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Engineered Nano−Bio Interfaces for Stem Cell Therapy

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Precision Chemistry 2023年第6期1卷 341-356页

作者： Arsalan Umer muhammad daniyal ghouri Theoneste Muyizere Raja muhammad Aqib Abdul Muhaymin Rong Cai Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience and Technology of China Chinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China GBA National Institute for Nanotechnology Innovation Guangdong 5110700China

Engineered nanomaterials(ENMs)with different topographies provide effective nano−bio interfaces for controlling the differentiation of stem *** interaction of stem cells with nanoscale topographies and chemical cues in their microenvironment at the nano−bio interface can guide their *** use of nanotopographical cues,in particular nanorods,nanopillars,nanogrooves,nanofibers,and nanopits,as well as biochemical forces mediated factors,including growth factors,cytokines,and extracellular matrix proteins,can significantly impact stem cell *** factors were seen as very effective in determining the proliferation and spreading of stem *** specific outgrowth of stem cells can be decided with size variation of topographic nanomaterial along with variation in matrix stiffness and surface structure like a special *** precision chemistry enabled controlled design,synthesis,and chemical composition of ENMs can regulate stem cell *** parameters of size such as aspect ratio,diameter,and pore size of nanotopographic structures are the main factors for specific termination of stem *** corona nanoparticles(NPs)have shown a powerful facet in stem cell therapy,where combining specific proteins could facilitate a certain stem cell differentiation and cellular ***−bio reactions implicate the interaction between biological entities and nanoparticles,which can be used to tailor the stem cells’*** ion release can also be a parameter to enhance cellular proliferation and to commit the early differentiation of stem *** research is needed to fully understand the mechanisms underlying the interactions between engineered nano−bio interfaces and stem cells and to develop optimized regenerative medicine and tissue engineering designs.

关键词： nano−bio interface protein corona stem cell therapy extracellular matrix biochemical forces

On the construction of balanced repeated measurements designs with good circular properties

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Statistical Theory and Related Fields 2023年第2期7卷 121-129页

作者： muhammad daniyal Jigneshkumar Gondaliya Rashid Ahmed Department of Statistics The Islamia University of BahawalpurBahawalpurPakistan Gujarat Commerce College Gujarat UniversityAhmedabadIndia

Several fields,such as biological,medical,public health,agricultural sciences,etc.,require circular balanced repeated measurement designs with fewer unequal number of repeated measure-ments than the number of ***,the availability and high cost of experimental subjects in these fields prefer the design in fewer experimental ***,balancing the carryover effects of the treatments in minimal experimental subjects is one of the problems in this *** this paper,several new series of minimal circular nearly strongly balanced RMDs in periods of two and three different sizes are *** proposed construction of designs has high efficiency and,therefore,can save the cost of experimentations due to a fewer exper-imental *** of the designs are very useful because of the unavailability of strongly balanced RMDs for these combinations of parameters.A list of sets of shifts for the construction of minimal circular nearly SBRMDs has also been mentioned in the Appendix.

关键词： Carryover effects repeated measurement designs balanced repeated measurement designs strongly balanced repeated measurement designs circular nearly strongly balanced repeated measurement designs

Bit Rate Reduction in Cloud Gaming Using Object Detection Technique

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Computers, Materials & Continua 2021年第9期68卷 3653-3669页

作者： daniyal Baig Tahir Alyas muhammad Hamid muhammad Saleem Saadia Malik Nadia Tabassum Natash Ali Mian Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan Department of Statistics and Computer Science University of Veterinary and Animal SciencesLahore54000Pakistan Department of Industrial Engineering Faculty of EngineeringRabighKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information Systems Faculty of Computing and Information Technology-RabighKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Computer Science Virtual University of PakistanLahore54000Pakistan School of Computer and Information Technology Beaconhouse National University Lahore53700Pakistan

