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Rethinking the Encoder-decoder Structure in Medical Image Segmentation from Releasing Decoder Structure

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Journal of Bionic Engineering 2024年第3期21卷 1511-1521页

作者： Jiajia Ni wei mu An Pan Zhengming Chen School of Artificial Intelligence Anhui Polytechnic UniversityWuhu241000China School of Information Science and Engineering HoHai UniversityChangzhou213000China

Medical image segmentation has witnessed rapid advancements with the emergence of encoder-decoder based *** the encoder-decoder structure,the primary goal of the decoding phase is not only to restore feature map resolution,but also to mitigate the loss of feature information incurred during the encoding ***,this approach gives rise to a challenge:multiple up-sampling operations in the decoder segment result in the loss of feature *** address this challenge,we propose a novel network that removes the decoding structure to reduce feature information loss(CBL-Net).In particular,we introduce a Parallel Pooling Module(PPM)to counteract the feature information loss stemming from conventional and pooling operations during the encoding ***,we incorporate a multiplexed Dilation Convolution(MDC)module to expand the network's receptive ***,although we have removed the decoding stage,we still need to recover the feature map ***,we introduced the Global Feature Recovery(GFR)*** uses attention mechanism for the image feature map resolution recovery,which can effectively reduce the loss of feature *** conduct extensive experimental evaluations on three publicly available medical image segmentation datasets:DRIVE,CHASEDB and MoNuSeg *** results show that our proposed network outperforms state-of-the-art methods in medical image *** addition,it achieves higher efficiency than the current network of coding and decoding structures by eliminating the decoding component.

关键词： Medical image segmentation Encoder-decoder architecture Attention mechanisms Releasing decoder architecture Neural network

Fatigue-crack-initiation numerical modelling of a Ni-base powder metallurgy alloy

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航空动力学报 2012年第12期27卷 2778-2785页

作者： mu, Yuan-wei Lu, Shan Zhang, Hong School of Power and Energy Northwestern Polytechnical University Xi'an 710072 China

A simplified three-dimensional numerical model was presented to simulate the micro-crack nucleation and growth to some predefined dimension(approximately 0.38 mm) on the throat surface of a Ni-base powder metallurgy(PM) *** numerical simulation of micro-crack initiation was based on the Tanaka-mura micro-crack initiation models,where individual grains of the mesoscopic model were simulated using the Voronoi *** improvements were made in the model.(1) Considering crack initiation along with 12 principal slip systems on octahedral slip planes of face centered cubic(FCC) crystal in three-dimensional(3-D) models.(2) Considering the effect of secondary phase precipitate due to impinging slip and dislocation pileup.(3) The Tanaka-mura theory of fatigue-crack-initiation from notches was applied to simulate the crack initiation from another crack tip.(4) The coalescence of random initiated micro-cracks was simulated once they intersected with each other and a macro-crack was finally *** calculated results were in good agreement with the experimental data which verified the rationality of the simulation *** applicability of the proposed model for treating fatigue-crack-initiation life in engineering structures was preliminarily achieved.

关键词：信号模拟动力系统数字化 3D模型

Gene editing in T cell therapy

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Journal of Genetics and Genomics 2017年第9期44卷 415-422页

作者： Yongping Zhang wei mu Haoyi Wang State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Department of Hematology Aerospace Center Hospital Aerospace Clinical Medical College Peking University University of Chinese Academy of Sciences

The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise. Gene editing holds tremendous potential for further improvements of T cell therapy. Here we review the applications of gene editing in various T cell therapies, focusing on antiviral strategies and cancer immunotherapies, and discuss the challenges and future prospects.

关键词： Gene editing CRISPR-Cas9 T cells

On a Solution of the Quaternion Matrix Equation X-A B=C and Its Application

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Acta Mathematica Sinica,English Series 2005年第3期21卷 483-490页

作者： Tong Song JIANG mu Sheng wei Department of Mathematics Linyi Teacher's University Linyi 276005 P. R. China Department of Computer Science and Technology Shandong University Jinan 250100 P. R. China Department of Mathematics East China Normal University Shanghai 200062 P. R. China

This paper first studies the solution of a complex matrix equation X - AXB = C, obtains an explicit solution of the equation by means of characteristic polynomial, and then studies the quaternion matrix equation X - A X B = C, characterizes the existence of a solution to the matrix equation, and derives closed-form solutions of the matrix equation in explicit forms by means of real representations of quaternion matrices. This paper also gives an application to the complex matrix equation X - AXB =C.

关键词： Quaternion matrix equation Solution Real representation

On the Block Independence in G-Inverse and Reflexive Inner Inverse of A Partitioned Matrix

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Acta Mathematica Sinica,English Series 2007年第4期23卷 723-730页

作者： Yong Hui LIU mu Sheng wei Institute of Computational Mathematics and Scientific Engineering Computing Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080 P. R. China Department of Applied Mathematics Shanghai Finance University Shanghai 201209 P. R. China Department of Mathematics East China Normal University Shanghai 200062 P. R. China

By applying the multiple quotient singular value decomposition QQQQQ-SVD, we study the block independence in g-inverse and reflexive inner inverse of 2× 2 partitioned matrices, and prove a conjecture in [Yiju Wang, S... 详细信息

关键词： G-inverse reflexive inner inverse partitioned matrices block independence QQQQQ-SVD

Mechanism involved in Danshen-induced fluid secretion in salivary glands

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World Journal of Gastroenterology 2015年第5期21卷 1444-1456页

作者： Fei wei mu-Xin wei Masataka murakami Division of Physiological Sciences School of Life ScienceGraduate University for Advanced StudiesOkazaki 444-8585Japan Department of Traditional Chinese Medicine The first Affiliated Hospital with Nanjing Medical University Division of Cellular Physiology National Institute for Physiological SciencesNational Institutes of Natural SciencesOkazaki 444-8787Japan

