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The nature and variety of innovation

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International Journal of Innovation Studies 2018年第2期2卷 65-79页

作者： monica Edwards-Schachter Collaborator at Polytechnic University of Valencia Camino de vera s/n.46022ValenciaSpain

What is our current understanding of innovation and how many types of innovation do we know?Broadly,innovation landscapes are characterized by well-established categories,such as product,process,organizational,and marketing innovation,explained and theorized in terms of their links with technological *** global challenges and changes in the structure of knowledge production,have led to diverse innovations,and recognizing and classifying such innovations is more complex,fragmented,and geographically dispersed than ever *** progressive incorporation of hidden and non-technological innovations,together with the emergence of the fourth industrial revolution,is contributing to change our understanding of innovation and its *** paper provides an overview of the most salient types of innovation in recent decades,enabling both researchers and practitioners to navigate the complex web of innovation definitions and *** studies face the challenge of finding a comprehensive and inclusive definition that captures the significance of innovation,and overcoming the terminological‘Babel'ization and increased fragmentation of the field of innovation research.

关键词： Innovation Nature of innovation Innovation types Knowledge society Technological innovation Social innovation

New Linkage with Linear Actuator for Tracking PV Systems with Large Angular Stroke

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Chinese Journal of Mechanical Engineering 2011年第5期24卷 744-751页

作者： VISA Ion DIACONESCU Dorin SAULESCU Radu VATASESCU monica BURDUHOS Bogdan Renewable Energy Systems and Recycling Research Centre Transilvania University of Brasov

This paper focuses on the development of an optimized photovoltaic tracking system involving low-cost, relative simple mechanisms, with linear actuators able to insure strokes comparable with those resulted when using gear rotary actuators. Starting with a rhombus linkage, with a linear actuator on the diagonal used for the elevation motion till 90°, a new performance solution is generated. This new linkage allows large angular strokes by using an asymmetric rhombus and an eccentrically positioned linear actuator. The paper can be divided in three main parts. Firstly the kinematical modeling of the new linkage is addressed, which permits the establishing of the linkage dimensions according to two adjustable parameters （k2, k5）. Using the resulted correlations, in the second part the linkage synthesis algorithm is developed; the steps followed in this algorithm are presented in a numerical application considering a tracked PV platform, where the azimuthal vertical movement is obtained with the new proposed rhomboidal linkage. In the last part of the paper an analysis is done with the aim of determining the PV platform tracking efficiency （which represents the ratio between the received and the available beam solar energy） using the new linkage, in the meteorological conditions of Brasov, Romania implementation site.

关键词： solar tracking linkage linear actuator angular stroke transmission angle

Clinical Significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 and MicroRNA Axis in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1291-1307页

作者： Giovanna Mangiapane Devis Pascut Emiliano Dalla Giulia Antoniali monica Degrassi Lory Saveria Crocè Veronica De Sanctis Silvano Piazza Giulia Canarutto Claudio Tiribelli Gianluca Tell Laboratory of Molecular Biology and DNA Repair Department of MedicineUniversity of UdineUdineItaly Fondazione Italiana Fegato-ONLUS Liver Cancer UnitTriesteItaly Department of Medical Sciences University of TriesteTriesteItaly Clinica Patologie Fegato Azienda Sanitaria Universitaria Giuliano Isontina(ASUGI)TriesteItaly NGS Core Facility Department CIBIOUniversity of TrentoTrentoItaly Computational Biology International Centre for Genetic Engineering and BiotechnologyICGEBTriesteItaly

Background and Aims:Identification of prognostic factors for hepatocellular carcinoma(HCC)opens new perspectives for *** and cellular onco-miRNAs are noncoding RNAs which can control the expression of genes involved in oncogenesis through post-transcriptional *** microRNAs(miRNAs)are considered novel prognostic and predictive factors in *** apurinic/apyrimidinic endodeoxyribonuclease 1(APE1)contributes to the quality control and processing of specific onco-miRNAs and is a negative prognostic factor in several *** present work aims to:a)define APE1 prognostic value in HCC;b)identify miRNAs regulated by APE1 and their relative target genes and c)study their prognostic ***:We used The Cancer Genome Atlas(commonly known as TCGA)data analysis to evaluate the expression of APE1 in *** identify differentially-expressed miRNAs(DEmiRNAs)upon APE1 depletion through specific small interfering RNA,we used NGS and nanostring approaches in the JHH-6 HCC tumor cell *** analyses were performed to identify signaling pathways involving APE1-regulated *** analysis was performed to identify miRNAs correlating with serum APE1 ***:APE1 is considerably overexpressed in HCC tissues compared to normal liver,according to the TCGA-liver HCC(known as LIHC)*** analyses showed that APE1-regulated miRNAs are implicated in signaling and metabolic pathways linked to cell proliferation,transformation,and angiogenesis,identifying Cyclin Dependent Kinase 6 and Lysosomal Associated Membrane Protein 2 as ***-33a-5p,miR-769,and miR-877 are related to lower overall survival in HCC *** array profiling,we identified eight circulating DE-miRNAs associated with APE1 overexpression.A training phase identified positive association between sAPE1 and miR-3180-3p and ***:APE1 regulates specific miRNAs having prognostic value in HCC.

