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In situ synthesis of chemically bonded NaTi2（PO4）3/rGO 2D nanocomposite for high-rate sodium-ion batteries

Nano Research 2016年第6期9卷 1844-1855页

作者： Ha-Kyung Roh hyun-Kyung Kim Myeong-Seong Kim Dong-hyun Kim Kyung Yoon chung Kwang Chul Roh Kwang-Bum Kim Department of Material Science & Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou103722 Republic of Korea Department of Materials Science and Metallurgy University of Cambridge 27 Charles Babbage Road Cambridge CB30FS UK Center for Energy Convergence Korea Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seou102792 Republic of Korea Energy & Environmental Division Korea Institute of Ceramic Engineering & Technology 101 Soho-ro Jinju-si Gyeongsangnam-do 52851 Republic of Korea

A phase-pure NaTi2（PO4）3/reduced graphene oxide （rGO） nanocomposite was prepared using a microwave-assisted one-pot method and subsequent heat treatment. The well-crystallized NaTi2（PO4）3 nanoparticles （30-40 nm） were uniformly precipitated on rGO templates through Ti-O-C bonds. The chemical interactions between the NaTi2（PO4）3 nanoparticles and rGO could immobilize the NaTi2（PO4）3 nanoparticles on the rGO sheets, which might be responsible for the excellent electrochemical performance of the nanocomposite. The NaTi2（PO4）B/rGO nanocomposite exhibited a specific capacity of 128.6 mA-h.g-1 approaching the theoretical value at a 0.1 C-rate with an excellent rate capability （72.9% capacity retention at 50 C-rate） and cycling performance （only 4.5% capacity loss after 1,000 cycles at a high rate of 10 C）. These properties were maintained even when the electrodes were prepared without the use of an additional conducting agent. The excellent sodium storage properties of the NaTi2（PO4）B/rGO nanocomposite could be attributed to the nano-sized NaTi2（PO4）3 particles, which significantly reduced the transport lengths for Na＋ ions, and an intimate contact between the NaTi2（PO4）3 particles and rGO due to chemical bonding.

关键词： NaTi2(PO4)dreducedgraphene oxide (rGO)nanocomposite chemical bonding energy-efficiency in situ synthesis high-rate sodium-ion batteries

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Effects of oxygen concentration and flow rate on cognitive ability and physiological responses in the elderly

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Neural Regeneration Research 2013年第3期8卷 264-269页

作者： hyun-Jun Kim hyun-Kyung Park Dae-Woon Lim Mi-hyun Choi hyun-Joo Kim In-Hwa Lee hyung-Sik Kim Jin-Seung Choi Gye-Rae Tack Soon-Cheol chung Department of Obstetrics & Gynecology Konkuk University Department of Laboratory Medicine Seoul Clinical Laboratories Department of Information & Communication Engineering Dongguk University Department of Biomedical Engineering Research Institute of Biomedical EngineeringCollege of Biomedical & Health ScienceKonkuk University

The supply of highly concentrated oxygen positively affects cognitive processing in normal young adults. However, there have been few reports on changes in cognitive ability in elderly subjects following highly concentrated oxygen administration. This study investigated changes in cognitive ability, blood oxygen saturation （%）, and heart rate （beats/min） in normal elderly subjects at three different levels of oxygen [21% （1 L/min）, 93% （1 L/min）, and 93% （5 L/min）] administered during a 1-back task. Eight elderly male （75.3 ＋ 4.3 years old） and 10 female （71.1 ＋ 3.9 years old） subjects, who were normal in cognitive ability as shown by a score of more than 24 points in the Mini-Mental State Examination-Korea, participated in the experiment. The experiment consisted of an adaptation phase after the start of oxygen administration （3 minutes）, a control phase to obtain stable baseline measurements of heart rate and blood oxygen saturation before the task （2 minutes） and a task phase during which the 1-back task was performed （2 minutes）. Three levels of oxygen were administered throughout the three phases （7 minutes）. Blood oxygen saturation and heart rate were measured during each phase. Our results show that blood oxygen saturation increased, heart rate decreased, and response time in the 1-back task decreased as the concentration and amount of administered oxygen increased. This shows that administration of sufficient oxygen for optimal cognitive functioning increases blood oxygen saturation and decreases heart rate.

