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Association between Uric Acid and Metabolic Syndrome in Homozygous Sickle Cell Patients

Advances in Biological Chemistry 2021年第3期11卷 142-148页

作者： Kandji Pape Matar Djite moustapha Barry Nene Oumou Kesso Sagne Rene Ngor Thioune Ndeye Mareme Mbacke Ndoumbé Mame Ndour El Hadji Malick Gueye-Tall Fatou Lopez-Sall Philomene cisse Aynina Diop Pape Amadou Gueye Papa Madieye Laboratory of Biochemistry-Hematology National University Hospital of Fann Dakar Senegal Laboratory of Pharmaceutical Biochemistry Faculty of Medicine Pharmacy Cheikh Anta Diop University Dakar Senegal

The objective of this study was to assess the association between uric acid and the metabolic syndrome and its components in homozygous sickle cell patients. This is a prospective case/control study of sickle cell SS patients. Each patient was matched to a control of the same sex and age ± 2 years. In our framework, we used the criteria for defining metabolic syndrome according to International Diabetes Federation (IDF) 2009. Assay of all biological parameters was performed with the ARCHITECT ci4100, Abbot (Chicago, Illinois, USA). Data were collected with Excel 2016 software and statistical analysis was done using XLSTAT 2019 software. Student’s T test was used to compare means and a p-

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Prolactin Adenomas in Senegal: Epidemiological, Diagnostic and Therapeutic Aspects of 89 Cases

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Open Journal of Internal Medicine 2023年第3期13卷 209-217页

作者： Michel Assane Ndour Demba Diédhiou Djiby Sow Boundia Djiba Mouhamed Dieng Ibrahima Mané Diallo Fatou Kiné Gadji Julie Borges Muriel Diembou Fama Mody Ndiaye El Hadj mouhamadou moustapha Thioye Charles Halim Philippe Moreira Anna Sarr Maïmouna Ndour Mbaye Medical Clinic II Abass Ndao Hospital Center Cheikh Anta Diop University Dakar Senegal

Introduction: In Senegal, there is very little data on prolactinomas despite their negative impact on couples fertility. Patients and methods: This was a multicentre, retrospective, descriptive, analytical study conducted from 1 January 2008 to 31 December 2022 in the neurosurgery departments of the Fann and Principal hospitals and the endocrinology department of the Abass Ndao Hospital. Results: We included 89 patients, representing a prevalence of 36.7% among all cases of pituitary adenoma. The mean age was 35.6 ± 10 years and the sex ratio was 0.34. The mean time to consultation was 27.1 ± 29 months. Clinical symptoms were dominated by gonadotropic disorders represented by galactorrhoea (71 cases, 79.8%), amenorrhoea (61 cases, 68.5%), and infertility in the couple (31 cases, 34.8%). Fifty-seven (58) patients presented with a tumour syndrome (65.2%, including 57 cases of headache (64%), 34 cases of visual disorders (38.2%) and 8 patients with a dysmorphic syndrome (8.9%). Imaging revealed a macroadenoma in 68.5% (61 cases) and extension of the adenoma in 11 patients (12.4%). The hormonal profile was isolated lactotropic hypersecretion (80 cases, 89.9%) and mixed in 9 cases (including concomitant secretion of GH in 8 cases and ACTH in 1 case). All patients had initially benefited? from dopaminergic agonist-based medical treatment. Pituitary surgery was effective in 45 patients (50.6%), including 44 cases by transsphenoidal approach. Postoperative incidents included transient diabetes insipidus (77.7%) and cerebrospinal fluid leakage (20%). We noted 7 cases (7.9%) of death presenting with a tumour syndrome (100%), a macro-adenoma (85.7%), having undergone pituitary surgery (42.9%). The factors significantly associated with prolactinoma were young age (p Conclusion: This series also demonstrates the impact of prolactin adenomas on reproductive function. Delayed diagnosis explains the predominance of macroadenomas, which are a source of pre- and post-operative compli

关键词： Prolactinoma Fertility Disorders Tumour Syndrome Pituitary Adenomas

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Profile of Female Hyperandrogenism at the Medical Clinic II: About 19 Cases

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Open Journal of Endocrine and Metabolic Diseases 2023年第5期13卷 63-74页

作者： Michel Assane Ndour Demba Diédhiou Djiby Sow Ibrahima Mané Diallo Mouhamed Dieng Fatou Gueye Astou Mbodj Julie Borges Preira Fatou Kiné Gadji Muriel Diembou Fama Ndiaye El Hadj mouhamadou moustapha Thioye Charles Halim Anna Sarr Maïmouna Ndour Mbaye Internal Medicine Department Abass Ndao Hospital Cheikh Anta Diop University of Dakar Dakar Senegal