关键词： APE1 miRNAs Prognostic factors Hepatocellular carcinoma

Multifocal G1-G2 gastric neuroendocrine tumors:Differentiating between Type Ⅰ, Ⅱ and Ⅲ, a clinicopathologic review

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World Journal of Clinical Cases 2019年第17期7卷 2413-2419页

作者： Khaled Algashaamy monica Garcia-Buitrago Department of Pathology and Laboratory Medicine Jackson Memorial Hospital University of Miami Miller School of Medicine

Gastric neuroendocrine tumors (gNETs) are a rare entity that is increasing in *** pathophysiological processes can lead to the development of these tumors,appropriate histological analysis is necessary to differentiate between grade 1 (G1) and grade 2 (G2) tumors as this will impact the management of these patients based on their increased risk of lymph node and distant *** provide a comprehensive clinicopathologic review of multifocal gastric neuroendocrine tumors,with particular emphasis on G1 and G2 tumors and differentiating between types I,II and II and risk stratification based upon immunohistochemical *** review is based on peer-reviewed literature and the authors’ *** are a heterogenous group of tumors that is rising in *** lesions while arise from the same cell type,they have different *** the type of gNETs is a collective effort of clinical and pathologic *** correct grading and staging of these lesions are of paramount significance,due its impact on patient management and prognosis.

关键词： Gastric neuroendocrine tumors Enterochromaffin like cells Histopathological features Immunohistochemistry Diagnosis Treatment

Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis:a systematic review

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World Journal of Pediatrics 2022年第2期18卷 91-99页

作者： Javier Arredondo Montero Carlos Bardaji Pascual monica Bronte Anaut Natalia Lopez-Andres Giuseppa Antona Nerea Martin-Calvo Pediatric Surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology Department Complejo Hospitalario de NavarraPamplonaSpain Cardiovascular Translational Research Navarrabiomed(Miguel Servet Foundation)Complejo Hospitalario de Navarra(CHN)Universidad Publica de Navarra(UPNA)IdiSNAPamplonaSpain Department of Preventive Medicine and Public Health Instituto de Investigacion Sanitaria de Navarra(IdiSNA).University of Navarra.PamplonaSpain CIBER Fisiopatologia de la Obesidad y Nutricion(CIBERobn) Health Institute CarlosⅢMadridSpain

Background Despite the radiological and analytical advances of the last decades,there is still a significant rate of diagnostic error in pediatric acute *** recent years,multiple biomarkers have emerged as potential diagnostic *** study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute *** We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography(Medline,PubMed,Web of Science and SciELO).Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion *** quality of the selected article was rated using the QUADAS2 *** extraction was performed by two independent *** The research in the medical bibliography databases resulted in 68 *** removed 26 *** the remaining 42 articles,we excluded 33 following the inclusion and exclusion *** the final 9 studies included in this review,8 provided measured serum interleukin-6 values,and all of them reported significant differences between groups,but inconsistent results regarding sensitivity and *** The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is *** sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated *** seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute *** increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated *** consider that this may be an avenue of research to explore in the future.

