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Open Journal of Veterinary Medicine 2015年第5期5卷 101-110页

作者： Sensuke Konno muhammad choudhury Department of Urology New York Medical College Valhalla USA

A variety of nutritional supplements are commercially available for the potential therapeutic purpose for dogs and other domestic animals with cancers. However, the efficacy of these supplements on those cancer-bearing animals has not been verified and remains uncertain, due to the lack of the sufficient scientific studies/data. To address this important issue, we examined actual anticancer effects of five selected commercial products on the two types of canine cancer models in vitro. Among them, PET-Fraction (PET-F) obtained from maitake mushroom has been shown to have potent anticancer effect on canine cancer cells. In comparison with this PET-F, possible anticancer effects of the rest of four products were examined. Two of four products were found to have the significant anticancer effects on both cancer cells, while other two products had little effects. Nevertheless, PET-F exhibited the best anticancer effect. Cell cycle analysis indicated that the PET- F-induced growth reduction was attributed to a G1 cell cycle arrest, and Western blot analysis further revealed that such a growth reduction was coupled with apoptosis. Moreover, anticancer activity of PET-F was remarkably enhanced with vitamin C, but no such synergistic effect was seen with other four products. Therefore, although two other products besides PET-F yet have anticancer activities, PET-F appears to be the most potent and promising commercial product that can be useful in effectively and safely treating canine cancers.

关键词： Canine Cancer Cells Commercial Supplements PET-Fraction Vitamin C Anticancer

Potential Anticancer Effect of Bioactive Extract of Monk Fruit (Siraitia grosvenori) on Human Prostate and Bladder Cancer Cells

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Journal of Cancer Therapy 2023年第5期14卷 211-224页

作者： Rogerio Haung Akhil Saji muhammad choudhury Sensuke Konno Department of Urology New York Medical College Valhalla USA

Prostate and bladder cancers are the two prevalent urological cancers, and several therapeutic options are currently available but the outcomes have not been satisfactory. To find the better therapeutic option, we investigated if the bioactive extracts of monk fruit, mogrosides, with potential anticancer activity might have anticancer effect against prostate and bladder cancer cells. Four of commercial products made of mogrosides known as Lakantoò (LKT) products, LK1, LK2, LLE, and MOG, were then tested. A dose-dependent study at given concentrations of four products showed that LK1 and LK2 had little effects, while LLE and MOG showed a significant cell viability reduction in both PC-3 and T24 cells. To explore the anticancer mechanism of such products, cell cycle analysis was first performed. Such analysis revealed that LLE and MOG, not LK1 and LK2, led to a G1 cell cycle arrest. Potential induction of endoplasmic reticulum (ER) stress was next examined because it is known to be linked to a cell cycle arrest. The three key regulators involved in ER stress were all up-regulated with LLE or MOG, indicating induction of ER stress. As ER stress is also known to induce apoptosis, this possibility was tested. The two apoptotic regulators were modulated in a specific manner with LLE or MOG, indicating induction of apoptosis. Lastly, to validate anticancer effect of LLE or MOG, anticancer effect of four chemotherapeutic drugs was also assessed in comparison with that of LLE/MOG. None of drugs had any effects but two products showed significant anticancer effect. In conclusion, two monk fruit products, LLE and MOG, demonstrated anticancer activity against PC-3 and T24 cells, significantly reducing cell viability and ultimately inducing apoptosis. Therefore, these two LKT products with few side effects may have clinical implications in the treatment of urological cancers.

关键词： Monk Fruit Mogroside Anticancer Prostate Cancer Bladder Cancer Lakanto

Improved Anticancer Effects on Various Cancers with Combinations of Chemotherapeutic Drugs or Vitamin C and D-Fraction

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Journal of Cancer Therapy 2013年第4期4卷 843-850页

作者： Sensuke Konno Bobby Alexander Drew Freilich muhammad choudhury Department of Urology New York Medical College Valhalla USA

Although chemotherapy is one of several therapeutic options for cancer patients, the outcomes have been less satisfactory with palpable side effects in many cases. To help improve the efficacy of chemotherapy, we examined whether D-fraction (DF), a bioactive mushroom extract, would potentiate anticancer effects of those drugs in vitro. Seven types of cancer cell lines, including breast, lung, stomach, colon, prostate, bladder, and kidney cancers, were tested with various chemotherapeutic drugs and their combinations with DF. Compared to individual drugs alone, combinations of those drugs and DF have indeed improved anticancer activity, resulting in the significant (p 0.05) cell viability reduction in all cancer cells. As vitamin C (VC) has been insinuated to potentiate bioactivity of DF, combination of DF (300 μg/ml) and VC (200 μM) was also examined. Such studies showed that DF/VC combination led to the drastic (≥90%) viability reductions in 6 cancer cells and the 70% reduction in 1 cancer cell type. These results were superior to those from combinations of drugs and DF. To assess if such a profound cell viability reduction by DF/VC combination might be attributed to apoptosis, this possibility was tested by Western blots. Analyses revealed that anti-apoptotic bcl-2 was down-regulated while pro-apoptotic Bax was up-regulated with DF/VC combination, indicating induction of apoptosis. It is plausible that DF/VC combination may induce apoptosis, resulting in the severe cell viability reduction. Therefore, DF may have a great potential as an adjuvant agent that can be combined with chemotherapeutic drugs or with VC for the improved treatment of various human malignancies.

