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Food and Nutrition Sciences 2023年第8期14卷 746-776页

作者： mohammed Haydar Awad Abd-Alrazig mohammed Abd-Almajid Omer Dakeen mohammed ali hamza mohamed ali Rashid mohamed Hassan Nasr College of Medicine Karary University Omdurman Sudan

Background: Nutritional knowledge and practise is an important measure to improve dietary habits and food choices. The daily food should contain balanced nutrition as needed to support optimal growth, avoid deficiency diseases and prevent the diseases which might interfere with the children health. Materials & Methods: A descriptive cross-sectional non-interventional hospital-based study was carried out among 122 mothers and 122 children by using a non-probability convenience sampling technique in the period of 15 March to 15 April 2023, and using interviews with structural questionnaires, the data was analyzed using SPSS version 26. Results: We found that most of the children had moderate health, while most of the mothers had moderate nutritional knowledge and practise towards their children, also we found that the relationship between mothers’ knowledge and practise and child health was significant (P Conclusion: Mothers’ knowledge and practise among children was moderate and children had moderate health. Wrong beliefs and cultural taboos play major roles in decreasing knowledge and practise.

关键词： Mothers Knowledge Practise Health children Infant Nutrition Cultural Taboos

Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli ali mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

Experimental and numerical study of effecting core configurations on the static and dynamic behavior of honeycomb plate with aluminum material

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Defence Technology（防务技术） 2024年第9期39卷 177-192页

作者： Nehad Abid Allah hamza Fatima mohammed K.AL-Fatlwe Muna ali Talib Engineering College Al-Qasim Green University51013BabylonIraq Engineering Technical College of Al-Najaf Al-Furat Al-Awsat Technical University(ATU)Najaf54003Iraq

The sandwich panel incorporated a honeycomb core,a widely utilized composite structure recognized as a fundamental classification of composite *** a core resembling a honeycomb,possessing thickness and softness,and is flank by rigid face sheets that sandwich various shapes and *** paper presents an examination of the static and dynamic analysis of lightweight plates made of aluminum honeycomb sandwich *** sandwich plate samples are 300 mm long,and 300 mm wide,the heights of the core have been varied at four values ranging from 10 to 25 *** honeycomb core is manufactured from Aluminum material by using a novel technique namely resistance spot welding(RSW)instead of using adhesive material,which is often used when an industrial flaw is *** optimization based on response surface methodology(RSM)and design of experiment software(DOE)was used to verify the current work.A theoretical examination of the crashworthiness behavior(maximum bending load,maximum deflection)and vibration attributes(natural frequency,damping ratio,transient temporal response)of honeycomb sandwich panels with different design parameters was also carried *** addition,the finite element method-based ANSYS software was used to confirm the theoretical *** findings of the present work showed that the relationship between the natural frequency,core height,and cell size is *** contrast,the relationship between the natural frequency and the thickness of the cell wall is ***,the damping ratio is inversely proportional to the core height and cell size but directly proportional to the thickness of the cell *** study indicates that altering the core height within 10-25 mm leads to a significant increase of 82%in the natural frequency and a notable decrease of 49%in the damping *** findings are based on a specific cell size value of 0.01 m and a cell wall thickness of 0.001 ***,the results indicate

关键词： Honeycomb Load Transient response Free vibration Natural frequency

Bioconvective Hybrid Flow with Microorganisms Migration and Buongiorno’s Model under Convective Condition

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Frontiers in Heat and Mass Transfer 2024年第2期22卷 433-453页

作者： Azad Hussain Saira Raiz ali Hassan mohamed R.ali Abdulkafi mohammed Saeed Department of Mathematics University of GujratGujrat50700Pakistan Department of Mechanics and Aerospace Engineering Southern University of science and TechnologyShenzhenChina Faculty of Engineering and Technology Future University in EgyptNew Cairo11835Egypt Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Heat transfer improves significantly when the working fluid has high thermal *** transfer can be found in fields such as food processing,solar through collectors,and drug *** this notable fact,this work is focused on investigating the bio-convection-enhanced heat transfer in the existence of convective boundary conditions in the flow of hybrid nanofluid across a stretching *** fluid model with hybrid nanoparticles has been employed along the swimming microorganisms to investigate the mixture base working *** developed nonlinear flow governing equations have been tackled numerically with the help of the *** effects of relevant parameters on the flowdynamic have been portrayed in a graphical *** velocity profile decreases by raising the levels of buoyancy ratio and mixed convection in the range of 0.1alidated by comparison with those that have previously been published,and an appropriate rate of agreement has been observed.

