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Incidental biliary dilation in the era of the opiate epidemic:High prevalence of biliary dilation in opiate users evaluated in the Emergency Department

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World Journal of Hepatology 2020年第12期12卷 1289-1298页

作者： monique t barakat Subhas Banerjee Divisions of Adult and Pediatric Gastroenterology and Hepatology Stanford University Medical CenterStanfordCA 94305United States Division of Gastroenterology and Hepatology Stanford University Medical CenterStanfordCA 94304United States

BACKGROUND Biliary dilation is frequently related to obstruction;however,non-obstructive factors such as age and previous cholecystectomy have also been *** the past two decades there has been a dramatic increase in opiate use/dependence and utilization of cross-sectional abdominal imaging,with increased detection of biliary dilation,particularly in patients who use *** to evaluate associations between opiate use,age,cholecystectomy status,ethnicity,gender,and body mass index utilizing our institution’s integrated informatics *** One thousand six hundred and eighty-five patients(20%sample)presenting to our Emergency Department for all causes over a 5-year period(2011-2016)who had undergone cross-sectional abdominal imaging and had normal total bilirubin were included and *** Common bile duct(CBD)diameter was significantly higher in opiate users compared to non-opiate users(8.67 mm vs 7.24 mm,Ptients with a history of cholecystectomy compared to those with an intact gallbladder(8.98 vs 6.72,Ptients with an intact gallbladder who did not use opiates(n=432),increasing age did not predict CBD diameter(r^2=0.159,P=0.873).Height weakly predicted CBD diameter(r^2=0.561,P=0.018),but weight,body mass index,ethnicity and gender did *** Opiate use and a history of cholecystectomy are associated with CBD dilation in the absence of an obstructive *** alone is not associated with increased CBD *** findings suggest that factors such as opiate use and history of cholecystectomy may underlie the previously-reported association of advancing age with increased CBD *** prospective study is warranted.

关键词： Biliary dilation Opiate Narcotic Endoscopic ultrasound Endoscopic retrograde cholangiopancreatography Bile duct

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Escalating complexity of endoscopic retrograde cholangiopancreatography over the last decade with increasing reliance on advanced cannulation techniques

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World Journal of Gastroenterology 2020年第41期26卷 6391-6401页

作者： monique t barakat Mohit Girotra Nirav thosani Shivangi Kothari Subhas Banerjee Divisions of Adult and Pediatric Gastroenterology and Hepatology Stanford University Medical CenterCupertinoCA 95014United States Division of Gastroenterology and Hepatology University of Miami Miller School of MedicineMiamiFL 33136United States Department of Internal Medicine Division of GastroenterologyHepatology&NutritionUniversity of Texas Health Science Center HoustonHoustonTX 77030United States Division of Gastroenterology and Hepatology University of Rochester Medical CenterRochesterNY 14627United States Division of Gastroenterology and Hepatology Stanford University Medical CenterStanfordCA 94304United States

BACKGROUND At our academic tertiary care medical center, we have noted patients referred for endoscopic retrograde cholangiopancreatography(ERCP) who increasingly require advanced cannulation techniques. this trend is noted despite increased endoscopist experience and annual ERCP volume over the same *** to evaluate this phenomenon of perceived escalation in complexity of cannulation at ERCP and assessed potential underlying *** Demographic/clinical variables and records of ERCP patients at the beginning(2008), middle(2013) and end(2018) of the last decade were reviewed retrospectively. Cannulation approaches were classified as "standard" or "advanced" and duodenoscope position was labeled as "standard"(short position) or "non-standard"(e.g., long, semi-long).RESULtS Patients undergoing ERCP were older in 2018 compared to 2008(69.7 ± 15.2 years vs 55.1 ± 14.7, P tortion and peri-ampullary diverticula were noted in 2018(P th a non-standard duodenoscope position, from 2.2%(2008) to 5.6%(2013) and 16.1%(2018)(P tilization of more than one advanced cannulation technique for a given ERCP increased from 0.7%(2008) to 0.9%(2013) to 6.6%(2018)(P 4 cm, pancreatic uncinate mass, and bilirubin > 10 mg/d L predicted use of advanced cannulation techniques(P ty of cannulation at ERCP has sharply increased over the past 5 years, with an increased proportion of elderly patients and those with malignancy requiring advanced cannulation approaches. these data suggest that complexity of cannulation at ERCP may be predicted based on patient/ampulla characteristics. this may inform selection of experienced, high-volume endoscopists to perform these complex procedures.

