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Current role of extracorporeal membrane oxygenation for the management of trauma patients:Indications and results

World Journal of Critical Care Medicine 2025年第1期14卷 42-48页

作者： mohammed Abdulrahman Maryam Makki Malak Bentaleb Dana Khamis Altamimi Marcelo AF Ribeiro Junior Department of Surgery College of Medicine and Health SciencesKhalifa UniversityAbu Dhabi 11001United Arab Emirates Department of Surgery Division of TraumaCritical Care and Acute Care SurgerySheikh Shakhbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Surgery Sheikh Shakhbout Medical CityAbu Dhabi 91888ADUnited Arab Emirates Department of Surgery R Adams Cowley Shock Trauma CenterUniversity of MarylandBaltimoreMD 21201United States

Extracorporeal membrane oxygenation(ECMO)has emerged as a vital circulatory life support measure for patients with critical cardiac or pulmonary conditions unresponsive to conventional *** allows blood to be extracted from a patient and introduced to a machine that oxygenates blood and removes carbon *** blood is then reintroduced into the patient’s circulatory *** process makes ECMO essential for treating various medical conditions,both as a standalone therapy and as adjuvant ***-venous(VV)ECMO primarily supports respiratory function and indicates respiratory ***,veno-arterial(VA)ECMO provides hemodynamic and respiratory support and is suitable for cardiac-related *** study reviews recent literature to elucidate the evolving role of ECMO in trauma care,considering its procedural intricacies,indications,contraindications,and associated ***,the use of ECMO in trauma patients,particularly for acute respiratory distress syndrome and cardiogenic shock,has demonstrated promising outcomes despite challenges such as anticoagulation management and complications such as acute kidney injury,bleeding,thrombosis,and *** studies have shown that VV ECMO was associated with significantly higher survival rates than conventional mechanical ventilation,whereas other studies have reported that VA ECMO was associated with lower survival rates than VV *** plays a critical role in managing trauma patients,particularly those with acute respiratory *** research is necessary to explore the full potential of ECMO in trauma *** should have a clear understanding of the indications and contraindications for the use of ECMO to maximize its benefits in treating trauma patients.

关键词： Extracorporeal membrane oxygenation treatments Multiple trauma Respiratory distress syndrome Cardiogenic shock Contraindications Anticoagulants

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Diabetes-inducing effects of bronchial asthma

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World Journal of Diabetes 2025年第1期16卷 121-139页

作者： mohammed Al-Beltagi Adel Salah Bediwy Nermin Kamal Saeed Hosameldin A Bediwy Reem Elbeltagi Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 26671ManamaBahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503MuharraqBahrain Faculty of Medicine Tanta UniversityTanta 31527AlgharbiaEgypt Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain

BACKGROUND The relationship between diabetes mellitus(DM)and asthma is complex and can impact disease *** To explore the bidirectional influences between the two conditions on clinical outcomes and disease *** We systematically reviewed the literature on the relationship between DM and asthma,focusing on their impacts,mechanisms,and therapeutic *** studies were assessed,which investigated the effect of glycemic control on asthma outcomes,lung function,and *** study highlighted the role of specific diabetes medications in managing *** The results showed that poor glycemic control in diabetes can exacerbate asthma,increase hospitalizations,and reduce lung ***,severe asthma,especially in obese individuals,can complicate diabetes management and make glycemic control more *** diabetes-associated mechanisms,such as inflammation,microangiopathy,and oxidative stress,can exacerbate asthma and decrease lung *** diabetes medications exhibit anti-inflammatory effects that show promise in mitigating asthma *** The complex interrelationship between diabetes and asthma suggests bidirectional influences that affect disease course and *** and microvascular complications associated with diabetes may worsen asthma outcomes,while asthma severity,especially in obese individuals,complicates diabetes ***,the current research has limitations,and more diverse longitudinal studies are required to establish causal relationships and identify effective treatment strategies for individuals with both conditions.

