中的基础性作用及其可通过有效的绿色供应链管理(GSCM)进行研究,世界发达国家已经建立了大量的基... 详细信息

随着现代社会的发展,世界主要国家认识到,由于土地资源的日益减少,重视开发海洋资源作为替代成为重中之重。考虑到环境可持续性在这一过程中的基础性作用及其可通过有效的绿色供应链管理(GSCM)进行研究,世界发达国家已经建立了大量的基础设施以充分积累未开发海事部门的利益。而巴基斯坦作为一个海洋国家,却一直未能有效开发海洋资源。几十年来,对环境可持续性和生产增长的忽视影响了海事部门的健康发展,这又反过来阻碍该国的经济增长。虽然海运贸易是巴基斯坦经济的支柱,但其国内航运和造船业却处于混乱状态。因此,研究导致海运业没落的主要原因和巴基斯坦海运业达到国际标准所需做出的努力和采取的措施十分必要。首先,本文通过PEST分析法,研究了巴基斯坦海事部门的基本环境。PEST分析法从政治、经济、社会和技术四个方面提供了对相关海事部门结构的详细概述,这有助于理解是否有改善的空间,哪一方面更需要改善以及这样的改善能产生何种程度的积极影响。其次,本文采用层次分析法(AHP)评估了最适合巴基斯坦海事部门发展绿色供应链运营管理的方法,此法也有助于识别问题所在并确定更重要、影响更大的问题。PEST和AHP分析法可以确定问题及其严重性。运用SWOT分析法,通过案例分析本文为巴基斯坦海事部门的战略环境构造了简明的轮廓,同时也暗示了为实现战略目标应寻求的明确的战略方向。最后,通过利用优势、抓住机遇、弥补劣势、应对威胁,构建了巴基斯坦海事部门的绿色供应链运营管理策略。本文研究发现,内部和外部因素如政治不稳定、恐怖主义和外商投资对巴基斯坦海运业环境可持续性发展的影响较大,安全问题是巴基斯坦日益增长的海运市场中最令人担忧的问题,而政治不稳定也是海运业发展缓慢的重要因素。因此,本文建议通过聚焦安全问题、关注巴基斯坦海运业的政治稳定并采取有吸引力的商业政策创造引进外资机会从而解决这些问题。本文的研究将对海事部构建巴基斯坦海事部门的绿色供应链管理体系有一定的参考意义。

关键词：海运业巴基斯坦海运业绿色供应链管理(GSCM) PEST分析法 SWOT分析层次分析法(AHP)

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Acylhydrazide and Isatin Schiff Bases as Alternate UV-Laser Desorption Ionization (LDI) Matrices for Low Molecular Weight (LMW) Peptides Analysis

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American Journal of Analytical Chemistry 2012年第12期3卷 779-789页

作者： Syed Ghulam Musharraf Aisha Bibi Najia Shahid muhammad Najam-ul-Haq Momin Khan muhammad taha Uzma Rasool Mughal Khalid Mohammed Khan Department of Chemistry Bahauddin Zakariya University Multan Pakistan Hussain Ebrahim Jamal Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences University of Karachi Karachi Pakistan

Matrix-assisted laser desorption/ionization (MALDI) is a preferred and widely used mass spectrometric technique for the analysis of macromolecules. Limited UV-LDI matrices are available for the analysis of biomolecules due to the restricted structural features to serve in the laser desorption/ionization mechanism with a problem of background signals appearing in the low mass region. This paper describes the application of Schiff base derivatives of acylhydrazide and isatin as alternate UV-LDI matrices for the analysis of peptides with significantly low background signals. Thirty one compounds have been successfully employed as matrices for the analysis of low molecular weight (LMW) peptides (α-Cyano-4-hydroxycinnamic acid (HCCA), a preferred choice for peptide analysis.

关键词： MALDI-MS LDI Matrix Acylhydrazide Schiff Bases Bis-Schiff Bases of Isatin Schiff Bases of Isatin Peptides

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Enhancing sustainability in phosphate ore processing:Performance of frying oil as alternative flotation collector for carbonate removal

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International Journal of Mining Science and Technology 2024年第4期34卷 557-571页

作者： Asmae El-bahi Yassine taha Yassine Ait-Khouia Abdellatif Elghali Mostafa Benzaazoua Geology&Sustainable Mining Institute(GSMI) Mohammed VI Polytechnic UniversityBen Guerir 43150Morocco

