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Cytotoxic,antibacterial and analgesic activities of Rhaphidophora glauca(Wall.)Schott leaves

Journal of Coastal Life Medicine 2016年第9期4卷 750-756页

作者： Mir Muhammad Nasir Uddin Raju Dash mohammad shah hafez kabir MdMominur Rahman mohammad Nazmul Islam Arkajyoti Paul Department of Pharmacy University of ChittagongChittagong-4331Bangladesh Department of Pharmacy BGC Trust University BangladeshChittagong-4000Bangladesh Department of Pharmacy International Islamic University ChittagongChittagong-4203Bangladesh

Objective:To investigation of cytotoxic,antimicrobial and analgesic activities of different fractions of Rhaphidophora glauca(Wall.)***:Two partially purified aqueous methanolic fractions from ethyl acetate extract(AMF-1)and chloroform extract(AMF-2)obtained from the partitioning were used in *** cytotoxic effect was determined by brine shrimp lethality *** activity was investigated by disc diffusion and minimal inhibitory concentration *** plate method and acetic acid test was used for determining analgesic ***:The LC_(50)values of AMF-1 and AMF-2 were found to be 287.73 and 428.54μg/mL respectively,where colchicines showed LC_(50)of 11.16μg/*** zone of inhibition of the fractions AMF-1 and AMF-2 was found to be in the range of 8-26 mm in 2000μg/disc,as compared to reference antibiotics kanamycin(11-28 mm at 30μg/disc)and ciprofloxacin(20-25 mm at 30μg/disc)indicating the antibacterial *** hot plate test,the highest pain inhibitory activity was found at a dose of 250 mg/kg for AMF-1 which was statistically significant(P<0.05)compared to both positive and negative control at 30 min *** acid induced model,both AMF-1 and AMF-2 at a dose of 500 mg/kg showed significant activity compared to positive and negative ***:This study found that Rhaphidophora glauca possesses potential cytotoxic,antibacterial and analgesic *** study may be needed to isolate the bioactive compounds responsible for different activities with subsequent mechanistic study.

关键词： Rhaphidophora glauca Cytotoxicity Antimicrobial Analgesic Kanamycin

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Curculigo recurvata *** exhibits anti-nociceptive and anti-diarrheal effects in Albino mice and an in silico model

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Animal Models and Experimental Medicine 2020年第2期3卷 169-181页

作者： Shabbir Ahmad Mst.Samima Nasrin A.S.M.Ali Reza Nishan Chakrabarty Md.Akramul Hoque Sanjida Islam mohammad shah hafez kabir Syed Mohammed Tareq A.H.M.Khurshid Alam Md.Areeful Haque Md.Saiful Islam Arman Department of Pharmacy International Islamic University ChittagongChittagongBangladesh Department of Biochemistry&Molecular Biology University of ChittagongChittagongBangladesh Department of Chemistry Wayne State UniversityDetroitMIUSA Department of Pharmacy University of RajshahiRajshahiBangladesh Drug and Herbal Research Centre Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia

Background: Curculigo recurvata(C. recurvata) is an enthnomedicinally important herb reported to have significant medicinal values. The present study aimed to explore the in vivo and in silico anti-nociceptive and anti-diarrheal effects of a C. recurvate rhizome methanol extract(Me-RCR).Methods: The analgesic effects of Me-RCR were assessed using acetic acid-induced writhing and the formalin-induced flicking test. The drugs were administered intraperitoneally(IP) at doses of 200 and 400 mg/kg body weight(bw). Anti-diarrheal activity was evaluated by assessing intestinal motility, hypersecretion, and fecal score in mice at oral doses of 200 and 400 mg/kg·bw. Computer facilitated analyses for anti-nociceptive and anti-diarrheal activities of three isolated compounds from C. recurvata were undertaken to identify the best-fit ***: The Me-RCR showed significant(P <.05) peripheral anti-nociception at the highest dose. The extract inhibited both early and late phases of nociception in the formalin-induced writhing test. In the castor oil-induced diarrhoea model, the extract significantly(P <.05) prolonged the onset time of diarrhoea, inhibited percentage of diarrhoea, and decreased both the volume and weight of intestinal contents. Rates of intestinal fluid accumulation inhibition were(33.61 ± 1.00)% and(46.44 ± 0.89)% at Me-RCR doses of 200 and 400 mg/kg·bw, respectively. Moreover, a significant(P <.05) reduction in gastrointestinal motility was observed. An absorption, distribution, metabolism, excretion and/or toxicity(ADME/T) test showed that the selected compounds yielded promising results, satisfying Lipinski's rule of five for predicting drug-like potential. Notably, of the three phytoconstituents curculigine and isocurculigine possessed the highest affinity for the COX-1 and COX-2. Isocurculigine was also identified as the most effective anti-diarrheal compound in the computer-facilitated ***: An extract of the plant C. recurvata

关键词： analgesic anti-diarrheal anti-nociceptive curculigine Curculigo recurvata isocurculigine

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Comparative study of hypoglycemic and antibacterial activity of organic extracts of four Bangladeshi plants

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Journal of Coastal Life Medicine 2016年第3期4卷 231-235页

作者： mohammad shah hafez kabir Shabbir Ahmad Md.Sofi Mahamoud Nishan Chakrabarty Md.Akramul Hoque Mohammed Munawar Hossain Md.Nazim Uddin Chy Mohammed Shoibe Department of Pharmacy International Islamic University ChittagongChittagongBangladesh

