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Dill tablet: a potential antioxidant and anti-diabetic medicine

Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 696-702页

作者： Ebrahim Abbasi Oshaghi Heidar Tavilani Iraj Khodadadi mohammad taghi goodarzi Department of Clinical Biochemistry School of Medicine Hamadan University of Medical Sciences Research Center for Molecular Medicine Hamadan University of Medical Sciences

Objective:To evaluate the antiglycation and antioxidant properties of the dill tablet, an herbal product used in Iran as a hypolipidemic medicine. Methods: In this descriptive study, the antioxidant and antiradical properties of dill tablet at dif erent concentration(0.032, 0.065, 0.125, 0.25, 0.5 and 1 mg/m L) were measured. The total phenolic, l avonols and l avonoid, alkaloids, anthocyanin, tannin and saponin contents in dill tablet were determined. Furthermore, antiglycation properties of dill tablet were assayed. In the in vivo experiments, male rats were randomly divided into three groups(n = 6): Group 1: normal rats; Group 2: diabetic rats; Group 3: diabetic rats + 300 mg/kg dill tablet, and Group 4: diabetic rats + 100 mg/kg dill tablet. After 2 months, the blood glucose was measured enzymatically and advanced glycation end-products(AGEs) formation was determined using a l uorometric ***: Our results illustrated that different concentrations of dill tablet had significant antioxidant activity. Dill tablet markedly declined AGEs formation and fructosamine levels(P < 0.001) compared with glycated sample. Oxidation of protein carbonyl and thiol group was signii cantly reduced by dill tablet in a dose dependent manner(P < 0.001). Formation of amyloid cross-β and fragmentation were markedly inhibited by dill tablet(P < 0.001) compared with glycated sample. After 2 months, fasting blood glucose levels(P < 0.001) and AGEs formation(P < 0.05) were signii cantly reduced by dill tablet in diabetic animals. Conclusions: Dill tablet exhibited significant antiglycation and antioxidant activities. This study provides a scientii c basis for using dill in treatment of diabetic patients.

关键词： Anethum graveolens Antioxidants Flavonoids Hypoglycemic agents Herbal medicine Dill

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Bayesian estimation of the time-varying reproduction number for pulmonary tuberculosis in Iran:A registry-based study from 2018 to 2022 using new smear-positive cases

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Infectious Disease Modelling 2024年第3期9卷 963-974页

作者： Maryam Rastegar Eisa Nazar Mahshid Nasehi Saeed Sharafi Vahid Fakoor mohammad taghi Shakeri Department of Biostatistics School of HealthMashhad University of Medical SciencesMashhadIran Orthopedic Research Center Mazandaran University of Medical SciencesSariIran Centre for Communicable Diseases Control Ministry of Health and Medical EducationTehranIran Department of Statistics Faculty of Mathematical SciencesFerdowsi University of MashhadMashhadIran Social Determinants of Health Research Center Mashhad University of Medical SciencesMashhadIran Department of Epidemiology School of Public HealthIran University of Medical SciencesTehran

Introduction Tuberculosis(TB)is one of the most prevalent infectious diseases in the world,causing major public health problems in developing *** rate of TB incidence in Iran was estimated to be 13 per 100,000 in *** study aimed to estimate the reproduction number and serial interval for pulmonary tuberculosis in *** and methods The present national historical cohort study was conducted from March 2018 to March 2022 based on data from the National Tuberculosis and Leprosy Registration Center of Iran's Ministry of Health and Medical Education(MOHME).The study included 30,762 tuberculosis cases and 16,165 new smear-positive pulmonary tuberculosis patients in *** estimated the reproduction number of pulmonary tuberculosis in a Bayesian framework,which can incorporate uncertainty in estimating *** analyses were accomplished in R *** The mean age at diagnosis of patients was 52.3±21.2 years,and most patients were in the 35–63 age group(37.1%).Among the data,9121(56.4%)cases were males,and 7044(43.6%)were *** patients,7459(46.1%)had a delayed diagnosis between 1 and 3 ***,3039(18.8%)cases were non-Iranians,and 2978(98%)were *** time-varying reproduction number for pulmonary tuberculosis disease was calculated at an average of 1.06±0.05(95%Crl 0.96–1.15).Conclusions In this study,the incidence and the time-varying reproduction number of pulmonary tuberculosis showed the same *** mean of the time-varying reproduction number indicated that each infected person is causing at least one new infection over time,and the chain of transmission is not being disrupted.

