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Homeostatic relevance of vitamin D in maintaining male fertility in human: Down-regulation of oxidative stress and up-regulation of anti-oxidative defense and steroidal hormones

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Asian pacific Journal of Reproduction 2018年第2期7卷 56-61页

作者： Fahad Hussain Arif Malik muhammad saeed qureshi muhammad Imran Sulayman Waquar Hassan Shafique Zohaib Rana Hnin Ei Thu Zahid Hussain Institute of Molecular Biology and Biotechnology The University of LahoreRaiwind Road55150LahorePakistan Department of Biochemistry Akhtar Saeed Medical and Dental CollageLahorePakistan Department of Physiology Nishtar Medical University66000MultanPakistan Department of Biochemistry University of AgricultureFaisalabad38040Pakistan Department of Pharmacology Faculty of MedicineUniversiti Kebangsaan MalaysiaJalan Yaacob LatifBandar Tun Razak56000CherasKualaLumpurMalaysia Department of Pharmaceutics Faculty of PharmacyUniversiti Teknologi MARAPuncak Alam CampusBandar Puncak Alam42300SelangorMalaysia

Objective:To evaluate correlation between the levels of vitamin D and male infertility as well as to determine the efficacy of vitamin D in improving the male fertility by up-regulating the levels of testosterone and ***: In the present study, 130 male patients (aged 25-70 years) having fertility defects were screened and 145 healthy individuals were taken as control. All human subjects were screened for 4-hydroxynonenal, isoprostane-F2α, 8-hydroxy-2′-deoxyguanosine, vitamin D, luteinizing hormone, follicle stimulating hormone, testosterones, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, and nitric ***: The screening analysis revealed that the levels of luteinizing hormone, follicle stimulating hormone, and testosterone were lower in male infertile subjects compared to healthy subjects. Similarly, the levels of vitamin D [(17.17 ± 2.30) ng/mL] and calcium[(6.29 ± 0.31) mg/dL] were significantly lower in infertile groups compared to the normal healthy groups. Moreover, the study revealed that the levels of superoxide dismutase, catalase, and glutathione peroxidase were significantly higher in healthy subjects compared to the infertile ***:Vitamin D exhibits strong relevance to male fertility by maintaining the levels of sex hormones (luteinizing hormone, follicle stimulating hormone, and testosterone), up-regulating the antioxidant defense (superoxide dismutase, catalase, and glutathione peroxidase), and down-regulating the oxidative stress (malondialdehyde, nitric oxide, and inducible nitric oxide synthase species).

关键词： Vitamin D Male fertility Luteinizing hormone Follicle-stimulating hormone Testosterone Oxidative stress Spermatogenesis

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Assessment of Biochemical and Antioxidative Status in Patients Suffering from Dengue Fever

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第3期35卷 411-418页

作者： Mahmood Rasool Arif Malik Khalid Mahmud Khan muhammad saeed qureshi Beenish Shabbir Sara Zahid muhammad Asif Abdul Manan Sana Rashid Saima Rubab Khan Hafiz muhammad Arsalan Rabail Alam Mahwish Arooj Mahmood Husain Qazi Adeel Gulzar Ahmed Chaudhary Adel Mohammed Abuzenadah Mohammed Hussain Al-Qahtani Sajjad Karim Center of Excellence in Genomic Medicine Research Faculty of Applied Medical SciencesKing Abdulaziz University Institute of Molecular Biology and Biotechnology the University of Lahore Fatima Jinnah Medical College Sir Gangaram Hospital Lahore Institute of Molecular Biology and Biotechnology the University of Lahore Department of Biotechnology and Informatics BUITEMS Quetta 87300 Pakistan Center for Research in Molecular Medicine the University of Lahore KACST Technology Innovation Center in Personalized Medicine King Abdulaziz University Center of Excellence in Genomic Medicine Research Faculty of Applied Medical Sciences King Abdulaziz University

Summary：A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever（DF） by evaluating biochemical and oxidative status of patients. ELISA Ig M antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever（DHF） and dengue shock syndrome（DSS） showed significant difference. Significant increases in serum alanine amino transferase（ALT）（P=0.000）, aspartate amino transferase（AST）（P=0.000）, alkaline phosphatase（ALP）（P=0.000）, malondialdehyde（MDA） along with significant decreases in total protein（TP）（P=0.000）, reduced glutathione（GSH）（P=0.000）, superoxide dismutase（SOD）, catalase（CAT）（P=0.000）, and sialic acid contents（P=0.016） were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants（r=0.656, P=0.016）. In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process.