Objective:To examine hypoglycemic and antibacterial activity against some Gram-positive and Gram-negative bacteria of organic extracts of four Bangladeshi ***:An in vivo hypoglycemic effect on mice model was used to check the hypoglycemic effect of four Bangladeshi herbal organic extracts viz.,roots of Curculigo recurvata ***(Satipata)(***),leaf of Amorphophallus bulbifer Roxb.(Olkachu)(***),whole plant of Thunbergia grandiflora Roxb.(Nillata)(***)and leaf of Steudnera colocasiifolia ***(Yunnan)(***)using glibenclamide as a positive control and water as a negative *** were also tested for antibacterial activity on three Grampositive and four Gram-negative bacteria by disk diffusion ***,*** and *** were extracted with methanol and *** was extracted with ***:Among all the plant extract,only ethanol extract of *** leaves at 800 mg/kg dose significantly(P<0.01)reduced fasting glucose level in normal mice as compared to standard drug glibenclamide(5 mg/kg).Ethanol extract of *** leaves at 800 mg/kg dose decreased 20.28%of blood glucose level after 2 h of administration in normal mice,where glibenclamide decreased 39.63%.Methanol extract of *** didn’t show any zone of inhibition against the tested bacteria,but other three extracts showed a wide range of zone of ***,none of the extract showed antibacterial activity against all the tested *** extract of *** showed maximum zone of inhibition against Bacillus cereus[(10.50±0.50)mm],Salmonella typhi[(16.20±1.26)mm],Escherichia coli[(13.00±1.00)mm]and ethanol extract of *** showed maximum zone of inhibition against Staphylococcus aureus[(11.20±1.26)mm],Bacillus subtilis[(12.00±0.50)mm],Salmonella paratyphi[(10.80±0.29)mm].Only methanol extract of *** showed(8.50±0.50)mm and(7.20±0.76)mm zone of inhibition against P

关键词： Curculigo recurvata Steudnera colocasiifolia Hypoglycemic Antibacterial Disc diffusion method

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Antidepressant,anxiolytic and anti-nociceptive activities of ethanol extract of Steudnera colocasiifolia *** leaves in mice model

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Journal of Coastal Life Medicine 2015年第11期 890-894页

作者： mohammad shah hafez kabir Mohammed Munawar Hossain Md.Mominur Rahman Shabbir Ahmad Abul Hasanat Tanvir Ahmad Chowdhury Md.Akramul Hoque Nishan Chakrabarty Md.Shakhawat Hossain Department of Pharmacy International Islamic University ChittagongBangladesh

Objective:To estimate the antidepressant,anxiolytic and antinociceptive activities of ethanol extract of Steudnera colocasiifolia ***(***)***:Swiss albino mice treated with 1%Tween solution,standard drugs and ethanol extract of ***,respectively,were subjected to the neurological and antinociceptive *** tail suspension test and forced swimming test were used for testing antidepressant activity,where the parameter is the measurement of immobility *** activity was evaluated by hole board ***-nociceptive potential of the extract was also screened for centrally acting analgesic activity by using formalin induced licking response model and acetic acid induced writhing test was used for testing peripheral analgesic ***:Ethanol extract of *** significantly decreased the period of immobility in both tested models(tail suspension and forced swimming models)of antidepressant *** the hole board model,there was a dose dependant(at 100 and 200 mg/kg)and a significant increase in the number of head dipping by comparing with control(1%Tween solution)(P<0.05 and P<0.001).In formalin induced licking model,a significant inhibition of pain compared to standard diclofenac sodium was observed(P<0.05 and P<0.001).In acetic acid induced test,there was a significant reduction of writhing response and pain in mice treated with leaves extract of *** at 200 mg/kg body weight(P<0.05 and P<0.001).Conclusions:The results proofed the prospective antidepressant,anxiolytic and antinociceptive activities of ethanol extract of *** leaves.

关键词： Steudnera colocasiifolia K.Koch Antinociceptive Antidepressant Anxiolytic Hole board

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Wind Field in Greater Tehran Area (GTA) in Autumn Season

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Journal of Thermal Science 2000年第3期9卷 205-210页

作者： Kh. Badii B. Dabir N.S. Moussiopoulos P. Sahm S.M. Alaie Th. Nitis (Chemical Engineering Department, Amir-kabir University of Technology, hafez Ave., Tehran, Iran. Mechanical Engineering Department, Aristotle University of Thessalonild, Thessaloniki, Chemical Engineering Department Amir-Kabir University of Technology Tehran Iran Mechanical Engineering Department Aristotle University of Thessaloniki Thessaloniki Greece

Air Pollution is one of the main contaminants in industrial cities like Tehran, but it depends on many factors. One of the most important factors is wind field. Wind field shows how the pollutants transfer by convective mechanism. Tehran as the most polluted city of Iran (or may be Middle East) locates in a mountainous situation and is surrounded from two sides by high mountains and from two sides by desert. Therefore, the topography of Greater Tehran Area is so complex and needs more attention. We have studied the air pollution in Tehran from this point of view in this paper and used MEMO software for simulation of wind field in this area. The results show good agreement with experimental observations and show stronger wind from south to north and west-south to east-north in days and then night in reverse direction. It causes that the pollutants remain at urban area and the concentrations of pollutants reach to a serious level.

关键词： wind field air pollution inversion modelling MEMO software.

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