关键词： Reproduction number Bayesian modeling Tuberculosis Iran

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The effect of celastrol in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cell lines

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Oncology Research 2024年第7期32卷 1231-1237页

作者： mohammad-taghi MORADI DHIYA ALTEMEMY MAJID ASADI-SAMANI PEGAH KHOSRAVIAN MARZIYEH SOLTANI LEILA HASHEMI AZADEH SAMIEI-SEFAT Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Pharmaceutics College of PharmacyAl-Zahraa University for WomenKarbalaIraq Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran

Background:Despite the availability of chemotherapy drugs such as 5-ﬂuorouracil(5-FU),the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side *** study aimed to investigate the effect of celastrol in combination with the chemotherapy drug 5-FU on proliferation and induction of apoptosis in human gastric cancer cell lines(AGS and EPG85-257).Materials and Methods:In this in vitro study,AGS and EPG85-257 cells were treated with different concentrations of celastrol,5-FU,and their *** proliferation was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)*** synergistic effect of 5-FU and celastrol was studied using Compusyn *** DNA content at different phases of the cell cycle and apoptosis rate was measured usingﬂow ***:Co-treatment with low concentrations(10%inhibitory concentration(IC10))of celastrol and 5-FU signiﬁcantly reduced IC50(p<0.05)so that 48 h after treatment,IC50 was calculated at 3.77 and 6.9μM for celastrol,20.7 and 11.6μM for 5-FU,and 5.03 and 4.57μM for their combination for AGS and EPG85-257 cells,*** mean percentage of apoptosis for AGS cells treated with celastrol,5-FU,and their combination was obtained 23.9,41.2,and 61.9,and for EPG85-257 cells 5.65,46.9,and 55.7,*** addition,the 5-FU and celastrol-5-FU combination induced cell cycle arrest in the synthesis ***:Although celastrol could decrease the concentration of 5-ﬂuorouracil that sufﬁced to suppress gastric cancer cells,additional studies are required to arrive at conclusive evidence on the anticancer effects of celastrol.

关键词： Gastric cancer Celastrol Terpenoid Cell cycle regulation Apoptosis Synergism

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Isoimperatorin alleviates acetic acid-induced colitis in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 147-153页

作者： Saied goodarzi Amir Hossein Abdolghaffari Behnaz Najafi Mostafa Pirali Hamedani Saeed Tavakoli Mahshad Marvi Maryam Baeeri Narguess Yassa Abbas Hadjiakhoondi mohammad Abdollahi Zahra Tofighi Medicinal Plants Research Center Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran International Campus School of Pharmacy Tehran University of Medical SciencesTehranIran Toxicology and Diseases group The Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehranIran

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis ***:Colitis was induced by intracolonic administration of acetic acid solution(4%v/v)in *** were divided into six groups including the sham group,the negative control group,the dexamethasone-treated group,and the groups treated with isoimperatorin(0.1,1,and 10 mg/kg/d by gavage).The treatments were administered for three days and then colonic status was assessed by macroscopic,histopathological,and biochemical ***:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced *** also significantly reduced myeloperoxidase,TNF-α,IL-1β,and malodialdehyde ***:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

关键词： Isoimperatorin Inflammatory bowel disease Acetic acid Colitis TNF-α IL-1β

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Mechanical properties and microstructural evolution of rheocast A356 semi-solid slurry prepared by annular electromagnetic stirring

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China Foundry 2023年第4期20卷 315-328页

作者： mohammad taghi Asadi Khanouki Department of Materials and Metallurgy Engineering Shahid Bahonar University of KermanP.O.Box ***KermanIran Mineral Industries Research Center(MIRC) Shahid Bahonar University of KermanP.O.Box ***KermanIran