关键词： Prandtl hybrid nanofluid mixed convection stretched sheet bioconvection motile microorganisms

Generating Pairs for the Fischer Group Fi_(23)

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Algebra Colloquium 2020年第4期27卷 713-730页

作者： Faryad ali mohammed Al-Kadhi Department of Mathematics and Statistics College of Science Imam Mohammad Ibn Saud Islamic University(IMSIU)P.O.Box 90950Riyadh 11623Saudi Arabia

A group G is said to be(l,m,n)-generated if it is a quotient of the triangle groupT(l,m,n)=(x,y,z|x^(l)=y^(m)=z^(n)=xyz=1).Moori posed in 1993 the question of finding all the triples(l,m,n)such that non-abelian finite simple groups are(l,m,n)-*** partially answer this question for the Fischer sporadic simple group *** particular,we investigate all(2,q,r)-generations for the Fischer sporadic simple group Fi23,where q and r are distinct prime divisors of|Fi_(23)|.

关键词： generating pair Fischer group Fi_(23) sporadic group generating triple

Raspberry ketone attenuates high-fat diet-induced obesity by improving metabolic homeostasis in rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第1期10卷 18-22页

作者： ali Alkaladi Haytham ali Aaser MAbdelazim mohamed Afifi mohammed Baeshen Ammar AL-Farga University of Jeddah College of ScienceDepartment of BiologyJeddahSaudi Arabia University of Jeddah College of ScienceDepartment of BiochemistryJeddahSaudi Arabia Department of Biochemistry Faculty of Vet.MedicineZagazig UniversityZagazigEgypt Department of Basic Medical Sciences College of Applied Medical SciencesUniversity of BishaBishaSaudi Arabia

Objective:To investigate the molecular mechanisms of the antiobese effect of raspberry ketone against high-fat diet fed ***:Fifty adult male rats were randomly assigned to receive a standard diet,a high fat diet,and the high-fat diet and 0.5%,1%or 2%raspberry *** weight,biochemical parameters and gene expression of CCAAT enhancer-binding protein(C/EBP)-δ,fatty acid synthase(FAS),acetyl Co A carboxylase(ACC),peroxisome proliferator-activated receptor alpha(PPAR-α),hormone-sensitive lipase(HSL)and hepatic carnitine palmitoyltransferase 1A(CPT1A)were ***:Body weight,blood glucose,insulin,total lipids,triacylglycerols,total cholesterol and low-density lipoprotein cholesterol were increased in high-fat diet fed *** high fat diet-induced changes were attenuated by treatment with raspberry ***-density lipoprotein cholesterol was decreased in highfat diet fed rats but increased in rats treated with raspberry *** investigations showed induction of gene expression of C/EBP-δ,FAS,ACC,CPT1A and inhibition of gene expression of PPAR-αand HSL in high-fat diet fed rats as compared with *** ketone treament reversed these changes except ***:Raspberry ketone can prevent obesity induced by a high-fat diet in rats by induction of the expression of enzymes,controlling lipolysis and fatty acidsβoxidation as well as inhibition of gene expressions of adipogenic factors.

关键词： Raspberry ketone Obesity Molecular mechanism

Machine learning-based seismic assessment of framed structures with soil-structure interaction

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Frontiers of Structural and Civil Engineering 2023年第2期17卷 205-223页

作者： mohamed NOURELDIN Tabish ali Jinkoo KIM Department of Global Smart City Sungkyunkwan UniversitySuwon 16419Korea