The past two decades witnessed a broad-increase in web technology and on-line *** the broadband confinements is viewed as one of the most significant variables that prompted new gaming *** immense utilization of web applications and games additionally prompted growth in the handled devices and moving the limited gaming experience from user devices to online cloud *** internet capabilities are enhanced new ways of gaming are being used to improve the gaming *** cloud-based video gaming,game engines are hosted in cloud gaming data centers,and compressed gaming scenes are rendered to the players over the internet with updated *** such systems,the task of transferring games and video compression imposes huge computational complexity is required on cloud *** basic problems in cloud gaming in particular are high encoding time,latency,and low frame rates which require a new methodology for a better *** improve the bandwidth issue in cloud games,the compression of video sequences requires an alternative mechanism to improve gaming adaption without input *** this paper,the proposed improved methodology is used for automatic unnecessary scene detection,scene removing and bit rate reduction using an adaptive algorithm for object detection in a game *** a result,simulations showed without much impact on the players’quality experience,the selective object encoding method and object adaption technique decrease the network latency issue,reduce the game streaming bitrate at a remarkable scale on different *** proposed algorithm was evaluated for three video game *** this paper,achieved 14.6%decrease in encoding and 45.6%decrease in bit rate for the first video game scene.

关键词： Video encoding object detection bit rate reduction game video motion estimation computational complexity

Gain-Enhanced Metamaterial Based Antenna for 5G Communication Standards

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Computers, Materials & Continua 2020年第9期64卷 1587-1599页

作者： daniyal Ali Sehrai Fazal muhammad Saad Hassan Kiani Ziaul Haq Abbas muhammad Tufail Sunghwan Kim Department of Electrical Engineering City University of Science and Information TechnologyPeshawar25000Pakistan Faculty of Electrical Engineering Ghulam Ishaq Khan Institute of Engineering Sciences and TechnologyTopi23640Pakistan Department of Mechatronics Engineering University of Engineering and TechnologyPeshawar25000Pakistan School of Electrical Engineering University of UlsanUlsan44610Korea

Metamaterial surfaces play a vital role to achieve the surface waves suppression and in-phase reflection,in order to improve the antenna *** this paper,the performance comparison of a fifth generation(5G)antenna design is analyzed and compared with a metamaterial-based antenna for 5G communication system *** surface is utilized as a reflector due to its in-phase reflection characteristic and high-impedance nature to improve the gain of an *** conventional conducting ground plane does not give enough surface waves suppression which affects the antenna performance in terms of efficiency and gain *** factors are well considered in this work and improved by using the metamaterial *** radiating element of the proposed metamaterial based antenna is made up of copper material which is backed by the substrate,i.e.,Rogers-4003 with a standard thickness,loss tangent and a relative permittivity of 1.524 mm,0.0027 and 3.55,*** proposed antenna with and without metamaterial surface operates at the central frequency of 3.32 GHz and 3.60 GHz,*** traditional antenna yields a boresight gain of 2.76 dB which is further improved to 6.26 dB,using the metamaterial *** radiation efficiency of the proposed metamaterial-based 5G antenna is above 85%at the desired central frequency.

关键词： Metamaterial surface in-phase reflection 5G high gain

PEGylated mBPEI-rGO nanocomposites facilitate hepotocarcinoma treatment combining photothermal therapy and chemotherapy

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Science Bulletin 2018年第14期63卷 935-946页

作者： Chunyi Tong Xizhi Zhang Jialong Fan Bin Li Bin Liu muhammad daniyal Wei Wang College of Biology Hunan Province Key Laboratory of Plant Functional Genomics and Developmental RegulationHunan University TCM and Ethnomedicine Innovation&Development Laboratory School of PharmacyHunan University of Chinese Medicine