Nowadays,having an effective technique in preparing semi-solid slurries for rheocasting process seems to be an essential *** this study,semi-solid slurry of A356 aluminum alloy was prepared by three-phase annular electromagnetic stirring(A-EMS)technique under different *** effects of stirring current,pouring temperature and stirring time on microstructural evolution,mean particle size,shape factor and solid fraction were *** rheocasting process was carried out by using a drop weight setup and to inject the prepared semi-solid slurry in optimal conditions into the step-die *** filling behavior and mechanical properties of parts were *** evolution showed that the best semi-solid slurry which had fine spherical particles with the average size of~27μm and a shape factor of~0.8 was achieved at the stirring current of 70 A,melt pouring temperature of 670℃,and stirring time of 30 *** these conditions,the step-die cavity was completely filled at die preheating temperature of 470℃.The hardness increases by decreasing step thickness as well as die preheating ***,the tensile properties are improved at lower die preheating *** fracture surface,which consists of a complex topography,indicates a typical ductile fracture.

关键词： semi-solid slurry annular electromagnetic stirring rheocast A356 aluminum alloy microstructural evolution mechanical properties magnetic flux density

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Analytical modeling of static behavior of electrostatically actuatednano/micromirrors considering van der Waals forces

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Acta Mechanica Sinica 2012年第3期28卷 729-736页

作者： Hamid Moeenfard mohammad taghi Ahmadian School of Mechanical Engineering Sharif University of Technology Center of Excellence in Design Robotics and AutomationSchool of Mechanical EngineeringSharif University of Technology

In this paper, the effect of van der Waals （vdW） force on the pull-in behavior of electrostatically actuated nano/micromirrors is investigated. First, the minimum po- tential energy principle is utilized to find the equation gov- erning the static behavior of nano/micromirror under electro- static and vdW forces. Then, the stability of static equilib- rium points is analyzed using the energy method. It is found that when there exist two equilibrium points, the smaller one is stable and the larger one is unstable. The effects of dif- ferent design parameters on the mirror＇s pull-in angle and pull-in voltage are studied and it is found that vdW force can considerably reduce the stability limit of the mirror. At the end, the nonlinear equilibrium equation is solved numer- ically and analytically using homotopy perturbation method （HPM）. It is observed that a sixth order perturbation approx- imation can precisely model the mirror＇s behavior. The re- suits of this paper can be used for stable operation design and safe fabrication of torsional nano/micro actuators.

关键词： Nano/micromirror Electrostatic actuation vdW force Pull-in. Homotopy perturbation method (HPM)

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A Novel Method of Deinterleaving Radar Pulse Sequences Based on a Modified DBSCAN Algorithm

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China Communications 2023年第2期20卷 198-215页

作者： Abolfazl Dadgarnia mohammad taghi Sadeghi Department of Electrical Engineering Yazd UniversityYazdIran

A modified DBSCAN algorithm is presented for deinterleaving of radar pulses in modern EW environments.A main characteristic of the proposed method is that using only time of arrival of pulses,the method can sort the pulses *** PDW information such as rise time,carrier frequency,pulse width,modulation on pulse,fall time and direction of arrival are not *** identify the valid PRIs in a set of interleaved pulses,an innovative modification of the DBSCAN algorithm is introduced which is accurate and easy to *** proposed method determines valid PRIs more accurately and neglects the spurious ones more efficiently as compared to the classical histogram based algorithms such as ***,without specifying any input parameter,the proposed method can deinterleave radar pulses while up to 30%jitter is present in the associated *** accuracy and efficiency of the proposed method are verified by computer simulations and real data *** simulations are based on different real and operational scenarios where the presence of missing and spurious pulses are also ***,the simulation results can be of practical significance.

关键词： deinterleaving radar pulse sequences density based clustering pulse descriptor word

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Nanocrystalline Growth Activation Energy of Zirconia Polymorphs Synthesized by Mechanochemical Technique

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Journal of Materials Science & Technology 2014年第4期30卷 387-393页

作者： taghi Dallali Isfahani Jafar Javadpour Alireza Khav Massoud goodarzi Hamid Reza Rezaie Department of Materials Science and Engineering Golpayegan University of Technology School of Metallurgy and Materials Engineering Iran University of Science and Technology(IUST)