关键词： Diabetes mellitus Bronchial asthma Glycemic control Lung function Asthma exacerbation Disease interaction Microangiopathy

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Analgesia and Safety of Perioperative Bilateral Erector Spinae Infusion versus Thoracic Epidural Infusion in Upper Abdominal Oncological Surgeries: A Randomized Clinical Trial

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Open Journal of Anesthesiology 2025年第1期15卷 13-29页

作者： Amin Mohamed Ashraf Mohammad Abd El-Rahman Ahmad Hussein Mahmoud Mohamed mohammed Abdelemam Rania Department of Anesthesiology ICU and Pain Management South Egypt Cancer Institute Assiut University Assiut Egypt

Objective: Erector spinae plane block is a novel regional anaesthetic intervention that is said to have an effective analgesic profile in the upper abdominal region. We compared its analgesic efficacy with thoracic epidural block for upper abdominal cancer surgeries. Methods: This prospective study included 60 patients, 18 to 65 years old with ASA class II who underwent gastrectomy and Whipple’s procedures under general anesthesia. Patients were assigned into two groups: Thoracic epidural group, with injection of 0.1 ml/kg of bupivacaine 0.25% in epidural catheter followed by 0.1 ml/kg/h of 0.125% bupivacaine infusion for 48 hrs., and Erector spinae group, with insertion of bilateral erector spinae catheters to inject 0.1 ml/kg of bupivacaine 0.25% followed by bilateral infusion of 0.1 ml/kg/h of bupivacaine 0.125% for 48 hrs. The primary endpoint was postoperative VAS scores at rest and movement. Secondary endpoint included postoperative total opioid consumption, 1st request for analgesia, hemodynamic changes and satisfaction scores. Results: Pain scores and needed rescue analgesia in both groups were comparable. However, 1st request for opioid was significantly longer in TEPI compared to ESI group. Hemodynamics were significantly lower in TEPI group with no differences in the incidence of postoperative complications except for hypotension. Patient satisfaction scores were arbitrarily higher in ESI group without significance. Conclusion: Erector spinae infusion is a highly promising regional technique with comparable effects to thoracic epidural blockade in reducing pain and opioid needs while causing minimal hemodynamic consequences.

关键词： Erector Spinae Abdominal Cancer Surgeries Thoracic Epidural

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Comparison of different severity scores in correlating hemoglobin levels with the severity of hepatic decompensation: An observational study

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World Journal of Hepatology 2025年第1期17卷 55-63页

作者： Himayat Ullah Sarwat Huma Ghulam Yasin Muhammad Ashraf Nafisa Tahir Qazi Tahir uddin Hossam Shabana Mostafa A R Hussein Abdulrahman Shalaby Mohammad Mossaad Alsayyad Ashraf Said Ali Farahat Hani Ismail Hamed Hazem Sayed Ahmed Ayoub mohammed S Imam Essam Elmahdi Department of Medicine College of Medicine at ShaqraShaqra UniversityShaqra 15526Saudi Arabia Health Professions Education Health Services AcademyIslamabad 44000Pakistan Department of Orthopedics College of Medicine at ShaqraShaqra UniversityShaqra 15526Saudi Arabia Department of Medicine NUST School of Health SciencesIslamabad 44000Pakistan Department of Surgery College of Medicine at ShaqraShaqra UniversityShaqra 15526Saudi Arabia Faculty of Medicine Al-Azhar UniversityCairo 11865Egypt Faculty of Medicine for Boys Al-Azhar UniversityNew Damietta 34517Egypt Faculty of Medicine Mansoura UniversityMansoura 35511Egypt

