Raspberry ketone attenuates high-fat diet-induced obesity by improving metabolic homeostasis in rats

作     者：Ali Alkaladi Haytham Ali Aaser MAbdelazim Mohamed Afifi Mohammed Baeshen Ammar AL-Farga Ali Alkaladi;Haytham Ali;Aaser M. Abdelazim;Mohamed Afifi;Mohammed Baeshen;Ammar AL-Farga

作者机构：University of JeddahCollege of ScienceDepartment of BiologyJeddahSaudi Arabia University of JeddahCollege of ScienceDepartment of BiochemistryJeddahSaudi Arabia Department of BiochemistryFaculty of Vet.MedicineZagazig UniversityZagazigEgypt Department of Basic Medical SciencesCollege of Applied Medical SciencesUniversity of BishaBishaSaudi Arabia 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2020年第10卷第1期

页      面：18-22页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：funded by the University of Jeddah Saudi Arabia under Grant No(UJ-18-18-DR) 

主　　题：Raspberry ketone Obesity Molecular mechanism 

摘      要：Objective:To investigate the molecular mechanisms of the antiobese effect of raspberry ketone against high-fat diet fed ***:Fifty adult male rats were randomly assigned to receive a standard diet,a high fat diet,and the high-fat diet and 0.5%,1%or 2%raspberry *** weight,biochemical parameters and gene expression of CCAAT enhancer-binding protein(C/EBP)-δ,fatty acid synthase(FAS),acetyl Co A carboxylase(ACC),peroxisome proliferator-activated receptor alpha(PPAR-α),hormone-sensitive lipase(HSL)and hepatic carnitine palmitoyltransferase 1A(CPT1A)were ***:Body weight,blood glucose,insulin,total lipids,triacylglycerols,total cholesterol and low-density lipoprotein cholesterol were increased in high-fat diet fed *** high fat diet-induced changes were attenuated by treatment with raspberry ***-density lipoprotein cholesterol was decreased in highfat diet fed rats but increased in rats treated with raspberry *** investigations showed induction of gene expression of C/EBP-δ,FAS,ACC,CPT1A and inhibition of gene expression of PPAR-αand HSL in high-fat diet fed rats as compared with *** ketone treament reversed these changes except ***:Raspberry ketone can prevent obesity induced by a high-fat diet in rats by induction of the expression of enzymes,controlling lipolysis and fatty acidsβoxidation as well as inhibition of gene expressions of adipogenic factors.