关键词： D-Fraction Vitamin C Chemotherapy Apoptosis Human Cancers Maitake

Chemosensitizing Effect of Monk Fruit Extract on Human Bladder Cancer Cells

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Journal of Cancer Therapy 2024年第6期15卷 250-264页

作者： Sensuke Konno Jonathan Wong Andrew Penunuri Kelvin Zheng muhammad choudhury Department of Urology New York Medical College Valhalla New York USA

The outcomes of chemotherapy have been unsatisfactory with the palpable side effects. We hypothesized that natural products might help improve chemotherapy with few side effects. Recently, we came across the bioactive extracts of monk fruit (Siraitia grosvenori) with anticancer activity. We then investigated if these extracts might have chemosensitizing effect to improve the efficacy of drugs clinically used today. Four different drugs, cisplatin (CPL), carboplatin (CBL), mitomycin C (MMC), and gemcitabine (GEM), were used in this study. Human bladder cancer T24 cells were treated with each drug itself or drug combined with either LLE or MOG (two types of monk fruit extracts). Cell viability was determined to assess anticancer effect and also explored the anticancer mechanism of such combinations, focusing on the status of glycolysis, cell cycle, and chromatin structure. Cell viability test showed that all drugs had anticancer activity, reducing cell viability, but only CPL showed the enhanced anticancer effect when combined with LLE (not with MOG). The rest of three drugs had no such effects with LLE or MOG. The CPL/LLE combination was found to disrupt glycolysis, by inhibiting hexokinase activity, resulted in the decreased ATP synthesis. This combination also blocked the cell cycle progression, due to a G1 cell cycle arrest. Moreover, the two epigenetic regulators, DNA methyltransferase and histone deacetylase, were inactivated with the combination, indicating chromatin modifications. Ultimately, these treated cells were found to undergo apoptosis. In conclusion, anticancer activity of CPL can be significantly enhanced with LLE. This chemosensitizing effect is attributed to the glycolysis inhibition, a G1 cell cycle arrest, and chromatin modifications, ultimately leading to apoptosis. Thus, certain natural products such as LLE could be used as an adjuvant agent in current chemotherapy, improving the drug efficacy but minimizing side effects.

关键词： Monk Fruit Anticancer Bladder Cancer Chemosensitization Lakanto

Possible Chemosensitizing and Potent Anticancer Effects of D-Fraction in Combination with Vitamin C on Three Prevalent Urologic Cancer Cells

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Journal of Cancer Therapy 2014年第14期5卷 1402-1411页

作者： Drew Freilich Eric Moskowitz Nicholas Feuer muhammad choudhury John Phillips Sensuke Konno Department of Urology New York Medical College Valhalla USA

Chemotherapy is currently one of the most common therapeutic options for cancer patients despite the poor efficacy with considerable side effects. We then examined if D-fraction (DF), a bioactive mushroom extract, could potentiate (poor) anticancer effects of those drugs?in vitro. Three urologic cancers, prostate, bladder, and kidney cancers, were tested with various chemotherapeutic drugs and their combinations with DF. Compared to individual drugs alone, combinations of drugs and DF have improved anticancer activity, resulting in the significant (P < 0.05) cell viability reduction in all three cancer cells. As vitamin C (VC) has been postulated to potentiate the bioactivity of DF, this possibility was also examined. The specific combination of DF (300 μg/ml) and VC (200 μM) indeed led to the drastic (≥90%) viability reductions in all three cancer cells. To have a better understanding of such a profound viability reduction, the effect of DF/VC combination on cell cycle was examined next. Cell cycle analysis indicated that this combination induced a G1cell cycle arrest, which was also confirmed by the down-regulation of specific cell cycle regulators (CDK2, CDK4, and cyclin D1) detected on western blots. Moreover, it was crucial to address if the DF/VC-induced viability reduction could be also linked to apoptosis. Western blot analysis revealed that anti-apoptotic bcl-2 was down-regulated while pro-apoptotic Bax was up-regulated with DF/VC combination in all cancer cells, indicating induction of apoptosis. Therefore, the DF/VC combination could ultimately induce apoptosis, accounting for the severe cell viability reduction. In conclusion, DF appears to be a promising agent with chemosensitizing effect, enhancing the efficacy of chemotherapeutic drugs, and its combination with VC exhibits a potent anticancer effect, which is far superior to any combinations of drugs and DF tested in three prevalent urologic cancer cells.