The synthesis of ZrO2 by mechanochemical reaction using ZrCI4 and CaO as raw materials and subsequent annealing of the products were investigated. The effect of thermal treatment on the structural evolution and morphological characteristics of the nanopowders was studied by X-ray diffractometry, Raman spectroscopy, transmission electron microscopy, scanning electron microscopy, differential thermal analysis and Rietveld refinement. The results showed that the average crystallite size of Zr02 was less than 100 nm up to around 1100 ℃. The activation energy for ZrO2 nanocrystallite growth during calcination was calculated to be about 13,715 and 27,333 J/too Mechanism of the nanocrysta for tetragonal （t-ZrO2） and monoclinic （m-Zr02） polymorphs, respectively. ite growth of the ZrO2 polymorphs during annealing is primarily investigated.

关键词： Zirconia nanoparticles Mechanochemical synthesis Characterization methods Activation energy Phase transformation

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The first occurrence of Phlebopteris dunkeri and P. woodwardii(Matoniaceae) from the middle Jurassic of Iran

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Journal of Palaeogeography 2019年第1期8卷 99-108页

作者： mohammad taghi Badihagh Dieter Uhl School of Geology Faculty of Science University of Tehran Senckenberg Forschungsinstitut und Naturmuseum Frankfurt

The coal horizons of the Middle Jurassic Hojedk Formation of East-Central Iran are fossiliferous, bearing numerous well-preserved fossil plants, comparable to the Shemshak Group/Formation in the Alborz Mountains in Northern Iran. Here we present two recently discovered fossil taxa from the Middle Jurassic Hojedk Formation of the Tabas Block(Central Iran). Based on their distinct morphologies, impression/compression specimens can be assigned to Phlebopteris dunkeri(Schenk) Schenk(Palaeontographica 23: 157–163, 1875) and P. woodwardii Leckenby(Quarterly Journal of the Geological Society 20(1–2): 74–82, 1864), belonging to Matoniaceae. This is the first record of these two taxa in Iran. Taxa belonging to Equisetaceae, Marattiaceae, Dipteridaceae, Schizaeaceae, Dicksoniaceae,Caytoniales, Bennettitales, Cycadales and Podozamitaceae were observed as accompanying taxa in the studied section. Ecology comparison of the Hojedk Formation plant fossils with the extant relatives of the fossil plant taxa occurring in these deposits indicates accumulation of the host strata under a moist warm(tropical to subtropical)climate during the Middle Jurassic.

关键词： Matoniaceae Phlebopteris Middle Jurassic Palaeoecology Central Iran

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Mineralogical and sink-float studies of Jajarm low-grade bauxite

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International Journal of Minerals,Metallurgy and Materials 2010年第3期17卷 251-256页

作者： mohammad Zarbayani Esmaeil Jorjani Mirsaleh Mirmohammadi mohammad taghi Shadloo mohammad Noaparast Science and Research Branch Islamic Azad University School of Mining Engineering University of Tehran Jajarm Alumina Company

Jajarm＇s bauxite deposits are mainly diasporic, and they have a low mass ratio of Al2O3/SiO2. It is necessary to increase the run-of-mine mass ratio before feeding the material to the Bayer process. Chemical analysis indicated that the low-grade bauxite sample from Jajarm contained 43.9wt% Al2O3 and 13.35wt% SiO2, resulting in a mass ratio of 3.29. According to mineralogical studies, the presence of aluminosilicate minerals such as kaolinite, illite, and quartz was the main reason for the decrease of the mass ratio. Microscopic observations revealed that, with the size reduction from -1000＋710 to -38 μm, the liberation degree of diaspore increased from 10% to 60%, and that of aluminosilicates increased from 20% to 85%. Heavy liquids with the densities of 2.8, 3.0, 3.2, and 3.4 g/cm3 were used to evaluate the heavy media separation in three sizes, i.e., -3350＋710, -710＋212, and -212＋125 μm. Laboratory studies confirm that the density of 3.2 g/cm3 can produce the concentrates （in sunk fractions） with recoveries of 89.09%, 91.24%, and 84.68% with the Al2O3/SiO2 mass ratios of 5.03, 5.16, and 5.15 for the -3350＋710, -710＋212, and -212＋ 125 μ m sizes, respectively.

关键词： bauxite diaspore aluminosilicate mass ratio heavy media

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