关键词： dengue fever alanine amino transferase aspartate amino transferase malondialdehyde superoxide dismutase catalase

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Behavioral effects of a four-wing attractor with circuit realization: a cryptographic perspective on immersion

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Communications in Theoretical Physics 2020年第12期72卷 35-70页

作者： Najeeb Alam Khan muhammad Ali qureshi Tooba Hameed saeed Akbar Saif Ullah Department of Mathematics University of KarachiKarachi 75270Pakistan Department of Physics University of KarachiKarachi 75270Pakistan Department of Mathematics Government College UniversityLahore 54000Pakistan

In this paper,we propose an innovative chaotic system,combining fractional derivative and sinehyperbolic nonlinearity with circuit *** study of this system is conducted via an analog circuit simulator,using two anti-parallel semiconductor diodes to provide hyperbolic sine nonlinearity,and to function as operational *** multi-stability of the system is also enhanced with the help of multi-equilibrium points for distinct real orders of *** system explores the generation of a four-wing attractor in different phases,both numerically and *** changing the input parameters of the system,different graphs are generated for current flow in state,phase,and space,to confirm the precision of the fractional order derivatives.A reasonable simulation shows that the deliberate circuit provides effective chaos in terms of speed and accuracy,which is comensurate with the numerical *** nonlinear chaotic behavior is utilized to encrypt sound(.wav),images(.jpg),and animated(.gif)data which are a major requirement for the security of communication *** proposed circuit performs chaos and cryptographic tasks with high-effective analog computation,and constitutes a novel approach to this area of research.

关键词： multi-wing attractors hyperbolic sine circuit realization encryption

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De-Noising Brain MRI Images by Mixing Concatenation and Residual Learning(MCR)

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Computer Systems Science & Engineering 2023年第5期45卷 1167-1186页

作者： Kazim Ali Adnan N.qureshi muhammad Shahid Bhatti Abid Sohail muhammad Hijji Atif saeed Department of Computer Science Faculty of Information TechnologyUniversity of Central Punjab LahoreLahore54000Pakistan Department of Computer Science COMSAT University IslamabadLahore CampusLahore54000Pakistan Faculty of Computers and Information Technology Computer Science DepartmentUniversity of TabukTabuk47711Saudi Arabia

Brain magnetic resonance images(MRI)are used to diagnose the different diseases of the brain,such as swelling and tumor *** quality of the brain MR images is degraded by different noises,usually salt&pepper and Gaussian noises,which are added to the MR images during the acquisition *** the presence of these noises,medical experts are facing problems in diagnosing diseases from noisy brain MR ***,we have proposed a de-noising method by mixing concatenation,and residual deep learning techniques called the MCR de-noising *** proposed MCR method is to eliminate salt&pepper and gaussian noises as much as possible from the brain MRI *** MCR method has been trained and tested on the noise quantity levels 2%to 20%for both salt&pepper and gaussian *** experiments have been done on publically available brain MRI image datasets,which can easily be accessible in the experiments and result *** Structure Similarity Index Measure(SSIM)and Peak Signal-to-Noise Ratio(PSNR)calculate the similarity score between the denoised images by the proposed MCR method and the original clean ***,the Mean Squared Error(MSE)measures the error or difference between generated denoised and the original *** proposed MCR denoising method has a 0.9763 SSIM score,84.3182 PSNR,and 0.0004 MSE for salt&pepper noise;similarly,0.7402 SSIM score,72.7601 PSNR,and 0.0041 MSE for Gaussian noise at the highest level of 20%*** the end,we have compared the MCR method with the state-of-the-art de-noising filters such as median and wiener de-noising filters.