关键词： Endoscopic retrograde cholangiopancreatography Biliary cannulation Goff trans-pancreatic septotomy Needle knife precut sphincterotomy Endoscopy Complexity

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Higher Order Multipole Potentials and Electrostatic Screening Effects on Cohesive Energy and Bulk Modulus of Metallic Nanoparticles

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Communications in theoretical Physics 2011年第12期56卷 1125-1129页

作者： t.barakat Physics Department King Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

Higher order rnultipole potentials and electrostatic screening effects are introduced to incorporate the dan gling bonds on the surface of a metallic nanopaticle and to modify the coulornb like potential energy terms, respectively. the total interaction energy function for any rnetallic nanoparticle is represented in terms of two- and three-body potentials. the two-body part is described by dipole-dipole interaction potential, and in the three-body part, triple-dipole （DDD） and dipole-dipole-quadrupole （DDQ） terrns are included. the size-dependent cohesive energy and bulk modulus are observed to decrease with decreasing sizes, a result which is in good agreement with the experimental values of Mo and W nanoparticles.

关键词： higher order multipole potentials electrostatic screening effect size-dependent cohesive energy size-dependent bulk modulus metallic nanoparticles

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Elucidating the molecular basis of AtP-induced cell death in breast cancer: Construction of a robust prognostic model

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World Journal of Clinical Oncology 2024年第2期15卷 208-242页

作者： Hao-Ling Zhang Sandai Doblin Zhong-Wen Zhang Zhi-Jing Song Babu Dinesh Yasser tabana DahhamSabbar Saad Mowaffaq Adam Ahmed Adam Yong Wang Wei Wang Hao-Long Zhang Sen Wu Rui Zhao barakat Khaled Department of Biomedical Sciences Advanced Medical and Dental InstituteUniversiti Sains MalaysiaPenang 13200Malaysia School of Public Health Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Clinical College of Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmonton AB T6G 2E1Canada Department of Science University of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA 92182United States Department of Pathology Center Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina College of Acupuncture-moxibustion and tuina Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Universiti Sains Malaysia Advanced Medical and Dental InstitutePenang 13200Malaysia Department of Biomedical Science Universiti Sains MalaysiaPenang 13200Malaysia

BACKGROUND Breast cancer is a multifaceted and formidable disease with profound public health *** demise mechanisms play a pivotal role in breast cancer pathogenesis,with AtP-triggered cell death attracting mounting interest for its unique specificity and potential therapeutic *** to investigate the impact of AtP-induced cell death(AICD)on breast cancer,enhancing our understanding of its *** the foundational genes orchestrating AICD mechanisms were extracted from the literature,underpinning the establishment of a prognostic ***,a microRNA(miRNA)prognostic model was constructed that mirrored the gene-based prognostic *** between high-and low-risk cohorts within mRNA and miRNA characteristic models were scrutinized,with the aim of delineating common influence mechanisms,substantiated through enrichment analysis and immune infiltration *** the mRNA prognostic model in this study encompassed four specific mRNAs:P2X purinoceptor 4,pannexin 1,caspase 7,and cyclin *** miRNA prognostic model integrated four pivotal miRNAs:hsa-miR-615-3p,hsa-miR-519b-3p,hsa-miR-342-3p,and hsa-miR-324-3p.B cells,CD4+t cells,CD8+t cells,endothelial cells,and macrophages exhibited inverse correlations with risk scores across all breast cancer ***,Kyoto Encyclopedia of Genes and Genomes analysis revealed that genes differentially expressed in response to mRNA risk scores significantly enriched 25 signaling pathways,while miRNA risk scores significantly enriched 29 signaling pathways,with 16 pathways being jointly *** Of paramount significance,distinct mRNA and miRNA signature models were devised tailored to AICD,both potentially autonomous prognostic *** study's elucidation of the molecular underpinnings of AICD in breast cancer enhances the arsenal of potential therapeutic tools,offering an unparalleled window for innovative ***,this paper revea

关键词： AtP-induced cell death mRNA miRNA Prognostic model Breast cancer

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Magnetoresistivity studies for BiPb-2223 phase added by BaSnO3 nanoparticles

