Comparative study of hypoglycemic and antibacterial activity of organic extracts of four Bangladeshi plants
Comparative study of hypoglycemic and antibacterial activity of organic extracts of four Bangladeshi plants作者机构：Department of PharmacyInternational Islamic University ChittagongChittagongBangladesh
出 版 物：《Journal of Coastal Life Medicine》 (海岸生命医学杂志（英文版）)
年 卷 期：2016年第4卷第3期
页 面：231-235页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by Department of Pharmacy International Islamic University Chittagong Bangladesh with a research grant to accomplish the study(Grant No.Pharm-P&D 71/09-15/09)
主 题：Curculigo recurvata Steudnera colocasiifolia Hypoglycemic Antibacterial Disc diffusion method
摘 要：Objective:To examine hypoglycemic and antibacterial activity against some Gram-positive and Gram-negative bacteria of organic extracts of four Bangladeshi ***:An in vivo hypoglycemic effect on mice model was used to check the hypoglycemic effect of four Bangladeshi herbal organic extracts viz.,roots of Curculigo recurvata ***(Satipata)(***),leaf of Amorphophallus bulbifer Roxb.(Olkachu)(***),whole plant of Thunbergia grandiflora Roxb.(Nillata)(***)and leaf of Steudnera colocasiifolia ***(Yunnan)(***)using glibenclamide as a positive control and water as a negative *** were also tested for antibacterial activity on three Grampositive and four Gram-negative bacteria by disk diffusion ***,*** and *** were extracted with methanol and *** was extracted with ***:Among all the plant extract,only ethanol extract of *** leaves at 800 mg/kg dose significantly(P0.01)reduced fasting glucose level in normal mice as compared to standard drug glibenclamide(5 mg/kg).Ethanol extract of *** leaves at 800 mg/kg dose decreased 20.28%of blood glucose level after 2 h of administration in normal mice,where glibenclamide decreased 39.63%.Methanol extract of *** didn’t show any zone of inhibition against the tested bacteria,but other three extracts showed a wide range of zone of ***,none of the extract showed antibacterial activity against all the tested *** extract of *** showed maximum zone of inhibition against Bacillus cereus[(10.50±0.50)mm],Salmonella typhi[(16.20±1.26)mm],Escherichia coli[(13.00±1.00)mm]and ethanol extract of *** showed maximum zone of inhibition against Staphylococcus aureus[(11.20±1.26)mm],Bacillus subtilis[(12.00±0.50)mm],Salmonella paratyphi[(10.80±0.29)mm].Only methanol extract of *** showed(8.50±0.50)mm and(7.20±0.76)mm zone of inhibition against P
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