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Decoding molecular mechanisms:brain aging and Alzheimer's disease

Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali Syed Hammad Qaiser mohammad uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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Transcranial magnetic stimulation in animal models of neurodegeneration

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Neural Regeneration Research 2022年第2期17卷 251-265页

作者： mohammad uzair Turki Abualait Muhammad Arshad Woo-Kyoung Yoo Ali Mir Reem Fahd Bunyan Shahid Bashir Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University IslamabadPakistan College of Applied Medical Sciences Imam Abdulrahman Bin Faisal UniversityDammamSaudi Arabia Department of Physical Medicine and Rehabilitation Hallym University College of MedicineAnyangSouth Korea Hallym Institute for Translational Genomics&Bioinformatics Hallym University College of MedicineAnyangSouth Korea Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

Brain stimulation techniques offer powerful means of modulating the physiology of specific neural structures. In recent years, non-invasive brain stimulation techniques, such as transcranial magnetic stimulation(TMS) and transcranial direct current stimulation, have emerged as therapeutic tools for neurology and neuroscience. However, the possible repercussions of these techniques remain unclear, and there are few reports on the incisive recovery mechanisms through brain stimulation. Although several studies have recommended the use of non-invasive brain stimulation in clinical neuroscience, with a special emphasis on TMS, the suggested mechanisms of action have not been confirmed directly at the neural level. Insights into the neural mechanisms of non-invasive brain stimulation would unveil the strategies necessary to enhance the safety and efficacy of this progressive approach. Therefore, animal studies investigating the mechanisms of TMSinduced recovery at the neural level are crucial for the elaboration of non-invasive brain stimulation. Translational research done using animal models has several advantages and is able to investigate knowledge gaps by directly targeting neuronal levels. In this review, we have discussed the role of TMS in different animal models, the impact of animal studies on various disease states, and the findings regarding brain function of animal models after TMS in pharmacology research.

关键词： Alzheimer's disease depression glial cells neurorehabilitation Parkinson's disease repetitive transcranial magnetic stimulation transcranial direct current stimulation transcranial magnetic stimulation

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Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

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Neural Regeneration Research 2023年第5期18卷 959-968页

作者： Syed Aoun Mehmood Sherazi Asim Abbasi Abdullah Jamil mohammad uzair Ayesha Ikram Shanzay Qamar Adediji Ayomide Olamide Muhammad Arshad Peter J.Fried Milos Ljubisavljevic Ran Wang Shahid Bashir Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic UniversityIslamabadPakistan Department of Biological Sciences University of ArkansasFayettevilleARUSA Department of Pharmacology Government College UniversityFaisalabadPakistan Department of Bioinformatics and Biotechnology Government College UniversityFaisalabadPakistan Department of Chemistry Chulalongkorn UniversityThailand Department of Neurology Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive NeurologyBeth Israel Deaconess Medical Center(KS 158)Harvard Medical SchoolBostonMAUSA Department of Physiology College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Neuroscience Center King Fahad Specialist HospitalDammamSaudi Arabia

Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer’s disease. The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes. Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes(e.g., mouse, human, and rat) and their corresponding cell types, their organ-specific transcriptomes, and the tissue involved in aging. Traditional gene controllers such as DNA-and RNA-binding proteins significantly influence such programs, causing the need to sort out long non-coding RNAs, a new class of powerful gene regulatory elements. However, their functional significance in the aging process and senescence has yet to be investigated and identified. Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs. In this review article, we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes, including cellular senescence, aging, and age-related pathogenesis, which are the major hallmarks of long non-coding RNAs in aging.

关键词： aging Alzheimer’s disease DNA sequence epigenetics immune non-coding RNA oligonucleotides telomere-associated

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Origin of Quartz Cement in the Paleogene Sandstone Reservoir of Shahejie Formation,Bohai Bay Basin,China

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Acta Geologica Sinica(English Edition) 2022年第1期96卷 248-260页

作者： Muhammad KASHIF CAO Yingchang Nizam Ud DIN uzair SIDDIQUE XI Kelai Faisal REHMAN Noor AHMED GU Xihao mohammad Saleh GAGHMAN Department of Earth sciences University of SargodhaSargodha 40100Pakistan School of Geosciences China University of PetroleumQingdaoShandong 266580China College of Earth sciences and Engineering Hohai UniversityNanjing 210098China Institute of Marine Geology and Resources Ocean CollegeZhejiang UniversityZhoushanZhejiang 316021China Department of Earth sciences Quaid-I-Azam UniversityIslamabad 45320Pakistan