Recycling waste frying oils for the synthesis of flotation reagents presents a promising avenue for sustainable waste ***,it offers a cost-effective solution for crafting a specialized collector designed to efficiently remove carbonates and enhance phosphate enrichment in froth flotation *** study focuses on the synthesis of an anionic collector using the saponification reaction of a frying oil sample,subsequently applied to the flotation of calcite and *** elucidate the adsorption mechanisms of the frying oil collector(FrOC)and sodium oleate,a reference collector,on fluorapatite,calcite,dolomite,and quartz surfaces,comprehensive experiments were conducted,including zeta potential measurements and Fourier transform infrared *** revealed diverse adsorption affinities of the molecules towards these *** assess the practical performance of the collector,flotation tests were conducted using a natural phosphate ore mixture,employing a BoxBehnken experimental ***,under optimized conditions(pH 9,1000 g/t of FrOC,3.5 min of conditioning,and 6 min of flotation),FrOC exhibited excellent performance,with calcite and dolomite recoveries exceeding 80%,while apatite recovery in the concentrate fraction remained below 10%.This work exemplifies both circular economy practices and the distinctive approach to sustainable mineral processing.

关键词： Frying oils recycling Phosphate beneficiation Flotation separation Green surfactants Sustainability

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Identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN LI DANDAN LI BARBOD HAFEZ MOUNIR M.SALEM BEKHIT YOUSEF A.BIN JARDAN FARS KAED ALANAZI EHAB I.taha SAYED H.AUDA FAIQAH RAMZAN muhammad JAMIL The Second Affiliated Hospital of Harbin Medical University Harbin Medical UniversityHarbinChina Department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina Department of Biological Engineering University of SalfordSalfordUK Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan Department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and *** MMP family assumes a crucial role in tumor invasion and *** study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular ***,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TIMER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for *** performing STRING and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree *** analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to *** notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KIRC ***,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).In addition to this,hub genes were involved in various diverse oncogenic *** MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KIRC.

关键词： KIRC MMP gene family Chemotherapy Overall survival

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Biomarker bust:meta-analyses reveal unreliability of neuronal extracellular vesicles for diagnosing parkinsonian disorders

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Neural Regeneration Research 2025年第1期20卷 201-202页

作者： Hash Brown taha Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA

A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor *** in this group are Parkinson’s disease(PD),dementia with Lewy bodies(DLB),multiple system atrophy(MSA),corticobasal syndrome(CBS),and progressive supranuclear palsy(PSP).These disorders are differentiated neuropathologically by their dominant protein pathologies involvingα-synuclein(α-syn)and/or tau,the types of brain cells affected,such as neurons,oligodendroglia,and astrocytes,and the specific brain regions involved(Tolosa et al.,2021).

关键词： disorders parkin

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Cloud Datacenter Selection Using Service Broker Policies:A Survey

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1-41页

作者： Salam Al-E’mari Yousef Sanjalawe Ahmad Al-Daraiseh Mohammad Bany taha Mohammad Aladaileh Department of Information Security Faculty of ITUniversity of PetraAmman11196Jordan Department of Cybersecurity School of ITAmerican University of Madaba(AUM)Amman11821Jordan Department of Computer Science School of ITAmerican University of Madaba(AUM)Amman11821Jordan Department of Data Science and Artificial Intelligence School of ITAmerican University of Madaba(AUM)Amman11821Jordan

Amid the landscape of Cloud Computing(CC),the Cloud Datacenter(DC)stands as a conglomerate of physical servers,whose performance can be hindered by bottlenecks within the realm of proliferating CC services.A linchpin in CC’s performance,the Cloud Service Broker(CSB),orchestrates DC *** to adroitly route user requests with suitable DCs transforms the CSB into a bottleneck,endangering service *** tackle this,deploying an efficient CSB policy becomes imperative,optimizing DC selection to meet stringent Qualityof-Service(QoS)*** numerous CSB policies,their implementation grapples with challenges like costs and *** article undertakes a holistic review of diverse CSB policies,concurrently surveying the predicaments confronted by current *** foremost objective is to pinpoint research gaps and remedies to invigorate future policy ***,it extensively clarifies various DC selection methodologies employed in CC,enriching practitioners and researchers *** synthetic analysis,the article systematically assesses and compares myriad DC selection *** analytical insights equip decision-makers with a pragmatic framework to discern the apt technique for their *** summation,this discourse resoundingly underscores the paramount importance of adept CSB policies in DC selection,highlighting the imperative role of efficient CSB policies in optimizing CC *** emphasizing the significance of these policies and their modeling implications,the article contributes to both the general modeling discourse and its practical applications in the CC domain.

关键词： Cloud computing cloud service broker datacenter selection quality-of-service user request

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