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Journal of Advanced Ceramics 2017年第2期6卷 100-109页

作者： Mai ME.barakat Khulud HABANJAR Department of Physics Faculty of Science Alexandria University Alexandria Egypt Department of Physics Faculty of Science Beirut Arab University Beirut Lebanon

Co-precipitation method and conventional solid-state reaction technique were used to synthesize BaSnO3 nanoparticles and (BaSnO3)x/Bi1.6Pb0.4Sr2Ca2Cu3O10+δ (0≤x≤ 1.50w t％) samples,respectively.X-ray powder diffraction (XRD),scanning electron microscopy (SEM),and electrical resistivity data were used to characterize BiPb-2223 phase added by BaSnO3 *** relative volume fraction and superconducting transition temperature tc of BiPb-2223 phase were enhanced by increasing BaSnO3 addition up to 0.50 wt％.these parameters were decreased with further increase of *** resistive transition broadening under different applied DC magnetic fields (0.29-4.40kG) was analyzed through thermally activated flux creep (tAFC) model and Ambegaokar-Halperin (AH) *** of the derived flux pinning energy U,critical current density Jc (0) estimated from AH parameter C(B),and upper critical magnetic field Bc2 (0),were recorded by adding BaSnO3 nanoparticles up to 0.50 wt％,beyond which these parameters were *** magnetic field dependence of the flux pinning energy and critical current density decreased as a power-law relation,which indicated the single junction sensitivity between the superconducting grains to the applied magnetic ***,the increase in the applied magnetic field did not affect the electronic thermal conductivity Ke above the superconducting transition temperature and suppressed it below tc.

关键词： BiPb-2223 BaSnO3 nanoparticles flux pinning energy critical current density

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Superconducting parameter determination for (Co0.5Zn0.5Fe2O4)x/Cu0.5tl0.5-1223 composite

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Journal of Advanced Ceramics 2016年第3期5卷 210-218页

作者： M.ME.barakat N.AL-SAYYED R.AWAD A.I.ABOU-ALY Physics Department Faculty of Science Alexandria University Alexandria Egypt Physics Department Faculty of Science Beirut Arab University Beirut Lebanon

the addition of magnetic Co0.5Zn0.5Fe2O4 nanoparticles to the superconducting Cu0.5tl0.5-1223 phase has been used to investigate the electrical resistivity behavior of the composite above the superconducting transition temperature t c. this was studied according to the opening of spin gap and fluctuation conductivity. the results indicated that the pseudogap temperature (t*) and superconducting fluctuation temperature (t scf) change by increasing the addition of Co0.5Zn0.5Fe2O4 nanoparticles. It was found that t* is related to hole carrier concentration P and it also depends on the antiferromagnetic fluctuation affected by magnetic nanoparticles. the excess-conductivity analysis showed four different fluctuation regions started from high temperature up to t c, and they were denoted by short wave (sw), two-dimensional (2D), three-dimensional (3D), and critical (cr) fluctuations. the crossover temperature between 3D and 2D (t 3D–2D) in the mean field region was decreased by increasing the addition of Co0.5Zn0.5Fe2O4 nanoparticles, in accordance with the decrease in t scf with x. the coherence length at 0 K along c-axis ξ c(0), effective layer thickness of the 2D system d, and inter-layer coupling strength J were estimated as a function of Co0.5Zn0.5Fe2O4 nanoparticle addition. Moreover, the thermodynamics, lower and upper critical magnetic fields, as well as critical current density have been calculated from the Ginzburg number N G. It was found that the low concentration of Co0.5Zn0.5Fe2O4 nanoparticles up to x = 0.08 wt% improves the superconducting parameters of Cu0.5tl0.5-1223 phase. On the contrary, these parameters were deteriorated for (Co0.5Zn0.5Fe2O4) x /Cu0.5tl0.5-1223 composite with x > 0.08 wt%.