关键词： MR brain images median filter wiener filter concatenation learning residual learning MCR de-noising method

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Hybridization of CNN with LBP for Classification of Melanoma Images

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Computers, Materials & Continua 2022年第6期71卷 4915-4939页

作者： saeed Iqbal Adnan N.qureshi Ghulam Mustafa Faculty of Information Technology University of Central PunjabLahorePakistan Department of Computer Sciences Bahria University Lahore CampusPakistan

Skin cancer(melanoma)is one of the most aggressive of the cancers and the prevalence has significantly increased due to increased exposure to ultraviolet ***,timely detection and management of the lesion is a critical consideration in order to improve lifestyle and reduce *** this end,we have designed,implemented and analyzed a hybrid approach entailing convolutional neural networks(CNN)and local binary patterns(LBP).The experiments have been performed on publicly accessible datasets ISIC 2017,2018 and 2019(HAM10000)with data augmentation for in-distribution *** a novel contribution,the CNN architecture is enhanced with an intelligible layer,LBP,that extracts the pertinent visual *** of Basal Cell Carcinoma,Actinic Keratosis,Melanoma and Squamous Cell Carcinoma has been evaluated on 8035 and 3494 cases for training and testing,*** outcomes with cross-validation depict a plausible performance with an average accuracy of 97.29%,sensitivity of 95.63%and specificity of 97.90%.Hence,the proposed approach can be used in research and clinical settings to provide second opinions,closely approximating experts’intuition.

关键词： Skin cancer convolutional neural network feature extraction local binary pattern classification

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Synthesis,Characterization,Biological and Docking Simulations of 4-(Benzylideneamino) Benzoic Acids

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Chinese Journal of Structural Chemistry 2021年第3期40卷 291-300,271页

作者： HAMID Aziz AAMER saeed FARUKH Jabeen ABDUL Basit IRFAN Zia qureshi ABDUL Aziz ATIF Haroon ASHFAQ Ur Rehman Department of Chemistry Quaid-I-Azam University Islamabad 45320 Pakistan Computation ScienceResearch and Development Organization14012485 Hurontraio StreetMississaugaONCaL5A2G6 Department of Biology Laurentian University935 Ramsey Lake RoadSudburyONCanada P3E2C6 Department of Animal Sciences Quaid-I-Azam University Islamabad 45320 Pakistan Department of Microbiology Quaid-I-Azam University Islamabad 45320 Pakistan Department of Biochemistry Shankar CampusAbdul Wali Khan UniversityMardan 23200Khyber PukhtoonkhwaPakistan Department of Bioinformatics and Biostatistics Shanghai Jiaotong UniversityShanghai 200240China

The present research paper presents the synthesis, characterization, biological and computational studies of 4-(benzylideneamino) benzoic acid derivatives(3a~3g). Derivatives 3a~3c displayed best antidiabetic potential with a glucose-lowering effect compared to the reference drug Glibenclamide. Biochemical parameters including plasma glucose, serum triglycerides, cholesterol, alanine amino transferase and aspartate amino transferase levels showed significant alterations in concentrations relative to the control. Similarly, the derivatives 3a, 3d and 3e displayed potent in vitro antibacterial potential. Molecular docking simulations delineated that the ligands and complexes were stabilized at the active site by electrostatic and hydrophobic forces, consistent with the corresponding experimental results. In silico study of the binding pattern predicted that the synthesized ligands, 3d and 3a could serve as a potential surrogate for hit-to-lead generation and the design of novel antibacterial drugs.

关键词： antidiabetic biochemical cholesterol glibenclamide simulations

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Countrywide Survey for MERS-Coronavirus Antibodies in Dromedaries and Humans in Pakistan

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Virologica Sinica 2018年第5期33卷 410-417页

作者： Ali Zohaib muhammad Saqib muhammad Ammar Athar Jing Chen Awais-ur-Rahman Sial saeed Khan Zeeshan Taj Halima Sadia Usman Tahir muhammad Haleem Tayyab muhammad Asif qureshi muhammad Khalid Mansoor muhammad Ahsan Naeem Bing-Jie Hu Bilal Ahmed Khan Ikram Din Ujjan Bei Li Wei Zhang Yun Luo Yan Zhu Cecilia Waruhiu Iahtasham Khan Xing-Lou Yang muhammad Sohail Sajid Victor Max Corman Bing Yan Zheng-Li Shi CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Ctunese Academy of Sciences Beijing 100049China Faculty of Veterinary Medicine University of AgricultureFaisalabad 38040Pakistan Laboratory of Cancer Biomarkers and Liquid Biopsy College of PharmacyHenan UniversityHenan 475004China Department of Clinical Studies Faculty of Veterinary and Animal SciencesPMAS-Arid Agriculture UniversityRawalpindi 46000Pakistan Dow University of Health Science Pakistan Karachi 74200 Department of Microbiology Government College University FaisalabadFaisalabad 38000Pakistan Livestock and Dairy Development Department(L&DD) Lahore 54000Pakistan College of Veterinary and Animal Sciences The Islamia University of BahawalpurBahawalpur 63100Pakistan State Key Laboratory of Agricultural Mlcroblology Huazhong Agricultural UniversityWuhan 430070China Liaqat University of Medical and Health Science Pakistan Jamshoro 76090 Section of Epidemiology and Public Health Department of Chnical SciencesUniversity of Veterinary and Animal SciencesLahore subcampusJhang 35200Pakistan Institute of Virology Chadte-Universitatsmedizin BerlinCorporate member of Free UniversityHumboldt-University and Berlin Institute of HealthBerlin 10117Germany German Center for Infection Research(DZIF) Berlin 10117Germany