AIM:Danshen's capability to induce salivary fluid secretion and its mechanisms were studied to determine if it could improve ***:Submandibular glands were isolated from male Wistar rats under systemic anesthesia with pentobarbital *** artery was cannulated and vascularly perfused at a constant *** excretory duct was also cannulated and the secreted saliva was weighed in a cup on an electronic *** weight of the accumulated saliva was measured every 3 s and the salivary flow rate was *** addition,the arterio-venous difference in the partial oxygen pressure was measured as an indicator of oxygen *** order to assess the mechanism involved in Dansheninduced fluid secretion,either ouabain(an inhibitor of Na+/K+ ATPase) or bumetanide(an inhibitor of NKCC1) was additionally applied during the Danshen *** order to examine the involvement of the main membrane receptors,atropine was added to block the M3 muscarinic receptors,or phentolamine was added to block the α1 adrenergic *** order to examine the requirement for extracellular Ca2+,Danshen was applied during the perfusion with nominal Ca2+ free ***:Although Danshen induced salivary fluid secretion,88.7 ± 12.8 μL/g-min,n = 9,(the highest value around 20 min from start of DS perfusion was significantly high vs 32.5 ± 5.3 μL/g-min by carbamylcholine,P = 0.00093 by t-test) in the submandibular glands,the time course of that secretion differed from that induced by *** was a latency associated with the fluid secretion induced by Danshen,followed by a gradual increasein the secretion to its highest value,which was in turn followed by a slow decline to a near zero *** application of either ouabain or bumetanide inhibited the fluid secretion by 85% or 93%,and suppressed the oxygen consumption by 49% or 66%,*** results indicated that Danshen activates Na+/K+ ATPase and NKCC1 to maintain Cl- release and K+ r

关键词： Salivary fluid secretion Xerostomia Chinese herb D

Effects of Tebufenozide on the Biological Characteristics of Beet Armyworm (Spodoptera exigua Hübner) and Its Resistance Selection

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Agricultural Sciences in China 2008年第10期7卷 1222-1227页

作者： LIU wei-wei mu wei ZHU Bing-yu LIU Feng Key Laboratory of Pesticide Toxicology ＆ Application Technique College of Plant Protection Shandong Agricultural University Tai＇an271018 P.R.China

In this article, the selection of tebufenozide to beet armyworm （Spodoptera exigua Htibner） was studied by the treatments to alternative generations＇ 3rd-instar larvae with LC50 dose and to continuous generations＇ larvae with LC10 dose; the effects of tebufenozide on the biological characteristics of current and subsequent generations were examined by the treatments to 3rd-instar larvae and egg pods in different concentrations. After treatments with LC50 dose till F11, the toxicity of tebufenozide to beet armyworm had no significant change, whereas the pupation rate, pupal weight, and fecundity were reduced markedly. After treatments with LC10 dose till Fl9, the beet armyworm only developed 3.52-fold resistance, and the main biological characteristics were nearly accordant in each generation. The livability was reduced 72 h later after treatments to 3rd-instar larvae, respectively in 2.5-40 μg mL^-1, and larval duration, pupation rate, and pupal weight changed considerably with the increase in concentrations. The fecundity, larval livability, larval weight and pupal weight of subsequent generations were reduced as the dose increased over 10 μg mL^-1. The hatching rate of egg pods did not differ with that of the controls obviously after treatment in 10-300 μg mL^-1. But the larval livability, larval weight and pupal weight were reduced when eggs were exposed to 50 μg mL^-1 dose or more. The results indicated that tebufenozide had low resistance risk to the current and subsequent generations of beet armyworm even if tebufenozide had significant effects on the biological characteristics of this insect.

关键词： tebufenozide beet armyworm growth and development resistance selection

5'capped and 3'polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system

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Protein & Cell 2019年第3期10卷 223-228页

作者： wei mu Yongping Zhang Xutong Xue Lei Liu Xiaofei wei Haoyi Wang State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Hematology Aerospace Center HospitalAerospace Clinical Medical CollegePeking UniversityBeijing 100049China Hebei University Baoding 071002China Beijing Cord Blood Bank Beijing 100044China

Dear Editor,The clustered regularly interspaced short palindromic repeats(CRISPR)-associated(Cas)system is an adaptive immune system in a variety of bacteria and archaea(Terns and Terns,2011).The most commonly used Streptococcus pyogenes type II CRISPR-Cas9 system consists of Cas9 nuclease and two short RNAs,crRNA and tracrRNA,which can be linked together forming one chimeric single guide RNA(sgRNA)(Jinek et al.,2012).

关键词： Editor CRISPR Cas

On the Structure of the Arginine-carboxylate Salt Bridge:A Density Functional Theory Study

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Chinese Chemical Letters 2001年第3期12卷 219-222页

作者： Ting wei mu Yong FENG Lei LIU Qing Xiang GUO Department of Chemistry University of Science and Technology of ChinaHefei 230026

High level density functional theory (DFT) calculations are performed for the first time to answer the question whether the arginine-carboxylate salt bridge stays in a zwitterionic state or a neutral one. The results indicate that in the gas phase, the neutral form is more stable and hence proton transfer occurs from guanidinium to carboxylate. However, in an aqueous solution the zwitterionic form should be favored. The difference might he caused by the electrostatic interaction between the salt bridge and its molecular environment. Therefore, the solvation effect has to be considered in the modeling of proteins, whose stabilization depends heavily on the salt-bridges.

关键词： Arginine-carboxylate interaction salt bridge DFT proton transfer solvation effect