关键词： Co0.5Zn0.5Fe2O4 nanoparticles Cu0.5tl0.5-1223 phase pseudogap temperature fluctuation conductivity

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Elimination of schistosomiasis requires multifactorial diagnostics: evidence from high- and low-prevalence areas in the Nile Delta, Egypt

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Infectious Diseases of Poverty 2020年第2期9卷 63-75页

作者： Hala Elmorshedy Robert Bergquist Amel Fayed Wafaa Guirguis Ensaf Abdel-Gawwad Safaa Eissa Rashida barakat College of Medicine Princess Nourah bint Abdulrahman UniversityP.O.Box:84428Riyadh Postal Code:11671Saudi Arabia High Institute of Public Health Alexandria UniversityAlexandriaEgypt Ingerod SE-45494 BrastadSweden

Background:Schistosomiasis is one of the neglected tropical diseases(NtDs)selected for worldwide elimination in the near *** has made strong progress against its two endemic species of Schistosoma mansoni and *** former is prevalent in the Nile Delta with the latter dominating in the Nile south of *** efforts are needed to reach the goal as further reduction of the prevalence has stalled due to ongoing *** this study we aimed to explore the difference between low and high prevalence villages with regard to knowledge attitude and practice about schistosomiasis,utilization of health services,infection and transmission ***:A hybrid cross-sectional longitudinal study was conducted with three annual follow-ups conducted during *** used a representative systematic random sampling technique investigating 993 individuals from the high prevalence village and 614 from the low prevalence *** were analyzed using SPSS,comparing proportions with the Chi square test and means with the Student t test,and ***:Compliance of faecal sampling and chemotherapy was above 70%in both villages over the whole study *** praziquantel treatment resulted in a significant reduction of prevalence and intensity of infection in both villages,dropping from 35.8%prevalence to 20.6%,in the low-prevalence village,and from 69.5 to 45.9%in the high-prevalence *** of infection at the base line was 30 eggs per gram(EPG)of stool in the low-prevalence village versus 105 EPG in the high-prevalence ***,after the second round,reinfection rebounded by 22%in the high-prevalence village,while a slight improvement of the infection indices was demonstrated in the low-prevalence *** level of knowledge was modest in both villages:people knew about self-protection and treatment,but not much about the role of human excreta for schistosomiasis *** all participants maintained that usi

关键词： Schistosomiasis transmission Praziquantel Knowledge attitude and practice Utilization of health services Poverty Egypt

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Mineralogy,Chemical Characteristics and Upgrading of Beach Ilmenite of the top Meter of Black Sand Deposits of the Kafr Al-Sheikh Governorate,Northern Egypt

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Acta Geologica Sinica(English Edition) 2017年第4期91卷 1326-1338页

作者： Abdel-Aal M. ABDEL-KARIM Mohamed I. MOUStAFA Adel H. EI-AFANDY Mohamed G. barakat Faculty of Science Zagazig University Egypt Engineering Colleges Northern Border University Saudi Arabia Nuclear Materials Authority P. O. Box 530 Maadi Cairo Egypt

Egyptian beach ilmenite occurs in a relatively high content in the naturally highly concentrated superficial black sand deposits at specific beach zones in the northern parts of the Nile Delta at Rosetta. Microscopic study shows that the ilmenite occurs as fresh homogeneous black or heterogeneous multicoloured altered grains and exhibits three types （homogeneous, exsolved and altered） of ilmenite varieties. XRD data of ilmenite indicates their association with minor hematite and quartz, whereas leucoxene shows its association with Nb-rutUe, pseudorutile and hematite. Grain size distribution suggests a very fine sand size of 〉89% and 80% and a fine sand size of 10.5% and 18.3% for fresh and altered ilmenites, respectively. the density of fresh, altered ilmenite and leucoxene concentrates varies from 2.70, 2.50 to 2.40 ton/m^3, suggesting a gradual decrease from high grade fresh to leucoxene and consistent with variation in magnetic susceptibility as a consequence of the leaching of iron. Mass magnetic susceptibility reveals 97.6% of ilmenite and 92% of the altered form are obtained at 0.20 and 0.48 ampere. Fresh iimenite exhibits variable tiO2 （47.18%） and Fe2O3^t （46.10%） with minor MnO, MgO and Cr2O3 （1.22, 1.10 and 0.51%）. the altered ilmenite is higher in tiO2 （76.16%） and SiO2 （4.68%） and lower in Fe2O3^t （14.45%）, MnO, MgO and Cr2O3 （0.39, 0.52 and 0.11%） compared with the fresh form. three concentrates of ilmenites （G1, G2 and G3） were prepared from crude ore using a Reading cross belt magnetic separator under different conditions, revealing a gradual increase of tiO2, SiO2, Al2O3 and CaO accompanied by a decrease of Fe2O3^t, MgO and Cr2O3 with repetition of the separation processes. Several ore dressing techniques were carried out to upgrade the iimenite concentrate.