The objective of the current study is to propose an expert system framework based on a supervised machine learning technique(MLT)to predict the seismic performance of low-to mid-rise frame structures considering soil-structure interaction(SSI).The methodology of the framework is based on examining different MLTs to obtain the highest possible accuracy for *** the MLT,a sensitivity analysis was conducted on the main SSI parameters to select the most effective input *** limit state criteria were used for the seismic evaluation within the process.A new global seismic assessment ratio was introduced that considers both serviceability and strength aspects by utilizing three different engineering demand parameters(EDPs).The proposed framework is novel because it enables the designer to seismically assess the structure,while simultaneously considering different EDPs and multiple limit ***,the framework provides recommendations for building component design based on the newly introduced global seismic assessment ratio,which considers different levels of seismic *** proposed framework was validated through comparison using non-linear time history(NLTH)*** results show that the proposed framework provides more accurate results than conventional ***,the generalization potential of the proposed framework was tested by investigating two different types of structural irregularities,namely,stiffness and mass *** results from the framework were in good agreement with the NLTH analysis results for the selected case studies,and peak ground acceleration(PGA)was found to be the most influential input parameter in the assessment process for the case study models *** proposed framework shows high generalization potential for low-to mid-rise structures.

关键词： seismic hazard artificial neural network soil-structure interaction seismic analysis

Potential Antidiabetic and Anti-Genotoxic Activities of Silver Nanoparticles of Alkaloid Extract of Rhazya stricta in Rat Animal Model

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Phyton-International Journal of Experimental Botany 2021年第6期90卷 1749-1762页

作者： mohammed ali Ashehri Biology Department Faculty of ScienceUniversity of TabukTabuk47512Saudi Arabia

In most of Arabian courtiers Rhazya stricta is extensively utilized in public medicine for several diseases *** this study,crude alkaloid extract of ***(CAERS)coated with silver nanoparticles(CAERS-AgNPs)as potential treatment against diabetes in DM animal model was *** albino male rats(n=80)were injected with STZ to induce Diabetes Mellitus type-2(DM).DM-rats were injected different doses of CAERS or CAERS-nanoparticles(CAERS-NPs)for 2 *** results exhibited that mRNA expression of insulin and insulin receptor was down-regulated,activity levels of antioxidant enzymes were decreased,generation of ROS mediated DNA adducts and apoptosis in DM-rats was increased significantly than those in negative control *** contrast,the expression of insulin and insulin receptor genes was up-regulated,activity levels of antioxidant enzymes,ROS generation,DNA adducts and apoptosis incidence in DM-rats supplemented with high dose of CAERS and all doses of CAERS-NPs were *** conclusion:*** nanoparticles improved the anti-diabetic effect of the plant much more than the powder form of the *** action could be attributed to modification of the chemical and physical properties of the plant *** properties modification might be improved the ability of plant compounds to penetrate the cell membrane which facilitating release of plant materials into the target cells.

关键词： Diabetes Rhazya stricta nanotechnology gene expression DNA damage apoptosis

Anti-wear properties evaluation of frictional sliding interfaces in automobile engines lubricated by copper/graphene nanolubricants

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Friction 2020年第5期8卷 905-916页

作者： mohamed Kamal Ahmed ali Xianjun HOU mohamed AAABDELKAREEM Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Automotive and Tractors Engineering Department Faculty of EngineeringMinia UniversityEl-Minia 61111Egypt Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan 430070China

Owing to the significance of improving fuel economy, reducing emissions, and extending the durability of engine components, this study focused on the tribological performance of nano-additives. In this study, copper (Cu) and graphene (Gr) nanomaterials were dispersed in a fully formulated engine oil (5W-30) with different concentrations. The tribological trials were investigated under various speeds and loads, utilizing a reciprocating tribometer to mimic the ring/liner interfaces in the engine. The frictional surface morphologies were com-prehensively analyzed using electron probe X-ray microanalysis (EPMA), field emission scanning electron microscopy (FESEM), energy dispersive spectrometer (EDS), and three dimensional (3D) surface profilometry to explore the mechanisms responsible for improving the tribological performance of the frictional sliding parts in the engine. The tribological test results illustrated that lubrication by nano-additives reduced the wear rate (WR) and friction coefficient (COF) by 25%–30% and 26.5%–32.6%, respectively, as compared with 5W-30. The results showed that this is a promising approach for increasing the durability and lifespan of frictional sliding components and fuel economy in automobile engines.

关键词： engine tribology nanomaterial nanolubricant friction wear tribofilm