关键词： neural regeneration clinical practice highly concentrated oxygen cognitive task 1-back task cognitive ability blood oxygen saturation heart rate physiological responses elderly grant-supported paper neuroregeneration

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SlowFast Based Real-Time Human Motion Recognition with Action Localization

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Computer Systems Science & Engineering 2023年第11期47卷 2135-2152页

作者： Gyu-Il Kim hyun Yoo Kyungyong chung Department of Computer Science Kyonggi UniversitySuwon16227Korea Contents Convergence Software Research Institute Kyonggi UniversitySuwon16227Korea Division of AI Computer Science and Engineering Kyonggi UniversitySuwon16227Korea

Artificial intelligence is increasingly being applied in the field of video analysis,particularly in the area of public safety where video surveillance equipment such as closed-circuit television(CCTV)is used and automated analysis of video information is ***,various issues such as data size limitations and low processing speeds make real-time extraction of video data *** analysis technology applies object classification,detection,and relationship analysis to continuous 2D frame data,and the various meanings within the video are thus analyzed based on the extracted basic *** recognition is key in this *** recognition is a challenging field that analyzes human body movements,requiring the interpretation of complex movements of human joints and the relationships between various *** deep learning-based human skeleton detection algorithm is a representative motion recognition ***,motion analysis models such as the SlowFast network algorithm,have also been developed with excellent ***,these models do not operate properly in most wide-angle video environments outdoors,displaying low response speed,as expected from motion classification extraction in environments associated with high-resolution *** proposed method achieves high level of extraction and accuracy by improving SlowFast’s input data preprocessing and data structure *** input data are preprocessed through object tracking and background removal using YOLO and DeepSORT.A higher performance than that of a single model is achieved by improving the existing SlowFast’s data structure into a frame unit *** on the confusion matrix,accuracies of 70.16%and 70.74%were obtained for the existing SlowFast and proposed model,respectively,indicating a 0.58%increase in *** detection,based on behavioral classification,the existing SlowFast detected 2,341,164 cases,whereas the proposed model detected 3,11

关键词： Artificial intelligence convolutional neural network video analysis human action recognition skeleton extraction

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Multicenter phase Ⅱ trial of modified FOLFIRINOX in gemcitabine-refractory pancreatic cancer

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World Journal of Gastrointestinal Oncology 2018年第12期10卷 505-515页

作者： moon Jae chung Huapyong Kang Ho Gak Kim Jong Jin hyun Jun Kyu Lee Kwang Hyuck Lee Myung Hwan Noh Dae Hwan Kang Sang Hyub Lee Seungmin Bang 无 Division of Gastroenterology Department of Internal Medicine Yonsei University College of Medicine Seoul 03722 South Korea Department of Internal Medicine Daegu Catholic University School of Medicine Daegu 42471 South Korea Department of Internal Medicine Korea University Ansan Hospital Korea University College of Medicine Ansan 15355 South Korea Department of Internal Medicine Dongguk University Ilsan Hospital Dongguk University College of Medicine Goyang 10326 South Korea Division of Gastroenterology Department of Internal Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 06351 South Korea Department of Internal Medicine Dong-A University College of Medicine Busan 49201 South Korea Department of Internal Medicine Medical Research Institute Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 50612 South Korea Departments of Internal Medicine and Liver Research Institute Seoul National University Hospital Seoul National University College of Medicine Seoul 03080 South Korea Pancreatobiliary Cancer Study Group of Korean Society of Gastrointestinal Cancer