关键词： Acute appendicitis Children Interleukin-6 Pediatric Sensitivity Specificity Systematic review

Attenuated adenomatous polyposis of the large bowel: Present and future

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World Journal of Gastroenterology 2017年第23期23卷 4135-4139页

作者： luca roncucci monica pedroni francesco mariani Department of Diagnostic and Clinical Medicine and Public Health University of Modena and Reggio Emilia

Attenuated adenomatous polyposis(AAP) is a poorly understood syndrome, that can be defined as the presence of 10-99 synchronous adenomas in the large bowel, and it is considered a phenotypic variant of familial adenomatous polyposis(FAP). This definition has the advantage of simplicity, but it may include sporadic multiple adenomas of the large bowel at an extreme, or FAP cases on the other side. AAP shows a milder phenotype than FAP, with an older age of onset of adenomas and cancer, and less frequent extracolonic manifestations. AAP may be diagnosed as a single case in a family or, less frequently, it may be present in other family members, and it shows distinct pattern of inheritance. In less than 50% of cases, it may be caused by adenomatous polyposis coli(APC) or MUTYH mutations, referred to as APC-associated polyposis, inherited as an autosomal dominant trait, or MUTYH-associated polyposis, which shows an autosomal recessive mechanism of inheritance, respectively. Surveillance should rely on colonoscopy at regular intervals, with removal of adenomas and careful histological examination. When removal of polyps is not possible or advanced lesions are observed, the surgical approach is mandatory, being subtotal colectomy with ileo-rectal anastomosis the treatment of choice. Studies on this syndrome are lacking, and controversies are still present on many issues, thus, other clinical and genetic studies are requested.

关键词：稀释 adenomatous polyposis 基因测试监视稀释家庭 adenomatous polyposis Adenomatous polyposis coli MUTYH

Eco-Climatic Factors Influencing the Distribution of Black Ants (Carebara vidua) in Western Kenya

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Advances in Entomology 2022年第3期10卷 233-251页

作者： Davine Atieno Ondede Dennis Otieno Ochuodho monica A. Ayieko Department of Plant Animal and Food Sciences Jaramogi Oginga Odinga University of Science and Technology Bondo Kenya Jaramogi Oginga Odinga University of Science and Technology Bondo Kenya

Black ant, Carebara vidua (Smith) is an edible insect of critical value in nutrition. The population abundance of black ants has reduced drastically and they have become scarce in all the agro ecological zones in Western Kenya. Understanding factors influencing the distribution and abundance of C. vidua remains a challenge as C. vidua is an endangered species in many parts of Country Kenya. The decline in the insect population is worrying since black ants are an important source of food across the world. Our study aimed at determining the eco-climatic conditions influencing the distribution of black ants. Several factors and conditions have contributed to the decline in the population of black ants. The study was carried out in different agro ecological zones of Kisumu, Siaya, and Homabay Counties. The research presumed a cross-sectional approach to community representation. The purposive sampling technique was used to select the population for the qualitative study. Data was collected through Focused Group Discussion and Key Informant Interviews to get in-depth knowledge on the factors contributing to the change in the distribution of back ants. Verbatim transcription was done to the audio recorded data then data was translated into English. Thematic analysis was done using *** software version 7.5. The results showed various factors that led to the change in distribution and reduction of the population of black ants emerging across the lower midland zones, the factors include;climate change, advancement in agricultural equipment, land degradation, and habitat destruction. These factors made the emergence of the insect unpredictable. Over the years across the Lower midland zones, there have been changes in the distribution of C. vidua and the population of insects emerging has reduced hence the insect is disappearing.

关键词： Black Ant Ecological Zones Distribution Population

Effect of reducing agents on the structure of zinc oxide under microwave irradiation

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Advances in Manufacturing 2013年第2期1卷 183-186页

作者： monica Debbarma Soma Das Mitali Saha Department of Chemistry National Institute of Technology

Zinc oxide was synthesized from zinc sulphate using different reducing agents under microwave irradia- tion. The influence of sodium borohydride, hydrazine hydrate and urea on the shape and size of the products were investigated by scanning electron microscopy （SEM） and X-ray diffraction （XRD）. SEM showed the nano-sized spherical and rectangular shaped structures in case of sodium borohydride and hydrazine hydrate, whereas micro-sized hexagonal structures were formed in case of urea under the same irradiation power. The reducing agents played an important role in forming the various structures. Thus different shapes and size of structures were produced by only varying the reducing agent, which had wide applications in various fields.

关键词： Zinc oxide Microwave Sodiumborohydride Hydrazine hydrate Urea

liver and the defects of cholesterol and bile acids biosynthesis: rare disorders many diagnostic pitfalls

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World Journal of Gastroenterology 2017年第29期23卷 5257-5265页

作者： Gaetano Corso Antonio Dello Russo monica Gelzo Department of Clinical and Experimental Medicine University of Foggia Department of Molecular Medicine and Medical Biotechnology University of Naples Federico Ⅱ

In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects.

关键词：胆固醇胆汁酸肝新陈代谢联合到集体 spectrometry 的煤气的层析联合到双人脚踏车团 spectrometry 的液体层析