关键词： Beach ilmenite mineralogy chemistry upgrading Northern Egypt

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Effect of <i>trichoderma harzianum</i>in Combination with Fungicides in Controlling Gray Mould Disease (<i>Botrytis cinerea</i>) of Strawberry

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American Journal of Plant Sciences 2017年第4期8卷 651-665页

作者： Radwan M. barakat Mohammad I. Al-Masri Plant Protection Research Center Faculty of Agriculture Hebron University Hebron Palestine

the effects of biofungicide formula containing the biocontrol agent trichoderma harzianum (Jn14) as wettable powder in combination with the fungicides pyrimethanil and a mixture of cyprodinil and flydioxonil on Botrytis cinerea of strawberry in vitro, in vivo and in greenhouse were studied. the pathogen B. cinerea was more affected in vitro by low concentrations of the fungicides tested above 0.4 μg·ml-1 than the bioagent t. harzianum (Jn14). the later was almost insensitive to pyrimethanil. In the same direction, gray mould disease severity on strawberry detached leaves and whole plants was reduced up to 89% by the tested fungicides, compared to the control, while the application of t. harzianum (Jn14) alone reduced disease severity up to 45% on strawberry detached leaves, compared to the control. In the integrated control approach, the combination of t. harzianum (Jn14) with higher concentrations of the tested fungicides (ED50) completely inhibited strawberry gray mould disease severity in pots and the greenhouse.

关键词： Fungicides trichoderma harzianum Botrytis cinerea Gray Mould Strawberry

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Characteristics, management, and outcome of squamous carcinoma of the conjunctiva in a single tertiary cancer center in Jordan

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1132-1138页

作者： Ata Rajeh Fareed barakat Samer Khurma Khaleel Al Rawashdeh Osama H.Ababneh Ibrahim AlNawaiseh Mustafa Mehyar Ghadeer Abdeen Imad Jaradat Mona Mohammad Yacoub A.Yousef Department of Surgery (Ophthalmology) King Hussein Cancer Centre (KHCC) Department of Pathology King Hussein Cancer Centre (KHCC) Department of Ophthalmology The University of Jordan and Jordan University Hospital Department of Medical Oncology King Hussein Cancer Centre (KHCC) Department of Radiation Oncology King Hussein Cancer Centre (KHCC)

AIM： to evaluate the features and outcome of management of malignant conjunctival squamous tumors in King Hussein Cancer Center（a referral tertiary cancer center in the Middle East）. MEtHODS： Retrospective case series of 31 eyes for 31 patients with conjunctival squamous neoplasia. Main outcome measures included： age, gender, laterality, tumor location, pathological features, tumor stage, treatment modality, and outcome. RESULtS： twenty（65%） patients were males and median age was 58 y. twenty-two（71%） eyes had the tumor in the nasal quadrant. tumor invasion to nearby structures was seen in 19（61%） eyes, including the cornea, fornix, eyelid, and orbit in 17（55%）, 1（3%）, 2（6%）, and 3（10%） eyes, respectively. Eye salvage was achieved by surgical excision with cryotherapy followed by topical chemotherapy in 28（90%） eyes, and orbital exenteration was necessary in 3（10%） eyes due to orbital tumor invasion. tumor recurrence was seen in 7（23%） eyes, and the significant predictive factors for recurrence were tumor extension onto the nearby structures（P=0.04）, tumor invasiveness（P=0.038）, and tumor tNM stage（P=0.031）. No significant change in visual acuity was seen, and disease related mortality was 6%（2 patients, both had orbital invasion by invasive squamous carcinoma）. CONCLUSION： Conjunctival squamous carcinoma is more common in males. Advanced American Joint Committee on Cancer（AJCC） t-stage, tumor local invasion, more pathologically aggressive tumors, and surgical treatment alone（without adjuvant therapy） are associated with higher risk for recurrence, and orbital invasion is the most important poor prognostic factor for metastasis and death. treatment strategies should be affected by tumor characteristics at presentation.

关键词： conjunctiva squamous cell carcinoma metastasis

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