BACKGROUND Chronic liver disease is a growing global health problem,leading to hepatic decompensation characterized by an array of clinical and biochemical *** scoring systems have been introduced in assessing the severity of hepatic decompensation with the most frequent ones are Child-Pugh score,model of end-stage liver disease(MELD)score,and MELD-Na *** is frequently observed in cirrhotic patients and is linked to worsened clinical *** studies have explored anemia in liver disease,few have investigated the correlation of hemoglobin level with the severity of hepatic *** To determine the relationship between hemoglobin levels and the severity of decompensated liver disease and comparing the strength of this correlation using the Child-Pugh,MELD,and MELD-Na *** This cross-sectional study was conducted at a tertiary care hospital with 652 decompensated liver disease patients enrolled in the *** was collected on demographics,clinical history,and laboratory findings,including hemoglobin levels,bilirubin,albumin,prothrombin time(international normalized ratio),sodium,and *** Child-Pugh,MELD,and MELD-Na scores were *** analysis was performed using Statistical Package for the Social Sciences version 26,and correlations between hemoglobin levels and severity scores were assessed using Spearman's correlation *** The study included 405 males(62.1%)and 247 females(37.9%)with an average age of 58.8 *** inverse correlations were found between hemoglobin levels and Child-Pugh,MELD,and MELD-Na scores(P<0.01),with the MELD scoring system being the strongest correlator among ***-way analysis of variance revealed significant differences in hemoglobin levels across the severity groups of each scoring system(P=0.001).Tukey's post hoc analysis confirmed significant internal differences among each severity *** Understanding the correlati

关键词： Hepatic decompensation Hemoglobin level Chronic liver disease Child Turcotte Pugh score Model of end-stage liver disease score Model of end-stage liver disease-Na score

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Meta‐analysis and candidate gene mining of low‐phosphorus tolerance in maize

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Journal of Integrative Plant Biology 2014年第3期56卷 262-270页

作者： Hongwei Zhang mohammed Shalim uddin Cheng Zou Chuanxiao Xie Yunbi Xu Wen‐Xue Li Institute of Crop Science National Key Facility of Crop Gene Resources and Genetic Improvement the Chinese Academy of Agricultural Sciences Bangladesh Agricultural Research Institute (BARI) International Maize and Wheat Improvement Center (CIMMYT)

Plants with tolerance to low-phosphorus （P） can grow better under Iow-P conditions, and understanding of genetic mechanisms of Iow-P tolerance can not only facilitate identifying relevant genes but also help to develop Iow-P tolerant cultivars. QTL meta-analysis was conducted after a comprehensive review of the reports on O, TL mapping for Iow-P tolerance-related traits in maize. Meta-analysis pro- duced 23 consensus QTL （cQTL）, 17 of which located in similar chromosome regions to those previously reported to influence root traits. Meanwhile, candidate gene mining yielded 215 genes, 22 of which located in the cQTL regions. These 22 genes are homologous to 14 functionally characterized genes that were found to participate in plant Iow-P tolerance, including genes encoding miR399s, Pi transporters and purple acid phosphatases. Four cQTL loci （cQTL2-L cQTLS-3, cQTL6-2, and cQTL10-2） may play important roles for low-P tolerance because each contains more original QTL and has better consistency across previous reports.

关键词： Candidate gene consensus QTL low-phosphorustolerance maize meta-analysis

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Role of Right Ventricular-Pulmonary Arterial Coupling Measured by Echocardiography in Predicting Right Ventricular Dysfunction after Cardiac Surgery

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World Journal of Cardiovascular Surgery 2025年第1期15卷 1-11页

作者： Ismail Nasr El-Sokkary Esam Ahmed Khalil mohammed Fawzy Eltaweel Ahmed Alherazi mohammed Samy Bahaa Abdelgawad Elkhonezy Mohamed El Sayed Moussa Mohamed Ahmed Mosaad Zaki Ibrahim Abdel Fattah Yassin Mohamed Kamal Rehan Department of Cardiothoracic Surgery Faculty of Medicine Al-Azhar University Cairo Egypt Department of Cardiology Al-Azhar University Faculty of Medicine Cairo Egypt Department of Cardiothoracic Surgery Faculty of Medicine Menoufia University Shibin El Kom Egypt Department of Cardiothoracic Surgery Faculty of Medicine Alexandria University Alexandria Egypt Department of Internal Medicine Faculty of Medicine Beni Suef University Cairo Egypt