关键词： Mushroom Extract Chemosensitizing Effect Anticancer Effect Combination Therapy Urologic Cancers

Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： Vishal Singh Arnab choudhury Hyung Jin Ahn Department of Pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

Dynamic analysis of buried pipeline with and without barrier system subjected to underground detonation

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Defence Technology（防务技术） 2023年第11期29卷 95-105页

作者： Chaidul Haque Chaudhuri Deepankar choudhury Department of Civil Engineering Indian Institute of Technology BombayMumbai400076India

Failure of pipe networks due to blast loads resulting from terrorist attacks or construction facilities, may cause economic loss, environmental pollution, source of firing or even it may lead to a disaster. The present work develops a closed-form solution of buried pipe with barrier system subjected to subsurface detonation. The solution is derived based on the concept of double-beam system. Euler Bernoulli's beams are used to simulate the buried pipe and the barrier system. Soil is idealized as viscoelastic foundation along with shear interaction between discrete Winkler springs(advanced soil model). The finite SineFourier transform is employed to solve the coupled partial differential equations. The solution is validated with past studies. A parametric study is conducted to investigate the influence of TNT charge weight, pipe material, damping ratio and TNT offset on the response of buried pipe with and without barrier system. Further a statistical analysis is carried out to get the significant soil and pipe input parameters. It is perceived that peak pipe displacements for both the cases(with and without barrier) are increases with increasing the weight of TNT charge and decreases with increasing the damping ratio and TNT offset. The deformation of pipe also varies with pipe material. Pipe safety against blast loads can be ensured by providing suitable barrier layer. The present study can be utilized in preliminary design stage as an alternative to expensive numerical analysis or field study.

关键词： Buried pipeline Subsurface detonation Analytical solution Viscoelastic foundation Protective barrier

A Batch Arrival Retrial Queue with Two Phases of Service and Bernoulli Vacation Schedule

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Acta Mathematicae Applicatae Sinica 2013年第1期29卷 15-34页

作者： Gautam choudhury Kandarpa Deka Mathematical Sciences Division Institute of Advanced Study in Science and Technology Paschim Boragaon Guwahati-781035 Assam India

We consider an MX/G/1 queueing system with two phases of heterogeneous service and Bernoulli vacation schedule which operate under a linear retrial policy. In addition, each individual customer is subject to a control admission policy upon the arrival. This model generalizes both the classical M/G/1 retrial queue with arrivals in batches and a two phase batch arrival queue with a single vacation under Bernoulli vacation schedule. We will carry out an extensive stationary analysis of the system, including existence of the stationary regime, embedded Markov chain, steady state distribution of the server state and number of customer in the retrial group, stochastic decomposition and cMculation of the first moment.

关键词： Batch arrival retrial queue two phase service linear retrial policy bernoulli admission mechanism bernoulli vacation schedule

On vector variational-like inequalities and vector optimization problems with (G, α)-invexity

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Applied Mathematics(A Journal of Chinese Universities) 2017年第3期32卷 323-338页

作者： JAYSWAL Anurag choudhury Sarita Department of Applied Mathematics Indian Institute of Technology (Indian School of Mines)Dhanbad-826004 Jharkhand India Department of Mathematics Science College (Autonomous) Hinjilicut Ganjam-761102 Odisha India

The aim of this paper is to study the relationship among Minty vector variational-like inequality problem, Stampacchia vector variational-like inequality problem and vector optimization problem involving (G, α)-invex functions. Furthermore, we establish equivalence among the solutions of weak formulations of Minty vector variational-like inequality problem, Stampacchia vector variational-like inequality problem and weak efficient solution of vector optimization problem under the assumption of (G, α)-invex functions. Examples are provided to elucidate our results.

关键词： Minty vector variational-like inequality problem Stampacchia vector variational-like inequality problem vector optimization problem (G, α)-invexity vector critical point

Analysis of Metamaterial Cloaks Using Circular Split Ring Resonator Structures

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Computers, Materials & Continua 2016年第6期52卷 133-141页

作者： Susan Thomas Balamati choudhury REVA University Bengaluru NAL Bengaluru.

A novel microwave cloak using circular split ring resonator(SRR)based metamaterial structure has been proposed in this *** cloak which operates at a frequency of 10.6 GHz is composed of cylindrical dielectric sheets printed with circular split ring resonators of spatially varying and anisotropic material *** article also focuses on the phenomenon of resonant splitting in circular SRR microwave cloak.A detailed analysis of various linear metamaterial arrays and their response has also been elucidated.

关键词： Cloaking metamaterial circular split ring resonator.