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New insight into the role of the complement in the most common types of retinopathy-current literature review

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1856-1864页

作者： Martyna Chrzanowska Anna Modrzejewska monika Modrzejewska Department of Ophthalmology Pomeranian Medical University

Pathological neovascularisation, which is a critical component of diseases such as age-related macular degeneration（AMD）, diabetic retinopathy（DR） and retinopathy of prematurity（ROP）, is a frequent cause of compromised vision or blindness. Researchers continuously investigate the role of the complement system in the pathogenesis of retinopathy. Studies have confirmed the role of factors H and I in the development of AMD, and factors H and B in the development of DR. Other components, such as C2, C3, and C5, have also been considered. However, findings on the involvement of the complement system in the pathogenesis of ROP are still inconclusive. This paper presents a review of the current literature data, pointing to the novel results and achievements from research into the role of complement components in the development of retinopathy. There is still a need to continue research in new directions, and to gather more detailed information about this problem which will be useful in the treatment of these diseases.

关键词： age-related macular degeneration diabetic retinopathy actors of the complement system retinopathy of prematurity single nucleotide polymorphism

Orotic Acid, More Than Just an Intermediate of Pyrimidine de novo Synthesis

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Journal of Genetics and Genomics 2015年第5期42卷 207-219页

作者： monika L?ffler Elizabeth A.Carrey Elke Zameitat Institute of Physiological Chemistry Faculty of Medicine Philipps University Marburg UCL Institute of Child Health University College London

It is timely to consider the many facets of the small molecule orotic acid （OA）, which is well-known as an essential intermediate of pyrimidine de novo synthesis. In addition, it can be taken up by erythrocytes and hepatocytes for conversion into uridine and for use in the pyrimidine recycling pathway. We discuss the link between dietary orotate and fatty liver in rats, and the potential for the alleviation of neonatal hyperbilirubinaemia. We address the development of orotate derivatives for application as anti-pyrimidine drugs, and of com- plexes with metal ions and organic cations to assist therapies of metabolic syndromes. Recent genetic data link human Miller syndrome to defects in the dihydroorotate dehydrogenase （DHODH） gene, hence to depleted orotate production. Another defect in pyrimidine biosynthesis, the orotic aciduria arising in humans and cattle with a deficiency of UMP synthase （UMPS）, has different symptoms. More recent work leads us to conclude that OA may have a role in regulating gene transcription.

关键词： Orotic acid Pyrimidines Orotic aciduria Miller syndrome Gene defects

Some Observations about the MOLSCAT

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Communications in Theoretical Physics 2015年第12期64卷 731-734页

作者： Mohit Kumar Sharma monika Sharma Suresh Chandra School of Studies in Physics Jiwaji University Physics Department Lovely Professional University

For calculation of cross sections for collisional transitions between rotational levels in a molecule,a computer code,MOLSCAT is *** the transitions between rotational levels in H_2 CS due to collisions with He atom,we have calculated cross sections under the CS approximation,for example,for total energy 11 cm^(-1).The calculations have been done for the single energy 11 cm"1 and for ten *** have found that the cross sections for the single energy 11 cm^(-1),differ from those in the first seven combinations,but are in agreement with those in the last three *** reason for the difference in the results appears that the MOLSCAT uses the intermediate data of calculations for one energy,in the calculations for other *** agreement with the last three combinations may be understood that when the energy of combination is in the decreasing trend,the cross sections for the first(common)energy are *** may be suggested to run the MOLSCAT for a single energy at a time.

关键词： ISM: molecules collisional transitions MOLSCAT

Transportation robot battery power forecasting based on bidirectional deep-learning method

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Transportation Safety and Environment 2019年第3期1卷 205-211页

作者： Kerstin Thurow Chao Chen Steffen Junginger Norbert stoll Hui Liu Center for Life Science Automation University of RostockFriedrich-Barnewitz-StraBe 818119 RostockGermany School of Traffic and Transportation Engineering Central South UniversityChangsha410075 HunanChina and Institute of Automation University of RostockRichard-Wagner-StraBe 3118119 RostockGermany

This paper proposes a data-driven hybrid model for forecasting the battery power voltage of transportation robots by combining a wavelet method and a bidirectional deep-learning *** the proposed model,the on-board battery power data is measured and transmitted.A WPD(wavelet packet decomposition)algorithm is employed to decompose the original collected non-stationary series into several relatively more stable *** each subseries,a deep learning–based predictor–bidirectional long short-term memory(BiLSTM)–is constructed to forecast the battery power voltage from one step to three steps *** experiments verify the effectiveness and generalization ability of the proposed hybrid forecasting model,which shows the highest forecasting *** obtained forecasting results can be used to decide whether the robot can complete the given task or needs to be recharged,providing effective support for the safe use of transportation robots.

