Dill tablet: a potential antioxidant and anti-diabetic medicine
Dill tablet: a potential antioxidant and anti-diabetic medicine作者机构：Department of Clinical Biochemistry School of Medicine Hamadan University of Medical Sciences Research Center for Molecular Medicine Hamadan University of Medical Sciences
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2015年第5卷第9期
页 面：696-702页
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by Hamadan University of Medical Sciences Hamadan Iran(Grant No.930126463)
主 题：Anethum graveolens Antioxidants Flavonoids Hypoglycemic agents Herbal medicine Dill
摘 要：Objective:To evaluate the antiglycation and antioxidant properties of the dill tablet, an herbal product used in Iran as a hypolipidemic medicine. Methods: In this descriptive study, the antioxidant and antiradical properties of dill tablet at dif erent concentration(0.032, 0.065, 0.125, 0.25, 0.5 and 1 mg/m L) were measured. The total phenolic, l avonols and l avonoid, alkaloids, anthocyanin, tannin and saponin contents in dill tablet were determined. Furthermore, antiglycation properties of dill tablet were assayed. In the in vivo experiments, male rats were randomly divided into three groups(n = 6): Group 1: normal rats; Group 2: diabetic rats; Group 3: diabetic rats + 300 mg/kg dill tablet, and Group 4: diabetic rats + 100 mg/kg dill tablet. After 2 months, the blood glucose was measured enzymatically and advanced glycation end-products(AGEs) formation was determined using a l uorometric ***: Our results illustrated that different concentrations of dill tablet had significant antioxidant activity. Dill tablet markedly declined AGEs formation and fructosamine levels(P 0.001) compared with glycated sample. Oxidation of protein carbonyl and thiol group was signii cantly reduced by dill tablet in a dose dependent manner(P 0.001). Formation of amyloid cross-β and fragmentation were markedly inhibited by dill tablet(P 0.001) compared with glycated sample. After 2 months, fasting blood glucose levels(P 0.001) and AGEs formation(P 0.05) were signii cantly reduced by dill tablet in diabetic animals. Conclusions: Dill tablet exhibited significant antiglycation and antioxidant activities. This study provides a scientii c basis for using dill in treatment of diabetic patients.
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