Background: The tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) is an indirect estimate of right ventricular-pulmonary arterial (RV-PA) coupling that has been shown to correlate with invasive measures. We aimed to assess the ability of the tricuspid annular plane systolic excursion/pulmonary systolic pressure ratio (TAPSE/PASP) as a measure for RV-PA coupling to predict the development of RV dysfunction after cardiac surgery. Methods: This prospective study was conducted on 100 patients with ischemic heart disease and undergoing cardiac surgery (coronary artery bypass graft (CABG)) with normal preoperative right ventricular function, classified according to RV function outcomes into 2 groups: Normal RV group (65 patients) and RV dysfunction group (35 patients). All cases underwent per and postoperative transthoracic echocardiography. Results: By using receiver operating characteristic curve analysis, pre-operative TAPSE/PASP ratio could significantly predict the RV dysfunction (P 0.58, with AUC of 94%, 88.6% sensitivity, and 89.2% specificity. Post-operative TAPSE/PASP Ratio could significantly predict the RV dysfunction (P 0.39, with AUC of 84%, 100% sensitivity, and 76.9% specificity. Pre-operative TAPSE/PASP ratio could significantly predict mortality (P Conclusion: The TAPSE/PASP ratio is an excellent tool for CABG patients for its ability to detect and predict the development of RV dysfunction after cardiac surgery, along with the prediction of mortality in post-operative CABG patients.

关键词： Right Ventricular Pulmonary Arterial Coupling Echocardiography Cardiac Surgery

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Donor-specific antibodies against HLA-C,HLA-DP and HLA-DQ and their implications in kidney transplantation

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World Journal of Transplantation 2025年第2期15卷 30-48页

作者： Muhammad Abdul Mabood Khalil Nihal mohammed Sadagah Ishida Hediki Jackson Tan Salem H Al-Qurashi Center of Renal Diseases and Transplantation King Fahad Armed Forces Hospital JeddahJeddah 23311Saudi Arabia Department of Urology and Transplantation Tokyo Women's Medical University HospitalTokyo 162-8666Japan Department of Nephrology RIPAS Hospital Brunei DarussalamBrunei Muara BA1710Brunei Darussalam

HLA-C,HLA-DP and HLA-DQ are thought to be benign due to low expression and few initial negative ***,most allocation programs used HLA-A,HLA-B and HLA-DR antigens for *** the advent and use of single-bead antigen assays,more was learned about donor-specific antibodies(DSAs)against these *** in these antigens and antibodies grew when cases of acute antibody-mediated rejection(AMR),mixed rejections,chronic AMR,and reduced graft survival were reported with DSAs against these *** the deleterious effects of these DSAs are more pronounced in retransplants,harmful effects have also been observed in first-time *** against each of these antigens can trigger rejection *** combination with DSAs against HLA-A,HLA-B and HLA-DR can cause more *** has been shown that strategies that reduce mismatches for these antigen lead to fewer rejections and better graft *** is a need for greater consensus on the universal typing of these antigens prior to transplantation for better patient and graft *** review focuses on the interaction of these antigens with lymphocytes and killer immunoglobulin receptors,arguments for not typing them,detailed analyses of the literature about their harmful effects,potential strategies moving forward,and recommendations for the future.

关键词： Kidney transplantation HLA-C HLA-DP HLA-DQ Donor specific antibodies Review

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Adaptive Attribute-Based Honey Encryption: A Novel Solution for Cloud Data Security

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Computers, Materials & Continua 2025年第2期82卷 2637-2664页

作者： Reshma Siyal Muhammad Asim Long Jun mohammed Elaffendi Sundas Iftikhar Rana Alnashwan Samia Allaoua Chelloug School of Computer Science and Engineering Central South UniversityChangsha410083China EIAS LAB College of Computer and Information Sciencesand Center of Excellence in Quantum and Intelligent ComputingPrince Sultan UniversityRiyadh11586Saudi Arabia Gianforte School of Computing Montana State UniversityBozemanMT 59717USA Department of Information Technology College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11671Saudi Arabia