AIM To evaluate the efficacy and safety of modified FOLFIRINOX as a second-line treatment for gemcitabine(GEM)-refractory unresectable pancreatic cancer(PC).METHODS This study was a prospective, multicenter, one-arm, open-label, phase Ⅱ trial. Patients with unresectable PC, who showed disease progression during GEMbased chemotherapy were enrolled. All patients were administered FOLFIRINOX with reduced irinotecan and oxaliplatin(RIO; irinotecan 120 mg/m^2 and oxaliplatin 60 mg/m^2), which was set according to the phase Ⅰ study of FOLFIRINOX. The objective response rate(ORR), disease control rate(DCR), progressionfree survival(PFS), overall survival(OS), adverse events were evaluated. Additionally, changes in quality of life(QoL) were assessed using a questionnaire on *** Between August 2015 and May 2016, a total of 48 patients were enrolled. The median follow-up time was 259 d with a median of 8.5 cycles. The ORR and DCR were 18.8% and 62.5%, respectively, including one patient who showed complete remission. The median PFS was 5.8 mo [95% confidence interval(CI): 3.7-7.9] and median OS was 9.0 mo(95%CI: 6.4-11.6). Neutropenia(64.6%) was the most common grade 3-4 adverse event, followed by febrile neutropenia(16.7%). Although 14.6% of patients experienced grade 3 fatigue, most non-hematologic AEs were under grade 2. In the QoL analysis, the global health status score before treatment was not different from the score at the last visit after treatment(45.43 ± 22.88 vs 48.66 ± 24.14, P = 0.548).CONCLUSION FOLFIRINOX with RIO showed acceptable toxicity and promising efficacy for GEM-refractory unresectable PC. However, this treatment requires careful observation of treatment-related hematologic toxicities.

关键词： Pancreatic cancer FOLFIRINOX Clinical Trial, Phase Ⅱ Chemotherapy Gemcitabine refractory

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FOLFIRINOX vs gemcitabine/nab-paclitaxel for treatment of metastatic pancreatic cancer: Single-center cohort study

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World Journal of Gastrointestinal Oncology 2020年第2期12卷 182-194页

作者： In Rae Cho Huapyong Kang Jung hyun Jo Hee Seung Lee moon Jae chung Jeong Youp Park Seung Woo Park Si Young Song Chansik An Mi-Suk Park Seungmin Bang Department of Internal Medicine International Saint Mary’s HospitalCatholic Kwandong University College of MedicineIncheon 22711South Korea Department of Medicine Yonsei University Graduate School50-1 Yonsei-roSeoul 03722South Korea Division of Gastroenterology Department of Internal MedicineYonsei University College of Medicine50-1 Yonsei-roSeoul 03722South Korea Department of Radiology Yonsei University College of Medicine50-1 Yonsei-roSeoul 03722South Korea

BACKGROUND FOLFIRINOX and gemcitabine plus nab-paclitaxel(Gem+nabPTX)were recently introduced for metastatic pancreatic cancer ***,studies that compared these two regimens and studies in Asian populations are *** To compare the treatment outcomes of FOLFIRINOX and Gem+nabPTX regimen for metastatic pancreatic cancer treatment in Korean *** Patients with metastatic or recurrent pancreatic cancer treated with FOLFIRINOX(n=86)or Gem+nabPTX(n=81)as the first-line since January 2015 were identified using the Severance Hospital Pancreatic Cancer Cohort *** efficacy,treatment-related adverse events and economic aspects were *** Patients in the FOLFIRINOX group were significantly younger(54 vs 65 years;P<0.001)and had better performance statuses at *** median overall survival(10.7 vs 12.1 mo;P=0.157),progression-free survival(8.0 vs 8.4 mo;P=0.134),and objective response rates(33.7%vs 46.9%;P=0.067)were not significantly different when compared with Gem+nabPTX ***≥3 neutropenia and gastrointestinal adverse events were more common in the FOLFIRINOX *** drug costs of both regimens were *** Treatment efficacy and economic burdens were comparable between the two ***,the details of adverse event were ***+nabPTX regimen might be considered preferentially in certain conditions.