关键词： robotic power management transportation robot time series forecasting wavelet packet decomposition bidirectional long short-term memory

A rare case of langerhans cell histiocytosis of the gastrointestinal tract

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World Journal of Gastroenterology 2012年第12期18卷 1410-1413页

作者： Uday Shankar monika Prasad Om P Chaurasia Internal Medicine Mount Sinai School of Medicine at Queens Hospital CenterJamaicaNY 11432United States Department of Medicine University of CaliforniaIrvineCA 92697United States

Langerhans cell histiocytosis （LCH） is a group of idiopathic disorders characterized by the proliferation of specialized, bone marrow-derived langerhans cells and mature eosinophils. The clinical spectrum ranges from an acute, fulminant, disseminated disease called Letterer Siwe disease to solitary or few, indolent and chronic lesions of the bone or other organs called eosinophilic granuloma. Involvement of the gastrointestinal tract is very rare in LCH. We present the case of a 53-year-old woman referred by her primary care physician for a screening colonoscopy. A single sessile polyp, measuring 4 mm in size, was found in the rectum. Histopathological examination revealed that the lesion was relatively well circumscribed and comprised mainly a mixture of polygonal cells with moderate-to-abundant pink slightly granular cytoplasm. The nuclei within these cells had frequent grooves and were occasionally folded. Immunohistochemical staining was positive for CD la which confirmed the diagnosis of LCH. On further workup, there was no evidence of involvement of any other organ. On follow up colonoscopy one year later, there was no evidence of disease recurrence. Review of the published literature revealed that LCH presenting as solitary colonic polyp is rare. However, with the increasing rates of screening colonoscopy, more colonic polyps may be identified as LCH on histopathology. This underscores the importance of recognizing this rare condition and ensuring proper follow-up to rule out systemic disease.

关键词： Langerhans cells Histiocytosis Colonic pol-yp CD-la Eosinophilic granuloma Screening Colono-scopy

Is Chloroplast Movement in Tobacco Plants Influenced Systemically after Local Illumination or Burning Stress?

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Journal of Integrative Plant Biology 2008年第10期50卷 1292-1299页

作者： Jan Nau monika Rolencov Vladimíra Hlavkov Laboratory of Biophysics Department of Experimental Physics Palacky' University tr. Svobody 26 77146 Olomouc Czech Republic

Chloroplast movement has been studied in many plants mainly in relation to the local light, mechanical or stress effects. Here we investigated possible systemic responses of chloroplast movement to local light or burning stress in tobacco plants （Nicotisna tabacum cv. Samsun）. Chloroplast movement was measured using two independent methods： one with a SPAD 502 Chlorophyll meter and another by collimated transmittance at a selected wavelength （676 nm）. A sensitive periodic movement of chloroplasts was used in high or low （2 000 or 50 μmol/m2 per s photosynthetically active radiation, respectively） cold white light with periods of 50 or 130 min. Measurements were carried out in the irradiated area, in the non-irradisted area of the same leaf or in the leaf located on the stem below the irradiated or bumed one. No significant changes in systemic chloroplast movement in non-irradiated parts of the leaf and in the non-treated leaf were detected. Our data indicate that chloroplast movement in tobacco is dependent dominantly on the intensity and spectral composition of the incident light and on the local stimulation and state of the target tissue. No systemic signal was strong enough to evoke a detectable systemic response in chloroplast movement in distant untreated tissues of tobacco plants.

关键词： buming chloroplast movement irradiance systemic response tobacco.

Construction of multiple new analytical soliton solutions and various dynamical behaviors to the nonlinear convection-diffusion-reaction equation with power-law nonlinearity and density-dependent diffusion via Lie symmetry approach together with a couple of integration approaches

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Journal of Ocean Engineering and Science 2023年第3期8卷 226-237页

作者： Shoukry El-Ganaini Sachin Kumar monika Niwas Department of Mathematics Faculty of ScienceDamanhour UniversityDamanhour 22514Egypt Department of Mathematics Faculty of Mathematical SciencesUniversity of DelhiDelhi 110007India Department of Mathematics University of DelhiDelhi 110007India