A basic procedure for transforming readable data into encoded forms is encryption, which ensures security when the right decryption keys are used. Hadoop is susceptible to possible cyber-attacks because it lacks built-in security measures, even though it can effectively handle and store enormous datasets using the Hadoop Distributed File System (HDFS). The increasing number of data breaches emphasizes how urgently creative encryption techniques are needed in cloud-based big data settings. This paper presents Adaptive Attribute-Based Honey Encryption (AABHE), a state-of-the-art technique that combines honey encryption with Ciphertext-Policy Attribute-Based Encryption (CP-ABE) to provide improved data security. Even if intercepted, AABHE makes sure that sensitive data cannot be accessed by unauthorized parties. With a focus on protecting huge files in HDFS, the suggested approach achieves 98% security robustness and 95% encryption efficiency, outperforming other encryption methods including Ciphertext-Policy Attribute-Based Encryption (CP-ABE), Key-Policy Attribute-Based Encryption (KB-ABE), and Advanced Encryption Standard combined with Attribute-Based Encryption (AES+ABE). By fixing Hadoop’s security flaws, AABHE fortifies its protections against data breaches and enhances Hadoop’s dependability as a platform for processing and storing massive amounts of data.

关键词： Cybersecurity data security cloud storage hadoop encryption and decryption privacy protection attribute-based honey encryption

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Effects of stand characteristics on tree species richness in and around a conservation area of northeast Bangladesh

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Journal of Mountain Science 2016年第6期13卷 1085-1095页

作者： Muha Abdullah Al PAVEL SharifA.MUKUL Mohammad Belal uddin Kazuhiro HARADA mohammed A.S.ARFIN KHAN Department of Forestry and Environment Science School of Agriculture and Mineral SciencesShahjalal University of Science and TechnologySylhet 3114Bangladesh Department of Land EnvironmentAgriculture and Forestry(TeSAF)School of Agriculture and Veterinary MedicineUniversity of PadovaViale dell Universitd1635020 LegnaroItaly Tropical Forestry Group School of Agriculture and Food SciencesThe University of QueenslandBrisbane QLD 4072Australia Tropical Forests and People Research Centre university of the sunshine coastMarooehydore DCOLD 4558Australia Centre for Research on Land-use Sustainability MaijdiNoakhali 3800Bangladesh Dept.of Biosphere Resources Science Graduate School of Bioagricultural SciencesNagoya UniversityNagoya 464-8601Japan

We investigated the effect of tree cover,forest patch and disturbances on tree species richness in a highly diverse conservation area of northeast Bangladesh.A systematic sampling protocol was adopted and 80 sub-plots from twenty five 1 ha plots were used for the vegetation *** regression analysis was performed to understand the effect of patch area,disturbances and tree cover on tree species *** using Redundancy analysis(RDA) and Non-metric Multi Dimensional Scaling(NMDS) were also performed to explore the tree species compositional similarities along the stand characteristics gradient and locations of the sample *** study revealed that,forest patch size has greater influence on species *** with medium level of disturbances have shown greater species *** constrained ordination the selected explanatory variables regulated the richness of common *** findings can be useful for better forest management and restoration of landscapes of conservation needs using ecologically important species.

关键词： Biodiversity Disturbance Forestconservation Tree cover Forest patch LawacharaNational Park

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Gut virome:New key players in the pathogenesis of inflammatory bowel disease

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World Journal of Methodology 2025年第2期15卷 27-43页

作者： Helal F Hetta Rehab Ahmed Yasmin N Ramadan Hayam Fathy mohammed Khorshid Mohamed M Mabrouk Mai Hashem Department of Medical Microbiology and Immunology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Division of Microbiology Immunology and BiotechnologyFaculty of pharmacyUniversity of TabukTabuk 71491Saudi Arabia Division of Microbiology Immunology and BiotechnologyDepartment of Natural Products and Alternative MedicineFaculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Internal Medicine Division HepatogastroenterologyAssiut UniversityAssiut 71515Egypt Department of Clinical Research Egyptian Developers of Gastroenterology and Endoscopy FoundationCairo 11936Egypt Department of Internal Medicine Faculty of Medicine.Tanta UniversityTanta 31527Egypt Department of Tropical Medicine Gastroenterology and HepatologyAssiut University HospitalAssiut 71515Egypt

Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the *** the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immunological response,environmental exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major *** gut virome is a group of viruses found in great frequency in the gastrointestinal tract of *** gut virome varies greatly among individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and *** majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the *** conducted this review to highlight the viral communities in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关键词： Inflammatory bowel disease Pathogenesis Gut virome Bacteriophage Eukaryotic viruses

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