The precipitation of authigenic quartz plays a significant role to reduce the reservoir characteristics and enhance the stiffness of the *** Es_(1) sandstone of Shahejie Formation is acting as a significant hydrocarbon producing rock in the Nanpu *** methods like thin section petrography,cathodoluminescence(CL),scanning electron microscope(SEM,with EDS),and electron microprobe analysis has been used to reveal the origin of quartz cement as well as to evaluate the effect of quartz cement on reservoir *** studied sandstone is classified as immature to mature feldspathic litharenite and lithic arkose and consists of quartz,feldspar,rock fragments and *** studies and SEM analysis shows that the authigenic quartz is acting a significant cement that reduces the reservoir *** clay minerals(kaolinite and mixed layer illite to smectite)are dominant in the Es_(1) sandstone,that can reduce the reservoir ***,CL and thin section analysis reveal that there are two stages of quartz cement in the studied samples;that are pore filling authigenic cement and quartz overgrowth *** inclusion homogenization temperatures shows that stages of quartz cement were developed with continuous process from 70℃ to 130℃.Quartz cements were generally originated from I/S reaction,feldspar dissolution,conversion of rock fragments and pressure *** dissolution(K-feldspar)and kaolinite to illite reaction is an insignificant silica source for the silica cement which is internally precipitated in a close system with diffusion transporting ***,quartz cement significantly enhance the rock strengthen and brittleness effectively as well as it reduce the overall reservoir quality.

关键词： origin authigenic quartz silica sources diffusion Shahejie Formation

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Resilience-oriented intentional islanding of reconfigurable distribution power systems

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Journal of Modern Power Systems and Clean Energy 2019年第4期7卷 741-752页

作者： mohammad Hossein OBOUDI mohammad mohammadI mohammad RASTEGAR Department of Power and Control Engineering School of Electrical and Computer EngineeringShiraz UniversityShirazIran

The participation of distributed energy resources in the load restoration procedure,known as intentional islanding,can significantly improve the distribution system *** system reconfiguration can effectively alter islanding procedure and thus provide an opportunity to supply more demanded energy and reduce distribution system *** addition,high-impact events such as hurricanes and earthquakes may complicate the procedure of load restoration,due to the disconnection of the distribution system from the upstream grid or concurrent component *** paper presents a two-level method for intentional islanding of a reconfigurable distribution system,considering high-impact *** thefirst level,optimal islands are selected according to the graph model of the distribution *** the second level,an optimal power flow(OPF)problem is solved to meet the operation constraints of the islands by reactive power control and demand side *** proposed problem in the first level is solved by a combination of depth first search and particle swarm optimization *** OPF problem in the second level is solved in DIgSILENT *** proposed method is implemented in the IEEE 69-bus test system,and the results show the validity and effectiveness of the proposed algorithm.

关键词： Intentional islanding Active distribution system Distributed energy resource Distribution system reconfiguration Distribution system resilience

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Global Practical Stabilization of Discrete-Time Switched Affine Systems via a General Quadratic Lyapunov Function and a Decentralized Ellipsoid

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IEEE/CAA Journal of Automatica Sinica 2021年第11期8卷 1837-1851页

作者： mohammad Hejri Department of Electrical Engineering Sahand University of TechnologySahand New TownTabriz 51335-1996Iran

This paper addresses the problem of global practical stabilization of discrete-time switched affine systems via statedependent switching *** attempts have been made to solve this problem via different types of a common quadratic Lyapunov function and an *** classical results require either the quadratic Lyapunov function or the employed ellipsoid to be of the centralized *** some cases,the ellipsoids are defined dependently as the level sets of a decentralized Lyapunov *** this paper,we extend the existing results by the simultaneous use of a general decentralized Lyapunov function and a decentralized ellipsoid parameterized *** proposed conditions provide less conservative results than existing works in the sense of the ultimate invariant set of attraction *** different approaches are proposed to extract the ultimate invariant set of attraction with a minimum size,i.e.,a purely numerical method and a numerical-analytical *** the former,both invariant and attractiveness conditions are imposed to extract the final set of matrix *** latter is established on a principle that the attractiveness of a set implies its ***,the stability conditions are derived based on only the attractiveness property as a set of matrix inequalities with a smaller *** examples are presented to prove the satisfactory operation of the proposed stabilization methods.

