Engineered Nano−Bio Interfaces for Stem Cell Therapy
作者机构：CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience and Technology of ChinaChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of SciencesBeijing 100049China GBA National Institute for Nanotechnology InnovationGuangdong 5110700China
出 版 物：《Precision Chemistry》 (精准化学（英文）)
年 卷 期：2023年第1卷第6期
页 面：341-356页
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：the National Key R&D Program of China(2021YFA1200900,2020YFA0710700 and 2021YFE0112600) the National Natural Science Foundation of China(32071402) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB36000000) the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS2019-I2M-5-018)
主 题：nano−bio interface protein corona stem cell therapy extracellular matrix biochemical forces
摘 要：Engineered nanomaterials(ENMs)with different topographies provide effective nano−bio interfaces for controlling the differentiation of stem *** interaction of stem cells with nanoscale topographies and chemical cues in their microenvironment at the nano−bio interface can guide their *** use of nanotopographical cues,in particular nanorods,nanopillars,nanogrooves,nanofibers,and nanopits,as well as biochemical forces mediated factors,including growth factors,cytokines,and extracellular matrix proteins,can significantly impact stem cell *** factors were seen as very effective in determining the proliferation and spreading of stem *** specific outgrowth of stem cells can be decided with size variation of topographic nanomaterial along with variation in matrix stiffness and surface structure like a special *** precision chemistry enabled controlled design,synthesis,and chemical composition of ENMs can regulate stem cell *** parameters of size such as aspect ratio,diameter,and pore size of nanotopographic structures are the main factors for specific termination of stem *** corona nanoparticles(NPs)have shown a powerful facet in stem cell therapy,where combining specific proteins could facilitate a certain stem cell differentiation and cellular ***−bio reactions implicate the interaction between biological entities and nanoparticles,which can be used to tailor the stem cells’*** ion release can also be a parameter to enhance cellular proliferation and to commit the early differentiation of stem *** research is needed to fully understand the mechanisms underlying the interactions between engineered nano−bio interfaces and stem cells and to develop optimized regenerative medicine and tissue engineering designs.
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