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 776) and serum (n = 1050)samples were collected from camels between November 2015 and February 2018. Samples were collected from animal markets, free-roaming herds and abattoirs. An in-house ELISA was developed to detect IgG against MERS-CoV. A total of 794 camels were found seropositive for MERS-CoV. Prevalence increased with the age and the highest seroprevalence was recorded in camels aged [ 10 years (81.37%) followed by those aged 3.1–10 years (78.65%) and B 3 years (58.19%).Higher prevalence was observed in female (78.13%) as compared to male (70.70%). Of the camel nasal swabs, 22 were found to be positive by RT-qPCR though with high Ct values. Moreover, 2,409 human serum samples were also collected from four provinces of Pakistan during 2016–2017. Among the sampled population, 840 humans were camel *** we found a high rate of MERS-CoV antibody positive dromedaries (75.62%) in Pakistan, no neutralizing antibodies were detected in humans with and without contact to camels.

关键词： Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Camel -Human Pakistan

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全球化与国家间的收入差距：来自81个国家面板数据的实证分析

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世界经济文汇 2008年第2期 28-45页

作者：万广华张藕香 Mahvash saeed qureshi 云南财经大学教授安徽农业大学管理科学学院 Mahvash saeed qureshi Trinity College University of Cambridge.

本文运用面板数据通过基于回归的不均等分解框架,研究了全球化对国家间收入差距的影响。这一框架不但可以帮助识别决定不均等的因素,还能量化这些因素对总的不均等的贡献。实证结果表明,用贸易和外商直接投资代表的全球化带来了不均等... 详细信息

本文运用面板数据通过基于回归的不均等分解框架,研究了全球化对国家间收入差距的影响。这一框架不但可以帮助识别决定不均等的因素,还能量化这些因素对总的不均等的贡献。实证结果表明,用贸易和外商直接投资代表的全球化带来了不均等的上升,而贸易对不均等的贡献要大于外商直接投资。另外,全球化指标的绝对和相对贡献一直在持续增加。有趣的是,当我们根据收入水平对样本进行分组研究时发现,在过去二十多年中,高收入组国家间的不均等基本保持稳定,而低收入组国家间的收入差距则扩大了。在贸易方式上的巨大差别可以解释低收入国家间的收入发散。

关键词：不均等基于回归的不均等分解全球化面板数据

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Study of a Stratigraphic Trap of Paleocene/Late Cretaceous Age with the Help of Seismic Data in Sulaiman Foredeep and Kirthar Foredeep Area (Central &Southern Indus Basin, Pakistan)

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International Journal of Geosciences 2014年第10期5卷 1049-1061页

作者： Shazia Asim Nasir Khan Shahid Nadeem qureshi Farrukh Hussain saeed Ahmed Bablani Department of Earth Sciences Quaid-i-Azam University Islamabad Pakistan Institute of Geophysics and Geomatics China University of Geosciences (CUG) Wuhan China Department of Metrology Comsats institute of Information Technology (CIIT) Islamabad Pakistan NREM University of Kurdistan Hewler Iraq

The Research work comprises area of Punjab Platform, Sulaiman Foredeep and Eastern Part of Sulaiman Fold Belt (from east to west), which is further extended to Zamzama and Dadu area of Lower Indus Basin. Seismic data interpretation suggests a presence of a stratigraphic trap of Paleocene/Late Cretaceous age. It can act as a stratigraphic trap of reservoir quality for hydrocarbons. This feature is marked and discussed on various seismic sections. Sometimes it is difficult to locate this feature due to effect of folding, resulting from later compressions associated with a collision of Indian Plate. This structure could be explored for a hydrocarbon prospect in future. Such stratigraphic traps were not explored in the past.

关键词： Stratigraphic Trap Shelf Margin Seismic Interpretation Central Indus Basin

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