关键词： Pancreatic cancer Chemotherapy FOLFIRINOX Gemcitabine Nabpaclitaxel Survival

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Diverse Functions of VDUP1 in Cell Proliferation,Differentiation,and Diseases

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Cellular & Molecular Immunology 2007年第5期4卷 345-351页

作者： Sang Yong Kim hyun-Woo Suh Jin Woong chung Suk-Ran Yoon Inpyo Choi Stem Cell Research Center Korea Research Institute of Bioscience and BiotechnologyYusongTaejon 305-333Republic of Korea

Vitamin D3 up-regulated protein 1 （VDUP1） is a multifunctional protein involved in maintaining cellular homeostasis. VDUP1 is induced by a variety of stresses. Inversely, VDUP1 is often reduced in various tumor tissues and cell lines. Over-expression of VDUP1 inhibits cell proliferation through cell cycle arrest. VDUP1 interacts with thioredoxin （Trx） and negatively regulates the expression and antioxidant function of Trx which is involved in redox regulation. VDUP1/ mice are more susceptible to carcinogenesis than wild-type mice and are defective in establishing immune system induding the development and function of natural killer cells. Furthermore, VDUP1^-/- mice show impaired Kreb cycle-mediated fatty acid utilization. In this review, we have discussed the multifunctional roles of VDUP1 in diverse cellular responses, in particular its relation to proliferation, apoptosis, differentiation, and diseases such as cancer and stress-related diseases.

关键词： VDUP1 thioredoxin proliferation immune cell

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Evaluation of Pre-Emergence and Post-Emergence Herbicides for Weed Management in Miscanthus sacchariflorus and Miscanthus sinensis

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Phyton-International Journal of Experimental Botany 2023年第5期92卷 1439-1467页

作者： Bimal Kumar Ghimire Chang Yeon Yu Seung hyun Kim Ill Min chung Department of Crop Science College of Sanghuh Life ScienceKonkuk UniversitySeoul05029Korea Bioherb Research Institute Kangwon National UniversityChuncheon24341Kore

Miscanthus,is a promising bioenergy crop,considered superior to other bioenergy crops because of its higher water and nutrient use efficiency,cold tolerance,and higher production of *** weeds and grass weeds,cause major problems in the Miscanthus field.A field experiment was conducted in 2018 and 2019,to assess the effects of pre-emergence(alachlor and napropamide)and post-emergence herbicides(nicosulfuron,dicamba,bentazon,and glufosinate ammonium)on broadleaf and grass weeds in *** and *** *** weed control efficiency and phytotoxicity of pre-and post-emergence herbicides were evaluated at 30 days after treatment(DAT)and compared to those of the control *** results showed wide variations in the susceptibility of the weed species to the treated *** with nicosulfuron 40 ***^(-1) provided the most effective overall weed control(with 10%visual injury),without affecting the height and biomass of neither Miscanthus species in the ***-emergence herbicides such as glufosinate ammonium 400 ***^(-1) and dicamba 482 ***^(-1) were effective and inhibited the growth and density of the majority of weeds to a 100%;however,they showed significant phytotoxicity(toxicity scale of 1-10)to both species of *** application of glufosinate ammonium caused severe injuries to the foliar region(90%visual injury)of both Miscanthus ***,*** showed a slightly higher tolerance to the herbicides nicosulfuron,bentazon and napropamide with 10%visual injury at the recommended dose than *** present study clearly showed that infestation of broadleaf and grass weeds in Miscanthus fields can cause significant damage to the growth and biomass of Miscanthus and applying pre-emergence and post-emergence herbicides effectively controls the high infestation of these weeds.

关键词： miscanthus herbicides weeds biomass chlorophyll visual injury

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Biliary reflux detection in anomalous union of the pancreaticobiliary duct patients

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World Journal of Gastroenterology 2012年第9期18卷 952-959页

作者： Suk Keu Yeom Seung Wha Lee Sang Hoon Cha Hwan Hoon chung Bo Kyung Je Baek hyun Kim Jong Jin hyun Department of Radiology Korea University Ansan Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalGyeonggi-do 425-707South Korea

AIM： To demonstrate the imaging findings of biliopan creatic and pancreatico-biliary reflux in patients with anomalous union of the pancreatico biliary duct （AUPBD） on gadoxetic acidenhanced functional magnetic res... 详细信息

