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Reproducibility of Test-Retest Cortical Evoked Responses in Patients with Focal Epilepsy

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Journal of Behavioral and Brain Science 2023年第1期13卷 1-13页

作者： Mackenzie C. Cervenka monika Rozycka Erik Sass Dana Boatman Reich Department of Neurology Johns Hopkins School of Medicine Baltimore USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore USA

This exploratory study examined the short-term reliability of cortical auditory evoked responses recorded from patients undergoing whole-head scalp elec-troencephalography (EEG) monitoring to assess their candidacy for surgical treatment of intractable focal seizures. Participants were 26 patients with either left-sided (N = 13) or right-sided focal epilepsy admitted to the hospital for continuous scalp EEG monitoring for possible epilepsy surgery planning. Cortical auditory evoked responses were recorded over multiple days from scalp EEG electrodes using tones presented binaurally in a passive oddball paradigm. Test-retest intervals were 1 - 6 days (mean 2 days). Test-retest reproducibility of the auditory N1 response was assessed by paired t-test (latency) and cross-correlation analysis (amplitude and latency). Within-patient comparisons of test-retest auditory N1 peak latencies revealed no significant differences. The cross-correlation coefficient indicated high test-retest reproducibility of the N1 waveform (rcc = 0.88). Seizure lateralization was not associated with asymmetries in N1 latencies or amplitudes. An N1 amplitude asymmetry (right > left) in patients with focal seizures originating from the left hemisphere was initially observed, but disappeared when patients with prior resections were excluded, suggesting that reduced left hemisphere tissue volume may account for the smaller N1 amplitudes. Test-retest reliability of cortical auditory evoked responses was unexpectedly high in patients with focal epilepsy regardless of seizure lateralization or localization. These findings challenge the view that neural responses are intrinsically unstable (unreliable) in patients with seizures.

关键词： Auditory Evoked Response Seizure Epilepsy Reproducibility Reliability

Evolutionary History of the Non-Specific Lipid Transfer Proteins

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Molecular Plant 2011年第6期4卷 947-964页

作者： monika M. Edstam Lenita Viitanen Tiina A. Salminen Johan Edqvist IFM Molecular Genetics Link6ping University 581 83 LinkSping Swedenb Structural Bioinformatics Laboratory Department of Biosciences Abo Akademi University Artillerigatan 6 A III FIN-20520 Turku Finland

The non-specific lipid transfer proteins （nsLTPs） are small, basic proteins characterized by a tunnel-like hydrophobic cavity, capable of transferring various lipid molecules between lipid bilayers. Most nsLTPs are synthesized with an N-terminal signal peptide that localizes the protein to the apoplastic space. The nsLTPs have only been identified in seed plants, where they are encoded by large gene families. We have initiated an analysis of the evolutionary history of the nsLTP family using genomic and EST information from non-seed land plants and green algae to determine：（1） when the nsLTP family arose, （2） how often new nsLTP subfamilies have been created, and （3） how subfamilies differ in their patterns of expansion and loss in different plant lineages. In this study, we searched sequence databases and found that genes and transcripts encoding nsLTPs are abundant in liverworts, mosses, and all other investigated land plants, but not present in any algae. The tertiary structures of representative liverwort and moss nsLTPs were further studied with homology modeling. The results indicate that the nsLTP family has evolved after plants conquered land. Only two of the four major subfamilies of nsLTPs found in flowering plants are present in mosses and liverworts. The additional subfamilies have arisen later, during land plant evolution. In this report, we also introduce a modified nsLTP classification system.

关键词： Lipids evolutionary genetics molecular biology molecular evolution bryophytes ferns.

Oral rehabilitation of a Parkinson's patient:A case report

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World Journal of Clinical Cases 2013年第1期1卷 67-70页

作者： Yashpal Singh monika Saini Neha Garg Department of Prosthodontics Subharti Dental College Meerut UP 250005India

Parkinson's disease is an idiopathic disorder of the central nervous system, characterized by resting tremors, muscular rigidity, slow and decreased movements. Oral rehabilitation of these patients requires special care, especially in those cases where the patient's socioeconomic status is not good and patient cannot come several times for fabrication of a complete denture. This clinical report presents a case of a Parkinson's patient who was completely rehabilitated in 3 appointments using special techniques. Border molding, f inal impression and jaw relation procedures were done in one appointment by using a custom tray with detachable handles and occlusal rims.

关键词： Parkinson’s disease Tich buttons Detachable handles and occlusal rims Monoplane teeth

Kinematic Analysis of Leaf Growth in Grasses:A Comment on Spatial and Temporal Quantitative Analysis of Cell Division and Elongation Rate in Growing Wheat Leaves under Saline Conditions

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Journal of Integrative Plant Biology 2009年第5期51卷 433-436页

作者： Hans Schnyder monika Kavanova C.Jerry Nelson Lehrstuhl für Grünlandlehre Technische Universitt München85350 Freising-WeihenstephanGermany Department of Cell & Developmental Biology John Innes Centre Division of Plant Sciences University of Missouri

Hu and Schmidhalter （2008） conducted a study with wheat seedlings growing in saline and non-stressed （control） conditions with the aim of identifying and quantifying the cellular basis for the reduction in leaf growth. We applaud their goals as salinity is an important issue for plant ecology and food production; however, we have concerns about the methodology used and the subsequent conclusJons that are drawn.