Despite chemotherapy has been widely used for tumor therapy, the serious side effect is still a major challenge. Recently, two dimensional nanomaterial-based drug delivery systems have attracted wide concern due to their high drug loading and low side effect. In addition, some kinds of nanomaterials can directly act as a photosensitizer to induce cancer destruction. In this study, we developed a drug delivery system of mixture of high/low molecular weight branched polyethylenimine-polyethylene glycol-reduced graphene oxide(mBPEI-PEG-rGO) using reduced graphene oxide as matrix. A model drug of doxorubicin(DOX) was loaded on the nanocomposites with the efficiency of 81% and the release rate of more than 50% at acidic environment. In vitro experiments indicated that mBPEI-PEG-rGO-DOX with enhanced stability and biocompatibility efficiently delivered and released DOX into cells mainly through micropinocytosis and killed SMMC-7721 cells by inducing reactive oxygen species(ROS) and cell apoptosis. Furthermore, in vivo experiments indicated that the combination of intratumoral injection of mBPEI-PEG-rGO-DOX and local laser irradiation nearly ablated hepatocarcinoma. In conclusion, this new drug delivery system provided an alternative for combinational photothermal and chemotherapy against hepatocarcinoma.

关键词： Reduced graphene oxide Branched polyethylenimine Doxorubicin Drug delivery Phototherapy

V-Shaped Monopole Antenna with Chichena Itzia Inspired Defected Ground Structure for UWB Applications

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Computers, Materials & Continua 2020年第10期65卷 19-32页

作者： Naeem Ahmad Jan Saad Hassan Kiani Fazal muhammad daniyal Ali Sehrai Amjad Iqbal muhammad Tufail Sunghwan Kim Department of Electrical Engineering Iqra National UniversityPeshawar25000Pakistan Department of Electrical Engineering City University of Science and Information TechnologyPeshawar25000Pakistan Department of Electrical Engineering Multimedia UniversityCyberjaya63100Malaysia Department of Mechatronics Engineering University of Engineering and TechnologyPeshawar25000Pakistan Department of Electrical Engineering University of UlsanUlsan44610Korea

Due to rapid growth in wireless communication technology,higher bandwidth requirement for advance telecommunication systems,capable of operating on two or higher bands with higher channel capacities and minimum distortion losses is *** this paper,a compact Ultra-Wideband(UWB)V-shaped monopole antenna is *** response is achieved by modifying the ground plane with Chichen Itzia inspired rectangular staircase *** proposed V-shaped is designed by incorporating a rectangle,and an inverted isosceles triangle using FR4 *** size of the antenna is 25 mm×26 mm×1.6 *** proposed V-shaped monopole antenna produces bandwidth response of 3 GHz Industrial,Scientific,and Medical(ISM),Worldwide Interoperability for Microwave Access(WiMAX),(IEEE 802.11/HIPERLAN band,5G sub 6 GHz)which with an additional square cut amplified the bandwidth response up to 8 GHz ranging from 3.1 GHz to 10.6 GHz attaining UWB defined by Federal Communications Commission(FCC)with a maximum gain of 3.83 *** antenna is designed in Ansys *** for key performance parameters of the antenna are *** measured results are in good agreement with the simulated *** to flat gain,uniform group delay,omni directional radiation pattern characteristics and well-matched impedance,the proposed antenna is suitable for WiMAX,ISM and heterogeneous wireless systems.

关键词： V-shape monopole gain staircase ultra-wideband omni-directional defected ground structure

Exploitation of tolerance to drought stress in carrot(Daucus carota L.):an overview

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Stress Biology 2023年第1期3卷 598-609页

作者： muhammad daniyal Junaid Zahide Neslihan Ozturk Ali Fuat Gokce Department of Agricultural Genetic Engineering Ayhan Sahenk Faculty of Agricultural Sciences and TechnologiesNigde Omer Halisdemir UniversityNigdeTurkiye Department of Plant Breeding and Genetics Faculty of Agricultural SciencesUniversity of The PunjabLahorePakistan

Drought stress is a significant environmental factor that adversely affects the growth and development of car-rot(Daucus carota L.),resulting in reduced crop yields and *** stress induces a range of physiological and biochemical changes in carrots,including reduced germination,hindered cell elongation,wilting,and disrupted photosynthetic efficiency,ultimately leading to stunted growth and decreased root *** research has focused on understanding the molecular mechanisms underlying carrot’s response to drought stress,identifying key genes and transcription factors involved in drought *** and proteomic analyses have provided insights into the regulatory networks and signaling pathways involved in drought stress *** biochemical processes,water scarcity alters carrot antioxidant levels,osmolytes,and *** review provides an overview of the effects of drought stress on carrots and highlights recent advances in drought stress-related studies on this *** recent advances in understanding the effects of drought stress on carrots and developing strategies for drought stress mitigation are crucial for ensuring sustainable carrot production in the face of changing climate ***,understanding the mechanisms underlying the plant’s response to drought stress is essential for developing strategies to improve its tolerance to water scarcity and ensure food security in regions affected by drought.