Introduction: Female hyperandrogenism is essentially manifested by hirsutism. It is present in Senegal but not yet elucidated for lack of data. This is why we proposed to study the profile of hyperandrogenism in our context. Patients and Methods: This was an observational, cross-sectional cohort study of 19 patients of reproductive age followed for hyperandrogenism at the Medical Clinic II of Abass Ndao Hospital, from November 1st, 2019 to August 31st, 2021. Results: Our cohort consisted of women with an average age of 25.3 years, single (73.7%), with a low socioeconomic level (42.1%). A family history of hirsutism was found in 31.6% of cases. The main reasons for consultation were a menstrual cycle disorder in 94.7% of cases, and hirsutism in 78.9% of cases. The latter was post-pubertal (66.7%), with a slow or progressive evolution. The physical examination revealed: hirsutism (100%) with an average modified Ferriman Gallwey score (mFG) of 8.9 ± 5.8, acne (36.8%), hyperseborrhea (57.9%), major signs of virilization (10.5%), acanthosis nigricans (47.4%) and galactorrhea (5.3%). Hormonal explorations revealed an elevation of: testosterone (31.6%), 17-hydroxyprogesterone (5.3%), dihydrotestosterone (31.6%), and prolactin (10.5%). The ovarian morphology was micropolycystic (84.2%). The etiological profile corresponded to polycystic ovarian syndrome or PCOS (68.4%), ovarian hyperthecosis (10.5%), hyperprolactinemia (10.5%), congenital adrenal hyperplasia or CAH (5.3%). Idiopathic hirsutism was found in 5.3% of cases. Conclusion: Female hyperandrogenism is a less frequent reason for consultation in endocrinology. It deserves to be further evaluated in a large-scale study focused on epidemiological, clinico-biological and etiological investigation, in order to assess its prevalence and better define its profile in our context.

关键词： Female Hyperandrogenism Hirsutism Senegal

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Energy Analysis of a Counter-Flow Plate Heat Exchanger Working in Stationary Mode and Using Geothermal Energy for Drying

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材料科学与工程（中英文A版） 2019年第2期9卷 64-74页

作者： Jean Pierre Tine Biram Dieng mouhamadou Lamine cisse Marie Pascaline Sarr Renewable Energy Research Team Materials and Laser Department of Physic UFR SATIC University Alioune DIOP of Bambey (UADB) Bambey 21400 BP30 Senegal

This paper presents an energy analysis of a counter-flow plate heat exchanger operating in stationary mode. The exchanger comprises a rectangular plate of which we vary the heat transfer surface (by fixing its width and varying its length) and analyze the evolution of some parameters as a function of this heat transfer surface. The parameters to be analyzed are the NTU (number of transfer units), the effectiveness, the temperatures of both primary and secondary fluids and the heat flux. The analysis carried out will help understand the behavior of the counter-flow plate heat exchanger operating in stationary mode. Then, the heat transfer surface of the exchanger is determined for the sizing of a counter-flow plate heat exchanger intended to produce hot air for drying. That plate heat exchanger uses water vapor heated by geothermal energy as a primary fluid and atmospheric air as a secondary fluid. The products to be dried are onions with a mass flow of water to be evacuated of 100 kg/h.

关键词： Exchanger flux temperature geothermal stationary mode

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Chest Trauma at the Emergency Department of the Gabriel TouréUniversity Hospital Bamako, Mali

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Open Journal of Emergency Medicine 2021年第2期9卷 18-24页

作者： Almeimoune Abdoulhamidou Diop Madane Thierno Mangane moustapha Démbele Seidou Alaji Coulibaly Mahamadoun Sogoba Youssouf Abdoulaye Chiad Mahamadoun cisse Harouna Sangare Sidy Yattara Ogalat Enyengue Murielle Ingrid Kassogue André Diallo Boubacar Amadou Bah Madiassa Konaté Yoro B. Sidibe Diango Djibo Mahamane Department of Anesthesia Resuscitation and Emergency Medicine at CHU Gabriel Toure Bamako Mali Bamako Faculty of Medicine and Odontostomatology Bamako Mali Resuscitation Anesthesia Service CHU IOTA Bamako Mali Anesthesia and Intensive Care Unit CHU Luxembourg Bamako Mali Neurosurgery Department The Gabriel Touré University Hospital Bamako Mali Emergency Department The Hospital of Mali Bamako Mali Department of Anesthesia Resuscitation and Emergency Medicine at CHU Point G Bamako Mali General Surgery Department The University Hospital of Gabriel Toure Bamako Mali