关键词： Kinematic Analysis of Leaf Growth in Grasses cell length

Classification of fires in coal waste dumps based on Landsat,Aster thermal bands and thermal camera in Polish and Ukrainian mining regions

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International Journal of Coal Science & Technology 2021年第3期8卷 441-456页

作者： Adam Nadudvari Anna Abramowicz monika Fabianska Magdalena Misz-Kennan Justyna Ciesielczuk Faculty of Natural Sciences University of Silesia60 Be˛dzin´ska Street41-205 SosnowiecPoland

A self-heating intensity index(SHII)based on the highest(pixel max.)and lowest(pixel min.)values taken from satellite thermal maps of burning coal waste dumps are *** index enables the classification of such fires in Ukrainian-and Polish coal waste *** in Ukraine and in Poland,varying thermal intensities during 1985–2019 are revealed,using the SHII and following thermal intensity threshold values,namely,extreme thermal activity([7),advanced(3–7),moderate(3–1.5),initial(1.5–1),no activity(<1).The SHII shows decreasing thermal activity in the selected Ukrainian coal waste dumps during 2017–*** aids in reconstructing the thermal history of the *** of satellite images revealed a large number of burning coal waste dumps in the Donetsk Coal Basin(Ukraine)with high thermal *** burning likely reflects large amounts of organic matter and sulphides in the dumped material subjected to self-heating and self-burning processes,lack of compaction of the coal waste and/or high methane *** of SHII values calculated from satellite-and drone thermal-camera images were compared to show that SHII from drone thermal images have much higher values than those from satellite images;the former have better ***,SHII from Landsat-and drone images should be used separately in dump heating studies.

关键词： Self-heating Coal waste dump Landsat Self-heating intensity index(SHII) Drone

Lipid bound extended release buprenorphine(high and low doses)and sustained release buprenorphine effectively attenuate post-operative hypersensitivity in an incisional pain model in mice(Mus musculus)

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Animal Models and Experimental Medicine 2021年第2期4卷 129-137页

作者： Kaela Navarro Katechan Jampachaisri monika Huss Cholawat Pacharinsak Department of Comparative Medicine Stanford UniversityStanfordCAUSA Department of Mathematics Naresuan UniversityPhitsanulokThailand

Background:Extended-release buprenorphine(XR)is indicated for pain management in rodents,but little is known about its use in *** study aimed to investigate whether high dose XR effectively attenuates post-operative hypersensitivity better than low dose XR in a mouse model of incisional ***:Mice(n 44)were randomly assigned to 1 of 4 treatment groups:(a)saline(1 ml/kg SC,once);(b)sustained release buprenorphine(Bup-SR,1 mg/kg SC,once);(c)low dose extended-release buprenorphine(XR-lo,3.25 mg/kg SC,once);(d)high dose extended-release buprenorphine(XR-hi,6.5 mg/kg SC,once).On days􀆴1,0(4 hours),1,2,and 3,mechanical and thermal hypersensitivities were evaluated,and plasma buprenorphine concentrations were ***:Mechanical(days 0-2)and thermal(days 0-1)hypersensitivities were ob-served in the saline ***-SR,XR-lo,and XR-hi attenuated mechanical hyper-sensitivity on days 0,1,and *** of the treatment groups,except XR-Lo on day 0,attenuated thermal hypersensitivity on days 0 or *** buprenorphine concen-tration peaked at 4 hours(day 0)in all treatment groups and remained greater than 1 ng/mL on days *** abnormal clinical observations or gross pathologic findings were seen in any ***:The results indicate XR-hi did not effectively attenuate post-operative hypersensitivity better than *** both 3.25 and 6.5 mg/kg XR are recom-mended for attenuating post-operative hypersensitivity for at least up to 48 hours in mice.