关键词： Bile reflux Choledochal cyst Encoscopicretrograde cholangio-pancreatography Gadolinium-eth-oxybenzyl-diethylenetriamine penta-acetic acid Magneticresonance imaging

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Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages

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International Journal of Oral Science 2018年第3期10卷 190-196页

作者： Yuri Song Hee Sam Na Eunjoo Park Mi Hee Park hyun Ah Lee Jin chung Department of Oral Microbiology School of Dentistry Pusan National University Institute of Translational Dental Sciences Pusan National University

Streptococcus mutans(S. mutans), a major aetiologic agent of dental caries, is involved in systemic diseases, such as bacterial endocarditis, if it enters the bloodstream through temporary bacteraemia. Interleukin(IL)-1β, a proinflammatory cytokine, is related to the host defences against pathogens, and its synthesis, maturation, and secretion are tightly regulated by the activation of the inflammasome, an inflammatory signalling complex. This study examined the signalling mechanism of IL-1β secretion and the inflammasome pathway induced by S. mutans to explain the molecular mechanism through which systemic infection by oral streptococci can occur. After infection of THP-1 cells with S. mutans, the expression of inflammasome components was detected using various methods. S. mutans induced IL-1β secretion via caspase-1 activation, and S. mutans-induced IL-1β secretion required absent in melanoma(AIM2), NLR family pyrin domain-containing 3(NLRP3) and NLR family CARD domain-containing 4(NLRC4)inflammasome activation. In particular, the S. mutans-induced NLRP3 inflammasome was mediated by adenosine triphosphate(ATP) release, potassium depletion and lysosomal damage. Our study provides novel insight into the innate immune response against S. mutans infection.

关键词： NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages THP Streptococcus mutans activates the AIM2 AIM

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Development of RuS_(2) for near-infrared photodetector by atomic layer deposition and post-sulfurization

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Rare Metals 2022年第9期41卷 3086-3099页

作者： Tatsuya Nakazawa Donghyun Kim Jaehyeok Kim Yohei Kotsugi Taehoon Cheon Seung-Min chung Soo-hyun Kim hyungjun Kim School of Electrical and Electronic Engineering Yonsei UniversitySeoul03722Korea Isehara Technical Center Metallic Materials Development DepartmentTANAKA Kikinzoku Kogyo K.KIseharaKanagawa259-1146Japan Institute of Materials Technology Yeungnam UniversityGyeongsan-si38541GyeongbukKorea Chemical Materials Development Department TANAKA Kikinzoku Kogyo K.KTsukuba Technical CenterIbaraki300-4247Japan School of Materials Science and Engineering Yeungnam UniversityGyeongsan-si38541GyeongbukKorea Center for Core Research Facilities Daegu Gyeongbuk Institute of Science&TechnologyDaegu711-873Korea

The chalcogenides of platinum-group metals(PGMs)have been known to be present in minerals and the intermediate products of *** recent years,their applications in various fields,including catalysis,have been *** that certain PGM chalcogenides behave as compound semiconductors,they can be used as materials for *** this study,RuS_(2),featuring a bandgap suitable for near-infrared photodetectors,was prepared by forming Ru on a SiO_(2)/Si substrate via the atomic layer deposition method using[Ru(TMM)(CO)_(3)]as the *** was conducted at 800℃ for 1 h under H_(2)S ***-resolution transmission electron microscopy(HRTEM)and X-ray diffraction(XRD)analysis clearly confirmed that the as-deposited hexagonal close-packed(hcp)Ru transformed to cubic RuS_(2) after *** surface morphologies,chemical states,and electrical and optical properties of RuS_(2) were *** influence of the metallic Ru surface morphology prior to sulfurization on the reaction between Ru and H_(2)S was also *** evaluate the potential of using RuS_(2) as a photodetector,a photodetector was fabricated by forming electrodes on RuS_(2) to measure its photocurrent under near-infrared ***,RuS_(2) was proven to exhibit a short response time(59μs)and generate a photocurrent of 84 nA under near-infrared light at 940 nm.

关键词： RuS_(2) Sulfurization Atomic layer deposition Photodetector

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