By taking advantage of three different computational analytical methods:the Lie symmetry analysis,the generalized Riccati equation mapping approach,and the modified Kudryashov approach,we construct multiple new analytical soliton solutions to the nonlinear convection-diffusion-reaction equation(NCDR)with power-law nonlinearity and density-dependent *** symmetry analysis is one of the pow-erful techniques that reduce the higher-order partial differential equation into an ordinary differential equation by reduction of independent *** the Lie group technique,we obtain one-parameter in-variant transformations,determining equations and corresponding vectors for the considered convection-diffusion-reaction *** treating the parameters of the governing equation as constants,the ap-plied methods yield a variety of new closed-form solutions,including inverse function solutions,periodic solutions,exponential function solutions,dark solitons,singular solitons,combo bright-singular solitons,and the combine of bright-dark solitons and dark-bright ***,using the Bäcklund transfor-mation of the generalized Riccati equation and modified Kudryashov method,we can construct multiple solitons and other solutions of the considered *** obtained new solutions of this work demon-strate that the used approaches are powerful and effective in dealing with nonlinear equations,and that these solutions are required to explain many biological and physical *** our obtained solutions of this paper with the ones obtained in the literature,we see that our solutions are new and not reported *** newly formed soliton solutions will be more beneficial in the various dis-ciplines of ocean engineering,plasma physics,and nonlinear sciences.

关键词： Lie symmetry analysis Generalized riccati equation mapping Modified kudryashov approach Nonlinear convection-diffusion-reaction equation Solitary wave solutions Closed form solutions Backlund transformation Exact solution Dynamical wave structures Bäcklund transformation

Abundant analytical soliton solutions and different wave profiles to the Kudryashov-Sinelshchikov equation in mathematical physics

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Journal of Ocean Engineering and Science 2022年第6期7卷 565-577页

作者： Sachin Kumar monika Niwas Shubham Kumar Dhiman Department of Mathematics Faculty of Mathematical SciencesUniversity of DelhiDelhi 110007India

The generalized exponential rational function(GERF)method is used in this work to obtain analytic wave solutions to the Kudryashov-Sinelshchikov(K S)*** K S equation depicts the occurrence of pressure waves in mixtures of liquid-gas bubbles while accounting for thermal expansion and *** applying the GERF method to the KS equation,we obtain analytic solutions in terms of trigonometric,hyperbolic,and exponential functions,among *** solutions include solitary wave solutions,dark-bright soliton solutions,singular soliton solutions,singular bell-shaped solutions,traveling wave solutions,rational form solutions,and periodic wave *** discuss the two-dimensional and three-dimensional graphics of some obtained solutions under the accurate range space by selecting appropriate values for the involved arbitrary parameters to make this research more *** obtained analytic wave solutions specify the GERF method’s dependability,capability,trustworthiness,and efficiency.

关键词： Solitary wave solutions Closed form solutions GERF technique Dynamical wave structures

Transition from radiatively inefficient to cooling dominated phase in two temperature accretion disks around black holes

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Research in Astronomy and Astrophysics 2009年第12期9卷 1331-1342页

作者： monika Sinha S.R.Rajesh Banibrata Mukhopadhyay Astronomy and Astrophysics Program Department of PhysicsIndian Institute of Science

We investigate the transition of a radiatively inefficient phase of a viscous two temperature accreting flow to a cooling dominated phase and vice versa around black holes. Based on a global sub-Keplerian accretion disk model in steady state, including explicit cooling processes self-consistently, we show that general advective accretion flow passes through various phases during its infall towards a black hole. Bremsstrahlung, syn- chrotron and inverse Comptonization of soft photons are considered as possible cooling mechanisms. Hence the flow governs a much lower electron temperature ～10^8 - 10^9.5 K compared to the hot protons of temperature ～10^10.2 - 10^11.8 K in the range of the accretion rate in Eddington units 0.01≤M≤ 100. Therefore, the solutions may potentially explain the hard X-rays and the γ-rays emitted from AGNs and X-ray binaries. We finally compare the solutions for two different regimes of viscosity and conclude that a weakly viscous flow is expected to be cooling dominated compared to its highly viscous counterpart which is radiatively inefficient. The flow is successfully able to reproduce the observed luminosities of the under-fed AGNs and quasars （e.g. Sgr A＊）, ultra-luminous X-ray sources （e.g. SS433）, as well as the highly luminous AGNs and ultra-luminous quasars （e.g. PKS 0743-67） at different combinations of the mass accretion rate and ratio of specific heats.

关键词： accretion accretion disk -- black hole physics -- hydrodynamics -- radia-tive transfer