关键词： Carrots Drought Hormonal regulation miRNAs Metabolites Quality

Provoking Buying Behaviors Amid Crises:Unfolding the Underlying Mechanisms of Psychological Impairments

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International Journal of Mental Health Promotion 2024年第4期26卷 279-292页

作者： muhammad Waleed Ayub ghouri Guofeng Wang muhammad Ali Hussain Zhisheng Li Tachia Chin School of Management Zhejiang University of TechnologyHangzhou310023China School of Management and Economics University of Electronic Science and Technology of ChinaChengdu611731China Business School NingboTech UniversityNingbo315100China

Crises in the past have caused devastating,long-lasting impacts on the global *** after-effects always bring some dynamic and rigorous challenges for businesses and *** challenges have always been a point of discussion for *** recent COVID-19 pandemic emaciated the global economy,leaving everyone mired in uncertainty,fear,and psychological *** of the headwind features utilized by consumers during pandemic was panic buying(PB),which must be explored in various contexts for policymakers and *** address this gap,this study deployed a moderated mediation mechanism,integrating the health belief model(HBM)and competitive arousal theory(CAT)to excavate the notions underlying PB with the intrusion of evolved real-time psychological disorders:intolerance of uncertainty(IU)and cyberchondria(CYC).The study was conducted as a natural experiment in a South Asian developing economy using online *** found that health beliefs—perceived severity(PSV)and perceived susceptibility(PSC)—positively impact perceived arousal(PA),which causes PB,and that PA has a sturdy mediator ***,in the relationship between health beliefs and arousal,the different psychological disorders were found to have significant moderating roles The study findings can help mitigate risk uncertainties and panic situations and thus contribute to consumers’wellbeing.

关键词： Panic buying health belief model mental health competitive arousal theory intolerance of uncertainty cyberchondria

Predictive modeling of COVID-19 death cases in Pakistan

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Infectious Disease Modelling 2020年第1期5卷 897-904页

作者： muhammad daniyal Roseline Oluwaseun Ogundokun Khadijah Abid muhammad Danyal Khan Opeyemi Eyitayo Ogundokun Department of Statistics Islamia University of BahawalpurPakistan Department of Computer Science Landmark University Omu AranNigeria Research Evaluation Unit College of Physicians&SurgeonsPakistan Gillani Law College BZU MultanPakistan Directoriate Department Audit SectionAgricultural and Rural Management Training InstituteIlorinNigeria

Background:The world is presently facing the challenges posed by COVID-19(2019-nCoV),especially in the public health sector,and these challenges are dangerous to both health and *** disease results in an acute respiratory infection that may result in pain and *** Pakistan,the disease curve shows a vertical trend by almost 256K established cases of the diseases and 6035 documented death cases till August 5,***:The primary purpose of this study is to provide the statistical model to predict the trend of COVID-19 death cases in *** age and gender of COVID-19 victims were represented using a descriptive ***:ology:Three regression models,which include Linear,logarithmic,and quadratic,were employed in this study for the modelling of COVID-19 death cases in *** three models were compared based on R2,Adjusted R2,AIC,and BIC *** data utilized for the modelling was obtained from the National Institute of Health of Pakistan from February 26,2020 to August 5,***:The finding deduced after the prediction modelling is that the rate of mortality would decrease by the end of *** total number of deaths will reach its maximum point;then,it will gradually *** indicates that the curve of total deaths will continue to be flat,i.e.,it will shift to be constant,which is also the upper bound of the underlying function of absolute death.

关键词： Coronavirus COVID-19 Public health Epidemic Modelling Model selection criteria