In Mali, chest injuries remain a real public health problem and are associated with heavy morbidity and mortality. Faced with a resurgence of urban civil violence and the explosion of road accidents, we decided to conduct this study in order to describe the epidemiological, clinical and therapeutic aspects of thoracic trauma in the emergency department. Method and Material: This is a descriptive prospective study over a period of one year in the emergency department of the CHU Gabriel Touré. Including all patients admitted for thoracic trauma. Analysis and Entry: Data were entered and analyzed on SPSS software version 20.0. The test was significant for a p value Results: We recorded 21,090 appeals in our structure among which 1284 patients were suspected of thoracic trauma. The diagnosis of thoracic trauma was retained in 119 (0.56%) patients. All patients were transported to the emergency room without prehospital medicalization. Clinical presentation was dominated by dyspnea in 54.6% of patients, however pain was the almost constant symptom in conscious victims. Various traumatic mechanisms had caused these lesions of the thorax, of which road traffic accidents represented half of the causes, followed by urban civil violence in 28.6% of patients. Landslides and falls from a great height were responsible for 19.5% of chest injuries. Open chest trauma was the type of lesion found in a third of the cases. This type of injury was exclusively due to blows and injuries during the brawls. Standard chest radiography was performed as the first intention in 60% of patients compared to 10.9% for the pleuropulmonary ultrasound. Thirteen patients required ventilatory assistance after orotracheal intubation. The average length of stay was 65.23 hours. During the period of our study, the overall mortality was 1.85% in the emergency departments with a lethality specific to chest trauma of

关键词： Chest Trauma Emergencies Bamako Mali

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Evaluation of Kidney Function in Patients with COVID-19 at the Epidemiological Treatment Centre in CHNU Fann

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Advances in Biological Chemistry 2023年第1期13卷 17-24页

作者： Thioune Ndeye Mareme Kandji Pape Matar Djite moustapha Barry Nene Oumou Kesso Zaamoumi Bassma Kane Mame Coumba Diagne Bineta Mbacke Mame Ndoumbé Sagne René Ngor Ndour El Hadji Malick Gueye-Tall Fatou Lopez-Sall Philomene cisse Aynina Diop Pape Amadou Gueye Papa Madieye Laboratory of Biochemistry-Hematology National University Hospital of Fann Dakar Senegal Laboratory of Pharmaceutical Biochemistry Faculty of Medicine Pharmacy Cheikh Anta Diop University Dakar Senegal

Alteration of renal function during SARS-CoV-2 infection is frequent and is associated with excess mortality. It is multifactorial, involving mechanisms more specific to COVID-19: viral invasion, endothelitis and thrombosis, activation of the renin-angiotensin-aldosterone system, and elevation of pro-inflammatory cytokines. Thus, the objective of this work was to assess renal function in patients with moderate and severe forms of COVID-19. This was a prospective cross-sectional study of patients with COVID-19. The parameters studied were age, sex, uremia, creatinine and glomerular filtration rate (GFR). All biological parameters were measured with the A15 Biosystems automated system (Barcelona, Spain) and the GFR was calculated according to the MDRD formula. Data processing was carried out with the SPSS (Statistical Package for Social Sciences) software version 23. Our study population consisted of 192 subjects with COVID-19, of which 111 were moderate and 81 were severe. The mean age of our subjects was 60 years and a sex ratio of 1.02. GFR assessment showed that 28% of the population had a lowered GFR (2). Analysis of the results according to the clinical forms showed frequencies of 19% of disturbance of renal function for the moderate forms against 40% for the severe forms. Impaired renal function appears to be frequent in patients with severe SARS-CoV-2 infection and is associated with a bad prognosis. Any patient hospitalized with SARS-CoV-2 should benefit from an initial nephrological assessment which could be used as a marker to dictate the prognosis of the severity of COVID-19.

关键词： COVID-19 CTE GFR Renal Function SARS-CoV-2

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Renewable Energy Powered Membrane Process for Removal of Excess Fluoride Ions and Safe Drinking Water Supply in Rural Areas in Senegal

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Journal of Environmental Science and Engineering(B) 2022年第6期11卷 241-247页

作者： Mohamad moustapha Dieme Saidou Nourou Diop mouhamadou Abdoulaye Diallo Amadou Dieye Amadou Lamine Diouf Courfia Kéba Diawara UFR Sciences et Technologies Universitéde Ziguinchor B.P 523 ZiguinchorSenegal Facultédes Science Technique UniversitéCheikh Anta DIOPB.P 5005 Dakar-FannSenegal

The analysis results made on drinking water from the rural areas of Kaolack,Diourbel and Fatick central region of Senegal showed the excess of fluoride and chloride *** on the area,the fluoride concentration in the water can reach 3.5 mg/*** values obtained are completely above of WHO(World Health Organization)*** objective of this study is to assess the performances of membrane filtration units powered by renewable energies for fluoride and salinity excess removal in remote village in *** membrane filtration units have been installed in rural areas of regions such as Kaolack,Fatick and *** membrane filtration units are equipped by the LPRO(Low Pressure Reverse Osmosis)membranes with 9 m^(2)of surface.A rejection rate of fluoride and chloride ions obtained is 99.33%and 95.25%*** conversion rates are ranged from 45%to 65%.These results clearly show that membrane processes can be used in Africa,especially in isolated rural areas,with the combination of renewable ***,more than twenty membrane filtration units are installed in Senegal and provide drinking water of very good quality for populations living in rural *** prospect is to expand it on a larger scale,which is already underway,with the construction of a desalination plant in Dakar.

关键词： Fluoride renewable energy LPRO membrane drinking water rural areas

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