关键词： analgesia analgesics buprenorphine mouse pain management

PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: Comprehensive physicochemical and biological evaluation

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Bioactive Materials 2021年第6期6卷 1811-1826页

作者： Michal Dziadek Kinga Dziadek Kamila Checinska Barbara Zagrajczuk monika Golda-Cepa monika Brzychczy-Wloch Elzbieta Menaszek Aneta Kopec Katarzyna Cholewa-Kowalska Jagiellonian University Faculty of Chemistry2 Gronostajowa St.30-387KrakowPoland AGH University of Science and Technology Faculty of Materials Science and CeramicsDepartment of Glass Technology and Amorphous Coatings30 Mickiewicza Ave.30-059KrakowPoland University of Agriculture in Krakow Faculty of Food TechnologyDepartment of Human Nutrition and Dietetics122 Balicka St.30-149KrakowPoland Jagiellonian University Medical CollegeDepartment of Molecular Medical Microbiology18 Czysta St.31-121KrakowPoland Jagiellonian University Medical CollegeDepartment of Cytobiology9 Medyczna St.30-688KrakowPoland

In this work,polymeric and bioactive glass(BG)-modified composite films were successfully loaded with polyphenols(PPh)extracted from *** was hypothesized that PPh,alone and in combination with BGs particles,would affect physicochemical and biological properties of the ***,sol-gel-derived BG particles would serve as an agent for control the release of the polyphenolic compounds,and other important properties related to the presence of *** results showed that polyphenolic compounds significantly modified numerous material properties and also acted as biologically active *** the one hand,PPh can be considered as plasticizers for PCL,on the other hand,they can act as coupling agent in composite materials,improving their mechanical *** presence of PPh in materials improved their hydrophilicity and apatite-forming ability,and also provided antioxidant *** is important is that the aforementioned properties and kinetics of PPh release can be modulated by the use of various concentrations of PPh,and by the modification of PCL matrix with sol-gel-derived BG particles,capable of binding *** films containing the lowest concentration of PPh exhibited cytocompatibility,significantly increased alkaline phosphatase activity and the expression of bone extracellular matrix proteins(osteocalcin and osteopontin)in human normal osteoblasts,while they reduced intracellular reactive oxygen species production in ***,materials loaded with PPh showed antibiofilm properties against Gram positive and Gram negative *** results suggest that obtained materials represent potential multifunctional biomaterials for bone tissue engineering with a wide range of tunable properties.

关键词： Tissue engineering Drug delivery Antioxidant properties Plant extract

Emerging alternative for artificial ammonia synthesis through catalytic nitrate reduction

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Journal of Materials Science & Technology 2021年第18期77卷 163-168页

作者： Derek Hao Zhi-gang Chen monika Figiela Izabela Stepniak Wei Wei Bing-Jie Ni Centre for Technology in Water and Wastewater(CTWW) School of Civil and Environmental EngineeringUniversity of Technology Sydney(UTS)UltimoNSW2007Australia Centre for Future Materials University of Southern QueenslandSpringfield CentralQueensland4300Australia School of Mechanical and Mining Engineering The University of QueenslandBrisbaneQueensland4072Australia Institute of Chemistry and Applied Electrochemistry Faculty of Chemical TechnologyPoznan University of TechnologyBerdychowo 4PL-60965PoznanPoland

Artificial catalytic synthesis of ammonia has become a hot research frontier in recent *** is regarded as a promising approach that may replace the Haber-Bosch process and reduce global carbon dioxide ***,it is extremely difficult for the cleavage of nitrogen molecules under ambient *** the ammonia yield rate is still low and the study is still limited in lab *** nitrites or nitrates are used as nitrogen sources,rather than nitrogen gas,the catalytic efficiency can be significantly improved,and the residual nitrate and nitrite contaminations in water systems can be efficiently eliminated and converted to energy sources at the same *** is an emerging alternative for artificial ammonia synthesis,while there is not enough focus on the reduction of nitrate and ***,we systematically compared the differences between the reduction of nitrogen and nitrates,as well as listed the challenges in this *** total conversion rate and energy efficiency of catalytic nitrate reduction are much higher than nitrogen gas reduction due to the much higher solubility and better converting pathway,which might be further enhanced by employing catalysts improvement ***,we also proposed suitable materials as well as a few future researches needs that may help boost the development of artificial ammonia synthesis using nitrate.

关键词： Nitrogen fixation Nitrate reduction Ammonia synthesis Electrocatalysis Photocatalysis

Somnambulism: Varenicline-Induced Sleep Driving

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Case Reports in Clinical Medicine 2023年第7期12卷 213-217页

作者： Samer Alkhuja monika Girgis Mohammad Ali Pravinkumar Patel Olutunde Odeyemi Department of Medicine The Commonwealth Medical College Lehigh Valley Health Network-Pocon Stroudsburg Pennsylvania USA

Background: Varenicline, which is derived from the cytisine compound, is used to assess in smoking cessation. Sleep driving (SD) is often classified as a variant of somnambulism. Although, somnambulism has been reported as a side effect of varenicline, varenicline-induced sleep driving (VISD) has not been reported. Case Report: A 56-year-old man with a history of 35 pack year smoking who presented for smoking cessation counseling. Treatment with varenicline was initiated. In the following night, the patient drove to a shopping center and woke up in his car. Varenicline was discontinued. SD has not been reported in the following nights. In a repeated attempt to stop smoking, treatment with varenicline was resumed by the patient. SD reoccurred in the following night. Varenicline was discontinued indefinitely, and SD has not been reported.

关键词： Varenicline Sleep Walking Arousal Parasomnia