关键词： Decentralized quadratic Lyapunov function decentralized ellipsoid discrete-time switched affine systems practical stabilization switching power converters

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Nonlinear analysis of cable structures using the dynamic relaxation method

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Frontiers of Structural and Civil Engineering 2021年第1期15卷 253-274页

作者： mohammad REZAIEE-PAJAND mohammad mohammadI-KHATAMI Department of Civil Engineering Ferdowsi University of MashhadMashhad ***Iran

The analysis of cable structures is one of the most challenging problems for civil and mechanical *** they have highly nonlinear behavior,it is difficult to find solutions to these *** far,different assumptions and methods have been proposed to solve such *** dynamic relaxation method(DRM)is an explicit procedure for analyzing these types of *** utilize this scheme,investigators have suggested various stiffness matrices for a cable *** this study,the efficiency and suitability of six well-known proposed matrices are assessed using the *** achieve this goal,16 numerical examples and two criteria,namely,the number of iterations and the analysis time,are *** on a comprehensive comparison,the methods are ranked according to the two *** numerical findings clearly reveal the best ***,a variety of benchmark problems are suggested by the authors for future studies of cable structures.

关键词： nonlinear analysis cable structure stiffness matrix dynamic relaxation method

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Stabilizing silica nanoparticles in high saline water by using polyvinylpyrrolidone for reduction of asphaltene precipitation damage under dynamic condition

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Chinese Journal of Chemical Engineering 2019年第5期27卷 1021-1029页

作者： mohammad Reza Aghajanzadeh mohammad Sharifi Department of Petroleum Engineering Amirkabir University of Technology

In this study, the performance of stable nanofluid containing SiO2 nanoparticles dispersed and stabilized in high salinity brine for asphaltene inhibition in dynamic condition is evaluated. In the first stage of this work, the stability of silica nanoparticles in different range of water salinity(0–100000 mg·L-1) is investigated. Next, stable nanofluid containing highest salinity is selected as asphaltene inhibitor agent to inject into the damaged core sample. The estimated values of oil recovery for base case, after damage process and after inhibition of asphaltene precipitation using nanofluid are 51.6%, 36.1% and 46.7%, respectively. The results showed the reduction in core damage after using nanofluid. In addition, the relative permeability curves are plotted for the base case, after damage process and also after inhibition of asphaltene precipitation using nanofluid. Comparison of relative permeability curves shows, relative permeability of oil phase decreased after damage process as compared with the base case. But after using nanofluid the oil relative permeability curve has shifted to the right and effective permeability of oil phase has been improved.

关键词： Formation damage Enhanced oil recovery Salinity Asphaltene Core flooding Nano particles

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DEM Numerical Simulation of Abrasive Wear Characteristics of a Bioinspired Ridged Surface

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Journal of Bionic Engineering 2010年第2期7卷 175-181页

作者： mohammad Almagzoub mohammad Carlo Menon Key Laboratory of Bionic Engineering Jilin University College of Biological and Agricultural Engineering Jilin University MENRVA Group Simon Fraser University

This paper presents numerical investigations into a ridged surface whose design is inspired by the geometry of a Farrer’*** objective of the performed research is to assess if the proposed Bioinspired Ridged Surface (BRS) can potentiallyimprove wear resistance of soil-engaging components used in agricultural machinery and to validate numerical simulationsperformed using software based on the Discrete Element Method (DEM).The wear performance of the BRS is experimentallydetermined and also compared with a conventional flat *** size of soil particles and relative velocities between theabrasive sand and the testing surfaces are *** results show that the numerical simulations are in agreement withthe experimental results and support the hypothesis that abrasive wear is greatly reduced by substituting a conventional flatsurface with the BRS.

关键词： bioinspired ridged surface abrasive wear numerical simulation Discrete Element Method (DEM)

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A Unified Optimization-Based Framework to Adjust Consensus Convergence Rate and Optimize the Network Topology in Uncertain Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2021年第9期8卷 1539-1548页

作者： mohammad Saeed Sarafraz mohammad Saleh Tavazoei Department of Electrical Engineering Sharif University of TechnologyTehran 11365-9363Iran

This paper deals with the consensus problem in an uncertain multi-agent system whose agents communicate with each other through a weighted undirected(primary)*** considered multi-agent system is described by an uncertain state-space model in which the involved matrices belong to some matrix *** the main contribution of the paper,a unified optimization-based framework is proposed for simultaneously reducing the weights of the edges of the primary communication graph(optimizing the network topology)and synthesizing a controller such that the consensus in the considered uncertain multi-agent system is ensured with an adjustable convergence *** the NP-hardness nature of the optimization problem related to the aforementioned framework,this problem is relaxed such that it can be solved by regular LMI ***/practical-based examples are presented to verify the usefulness of the obtained results.

关键词： Convergence-rate element-wise uncertainty robust controller topology design

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