Elucidating the molecular basis of ATP-induced cell death in breast cancer: Construction of a robust prognostic model
作者机构：Department of Biomedical SciencesAdvanced Medical and Dental InstituteUniversiti Sains MalaysiaPenang 13200Malaysia School of Public HealthGansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Clinical College of Chinese MedicineGansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of Pharmacy and Pharmaceutical SciencesUniversity of AlbertaEdmonton AB T6G 2E1Canada Department of ScienceUniversity of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of Chemistry and BiochemistrySan Diego State UniversitySan DiegoCA 92182United States Department of Pathology CenterGansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina College of Acupuncture-moxibustion and TuinaGansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Universiti Sains MalaysiaAdvanced Medical and Dental InstitutePenang 13200Malaysia Department of Biomedical ScienceUniversiti Sains MalaysiaPenang 13200Malaysia
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2024年第15卷第2期
页 面：208-242页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Natural Science Foundation of China,No.81960877 University Innovation Fund of Gansu Province,No.2021A-076 Gansu Province Science and Technology Plan(Innovation Base and Talent Plan),No.21JR7RA561 Natural Science Foundation of Gansu Province,No.21JR1RA267 and No.22JR5RA582 Education Technology Innovation Project of Gansu Province,No.2022A-067 Innovation Fund of Higher Education of Gansu Province,No.2023A-088 Gansu Province Science and Technology Plan International Cooperation Field Project,No.23YFWA0005 and Open Project of Key Laboratory of Dunhuang Medicine and Transformation of Ministry of Education,No.DHYX21-07,No.DHYX22-05,and No.DHYX21-01
主 题：ATP-induced cell death mRNA miRNA Prognostic model Breast cancer
摘 要：BACKGROUND Breast cancer is a multifaceted and formidable disease with profound public health *** demise mechanisms play a pivotal role in breast cancer pathogenesis,with ATP-triggered cell death attracting mounting interest for its unique specificity and potential therapeutic *** To investigate the impact of ATP-induced cell death(AICD)on breast cancer,enhancing our understanding of its *** The foundational genes orchestrating AICD mechanisms were extracted from the literature,underpinning the establishment of a prognostic ***,a microRNA(miRNA)prognostic model was constructed that mirrored the gene-based prognostic *** between high-and low-risk cohorts within mRNA and miRNA characteristic models were scrutinized,with the aim of delineating common influence mechanisms,substantiated through enrichment analysis and immune infiltration *** The mRNA prognostic model in this study encompassed four specific mRNAs:P2X purinoceptor 4,pannexin 1,caspase 7,and cyclin *** miRNA prognostic model integrated four pivotal miRNAs:hsa-miR-615-3p,hsa-miR-519b-3p,hsa-miR-342-3p,and hsa-miR-324-3p.B cells,CD4+T cells,CD8+T cells,endothelial cells,and macrophages exhibited inverse correlations with risk scores across all breast cancer ***,Kyoto Encyclopedia of Genes and Genomes analysis revealed that genes differentially expressed in response to mRNA risk scores significantly enriched 25 signaling pathways,while miRNA risk scores significantly enriched 29 signaling pathways,with 16 pathways being jointly *** Of paramount significance,distinct mRNA and miRNA signature models were devised tailored to AICD,both potentially autonomous prognostic *** study s elucidation of the molecular underpinnings of AICD in breast cancer enhances the arsenal of potential therapeutic tools,offering an unparalleled window for innovative ***,this paper revea
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